O desenvolvimento do Transtorno do Espectro Autista está relacionado com a suplementação de altas doses de ácido fólico no período periconcepcional?

Isabela Chaves Lira  Cruz; Brunna Michelly Silva Sousa; Tamyres Borges  Pereira; Irlane moraes Vasconcelos  Souza; Fernanda de Melo Franco  Machado

doi:10.33448/rsd-v10i16.23392

Autores/as

Isabela Chaves Lira Cruz Pontifícia Universidade Católica de Goiás https://orcid.org/0000-0001-6006-5832
Brunna Michelly Silva Sousa Pontifícia Universidade Católica de Goiás https://orcid.org/0000-0002-3187-3432
Tamyres Borges Pereira Pontifícia Universidade Católica de Goiás https://orcid.org/0000-0002-9721-2506
Irlane moraes Vasconcelos Souza Universidade Cidade de São Paulo https://orcid.org/0000-0001-7509-3967
Fernanda de Melo Franco Machado Universidade de Rio Verde https://orcid.org/0000-0001-8492-5235

DOI:

https://doi.org/10.33448/rsd-v10i16.23392

Palabras clave:

Ácido fólico; Trastorno del espectro autista; Autismo.

Resumen

El trastorno del espectro autista (TEA) define un grupo de trastornos del desarrollo neurológico, generalmente diagnosticados en la primera infancia. Durante las últimas dos décadas se ha detectado un aumento creciente en la prevalencia de TEA. Se han realizado cientos de estudios, sin embargo, no está claro por qué la incidencia del autismo aumentó rápidamente durante la década de 1990 y continúa aumentando en la década de 2000. Se realizó una encuesta bibliográfica en las siguientes bases de datos: PUBMED, LILACS y SCIELO entre 2015 y 2020. Se utilizaron los siguientes descriptores: “Ácido fólico” y “Trastorno del espectro autista”. Inicialmente se encontraron 46 artículos. De estos, solo 34 cumplieron con los criterios de inclusión y abordaron aspectos relacionados con la suplementación con ácido fólico durante el período periconcepcional y su influencia en el desarrollo de TEA. Con respecto a la TEA y la administración de altas dosis de ácido fólico durante el período periconcepcional, se concluye que se necesita más investigación con diseños de estudio debidamente estandarizados y con una metodología adecuada antes de poder extraer conclusiones definitivas. Los resultados de estudios clínicos recientes, aunque pocos y no concluyentes, plantean dudas sobre las dosis adecuadas o el uso más específico de ácido fólico que deben investigarse.

Citas

Altamimi, M. (2018). Could Autism Be Associated With Nutritional Status in the Palestinian population? The Outcomes of the Palestinian Micronutrient Survey. Nutrition and Metabolic Insights, 11, 117863881877307. https://doi.org/10.1177/1178638818773078

Cheng, J., Eskenazi, B., Widjaja, F., Cordero, J. F., & Hendren, R. L. (2019). Improving autism perinatal risk factors: A systematic review. Medical Hypotheses, 127, 26–33. https://doi.org/10.1016/j.mehy.2019.03.012

DeVilbiss, E. A., Magnusson, C., Gardner, R. M., Rai, D., Newschaffer, C. J., Lyall, K., Dalman, C., & Lee, B. K. (2017). Antenatal nutritional supplementation and autism spectrum disorders in the Stockholm youth cohort: population based cohort study. BMJ, j4273. https://doi.org/10.1136/bmj.j4273

Fluegge, K. (2018). Re: Folate status and autism spectrum disorders. Paediatric and Perinatal Epidemiology, 32(3), 308–308. https://doi.org/10.1111/ppe.12449

Gao, Y., Sheng, C., Xie, R., Sun, W., Asztalos, E., Moddemann, D., Zwaigenbaum, L., Walker, M., & Wen, S. W. (2016). New Perspective on Impact of Folic Acid Supplementation during Pregnancy on Neurodevelopment/Autism in the Offspring Children – A Systematic Review. PLOS ONE, 11(11), e0165626. https://doi.org/10.1371/journal.pone.0165626

Gogou, M., & Kolios, G. (2020). Nutritional Supplements During Gestation and Autism Spectrum Disorder: What Do We Really Know and How Far Have We Gone? Journal of the American College of Nutrition, 39(3), 261–271. https://doi.org/10.1080/07315724.2019.1635920

Guo, B.-Q., Li, H.-B., Zhai, D.-S., & Ding, S.-B. (2019). Association of maternal prenatal folic acid intake with subsequent risk of autism spectrum disorder in children: A systematic review and meta-analysis. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 94, 109650. https://doi.org/10.1016/j.pnpbp.2019.109650

