Efecto de diferentes polifenoles frente a la neurotoxicidad inducida por ácido quinolínico en células gliales U87-MG
DOI:
https://doi.org/10.33448/rsd-v11i1.24865Palabras clave:
neurodegeneración; Neurodegeneración; ácido quinolínico; Ácido quinolínico; polifenoles; Polifenoles; estrés oxidativo; Estrés oxidativo.Resumen
Enfermedades neurodegenerativas (EN) son transtornos altamente debilitantes relacionados con el envejecimento y la disfunción mitocondrial, estrés oxidativo y nitrosativo (EON) están asociados a la aparición del cuadro clínico. Las mitocondrias se destacan como organelas cruciales en la interacción entre neurodegeneración y neuroinflamación, y polifenoles son considerados como medicamentos prometedores dirigidos a las mitocondrias. Compuestos fenólicos pueden regular las mitocondrias controlando su estado redox, función y sistema de apoptosis. En este trabajo, fue investigado el potencial neuroprotetor de los extractos de Araucaria angustifolia (AAE) y Camellia sinensis (GT), y seis compuestos aislados (resveratrol, ácido gálico, ácido elágico, catequina, epicatequina e proantocianidinas) em um modelo de neurodegeneración utilizando ácido quinolínico (AQ). Células gliales U87-MG fueran pretratadas por 1 hora con AAE o GT o un de los compuestos aislados, y, después, expuestas al AQ por 24 horas. Las células expuestas al AQ presentaran viabilidad disminuida, alta producción de especies reactivas de oxígeno (EROs), reducción de la polarización mitocondrial y aumento de la respuesta inflamatoria. Apesar de los resultados similares encontrados para el GT y el AAE, este ultimo se destacó, siendo capaz de prevenir todos los parámetros testados en este trabajo. En conclusión, se sugiere que el AAE podrida ser un agente de prevención contra las EN relacionadas con la disfunción mitochindrial asociada al EON.
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Derechos de autor 2022 Júlia Maiara dos Santos; Ana Paula Vargas Visentin; Fernando Joel Scariot; Sergio Echeverrigaray; Mirian Salvador; Catia Santos Branco
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