Molecular Docking of Zingerone and Gamma-Mangostin to Inhibit MAO-B and Catechol-O-Methyltransferase (COMT) in the Treatment of Parkinson’s Disease

Aratã Andrande  Saraiva; João Paulo Oliveira da  Silva; José Vigno Moura  Sousa; Ayrton de Sá  Brandim

doi:10.33448/rsd-v11i16.37853

Autores/as

Aratã Andrande Saraiva Federal Institute of Education, Science and Technology of Piauí https://orcid.org/0000-0002-3960-697X
João Paulo Oliveira da Silva Faculty of Technology of Piauí https://orcid.org/0000-0003-1984-0264
José Vigno Moura Sousa State University of Piauí https://orcid.org/0000-0002-5164-360X
Ayrton de Sá Brandim Federal Institute of Education, Science and Technology of Piauí https://orcid.org/0000-0003-0626-6152

DOI:

https://doi.org/10.33448/rsd-v11i16.37853

Palabras clave:

Parkinson; Zingerona; Gamma-Mangostin; Catecol-O-Metiltransferasa.

Resumen

Actualmente, no existe ningún fármaco que tenga propiedades neuroprotectoras comprobadas en la enfermedad de Parkinson. El fármaco más conocido es la levodopa, que actúa como inhibidor de las enzimas MAO-B y COMT implicadas en la degradación de la dopamina. Aunque la levodopa es el "estándar de oro" del tratamiento, a medida que avanza la enfermedad, la mayoría de los pacientes desarrollan complicaciones a causa de la terapia y los efectos secundarios. En este sentido, se aborda la combinación de dos sustancias abundantes y fitoterapéuticos como alternativas al uso de las medicinas tradicionales, a saber, la Zingerona y la Gamma-Mangostin. En el cual presentaron resultados favorables en acoplamiento molecular.

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Acoplamiento Molecular de Zingerona y Gamma-Mangostin para Inhibir MAO-B y Catecol-O-Metiltransferasa (COMT) en el Tratamiento de la Enfermedad de Parkinson

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