Beneficios promovidos por el uso de un nutracéutico producido por fermentación de alta biodisponibilidad, rico en β-glucanos y aminoácidos, para pacientes con cáncer tratados con quimioterapia y radioterapia

Autores/as

DOI:

https://doi.org/10.33448/rsd-v11i15.36983

Palabras clave:

Suplementación; β-glucanos; Aminoácidos; Pacientes oncológicos; Quimioterapia; Radioterapia; Bionutri AR1®.

Resumen

Los pacientes con cáncer son generalmente sometidos a quimioterapia y radioterapia, que suelen causar problemas relacionados con procesos inflamatorios intensos, desnutrición, náuseas y emesis. Por tanto, realizar la suplementación en estos pacientes es importante y necesario, ya que favorece a los pacientes oncológicos desde el punto de vista nutricional. Los estudios muestran que la suplementación con β-glucanos promueve beneficios para los pacientes con cáncer que reciben quimioterapia y radioterapia. Los aminoácidos y β-glucanos obtenidos de los procesos de fermentación demostraron ser importantes en el cuidado de los pacientes con cáncer, ya que mejoran los parámetros nutricionales y el estado general del paciente. Por lo tanto, este trabajo tiene como objetivo discutir los beneficios obtenidos por los pacientes con cáncer sometidos a quimioterapia y radioterapia que recibieron la suplementación con un nutracéutico fermentado rico en β-glucanos y aminoácidos. Se realizó una revisión bibliográfica a través de una búsqueda activa de artículos científicos mediante el uso de los siguientes descriptores en portugués: β-glucanos, aminoácidos, pacientes con cáncer, quimioterapia y radioterapia. Además, también se comentan los beneficios que provoca el uso del producto denominado Bionutri AR1®, un nutracéutico que contribuye a la recuperación del estado nutricional, indicado para pacientes con desnutrición severa inducida por cáncer y los abordajes terapéuticos de quimioterapia y radioterapia. Concluimos que la utilización de productos capaces de promover la suplementación de β-glucanos y aminoácidos es sumamente beneficiosa para los pacientes oncológicos, especialmente los sometidos a quimioterapia y radioterapia y, por tanto, existe una indicación de suplementación para estos pacientes con el producto fermentado Bionutri AR1 ®.

Citas

Argilés J. M. (2005). Cancer-associated malnutrition. European journal of oncology nursing : the official journal of European Oncology Nursing Society, 9 Suppl 2, S39–S50. https://doi.org/10.1016/j.ejon.2005.09.006.

Behall, K. M., Scholfield, D. J., Hallfrisch, J. G., & Liljeberg-Elmståhl, H. G. (2006). Consumption of both resistant starch and beta-glucan improves postprandial plasma glucose and insulin in women. Diabetes Care, 29(5), 976–981. https://doi.org/10.2337/diacare.295976

Boligon, C. S., & Huth, A. (2011). O Impacto do Uso de Glutamina em Pacientes com tumores de cabeça e pescoço em tratamento radioterápico e quimioterápico. Revista Brasileira de Cancerologia; 57(1): 31-38.

Carling D. (2017). AMPK signalling in health and disease. Current Opinion in Cell Biology, 45, 31–37. https://doi.org/10.1016/j.ceb.2017.01.005.

Carvalho, A.C.L., Martins, P.C., Araujo, R.B., Cerdeira, C.D., Silva, R.B.V., & Baros, G.B.S. (2018). Parâmetros Nutricionais em Pacientes Oncológicos atendidos em um Centro de Referência no Sul de Minas Gerais, Brasil. Revista Brasileira de Cancerologia; 64(2): 159-166.

Cencioni, C., Trestini, I., Piro, G., Bria, E., Tortora, G., Carbone, C., & Spallotta, F. (2022). Gastrointestinal Cancer Patient Nutritional Management: From Specific Needs to Novel Epigenetic Dietary Approaches. Nutrients, 14(8), 1542. https://doi.org/10.3390/nu14081542.

Demir, G., Klein, H. O., Mandel-Molinas, N., & Tuzuner, N. (2007). Beta glucan induces proliferation and activation of monocytes in peripheral blood of patients with advanced breast cancer. International Immunopharmacology, 7(1), 113–116. https://doi.org/10.1016/j.intimp.2006.08.011.

Di Luzio, N. R., Williams, D. L., McNamee, R. B., Edwards, B. F., & Kitahama, A. (1979). Comparative tumor-inhibitory and anti-bacterial activity of soluble and particulate glucan. International Journal of Cancer, 24(6), 773–779. https://doi.org/10.1002/ijc.2910240613.

