Relación entre parámetros hematológicos y bioquímicos por días de síntomas en pacientes internados síndrome gripal y COVID-19

Autores/as

DOI:

https://doi.org/10.33448/rsd-v11i4.27439

Palabras clave:

COVID-19; SARS-CoV-2; Técnicas de laboratorio clínico; Biomarcadores.

Resumen

Además del síndrome respiratorio agudo causado por la COVID-19, el proceso inflamatorio exacerbado provoca trastornos sistémicos de la coagulación, trastornos cardiovasculares agudos, insuficiencia renal aguda, alteraciones metabólicas y otras manifestaciones clínicas, aumentando la mortalidad de los pacientes con formas graves de la enfermedad. El desarrollo de vacunas y fármacos eficaces para el tratamiento adecuado de las formas graves de la enfermedad se ha convertido en una prioridad para la comunidad científica y médica. Asimismo, constantemente se evalúa el descubrimiento de biomarcadores para la identificación temprana de casos graves con alto riesgo de muerte. Las pruebas de laboratorio, como el hemograma, las pruebas de coagulación, las pruebas hormonales y bioquímicas, se realizan a diario en el ámbito hospitalario y han demostrado ser de gran utilidad en la búsqueda de estos biomarcadores. En nuestro estudio, evaluamos los exámenes de laboratorio de 398 pacientes positivos y negativos para COVID-19 ingresados ​​en hospitales de Uberaba, de la Macrorregión del Triângulo Sur, estado de Minas Gerais, con una población de 800.000 habitantes. En nuestros resultados observamos que los pacientes que fallecieron presentaban anemia, leucocitosis con neutrofilia, aumento de PCR, urea y creatinina desde el 5°, 6° día de síntomas, y linfopenia el 1° día. En el análisis de gases en sangre, el pH, el SaO2 y la PO2 se redujeron desde el primer síntoma en los pacientes que fallecieron, y el pH se mantuvo reducido hasta el resultado clínico. Se observaron cambios en la dosificación de LDH, aPTT, albúmina y electrolitos. Nuestros resultados muestran que las pruebas de laboratorio pueden ser útiles como biomarcadores de gravedad en los primeros días de síntomas.

Citas

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26/03/2022

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SILVA, D. A. A. da .; ANDRADE-SILVA, L. E. de; DESIDÉRIO, C. S. .; FARNESI DE ASSUNÇÃO, T. S. .; OLIVEIRA, A. C. de M. .; TREVISAN, R. O. .; SANTOS, M. M. .; HELMO, F. R. .; BARBOSA, L. M. .; COSTA-MADEIRA, J. C. .; BARBOSA, R. M. .; BORGES, A. V. B. e .; CUNHA, A. C. C. H. .; PEREIRA, L. Q. .; BOVI, W. G. .; BUENO, G. F. .; MUNDIM, F. V. .; MONTEIRO, I. B. .; FERREIRA, Y. M. .; MACHADO, G. H. .; PAIM, K. F. .; MORAES-SOUZA, H. .; OLIVEIRA, C. J. F. .; SILVA, M. V. da .; RODRIGUES, V. . Relación entre parámetros hematológicos y bioquímicos por días de síntomas en pacientes internados síndrome gripal y COVID-19. Research, Society and Development, [S. l.], v. 11, n. 4, p. e54411427439, 2022. DOI: 10.33448/rsd-v11i4.27439. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/27439. Acesso em: 22 nov. 2024.

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Vol. 11 Núm. 4

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Ciencias de la salud

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Derechos de autor 2022 Djalma Alexandre Alves da Silva; Leonardo Eurípedes de Andrade-Silva; Chamberttan Souza Desidério; Thais Soares Farnesi de Assunção; Ana Carolina de Morais Oliveira; Rafael Obata Trevisan; Malu Mateus Santos; Fernanda Rodrigues Helmo; Laís Milagres Barbosa; Juliana Cristina Costa-Madeira; Rafaela Miranda Barbosa; Anna Victória Bernardes e Borges; Andrezza Cristina Cancian Hortolani Cunha; Loren Queli Pereira; Weslley Guimarães Bovi; Giovanna Ferreira Bueno; Fabiano Vilela Mundim; Ivan Borges Monteiro; Yulsef Moura Ferreira; Guilherme Henrique Machado; Kennio Ferreira Paim; Hélio Moraes-Souza; Carlo José Freire Oliveira; Marcos Vinicius da Silva; Virmondes Rodrigues

Creative Commons License

Esta obra está bajo una licencia internacional Creative Commons Atribución 4.0.

Los autores que publican en esta revista concuerdan con los siguientes términos:

1) Los autores mantienen los derechos de autor y conceden a la revista el derecho de primera publicación, con el trabajo simultáneamente licenciado bajo la Licencia Creative Commons Attribution que permite el compartir el trabajo con reconocimiento de la autoría y publicación inicial en esta revista.

2) Los autores tienen autorización para asumir contratos adicionales por separado, para distribución no exclusiva de la versión del trabajo publicada en esta revista (por ejemplo, publicar en repositorio institucional o como capítulo de libro), con reconocimiento de autoría y publicación inicial en esta revista.

3) Los autores tienen permiso y son estimulados a publicar y distribuir su trabajo en línea (por ejemplo, en repositorios institucionales o en su página personal) a cualquier punto antes o durante el proceso editorial, ya que esto puede generar cambios productivos, así como aumentar el impacto y la cita del trabajo publicado.