Chronic exposure to mercury and systemic arterial hypertension: Literature review
DOI:
https://doi.org/10.33448/rsd-v11i8.30631Keywords:
Mercury poisoning; Heavy metal poisoning; Hypertension.Abstract
Exposure to Hg has been extensively studied since the Minamata accident. Its deleterious effects were usually associated with the CNS, but recent research reveals this exposure as a possible risk factor for the development of heart diseases, such as systemic arterial hypertension. This review aims to evaluate a possible influence of chronic exposure to mercury in events of systemic arterial hypertension. This is a systematic review, using the Lilacs, PubMed and Scielo databases, with the use of keywords, and application of screening and eligibility criteria, as well as a filter in order to select publications from the last decade. The study identified 106 articles in different databases, where 6 of these were duplicates. In the screening and eligibility phase, 27 and 62 articles were excluded, respectively. Thus, only 11 articles were included for qualitative synthesis. Despite Hg being a heavy metal naturally present in the environment, professionals involved with mining and populations that have frequent fish consumption take the lead in this exposure, a fact demonstrated by the high levels of Hg in the capillary samples of these individuals. This chronic exposure causes severe imbalance to several biological systems, including the cardiovascular system, however, stating that this may be a driving force for the development of SAH may be wrong, and requires deeper and more detailed studies to be carried out on the subject.
References
Afridi, H. I., Kazi, T. G., Talpur, F. N., Kazi, A., Arain, S. S., Arain, S. A., ... & Ali, J. (2014). Interaction between essential elements selenium and zinc with cadmium and mercury in samples from hypertensive patients. Biological trace element research, 160(2), 185-196. Disponível em: https://link.springer.com/article/10.1007/s12011-014-0048-y
Afridi, H. I., Talpur, F. N., Kazi, T. G., & Brabazon, D. (2015). Assessment of toxic elements in the samples of different cigarettes and their effect on the essential elemental status in the biological samples of Irish hypertensive consumers. Journal of Human Hypertension, 29(5), 309-315. Disponível em: https://www.nature.com/articles/jhh201487
Costa, Á. de F., Custódio, F. B., Silva, N. D. O. C., & Labanca, R. A. (2020). Mercúrio em peixes comercializados em Minas Gerais e possíveis riscos associados ao seu consumo. Research, Society and Development, 9(9), e105996881-e105996881. DOI: https://doi.org/10.33448/rsd-v9i9.6881
Fardin, P. B. A., Simões, R. P., Schereider, I. R. G., Almenara, C. C. P., Simões, M. R., & Vassallo, D. V. (2020). Chronic mercury exposure in prehypertensive SHRs accelerates hypertension development and activates vasoprotective mechanisms by increasing NO and H2O2 production. Cardiovascular Toxicology, 20(3), 197-210. Disponível em: https://link.springer.com/article/10.1007/s12012-019-09545-6
Jennrich, P. (2013). The influence of arsenic, lead, and mercury on the development of cardiovascular diseases. International Scholarly Research Notices, 2013. Disponível em: https://www.hindawi.com/journals/isrn/2013/234034/
Kobal, A. B., Horvat, M., Prezelj, M., Briški, A. S., Krsnik, M., Dizdarevič, T., ... & Osredkar, J. (2004). The impact of long-term past exposure to elemental mercury on antioxidative capacity and lipid peroxidation in mercury miners. Journal of Trace Elements in Medicine and Biology, 17(4), 261-274. DOI: https://doi.org/10.1016/S0946-672X(04)80028-2
Lim, S., Chung, H. U., & Paek, D. (2010). Low dose mercury and heart rate variability among community residents nearby to an industrial complex in Korea. Neurotoxicology, 31(1), 10-16. DOI: https://doi.org/10.1016/j.neuro.2009.10.001
Nyantika, A. N., Tuomainen, T. P., Kauhanen, J., Voutilainen, S., & Virtanen, J. K. (2015). Serum long-chain omega-3 polyunsaturated fatty acids and future blood pressure in an ageing population. The journal of nutrition, health & aging, 19(5), 498-503. Disponível em: https://link.springer.com/article/10.1007/s12603-015-0463-6
Nyantika, A. N., Tuomainen, T. P., Kauhanen, J., Voutilainen, S., & Virtanen, J. K. (2016). Serum long-chain omega-3 polyunsaturated fatty acids and risk of orthostatic hypotension. Hypertension Research, 39(7), 543-547. Disponível em: https://www.nature.com/articles/hr201619
Pagan, L. U., Cezar, M. D. M., & Damatto, R. L. (2019). Alterations Resulting from Exposure to Mercury in Normotensive and Hypertensive Rats. Arquivos Brasileiros de Cardiologia, 112, 381-382. DOI: https://doi.org/10.5935/abc.20190025
Rajaee, M., Sánchez, B. N., Renne, E. P., & Basu, N. (2015). An investigation of organic and inorganic mercury exposure and blood pressure in a small-scale gold mining community in Ghana. International journal of environmental research and public health, 12(8), 10020-10038. Disponível em: https://www.mdpi.com/1660-4601/12/8/10020
Simões, R. P., Fardin, P. B. A., Simões, M. R., Vassallo, D. V., & Padilha, A. S. (2020). Long-term Mercury Exposure Accelerates the Development of Hypertension in Prehypertensive Spontaneously Hypertensive Rats Inducing Endothelial Dysfunction: the Role of Oxidative Stress and Cyclooxygenase-2. Biological Trace Element Research, 196(2), 565-578. Disponível em: https://link.springer.com/article/10.1007/s12011-019-01952-8
Vassallo, D. V., Simões, M. R., Furieri, L. B., Fioresi, M., Fiorim, J., Almeida, E. A. S., ... & Salaices, M. (2011). Toxic effects of mercury, lead and gadolinium on vascular reactivity. Brazilian Journal of Medical and Biological Research, 44, 939-946. DOI: https://doi.org/10.1590/S0100-879X2011007500098
Vassallo, D. V., Wiggers, G. A., Padilha, A. S., & Simões, M. R. (2020). Endothelium: A target for harmful actions of metals. Current Hypertension Reviews, 16(3), 201-209. Disponível em: https://www.ingentaconnect.com/content/ben/chyr/2020/00000016/00000003/art00008
Yorifuji, T., Tsuda, T., Kashima, S., Takao, S., & Harada, M. (2010). Long-term exposure to methylmercury and its effects on hypertension in Minamata. Environmental Research, 110(1), 40-46. DOI: https://doi.org/10.1016/j.envres.2009.10.011
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Copyright (c) 2022 André Luiz Bittencourt de Amorim Farias; Natasha Ponte Tabosa; Patrícia Michelly Mendonça Viana; Adriana Pereira Trindade; Julyana Lago Pinto da Silva; Claudia Simone Baltazar; Renata Suellen Souza Cauper Viana; Waldineia Lobato Garcia; Sara de Souza Pereira; Beatriz Oliveira Amaro
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