Dillon, E. L., Volpi, E., Wolfe, R. R., Sinha, S., Sanford, A. P., Arrastia, C. D., Urban, R. J., Casperson, S. L., Paddon-Jones, D., & Sheffield-Moore, M. (2007). Amino acid metabolism and inflammatory burden in ovarian cancer patients undergoing intense oncological therapy. Clinical Nutrition (Edinburgh, Scotland), 26(6), 736–743. https://doi.org/10.1016/j.clnu.2007.07.004.

Eagles, J. R., & Jimeno, A. (2016). Cobimetinib: inhibiting MEK1/2 in BRAF V600-mutant melanoma. Drugs of Today (Barcelona, Spain: 1998), 52(11), 593–605. https://doi.org/10.1358/dot.2016.52.11.2542234.

Errante, P. R., Menezes-Rodrigues, F. S., Leite, A. A., Caricati-Neto, A., & Bergantin, L. B. (2016). New antitumoral pharmacological strategies involving Ca2+ camp signaling pathways. Journal of Cancer Epidemiology and Prevention, 2(1).

Errante, P. R., Neto, A. C., & Bergantin, L. B. (2017). Insights for the inhibition of cancer progression: Revisinting Ca2+ and cAMP signalling pathways. Advances in Cancer Prevention, 2: e103. https://doi.org/10.4172/2472-0429.1000e103.

Errante, P. R., Rodrigues, F. S. M., Leite, A. A., Caricati-Neto, A., & Bergantin, L. B. (2017) The Second Messengers Ca2+ and camp as Potential Therapeutic Targets for the Control of Cancer Progression. Advances in Cancer Prevention, 2: e105. doi:10.4172/2472-0429.1000e105.

Ellsworth, D. L., Blackburn, H. L., Shriver, C. D., Rabizadeh, S., Soon-Shiong, P., & Ellsworth, R. E. (2017). Single-cell sequencing and tumorigenesis: improved understanding of tumor evolution and metastasis. Clinical and Translational Medicine, 6(1), 15. https://doi.org/10.1186/s40169-017-0145-6.

Fuller, R., Moore, M. V., Lewith, G., Stuart, B. L., Ormiston, R. V., Fisk, H. L., Noakes, P. S., & Calder, P. C. (2017). Yeast-derived β-1,3/1,6 glucan, upper respiratory tract infection and innate immunity in older adults. Nutrition (Burbank, Los Angeles County, Calif.), 39-40, 30–35. https://doi.org/10.1016/j.nut.2017.03.003.

Gonzalez, M. C., Borges, L. R., Silveira, D. H., Assunção, M. C. F., & Orlandi, S. P. (2010). Validação da versão em português da avaliação subjetiva global produzida pelo paciente. Revista Brasileira de Nutrição Clínica, Porto Alegre, 25(2), 102-108.

Hnisz, D., Weintraub, A. S., Day, D. S., Valton, A. L., Bak, R. O., Li, C. H., Goldmann, J., Lajoie, B. R., Fan, Z. P., Sigova, A. A., Reddy, J., Borges-Rivera, D., Lee, T. I., Jaenisch, R., Porteus, M. H., Dekker, J., & Young, R. A. (2016). Activation of proto-oncogenes by disruption of chromosome neighborhoods. Science (New York, N.Y.), 351(6280), 1454–1458. https://doi.org/10.1126/science.aad9024.

Jamal-Hanjani, M., Wilson, G. A., McGranahan, N., Birkbak, N. J., Watkins, T., Veeriah, S., Shafi, S., Johnson, D. H., Mitter, R., Rosenthal, R., Salm, M., Horswell, S., Escudero, M., Matthews, N., Rowan, A., Chambers, T., Moore, D. A., Turajlic, S., Xu, H., & Lee, S. M. (2017). Tracking the Evolution of Non-Small-Cell Lung Cancer. The New England Journal of Medicine, 376(22), 2109–2121. https://doi.org/10.1056/NEJMoa1616288.

Kachalaki, S., Ebrahimi, M., Mohamed Khosroshahi, L., Mohammadinejad, S., & Baradaran, B. (2016). Cancer chemoresistance; biochemical and molecular aspects: a brief overview. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 89, 20–30. https://doi.org/10.1016/j.ejps.2016.03.025.

Kim, K. S., & Yun, H. S. (2006). Production of soluble β-glucan from the cell wall of Saccharomyces cerevisiae. Enzyme and Microbial Technology, New York, 39(3), 496-500.

Kim, S. Y., Song, H. J., Lee, Y. Y., Cho, K. H., & Roh, Y. K. (2006). Biomedical issues of dietary fiber beta-glucan. Journal of Korean Medical Science, 21(5), 781–789. https://doi.org/10.3346/jkms.2006.21.5.781.

