Concentrados autólogos de plaquetas y su aplicabilidad en Odontología

Autores/as

DOI:

https://doi.org/10.33448/rsd-v11i15.36838

Palabras clave:

Odontología; Fibrina; Plasma rico en plaquetas; Sangre; Proliferación celular.

Resumen

El desarrollo de tecnologías basadas en concentrado de plaquetas obtenido mediante métodos de centrifugación y manipulación a partir de una muestra de sangre tiene como objetivo optimizar la cicatrización de los tejidos y favorecer la regeneración tisular. Objetivo: abordar las consideraciones sobre los concentrados plaquetarios autólogos y su aplicabilidad en Odontología. Metodología: se realizó un análisis retrospectivo de la literatura desde 2001 hasta 2022, centrándose en la evolución y uso de concentrados de sangre autóloga. Se utilizaron los siguientes términos de búsqueda: plasma rico en plaquetas, plasma rico en fibrina, hemoconcentrados autólogos, regeneración tisular y cicatrización. La búsqueda bibliográfica se realizó a través de una búsqueda en las bases de datos PubMed, Google Scholar, SciELO y BVS. Reseña bibliográfica: El plasma rico en plaquetas (PRP) fue la primera generación de derivados de muestras de sangre humana, utilizados para este fin. Según la técnica de preparación de los concentrados de plaquetas, se dividen en cuatro categorías según su contenido en leucocitos y fibrina. Conclusión: Los agregados plaquetarios pueden inducir la activación de fibroblastos y la formación de depósitos de colágeno, además de plaquetas y factores de crecimiento utilizados en la reparación tisular. Así, optimizan los resultados de tratamientos en odontología, como rellenos cutáneos, tratamiento de cicatrices de acné, implantes dentales y cirugías dentoalveolares.

Biografía del autor/a

Daniela Martins de Souza, Sociedade Brasileira dos Cirurgiões-Dentistas

Possui graduação em ODONTOLOGIA pela Universidade Federal do Rio Grande do Sul (1995), mestrado em Clinica Odontológica na área de Periodontia pela Universidade Federal do Rio Grande do Sul (2001) e doutorado em Biopatologia Bucal pela Universidade Estadual Paulista Júlio de Mesquita Filho (2006). Especialização em Periodontia (UFRGS), Patologia Bucal (UNESP) e Harmonização Orofacial (FUNORTE). Experiência docente UFRGS Substiruta Oclusão (1998/1999), e Uni FUNVIC de 2005 a 2018. Revisora de periódicos Nacionais e Internacionais. Editora Chefe da revista on-line Aesthetic Orofacial Science, Editora Assistente da Revista Ciência e Saúde On-line. Membro do Conselho Editorial do International Journal of Advance in Medical Science e Asian Journal of Research in Medical and Pharmaceutical Sciences. Habilitada em Ozonioterapia e com experiência clinica e em pesquisa com ênfase em Saúde Bucal, Periodontia, Radiologia, Diagnóstico Bucal, Harmonização Orofacial, Ozonioterapia, Clinica Integrada e odontologia integrativa.

Citas

A. Zumstein, M., Berger, S., Schober, M., Boileau, P., W. Nyffeler, R., Horn, M., & A. Dahinden, C. (2012). Leukocyte- and Platelet-Rich Fibrin (L-PRF) for Long-Term Delivery of Growth Factor in Rotator Cuff Repair: Review, Preliminary Results and Future Directions. Current Pharmaceutical Biotechnology, 13(7), 1196–1206. https://doi.org/10.2174/138920112800624337

Amable, P. R., Carias, R. B. V., Teixeira, M. V. T., Da Cruz Pacheco, Í., Corrêa Do Amaral, R. J. F., Granjeiro, J. M., & Borojevic, R. (2013). Platelet-rich plasma preparation for regenerative medicine: Optimization and quantification of cytokines and growth factors. Stem Cell Research and Therapy, 4(3). https://doi.org/10.1186/scrt218

