Alfa-Bisabolol: una revisión de las propiedades bioactivas antiflogístico
DOI:
https://doi.org/10.33448/rsd-v10i12.20618Palabras clave:
Aceites esenciales; BISA; Inflamación; Fitoquímicos.Resumen
El presente trabajo tuvo como objetivo identificar y sistematizar trabajos científicos que atribuyan al alfa-bisabolol (BISA) actividades antiflogísticas. Se trata de una revisión de la literatura, cuya selección de artículos se realizó en las bases de datos PubMed, Web of Science y Science Direct. Para fines de recolección de datos, se utilizaron las pautas PRISMA y el método de Bardin. La estrategia de búsqueda identificó 257 artículos que luego de la selección fueron elegibles para la revisión 37. Los criterios de inclusión definidos fueron: artículos originales, artículos de revisión, investigación experimental, ensayos clínicos, in vitro, in vivo y in silico, estudios de metaanálisis, en inglés, español y Lengua portuguesa. Solo se utilizaron trabajos con textos completos, accesibles y en el cronograma del estudio (enero de 2008 a julio de 2021). Se excluyó la literatura duplicada, pagada y no relacionada con el objetivo de la investigación. En cuanto al abordaje con temáticas específicas, tenemos que: 22 (59,45 %) artículos hacen referencia a los efectos antiinflamatorios, antioxidantes y analgésicos de BISA, 1 (2,70 %) publicación de revisión y 14 (37,83 %) investigan las acciones del sesquiterpeno sobre el tejido tegumentario. Del total de estudios seleccionados, el 89,18 % (n = 33) se realizaron en un entorno de laboratorio y solo el 10,82% (n = 4) utilizó otra fuente metodológica. Actualmente hay poca evidencia para informar estudios seguros sobre preparaciones tegumentarias utilizando BISA. Sin embargo, los estudios disponibles sobre las acciones antiflogísticas de BISA demuestran su eficacia antiinflamatoria, analgésica y antioxidante. Por tanto, los autores consideran que el sesquiterno tiene potencial clínico para ser utilizado en procesos inflamatorios de diferentes etiologías.
Citas
Abdulkhaleq, L. A., Assi M. A., Abdullah R., Zamri-Saad M., Taufiq-Yap Y. H., & Hezmee, M. N. M. (2018). The crucial roles of inflammatory mediators in inflammation: A review. Veterinary World.,11(5):627-635. https://doi.org/ 10.14202
Alves, A. M. H., Gonçalves, J. C., Cruz, J. S. R., & Araújo, D. A. M. (2010). Avaliação do sesquiterpeno (-) alfa-bisabolol como um novo bloqueador nervoso periférico. Neuroscience. Letters. 472(1), 11-15.
Amora-Silva, B. F., Ribeiro, S. C., Vieira, C. L. F., Mendes, R., Vieira-Neto, A. E., Abdon, A. P. V., Costa, F.N., & Camposet. A. R. (2019). Clinical efficacy of new α-bisabolol mouthwashes in postoperative complications of maxillofacial surgeries: a randomized, controlled, triple-blind clinical trial. Clinical Oral Investigation, 23, 577–584. http://doi.org/ 10.1007 / s00784-018-2464-4
Araújo, M. C., dos Santos, H. R., de Sousa, F. A. G.., Feitosa, J. V., & Martins, C. J. G. (2015). Content, Yield and quality of essential oil Vanillosmopsis arborea (Gardner) Baker (candeeiro) and its allelopathy, Revista Cubana de Plantas Medicinales, 20(1), 131-141.
Bardin, L. (2011). Análise de conteúdo. Editora 70, 288.
Barreto, R. S. S., Quintans, J. S. S, Amarante, R. K. L., Nascimento, T. S., Amarante, R. S., Barreto, A. S., Pereira. E. W. M., Duarte, M. C., Coutinho. H. D. M., Menezes, I. R. A., Zengin. G., Aktumsek, A., & Quintans-Júnior, L. J. (2016). Evidence for the involvement of TNF-α and IL-1β in the antinociceptive and anti-inflammatory activity of Stachys lavandulifolia Vahl. (Lamiaceae) essential oil and (-)-α-bisabolol, its main compound, in mice. Journal Ethnopharmacology, 15(191), 9-18. https:// doi.org/ 10.1016/j.jep.2016.06.022
Bergman, M. E., Davis, B., & Phillips, M. A. (2019). Medically Useful Plant Terpenoids: Biosynthesis, Occurrence, and Mechanism of Action. Molecules, 24(21), 3961. https://doi.org/ 10.3390 / moléculas24213961.