Ko, Y. T., & Lin, Y. L. (2004). 1,3-beta-glucan quantification by a fluorescence microassay and analysis of its distribution in foods. Journal of agricultural and food chemistry, 52(11), 3313–3318. https://doi.org/10.1021/jf0354085.

Kogan, G., Sandula, J., Korolenko, T. A., Falameeva, O. V., Poteryaeva, O. N., Zhanaeva, S. Y., Levina, O. A., Filatova, T. G., & Kaledin, V. I. (2002). Increased efficiency of Lewis lung carcinoma chemotherapy with a macrophage stimulator--yeast carboxymethyl glucan. International Immunopharmacology, 2(6), 775–781. https://doi.org/10.1016/s1567-5769(02)00015-2.

Kuroda, Y., & Hara, Y. (1999). Antimutagenic and anticarcinogenic activity of tea polyphenols. Mutation Research, 436(1), 69–97. https://doi.org/10.1016/s1383-5742(98)00019-2.

Lin, H., She, Y. H., Cassileth, B. R., Sirotnak, F., & Cunningham Rundles, S. (2004). Maitake beta-glucan MD-fraction enhances bone marrow colony formation and reduces doxorubicin toxicity in vitro. International Immunopharmacology, 4(1), 91–99. https://doi.org/10.1016/j.intimp.2003.10.012.

Matuoka-Chiocchetti, G., Viana, L. R., Lopes‐Aguiar, L., da Silva Miyaguti, N. A., & Gomes‐Marcondes, M. C. C. (2022). Nutraceuticals Approach as a Treatment for Cancer Cachexia. Handbook of Nutraceuticals and Natural Products: Biological, Medicinal, and Nutritional Properties and Applications, 1, 273-300.

Magnani, M., & Castro-Gomez, R.J.H. (2008). β-glucana de Saccharomyces cerevisiae:constituição, bioatividade e obtenção. Semina: Ciências Agrárias, Londrina, 29(3), 631-650.

Maiuolo, J., Gliozzi, M., Carresi, C., Musolino, V., Oppedisano, F., Scarano, F., Nucera, S., Scicchitano, M., Bosco, F., Macri, R., Ruga, S., Cardamone, A., Coppoletta, A., Mollace, A., Cognetti, F., & Mollace, V. (2021). Nutraceuticals and Cancer: Potential for Natural Polyphenols. Nutrients, 13(11), 3834. https://doi.org/10.3390/nu13113834.

Miadokova, E., Svidova, S., Vlckova, V., Duhova, V., Prazmariova, E., Tothova, K., Nadova, S., Kogan, G., & Rauko, P. (2005). The role of natural biopolymers in genotoxicity of mutagens/carcinogens elimination. Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, 149, 493-496.

Miranda, M. P., & Souza, D. S. (2015). Glutamina na Prevenção e Tratamento da Mucosite em Pacientes Adultos Oncológicos: uma Revisão Sistemática da Literatura. Revista Brasileira de Cancerologia, 61(3), 277-285.

Miola, T. M. (2016). Avaliação do estado nutricional de pacientes atendidos em ambulatório de quimioterapia. Nutrição Brasil, 15(1): 30-35.

Moon, S. H., Heo, J. C., Fine, R. L., Kim, H. M., Kim, S. U., Yoon, B. D., & Lee, S. H. (2005). BRD-glucan exhibits potent immunochemotherapeutic activity in vitro and in vivo. International Journal of Oncology, 26(2), 395–404.

Morigi, C. (2017). Highlights from the 15th St Gallen International Breast Cancer Conference 15-18 March, 2017, Vienna: tailored treatments for patients with early breast cancer. Ecancermedicalscience, 11, 732. https://doi.org/10.3332/ecancer.2017.732.

Muscaritoli, M., Lucia, S., Farcomeni, A., Lorusso, V., Saracino, V., Barone, C., Plastino, F., Gori, S., Magarotto, R., Carteni, G., Chiurazzi, B., Pavese, I., Marchetti, L., Zagonel, V., Bergo, E., Tonini, G., Imperatori, M., Iacono, C., Maiorana, L., Pinto, C., … PreMiO Study Group (2017). Prevalence of malnutrition in patients at first medical oncology visit: the PreMiO study. Oncotarget, 8(45), 79884–79896. https://doi.org/10.18632/oncotarget.20168

Oliveira, T. (2007). A importância do acompanhamento nutricional para pacientes com câncer. Prática Hospitalar, 51(3): 150-4.

Pohorska, J., Richter, J., Kral, V., Rajonohova, D. L., Stiborova, I., & Vetvicka, V. (2016). Reconstruction of NK cells during complex cancer treatment. Journal of Tumor, 4, 398–402.

Prado, C. D., & Campos, J. A. D. B. (2015). Malnutrition in patients with gastrointestinal cancer: effectiveness of different diagnostic methods. Nutricion hospitalaria, 32(1), 182–188. https://doi.org/10.3305/nh.2015.32.1.8657.