Iglesias Vázquez, L., Canals, J., & Arija, V. (2018). Review and meta‐analysis found that prenatal folic acid was associated with a 58% reduction in autism but had no effect on mental and motor development. Acta Paediatrica, apa.14657. https://doi.org/10.1111/apa.14657

Krsička, D., Geryk, J., Vlčková, M., Havlovicová, M., Macek, M., & Pourová, R. (2017). Identification of likely associations between cerebral folate deficiency and complex genetic- and metabolic pathogenesis of autism spectrum disorders by utilization of a pilot interaction modeling approach. Autism Research, 10(8), 1424–1435. https://doi.org/10.1002/aur.1780

Leppert, B., Havdahl, A., Riglin, L., Jones, H. J., Zheng, J., Davey Smith, G., Tilling, K., Thapar, A., Reichborn-Kjennerud, T., & Stergiakouli, E. (2019). Association of Maternal Neurodevelopmental Risk Alleles With Early-Life Exposures. JAMA Psychiatry, 76(8), 834. https://doi.org/10.1001/jamapsychiatry.2019.0774

Levine, S. Z., Kodesh, A., Viktorin, A., Smith, L., Uher, R., Reichenberg, A., & Sandin, S. (2018). Association of Maternal Use of Folic Acid and Multivitamin Supplements in the Periods Before and During Pregnancy With the Risk of Autism Spectrum Disorder in Offspring. JAMA Psychiatry, 75(2), 176. https://doi.org/10.1001/jamapsychiatry.2017.4050

Li, M., Francis, E., Hinkle, S. N., Ajjarapu, A. S., & Zhang, C. (2019). Preconception and Prenatal Nutrition and Neurodevelopmental Disorders: A Systematic Review and Meta-Analysis. Nutrients, 11(7), 1628. https://doi.org/10.3390/nu11071628

Li, Y.-M., Shen, Y.-D., Li, Y.-J., Xun, G.-L., Liu, H., Wu, R.-R., Xia, K., Zhao, J.-P., & Ou, J.-J. (2018). Maternal dietary patterns, supplements intake and autism spectrum disorders. Medicine, 97(52), e13902. https://doi.org/10.1097/MD.0000000000013902

Lintas, C. (2019). Linking genetics to epigenetics: The role of folate and folate-related pathways in neurodevelopmental disorders. Clinical Genetics, 95(2), 241–252. https://doi.org/10.1111/cge.13421

Maia, C. S., Menezes, K. M. C., Tenorio, F. C. A. M., Queiroz Júnior, J. R. A., & Maciel, G. E. S. (2019). Transtorno do espectro autista e a suplementação por ácido fólico antes e durante a gestação. Jornal Brasileiro de Psiquiatria, 68(4), 231–243. https://doi.org/10.1590/0047-2085000000251

Modabbernia, A., Velthorst, E., & Reichenberg, A. (2017). Environmental risk factors for autism: an evidence-based review of systematic reviews and meta-analyses. Molecular Autism, 8(1), 13. https://doi.org/10.1186/s13229-017-0121-4

Ornoy, A., Weinstein-Fudim, L., & Ergaz, Z. (2015). Prenatal factors associated with autism spectrum disorder (ASD). Reproductive Toxicology, 56, 155–169. https://doi.org/10.1016/j.reprotox.2015.05.007

Ornoy, Asher, Koren, G., & Yanai, J. (2018). Is post exposure prevention of teratogenic damage possible: Studies on diabetes, valproic acid, alcohol and anti folates in pregnancy: Animal studies with reflection to human. Reproductive Toxicology, 80, 92–104. https://doi.org/10.1016/j.reprotox.2018.05.006

Raghavan, R., Riley, A. W., Volk, H., Caruso, D., Hironaka, L., Sices, L., Hong, X., Wang, G., Ji, Y., Brucato, M., Wahl, A., Stivers, T., Pearson, C., Zuckerman, B., Stuart, E. A., Landa, R., Fallin, M. D., & Wang, X. (2018). Maternal Multivitamin Intake, Plasma Folate and Vitamin B 12 Levels and Autism Spectrum Disorder Risk in Offspring. Paediatric and Perinatal Epidemiology, 32(1), 100–111. https://doi.org/10.1111/ppe.12414