Biniecka, M., Kennedy, A., Fearon, U., Ng, C. T., Veale, D. J., & O'Sullivan, J. N. (2010). Oxidative damage in synovial tissue is associated with in vivo hypoxic status in the arthritic joint. Annals Rheumatic Diseases, 69,1172–1178. http://dx.doi.org/10.1136/ard.2009.111211
Brasil (2016). Ministério da Saúde. Secretaria de Ciência, Tecnologia e Insumos Estratégicos. Departamento de Assistência Farmacêutica. Política e Programa Nacional de Plantas Medicinais e Fitoterápicos / Ministério da Saúde, Secretaria de Ciência, Tecnologia e Insumos Estratégicos, Departamento de Assistência Farmacêutica. – Brasília: Ministério da Saúde. https://bvsms.saude.gov.br/bvs/publicacoes/politica_programa_nacional_plantas_medicinais_fitoterapicos.pdf
Cambui, Y. R. S., & Natali, M. R. M. (2015). Doenças inflamatórias intestinais: revisão narrativa da literatura. Revista Da Faculdade De Ciências Médicas De Sorocaba, 17(3), 116–119.
Carstens, E., Kuenzler, N., & Handwerker, H. O. (1998). Ativação de neurônios no subnúcleo caudal do trigêmeo de rato por diferentes produtos químicos irritantes aplicados à mucosa oral ou ocular. Journal Neurophysiology, 80(2), 465-492.
Carvalho, R. C., Maglioni, C. B., Machado, G. B., de Araújo, J. E., da Silva, J. R. T. & da Silva, M. L. (2018). Prevalence and characteristics of chronic pain in Brazil: a national internet-based survey study Prevalência e características da dor crônica no Brasil: um estudo nacional baseado em questionário pela internet. BrJP, 1(4), 331-338. https://doi.org/10.5935/2595-0118.20180063
Cavalcante, H. A. O., Silva-Filho, S. E., Wiirzler, L. A. M.., Cardia, G. F. E., Uchida, N. S., Silva-Comar, F.M. S., Bersani-Amado, C.A., & Cuman, R. K. N. (2020). Effect of (-)-α-Bisabolol on the Inflammatory Response in Systemic Infection Experimental Model in C57BL/6 Mice. Inflammation, 43(1), 193-203. https://doi.org/10.1007 / s10753-019-01109-8
Costa, E. F. S., & Dias, G. A. C. (2013). The pathogenesis of asthma. Revista HUPE, 12(2), 31-40.
D'Almeida, A., Pacheco de Oliveira, M. T., de Souza, É. T., de Sá Coutinho, D., Ciambarella, B. T., Gomes, C. R., Terroso, T., Guterres, S. S. Pohlmann, A.R.., Silva, P.M., Martins, M. A., & Bernardi, A. (2017). α-bisabolol-loaded lipid-core nanocapsules reduce lipopolysaccharide-induced pulmonary inflammation in mice. International Journal of Nanomedicine, 12, 4479–4491. https://doi.org/ 10.2147 / IJN.S130798.
Del Ré, P. V., & Jorge, N. (2012). Spices as natural antioxidants: their application in food and implication for health. Revista Brasileira de Plantas medicinais, 14(2), 389-399. https://doi.org/10.1590/S1516-05722012000200021
Felipe, L. O., & Bicas, J. L. (2017). Terpenos, aromas e a química dos compostos naturais. Química nova escola, 39(2), 120-130.
