Efecto protector del extracto amazónico de Himatanthus sucuuba sobre Drosophila melanogaster expuesta a Paraquat
DOI:
https://doi.org/10.33448/rsd-v11i17.38931Palabras clave:
Drosophila melanogaster; Neuroprotección; Antioxidantes; Plantas de la Amazonia.Resumen
La selva amazónica es un importante manantial de conocimientos científicos, por eso diversos grupos de investigación buscan comprender la acción de los compuestos amazónicos sobre las enfermedades. Entre la extensa flora, el Himatanthus sucuuba tiene una variedad de efectos terapéuticos y, en este caso, se utilizó por primera vez en la neuroprotección inducida por el Paraquat (PQ) en Drosophila melanogaster. En este estudio, se realizaron ensayos fitoquímicos con el extracto hidroalcohólico de H. sucuuba mostrando cualitativamente las clases de metabolitos secundarios y cuantitativamente los fenoles totales (43,33 mg EAG/g Extracto-1), los flavonoides totales (44,09 mg EAG/G Extracto-1) y la actividad antioxidante por DPPH y ABTS. Por otra parte, la exposición de adultos de D. melanogaster (cepa salvaje, Canton Special) frente al PQ por 15 días, causó un alto estrés oxidativo, como muestran los niveles elevados de proteínas carboniladas, el lactato y actividades de acetilcolinesterasa y por el citrato sintasa. Además, una dieta suplementada con el extracto de H. sucuuba (0,1 mg/mL) por 15 días evitó los daños por el estrés oxidativo provocado por el PQ. Nuestro estudio es demostrar el efecto protector del extracto de H. sucuuba en D. melanogaster sometida al PQ. De acuerdo nuestros resultados, sugerimos que los extractos de la cáscara de H. sucuuba podrán prevenir o minimizar las enfermedades del ser humano causadas por el estrés oxidativo.
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Derechos de autor 2022 Márcia Pinheiro da Silva; Douglas Ramalho Lisboa; Stephanie Figueiredo Santos; Cláudia Marlise Balbinotti Andrade; Klenicy Kazumy de Lima Yamaguchi; Rosany Piccolotto Carvalho; Anderson de Oliveira Souza
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