Andia, I., & Abate, M. (2013). Platelet-rich plasma: Underlying biology and clinical correlates. Regenerative Medicine, 8(5), 645–658. https://doi.org/10.2217/RME.13.59/ASSET/IMAGES/LARGE/FIGURE2.JPEG

Bielecki, T., & M. Dohan Ehrenfest, D. (2012). Platelet-Rich Plasma (PRP) and Platelet-Rich Fibrin (PRF): Surgical Adjuvants, Preparations for In Situ Regenerative Medicine and Tools for Tissue Engineering. Current Pharmaceutical Biotechnology, 13(7), 1121–1130. https://doi.org/10.2174/138920112800624292

Campos, J. H.., & Souza, D. M. de. (2021). Plasma Rico em Plaquetas Otimizando o Rejuvenescimento Dérmico nos Procedimentos Estéticos. Aesthetic Orofacial Science, 2(2). https://doi.org/10.51670/aos.v2i2.47

Cao, Y., Zhu, X., Zhou, R., He, Y., Wu, Z., & Chen, Y. (2021). A narrative review of the research progress and clinical application of platelet-rich plasma. Annals of Palliative Medicine, 10(4), 4823–4829. https://doi.org/10.21037/apm-20-2223

Carvalho, N. A. de, Morais, C. E. C., Nascimento, F., Dietrich, L., & Costa, M. D. M. de A. (2021). Applicability of PRF- platelet-rich fibrin in Dentistry and it’s benefits. Research, Society and Development, 10(13), e466101321570. https://doi.org/10.33448/rsd-v10i13.21570

Castro, R. L. B. de., Antonio, B. P., & Manoel, F. G. de O. M. (2022). Is the manual preparation of platelet rich plasma safe? Research, Society and Development, 11(10), e19111032270. https://doi.org/10.33448/rsd-v11i10.32270

Choukroun, J., Diss, A., Simonpieri, A., Girard, M. O., Schoeffler, C., Dohan, S. L., Dohan, A. J. J., Mouhyi, J., & Dohan, D. M. (2006). Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part IV: Clinical effects on tissue healing. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, 101(3). https://doi.org/10.1016/j.tripleo.2005.07.011

Choukroun, J., & Ghanaati, S. (2018). Reduction of relative centrifugation force within injectable platelet-rich-fibrin (PRF) concentrates advances patients’ own inflammatory cells, platelets and growth factors: the first introduction to the low speed centrifugation concept. European Journal of Trauma and Emergency Surgery, 44(1), 87–95. https://doi.org/10.1007/s00068-017-0767-9

Costa, D. G., Silva, T. C. B., Costa, M. D. M. de A., Martins, V. da M. and Dietrich, L. (2021a) “Fibrine rich in platelets”, Research, Society and Development, 10(6), p. e11510615520. doi: 10.33448/rsd-v10i6.1520.

Costa, K. L.., Santos, M. de V., & Santos, M. D. da S. (2021b). Fibrin rich in platelets and leukocytes-L-PRF- in Dentistry: literature review. Research, Society and Development, 10(11), e332101119473. https://doi.org/10.33448/rsd-v10i11.19473.

Davis, V. L., Abukabda, A. B., Radio, N. M., Witt-Enderby, P. A., Clafshenkel, W. P., Cairone, J. V., & Rutkowski, J. L. (2014). Platelet-rich preparations to improve healing. Part II: Platelet activation and enrichment, leukocyte inclusion, and other selection criteria. In Journal of Oral Implantology (Vol. 40, Issue 4, pp. 511–521). Allen Press. https://doi.org/10.1563/AAID-JOI-D-12-00106

Dohan, D. M., Choukroun, J., Diss, A., Dohan, S. L., Dohan, A. J. J., Mouhyi, J., & Gogly, B. (2006a). Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part I: Technological concepts and evolution. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, 101(3). https://doi.org/10.1016/j.tripleo.2005.07.008