Fernandes, M. Y. D., Carmo, M. R. S. D., Fonteles, A. A., Neves, J. C. S., Silva, A. T. A. D., Pereira, J. F., Ferreira, E. O., Lima, N. M. R., Neves, K. R, & Andrade, G. M. (2019). (-)-α-bisabolol prevents neuronal damage and memory deficits through reduction of proinflammatory markers induced by permanent focal cerebral ischemia in mice. European Journal of Pharmacology, 842, 270-280.https://doi.org/10.1016 / j. ejphar.2018.09.036
Figueiredo, C. R. L. V. (2019). The unusual paradox of cancer-associated inflammation: an update.Journal Brasilian Patology Medicine Laboratory. 2019; 55(3), 321-332. https://doi.org/10.5935/1676-2444.20190029
Fontinele, L. L., Heimfarth, L., Pereira, E. W. M., Rezende, M. M., Lima, N. T.,Carvalho, Y. M. B. G., Pires, E. A. M., Guimarães, A. G., Carvalho, M. T. B., Barreto, R. S. S., Campos, A. R., Antoniolli, A. R., Araújo A. A. S., Quintans-Júnior, L. J., & Quintans J. S. S. (2019). Anti-hyperalgesic effect of (-)-α-bisabolol and (-)-α-bisabolol/β-Cyclodextrin complex in a chronic inflammatory pain model is associated with reduced reactive gliosis and cytokine modulation. Neurochemistry International, 2019, 131, 104530.https://doi.org/10.1016 / j. neuint.2019.104530
Frikeche, J., Couteau, C., Roussakis, C., & Coiffard, L. J. (2015). Research on the immunosuppressive activity of ingredients contained in sunscreens. Arch Dermatology Research, 307(3), 211-8. https://doi.org/10.1007/s00403-014-1528-9
Fu, J., Li, F. H., Li, C. K., Li, B. M., Chen, R. Y., & Kang, J. (2019). Reviews on natural monocyclic sesquiterpenoids and their bioactivities. Zhongguo Zhong Yao Za Zhi, 44(17), 3672-3683.http://doi:.org/10.19540 / j.cnki.cjcmm.20190415.201
Germolec, D. R., Shipkowski, K. A., Frawley, R. P., & Evans, E. (2018). Markers of Inflammation. Methods in Molecular Biology, 1803, 57-79.
Glavin, G.B., & Szabo, S. (1992). Experimental gastric mucosal injury: laboratory models reveal mechanisms of pathogenesis and new therapeutic strategies. The FASB Journal, 6, 825-831.https://doi.org/10.1007 / 978-1-4939-8549-4_5.
Hu, S., Ma, Y. L., Guo, J. M., Wen, Q., Yan, G., Yang, S., Fu, Y. H., & Liu, Y. P. (2020). Bisabolane sesquiterpenes from Clausena sanki with their potential anti-inflammatory activities. Nat ural Prod uct Research, 34(24), 3499-3505. https://doi.org/10.1080/14786419.2019.1582042
Hussain, T., Tan, B., Yin, Y., Blachier, F., Tossou, M. C., & Rahu, N. (2016). Oxidative Stress and Inflammation: What Polyphenols Can Do for Us? Oxidative Medicine and Cellular Longevity, 7432797. https://doi.org//10.1155 / 2016/7432797
Hussien, Y. A., Abdalkadim, H., Mahbuba, W., Hadi, N. R., Jamil, D. A., & Al-Aubaidy, H. A. (2020). The Nephroprotective Effect of Lycopene on Renal Ischemic Reperfusion Injury: A Mouse Model. Indian Journal of Clinical Biochemistry, 35(4), 474-481. https://doi.org/10.1007 / s12291-019-00848-7
J
acob, S.E., Matiz, C., & Herro, E. M. (2011). Compositae-associated allergic contact dermatitis from bisabolol. Dermatitis, 22(2), 102-105.
Javed, H., Meeran, M. F. N., Azimullah, S., Bader Eddin, L., Dwivedi, V. D., Jha, N. K., & Ojha, S. (2020). α-Bisabolol, a Dietary Bioactive Phytochemical Attenuates Dopaminergic Neurodegeneration through Modulation of Oxidative Stress, Neuroinflammation and Apoptosis in Rotenone-Induced Rat Model of Parkinson's disease. Biomolecules, 10(10), 1421. https://doi.org/10.3390 / biom10101421
Jadoon, S., Karim, S., Bin Asad, M. H., Akram, M. R., Khan, A. K., Malik, A., Chen, C., & Murtaza, G. (2015). Anti-Aging Potential of Phytoextract Loaded-Pharmaceutical Creams for Human Skin Cell Longetivity. Oxidative Medicine and Cellular Longevity, 709628.https:// doi.org/10.1155/2015/709628
Kamatou, G. P., Makunga, N. P., Ramogola, W. P., & Viljoen, A. M. (2008). South African Salvia species: a review of biological activities and phytochemistry. Journal of Ethnopharmacology,119(3), 664-672. https://doi.org/10.3390 / biom10101421
Kim, S., Jung, E., Kim, J. H., Park, Y. H.., Lee, J., & Park, D. (2011). Inhibitory effects of (-)-α-bisabolol on LPS-induced inflammatory response in RAW264.7 macrophages. Food Chemistry Toxicology, 49(10), 2580-2585. https://doi.org/10.1016 / j.fct.2011.06.076
Kirsch-Volders, M., Bolognesi, C., Ceppi, M., Bruzzone, M., & Fenech, M. (2020). Micronuclei, inflammation and auto-immune disease. Mutatation Research Reviews Mutatation Researc, 786,108335. https://doi.org/10.1016/j.mrrev.2020.108335
Kumar, V., Abbas, A., Fausto, N. (2016). Robbins e Cotran – Patologia – Bases Patológicas das Doenças. Elsevier.