Ravasco P. (2015). Nutritional approaches in cancer: relevance of individualized counseling and supplementation. Nutrition (Burbank, Los Angeles County, Calif.), 31(4), 603–604. https://doi.org/10.1016/j.nut.2014.12.001.

Sagar, B., Lin, Y. S., & Castel, L. D. (2017). Cost drivers for breast, lung, and colorectal cancer care in a commercially insured population over a 6-month episode: an economic analysis from a health plan perspective. Journal of Medical Economics, 20(10), 1018–1023. https://doi.org/10.1080/13696998.2017.1339353.

Tartari, R. F., Busnello, F. M., Nunes, C. H. A. (2010). Perfil Nutricional de Pacientes em Tratamento Quimioterápico em um Ambulatório Especializado em Quimioterapia. Revista Brasileira de Cancerologia, 56(1): 43-50.

Uchida C. (2016). Roles of pRB in the Regulation of Nucleosome and Chromatin Structures. BioMed Research International, 2016, 5959721. https://doi.org/10.1155/2016/5959721.

Van Cutsem, E., & Arends, J. (2005). The causes and consequences of cancer-associated malnutrition. European journal of oncology nursing : the official journal of European Oncology Nursing Society, 9 Suppl 2, S51–S63. https://doi.org/10.1016/j.ejon.2005.09.007.

Vetvicka, V., Richter, J., Kral, V., Dobiasova, L. R., Stiborova I., & Pohorska J. (2015). Regulation of hematopoiesis in câncer patients: placebo-driven, double-blind clinical trails of β-glucan. Journal of Tumor. 3: 305–308.

Vetvicka, V., Vannucci, L., Sima, P., & Richter, J. (2019). Beta Glucan: Supplement or Drug? From Laboratory to Clinical Trials. Molecules (Basel, Switzerland), 24(7), 1251. https://doi.org/10.3390/molecules24071251.

Vosgerau, D. S. A. R. & Romanowski, J. P. (2014) Estudos de revisão: implicações conceituais e metodológicas. Revista de Diálogo Educacional, (14)41, 165-189.

Waitzberg, D. L. Novas oportunidades para o uso de aminoácidos parenterais – glutamina. (2008). Revista Brasileira de Medicina, 65(6): 66.

Xue, H., Le Roy, S., Sawyer, M., Field, C., Dieleman, L., & Baracos, V. (2009). Single and combined supplementation of glutamine and n-3 polyunsaturated fatty acids on host tolerance and tumour response to 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxy-camptothecin (CPT-11)/5-fluorouracil chemotherapy in rats bearing Ward colon tumour. British Journal of Nutrition, 102(3), 434-442. doi:10.1017/S0007114508199482.

Yajid, A. I., Zakariah, M. A., Mat Zin, A. A., & Othman, N. H. (2017). Potential Role of E4 Protein in Human Papillomavirus Screening: a Review. Asian Pacific Journal of Cancer Prevention : APJCP, 18(2), 315–319. https://doi.org/10.22034/APJCP.2017.18.2.315.

Yun, C. H., Estrada, A., Van Kessel, A., Park, B. C., & Laarveld, B. (2003). Beta-glucan, extracted from oat, enhances disease resistance against bacterial and parasitic infections. FEMS Immunology and Medical Microbiology, 35(1), 67–75. https://doi.org/10.1016/S0928-8244(02)00460-1

Zegarska, B., Pietkun, K., Zegarski, W., Bolibok, P., Wiśniewski, M., Roszek, K., Czarnecka, J., & Nowacki, M. (2017). Air pollution, UV irradiation and skin carcinogenesis: what we know, where we stand and what is likely to happen in the future? Postepy Dermatologii i Alergologii, 34(1), 6–14. https://doi.org/10.5114/ada.2017.65616.

Publicado

11/11/2022

Cómo citar

CRUZ, E. M. S. da .; FERNANDES JUNIOR, H. J.; TALLO, F. S.; PIRES-OLIVEIRA, M.; NICOLAU, A. L. D. .; CARVALHO, R. G. de .; GEHRKE, F. de S. .; CARICATI-NETO, A.; TAHA, M. O.; MENEZES RODRIGUES, F. S. Beneficios promovidos por el uso de un nutracéutico producido por fermentación de alta biodisponibilidad, rico en β-glucanos y aminoácidos, para pacientes con cáncer tratados con quimioterapia y radioterapia. Research, Society and Development, [S. l.], v. 11, n. 15, p. e92111536983, 2022. DOI: 10.33448/rsd-v11i15.36983. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/36983. Acesso em: 30 jun. 2024.

Número

Sección

Revisiones