Dohan, D. M., Choukroun, J., Diss, A., Dohan, S. L., Dohan, A. J. J., Mouhyi, J., & Gogly, B. (2006b). Platelet-rich fibrin (PRF): A second-generation platelet concentrate. Part II: Platelet-related biologic features. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, 101(3), e45–e50. https://doi.org/10.1016/j.tripleo.2005.07.009

Dohan Ehrenfest, D. M., Del Corso, M., Diss, A., Mouhyi, J., & Charrier, J.-B. (2010). Three-Dimensional Architecture and Cell Composition of a Choukroun’s Platelet-Rich Fibrin Clot and Membrane. Journal of Periodontology, 81(4), 546–555. https://doi.org/10.1902/jop.2009.090531

Dohan Ehrenfest, D., Bielecki, T., Mishra, A., Borzini, P., Inchingolo, F., Sammartino, G., Rasmusson, L., & A. Evert, P. (2012). In Search of a Consensus Terminology in the Field of Platelet Concentrates for Surgical Use: Platelet-Rich Plasma (PRP), Platelet-Rich Fibrin (PRF), Fibrin Gel Polymerization and Leukocytes. Current Pharmaceutical Biotechnology, 13(7), 1131–1137. https://doi.org/10.2174/138920112800624328

Dohan Ehrenfest, D. M., Rasmusson, L., & Albrektsson, T. (2009). Classification of platelet concentrates: from pure platelet-rich plasma (P-PRP) to leucocyte- and platelet-rich fibrin (L-PRF). In Trends in Biotechnology (Vol. 27, Issue 3, pp. 158–167). Trends Biotechnol. https://doi.org/10.1016/j.tibtech.2008.11.009

Estela, C. (2018). Metodologia Científica: Ciência, Ensino, Pesquisa. Editora Artes Médicas.

Fujioka-Kobayashi, M., Miron, R. J., Hernandez, M., Kandalam, U., Zhang, Y., & Choukroun, J. (2017). Optimized Platelet-Rich Fibrin With the Low-Speed Concept: Growth Factor Release, Biocompatibility, and Cellular Response. Journal of periodontology, 88(1), 112–121. https://doi.org/10.1902/jop.2016.160443

Ghanaati, S., Booms, P., Orlowska, A., Kubesch, A., Lorenz, J., Rutkowski, J., Landes, C., Sader, R., Kirkpatrick, C., & Choukroun, J. (2014). Advanced platelet-rich fibrin: a new concept for cell-based tissue engineering by means of inflammatory cells. The Journal of oral implantology, 40(6), 679–689. https://doi.org/10.1563/aaid-joi-D-14-00138

Kawase, T., Mubarak, S., & Mourão, C. F. (2020). The platelet concentrates therapy: From the biased past to the anticipated future. In Bioengineering (Vol. 7, Issue 3, pp. 1–20). MDPI AG. https://doi.org/10.3390/bioengineering7030082

Kobayashi, E., Flückiger, L., Fujioka-Kobayashi, M., Sawada, K., Sculean, A., Schaller, B., & Miron, R. J. (2016). Comparative release of growth factors from PRP, PRF, and advanced-PRF. Clinical Oral Investigations, 20(9), 2353–2360. https://doi.org/10.1007/s00784-016-1719-1

Le, A. D. K., Enweze, L., DeBaun, M. R., & Dragoo, J. L. (2019). Platelet-Rich Plasma. In Clinics in Sports Medicine (Vol. 38, Issue 1, pp. 17–44). W.B. Saunders. https://doi.org/10.1016/j.csm.2018.08.001

Masuki, H., Okudera, T., Watanebe, T., Suzuki, M., Nishiyama, K., Okudera, H., Nakata, K., Uematsu, K., Su, C.-Y., & Kawase, T. (2016). Growth factor and pro-inflammatory cytokine contents in platelet-rich plasma (PRP), plasma rich in growth factors (PRGF), advanced platelet-rich fibrin (A-PRF), and concentrated growth factors (CGF). International Journal of Implant Dentistry, 2(1). https://doi.org/10.1186/s40729-016-0052-4