Lampropoulou, V., Sergushichev, A., Bambouskova, M., Nair, S., Vincent, E. E., Loginicheva, E., Cervantes-Barragan, L., Ma, X., Huang, S. C., Griss, T., Weinheimer, C. J., Khader, S., Randolph, G. J., Pearce, E. J., Jones, R. G., Diwan, A., Diamond, M. S., & Artyomov, M. N. (2016). Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation. Cell Metabolism, 12:24(1), 158-166.https://doi.org/10.1016/j.cmet.2016.06.004
Lee, J., Jun, H., Jung, E., Ha, J., & Park, D. (2010). Whitening effect of alpha-bisabolol in Asian women subjects. International Journal Cosmetetic Science., 32(4), 299-303. https://doi.gov/ 10.1111/j.1468-2494.2010.00560. x.
Leite, G. O., Ecker, A., Seeger, R. L., Krum, B. N., Lugokenski, T. H., Fachinetto, R., Sudati, J. H., Barbosa, N. V., & Wagner, C. (2018). Protective effect of (-)-α-bisabolol on rotenone-induced toxicity in Drosophila melanogaster. Canadian Journal of Physiology and Pharmacology, 96(4), 359-365. https://doi.org/10.1139 / cjpp-2017-0207
Leite, G. O., Leite, L. H., Sampaio, R. S., Araruna, M. K., de Menezes, I. R., da Costa, J. G., & Campos A. R. (2011). (-)-α-Bisabolol attenuates visceral nociception and inflammation in mice. Fitoterapia, 82 (2), 208-211. https://doi.org/10.1016 / j. fitote.2010.09.012
Leite, G. O., Fernandes, C. N., de Menezes, I. A., da Costa, J. G. M., & Camposet. A. R. (2012). Attenuation of visceral nociception by α-bisabolol in mice: investigation of mechanisms. Organic and Medical Chemistry Letters, 2, 18. https://doi.org/10.1186%2F2191-2858-2-18
Leong, H. J., Jang, I., Hyun, K. S., Jung, S. K., Hong, G. H., Jeong, H. A., & Oh, S. G. (2016). Preparation of alpha-bisabolol and phenylethyl resorcinol/TiO2 hybrid composites for potential applications in cosmetics. International Journal Cosmetic Sci.ence, 38(5),524-34. https://doi.org/10.1111/ics.12339
Licari, A., Ruffinazzi, G., DE Filippo, M., Castagnoli, R., Marseglia, A., Agostinis, F., Puviani, M., Milani, M., & Marseglia, G.L. (2017). A starch, glycyrretinic, zinc oxide and bisabolol based cream in the treatment of chronic mild-to-moderate atopic dermatitis in children: a three-center, assessor blinded trial. Minerva Pediatrics, 69(6), 470-475. https://doi.org/10.23736/S0026-4946.17.05015-0
Lorena, O. F., & Bicas, J. L. (2017). Terpenos, aromas e a química dos compostos naturais.Química.Nova na Escola, 39 (2), 120-130. http://doi.org/10.21577/0104-8899.20160068.
Luqman, S., & Srivastava, S. (2012). Protective effect of (-) α-bisabolol on markers of oxidative stress in erythrocytes subjected to oxidative insult. Natural Precedings. https://doi.org/10.1038/npre.2012.6903.1
Marco, C A., Santos, H. R, Feitosa, A. G. S., Feitosa, J. A., & Costa, J. G. M. (2015). Teor, rendimento e qualidade do óleo essencial de Vanillosmopsis arbórea (Gardner) Baker (candeeiro) e sua ação alelopática. Revista Cubana de Plantas Medicinales, 20(1), 131-141.