Schmidt, R. J., Iosif, A.-M., Guerrero Angel, E., & Ozonoff, S. (2019). Association of Maternal Prenatal Vitamin Use With Risk for Autism Spectrum Disorder Recurrence in Young Siblings. JAMA Psychiatry, 76(4), 391. https://doi.org/10.1001/jamapsychiatry.2018.3901

Shaik Mohammad, N., Sai Shruti, P., Bharathi, V., Krishna Prasad, C., Hussain, T., Alrokayan, S. A., Naik, U., & Devi, A. R. R. (2016). Clinical utility of folate pathway genetic polymorphisms in the diagnosis of autism spectrum disorders. Psychiatric Genetics, 26(6), 281–286. https://doi.org/10.1097/YPG.0000000000000152

Sharman Moser, S., Davidovitch, M., Rotem, R. S., Chodick, G., Shalev, V., & Koren, G. (2019). High dose folic acid during pregnancy and the risk of autism; The birth order bias: A nested case-control study. Reproductive Toxicology, 89, 173–177. https://doi.org/10.1016/j.reprotox.2019.07.083

Strøm, M., Granström, C., Lyall, K., Ascherio, A., & Olsen, S. F. (2018). Research Letter: Folic acid supplementation and intake of folate in pregnancy in relation to offspring risk of autism spectrum disorder. Psychological Medicine, 48(6), 1048–1054. https://doi.org/10.1017/S0033291717002410

Surman, C., Ceranoglu, A., Vaudreuil, C., Albright, B., Uchida, M., Yule, A., Spencer, A., Boland, H., Grossman, R., Rhodewalt, L., Fitzgerald, M., & Biederman, J. (2019). Does l-Methylfolate Supplement Methylphenidate Pharmacotherapy in Attention-Deficit/Hyperactivity Disorder? Journal of Clinical Psychopharmacology, 39(1), 28–38. https://doi.org/10.1097/JCP.0000000000000990

Tan, M., Yang, T., Zhu, J., Li, Q., Lai, X., Li, Y., Tang, T., Chen, J., & Li, T. (2020). Maternal folic acid and micronutrient supplementation is associated with vitamin levels and symptoms in children with autism spectrum disorders. Reproductive Toxicology, 91, 109–115. https://doi.org/10.1016/j.reprotox.2019.11.009

Virk, J., Liew, Z., Olsen, J., Nohr, E. A., Catov, J. M., & Ritz, B. (2016). Preconceptional and prenatal supplementary folic acid and multivitamin intake and autism spectrum disorders. Autism, 20(6), 710–718. https://doi.org/10.1177/1362361315604076

Wang, M., Li, K., Zhao, D., & Li, L. (2017). The association between maternal use of folic acid supplements during pregnancy and risk of autism spectrum disorders in children: a meta-analysis. Molecular Autism, 8(1), 51. https://doi.org/10.1186/s13229-017-0170-8

Wiens, D., & DeSoto, M. (2017). Is High Folic Acid Intake a Risk Factor for Autism?—A Review. Brain Sciences, 7(12), 149. https://doi.org/10.3390/brainsci7110149

Yu, X.-F., Li, M., & Zheng, Y. (2017). [Association between maternal folate supplementation during pregnancy and the risk of autism spectrum disorder in the offspring: a Meta analysis]. Zhongguo Dang Dai Er Ke Za Zhi = Chinese Journal of Contemporary Pediatrics, 19(3), 286—291. https://doi.org/10.7499/j.issn.1008-8830.2017.03.007

Zhang, Z., Yu, L., Li, S., & Liu, J. (2018). Association Study of Polymorphisms in Genes Relevant to Vitamin B12 and Folate Metabolism with Childhood Autism Spectrum Disorder in a Han Chinese Population. Medical Science Monitor, 24, 370–376. https://doi.org/10.12659/MSM.905567

Zhou, J., Liu, A., He, F., Jin, Y., Zhou, S., Xu, R., Guo, H., Zhou, W., Wei, Q., & Wang, M. (2018). High prevalence of serum folate receptor autoantibodies in children with autism spectrum disorders. Biomarkers, 23(7), 622–624. https://doi.org/10.1080/1354750X.2018.1458152

Zou, M., Sun, C., Liang, S., Sun, Y., Li, D., Li, L., Fan, L., Wu, L., & Xia, W. (2019). Fisher discriminant analysis for classification of autism spectrum disorders based on folate-related metabolism markers. The Journal of Nutritional Biochemistry, 64, 25–31. https://doi.org/10.1016/j.jnutbio.2018.09.023

¿El desarrollo del Trastorno del Espectro Autista está relacionado con la suplementación de altas dosis de ácido fólico en el período periconcepcional?

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