Mijiritsky, E., Assaf, H. D., Peleg, O., Shacham, M., Cerroni, L., & Mangani, L. (2021). Use of PRP, PRF and CGF in periodontal regeneration and facial rejuvenation-a narrative review. Biology, 10(4). https://doi.org/10.3390/biology10040317

Moraes, V. Y., Lenza, M., Tamaoki, M. J., Faloppa, F., & Belloti, J. C. (2014). Platelet-rich therapies for musculoskeletal soft tissue injuries. In Cochrane Database of Systematic Reviews (Vol. 2014, Issue 4). John Wiley and Sons Ltd. https://doi.org/10.1002/14651858.CD010071.pub3

Nobrega, R. M. V. da., Castro, I., & Bastos, B. (2022). Eficácia clínica do Concentrado- Plasma Rico em Fibrina (C-PRF) associado à vitamina C como bioestimulador. Aesthetic Orofacial Science, 3(1), 49-57. https://doi.org/10.51670/aos.v3i1.79

Pallua, N., Wolter, T., & Markowicz, M. (2010). Platelet-rich plasma in burns. In Burns (Vol. 36, Issue 1, pp. 4–8). https://doi.org/10.1016/j.burns.2009.05.002

Peck, M., Hiss, D., & Stephen, L. (2016). Factors affecting the preparation, constituents, and clinical efficacy of leukocyte- and platelet- rich fibrin (L-PRF). SADJ: Journal of the South African Dental Association = Tydskrif van Die Suid-Afrikaanse Tandheelkundige Vereniging, 71, 298–302.

Qiao, J., An, N., & Ouyang, X. (2017). Quantification of growth factors in different platelet concentrates. Platelets, 28(8), 774–778. https://doi.org/10.1080/09537104.2016.1267338

Schär, M. O., Diaz-Romero, J., Kohl, S., Zumstein, M. A., & Nesic, D. (2015). Platelet-rich Concentrates Differentially Release Growth Factors and Induce Cell Migration In Vitro. Clinical Orthopaedics and Related Research, 473(5), 1635–1643. https://doi.org/10.1007/s11999-015-4192-2

Terra, M. P., Silva, K. N. G., Martins, A. L. da S., Vilela, L. de F., & Fulco, T. de O. (2022). The use of platelet-rich plasma (PRP) in facial rejuvenation. Research, Society and Development, 11(12), e190111231626. https://doi.org/10.33448/rsd-v11i12.31626

Ustaoğlu, G., Göller Bulut, D., & Gümüş, K. (2020). Evaluation of different platelet-rich concentrates effects on early soft tissue healing and socket preservation after tooth extraction. Journal of Stomatology, Oral and Maxillofacial Surgery, 121(5), 539–544. https://doi.org/10.1016/j.jormas.2019.09.005

Wu, C. L., Lee, S. S., Tsai, C. H., Lu, K. H., Zhao, J. H., & Chang, Y. C. (2012). Platelet-rich fibrin increases cell attachment, proliferation and collagen-related protein expression of human osteoblasts. Australian Dental Journal, 57(2), 207–212. https://doi.org/10.1111/j.1834-7819.2012.01686.x

Publicado

24/11/2022

Cómo citar

PACHECO, R. F. .; CUSTÓDIO, A. L. N.; SOUZA, D. M. de; PACHECO, C. L. de O. .; ALBERGARIA-BARBOSA, J. R. de . Concentrados autólogos de plaquetas y su aplicabilidad en Odontología. Research, Society and Development, [S. l.], v. 11, n. 15, p. e501111536838, 2022. DOI: 10.33448/rsd-v11i15.36838. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/36838. Acesso em: 30 jun. 2024.

Número

Sección

Ciencias de la salud