Maurya, A K., Singh, M., Dubey, V., Srivastava, S. Luqman, S., & Bawankule, D. U. (2014). α-(-)-bisabolol reduces pro-inflammatory cytokine production and ameliorates skin inflammation. Current Pharmaceutical Biotechnology, 15(2):173-181. https:/doi.org/10.2174 / 1389201015666140528152946
McGarry, T., Biniecka, M., Veale, D., & Fearon, U. (2018). Hypoxia, Oxidative Stress and Inflammation, Free Radical Biology and Medicine, 125, 15-24. https:/doi.org/10.1016 / j. freeradbiomed.2018.03.042
Medzhitov, R. (2010). Inflammation 2010: New Adventures of an Old Flame. Cell, 140(6), 771-776. https://doi.org/10.1016 / j. cell.2010.03.006.
Medzhitov, R. (2008). Origin and physiological roles of inflammation. Nature, 454, 428-435. https//:doi.org/10.1038/nature07201
Melo, LT., Panchalingam, V., Cherkas, P., Campos, A. R., Avivi-Arber, L., & Sessle, B. J. (2019). (-)-α-Bisabolol reduces nociception and trigeminal central sensitisation in acute orofacial neuropathic pain induced by infraorbital nerve injury. Life Sciences, 227, 122-128.https://doi.org/10.1016/j.lfs.2019.04.032
Miraj, S., & Alesaeidi, S. (2016). A systematic review study of therapeutic effects of Matricaria recuitta chamomile (chamomile). Electron Physician, 8(9), 3024-3031. https://doi.org/ 10.19082 / 3024
Muñoz-Pérez, V. M., Ortiz, M. I., Ponce-Monter, H. A., Monter-Pérez, V., & Barragán-Ramírez, G. (2018). Anti-inflammatory and utero-relaxant effect of α-bisabolol on the pregnant human uterus. Korean Journal Physiology Pharmacology, 22(4), 391-398. https://doi.org/10.4196 / kjpp.2018.22.4.391
Nóbrega, A.T., Wagemaker, T. A. L., & Maia Campos, P. M. B. G. (2013). Antioxidant activity of Matricaria chamomilla L. extract and clinical efficacy of cosmetic formulations containing this extract and its isolated compounds. Biomedical and Biopharmaceutical Research, (10) 2, 249-261.https://doi.org/10.19277 / BBR.10.2.69
Ojha, S., Azimullah, S., Al Taee, H., & Meeran, M. F. N. (2017). Cardioprotective effect of (-)-α-Bisabolol in animal model of myocardial infarction. Planta Medica International Open, 4(s01), S1- S202.https://doi.org/10.1055/s-0037-1608133
Ortiz, M. I., Cariño-Cortés, R., Ponce-Monter, H. A., Castañeda-Hernández, G., & Chávez-Piña, A. E. (2018). Pharmacological interaction of α-bisabolol and diclofenac on nociception, inflammation, and gastric integrity in rats. Drug Development Research, 79(1), 29-37. https://doi.org/10.1002 / ddr.21418
Pacífico, D. M., Araújo, T. S. L., Sousa, N. A., Costa,Souza, L. K. M., Pereira Júnior, J. L., & Medeiros, J. V. R. (2018). Scientific and technological forecasting of matricaria recutita l. (chamomile). Revista Gestão, Inovação e Tecnologias, 8(2), 4339-4356. https://doi.org./10.7198/geintec.v8i2.773
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T.C, & Mulrow, C. D. (2021). The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ, 372(71).
Moura Rocha, N. F., Venâncio, E. T., Moura, B. A., Gomes Silva, M. I., Aquino Neto, M. R., Vasconcelos Rios, E. R., de Sousa, D. P., Mendes Vasconcelos, S. M., de França Fonteles, M. M., & de Sousa, F. C. (2010). Gastroprotection of (-)-alpha-bisabolol on acute gastric mucosal lesions in mice: the possible involved pharmacological mechanisms. Fundamental & Clinical Pharmacology, 24(1),63-71. https:// doi.org/10.1111/j.1472-8206.2009. 00726.x
Repetto, M. G., & Llesuy, S. F. (2002). Antioxidant properties of natural compounds used in popular medicine for gastric ulcres. Brasilian Journal of Medical and Biological Research, 35,523-534.
Rocha, N. F. M., Oliveira, G. V., Araújo, F. Y. R., Rios, E. R. V., Carvalho, A. M. R., Vasconcelos, L. F., Macêdo, D. S., Soares, P. M. G., De Sousa, D. P., & de Sousa, F. C. F. (2011). (−)-α-Bisabolol-induced gastroprotection is associated with reduction in lipid peroxidation, superoxide dismutase activity and neutrophil migration, European Journal of Pharmaceutical Sciences, 44(4), 455-461. https://.doi.org/10.3390%2Fantibiotics9010028
Rocha, N. F.; Rios, E. R.; Carvalho, A. M.; Cerqueira, G. S.; Lopes Ade, A.; Leal, L. K.; Dias, M. L.; de Sousa, D. P., & de Sousa, F. C. (2011). Anti-nociceptive and anti-inflammatory activities of (-)-α-bisabolol in rodents. Naunyn Schmiedebergs Arch Pharmacology, 384(6), 525-533. https://doi.org/10.1007 / s00210-011-0679-x
Romagnoli C., Baldisserotto, A., Malisardi, G., Vicentini, C. B., Mares, D., Andreotti, E., Vertuani. S., & Manfredini, S. (2015). A Multi-Target Approach toward the Development of Novel Candidates for Antidermatophytic Activity: Ultrastructural Evidence on α-Bisabolol-Treated Microsporum gypseum. Molecules, 20(7):11765-, 76. https:// doi.gov/10.3390/molecules200711765
Russell, K. & Jacob, S. E. (2010). Bisabolol. Dermatitis, 21(1), 57-58.
Sampaio, T. L., Menezes, R. R., da Costa, M. F., Meneses, G. C., Arrieta, M. C., Chaves Filho, A. J., de Morais, G. B., Libório, A. B., Alves, R. S., Evangelista, J. S., & Martins, A. M. (2016). Nephroprotective effects of (−)-α-bisabolol against ischemic-reperfusion acute kidney injury, Phytomedicine, 23(14), 1843-1852. https://doi.org/10.1016/j.phymed.2016.11.008
Schweiger, D., Schoelermann, A. M., Filbry, A., Hamann, T., Moser, C., & Rippke, F. (2015). Highly efficient and compatible shampoo for use after hair transplant. Clinical Cosmetic Investigational Dermatology, 8, 355-60. https://doi.org/10.2147/CCID.S86015
Sharifi-Rad, J., Sureda, A., Tenore, G., Daglia, M., Sharifi-Rad, M., Valussi, M., Tundis, R., Sharifi-Rad, M., Loizzo, M., & Ademiluyi, A. (2017). Biological Activities of Essential Oils: From Plant Chemoecology to Traditional Healing Systems. Molecules, 22 (1), 70. https://doi.org/10.3390%2Fmolecules22010070
Sharifi-Rad, M., Nazaruk, J., Polito, L., Morais-Braga, M. F. B., Rocha, J. E., Coutinho, H. D. M., Salehi, B., Tabanelli, G., Montanari, C., Del Mar Contreras, M., Yousaf, Z.; Setzer, W. N., Verma, D. R., Martorell, M., Sureda, A., & Sharifi-Rad, J. (2018). Matricaria genus as a source of antimicrobial agents: From farm to pharmacy and food applications. Microbiological Research, 215, 76-88. https://doi.org/10.1016/j.micres.2018.06.010
Silva, E. D. F., & Dias, G. A. C. (2013). Patogenia da asma. Revista do Hospital Universitário Pedro Ernesto,12(2), 31-40. https://.doi.org/10.12957/rhupe.2013.8485
Singh, N., Baby, D., Rajguru, J. P., Patil, P. B., Thakkannavar, S. S., & Pujari, V. B. Inflammation and cancer. Annals of African Medicine, 18(3), 121-126.
https://doi.org/10.4103/aam.aam_56_18
Solovăstru, L. G., Stîncanu, A., De Ascentii, A., Capparé, G., Mattana, P. & Vâţă, D. (2015). Randomized, controlled study of innovative spray formulation containing ozonated oil and α-bisabolol in the topical treatment of chronic venous leg ulcers. Advances in Skin & Wound Care, 28(9), 406-409. https://doi: 10.1097 / 01.ASW.0000470155.29821.ed.
Souza, M. T., Silva, M. D., & Carvalho, R. (2010). Integrative review: what is it? How to do it? Einstein,8(1), 102-106. https://doi.org/10.1590/S1679-45082010RW1134
Tanini, S., Calabrese, S., Fisher, A. D., Maggi, M., & Lo Russo, G. (2020). When Testosterone Needs to be Contrasted: A Preliminary Study of Scar Prevention in Transmen Top Surgery with an Innovative Galenic Preparation. Aesthetic Plastic Surgery, 44(3), 1006-1013. https;//doi.org/10.1007 / s00266-020-01678-2
Teixeira, G. F. D., Vieira-Neto, A. E., a Costa, F. N., Silva, A. R. A., & Campos, A. R. (2017). Antinociceptive effect of (-)-α-bisabolol in nanocapsules. Biomedicine Pharmacotherapy, 91, 946-950. https://doi.org/10.1016/j.biopha.2017.05.024
Teixeira, G. F., Costa, F. N., & Campos, A. R. (2017). Corneal antinociceptive effect of (-)-α-bisabolol. Pharmaceutical Biology, 55(1), 1089-1092. https://doi.org/10.1080 / 13880209.2017.1285944
Tholl, D. (2015). Biosynthesis and biological functions of terpenoids in plants. Advances in Biochememical Engineering/ Biotechnology, 48, 63-106. https://doi.org/10.1007 / 10_2014_295
Torres-González, L., Cienfuegos-Pecina, E., Perales-Quintana, M. M., Alarcon-Galvan, G., Muñoz-Espinosa, L. E., Pérez-Rodríguez, E., & Cordero-Pérez, P. (2018). Nephroprotective Effect of Sonchus oleraceus Extract against Kidney Injury Induced by Ischemia-Reperfusion in Wistar Rats. Oxidative Medicine and Cellular Longevity, 2018, 9572803. https://doi.org/10.1155 / 2018/9572803
Wallace, J. L. (2008). Prostaglandns, NSAIDs, and gastric mucosal protection: why doens’t the stomach digest itself? Physiological Reviews, 88, 1547-1565.
Werner, M., Herling, M.; Garbe, B., Theek, C., Tronnier, H., Heinrich, U., & Braun, N. (2017). Determination of the Influence of the Antiphlogistic Ingredients Panthenol and Bisabolol on the SPF Value in vivo. Skin Pharmacology and Physiology, 30(6), 284-291. https://doi.org/10.1159/000480301
Xiao, M., Zhong, H., Xia, L., Tao, Y., & Yin, H. (2017). Pathophysiology of mitochondrial lipid oxidation: Role of 4-hydroxynonenal (4-HNE) and other bioactive lipids in mitochondria. Free Radical. Biology & Medicine, 111, 316–327. https://doi.org/10.1016 / j. freeradbiomed.2017.04.363
Xu, C., Sheng, S., Dou, H., Chen, J., Zhou, K., Lin, Y., & Yang, H. (2020). α-Bisabolol suppresses the inflammatory response and ECM catabolism in advanced glycation end products-treated chondrocytes and attenuates murine osteoarthritis. International Immunopharmacology,84, 106530. https://doi.org/10.1016 / j. intimp.2020.106530
Descargas
Publicado
Cómo citar
Número
Sección
Licencia
Derechos de autor 2021 Valéria do Amaral; Gabriel Fernando Esteves Cardia; Edvlakia Magna Teobaldo da Rocha; Carla Indianara Bonetti ; Roberto Kenji Nakamura Cuman
Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.
Los autores que publican en esta revista concuerdan con los siguientes términos:
1) Los autores mantienen los derechos de autor y conceden a la revista el derecho de primera publicación, con el trabajo simultáneamente licenciado bajo la Licencia Creative Commons Attribution que permite el compartir el trabajo con reconocimiento de la autoría y publicación inicial en esta revista.
2) Los autores tienen autorización para asumir contratos adicionales por separado, para distribución no exclusiva de la versión del trabajo publicada en esta revista (por ejemplo, publicar en repositorio institucional o como capítulo de libro), con reconocimiento de autoría y publicación inicial en esta revista.
3) Los autores tienen permiso y son estimulados a publicar y distribuir su trabajo en línea (por ejemplo, en repositorios institucionales o en su página personal) a cualquier punto antes o durante el proceso editorial, ya que esto puede generar cambios productivos, así como aumentar el impacto y la cita del trabajo publicado.
