Alzheimer's disease in Brazil: an epidemiological analysis between 2013 and 2022

Authors

DOI:

https://doi.org/10.33448/rsd-v12i2.40345

Keywords:

Alzheimer's disease; Epidemiology; Health of the elderly.

Abstract

Objective: To describe the epidemiological profile of Alzheimer's disease in Brazil between 2013 and 2022. Methods: This is an exploratory, time-series study of epidemiological data on Alzheimer's disease in the Brazilian population. Data were obtained through the SUS Information System (DATASUS). Results: It was verified that there were 14,024 hospitalizations due to Alzheimer's Disease in Brazil between January 2013 and December 2022 and the most confirmed Brazilian region was the Southeast. In addition, it was possible to observe that the most trained age group was 80 years or older, with 8,168 cases, followed by the population aged 70 to 79 years, with 4,061 hospitalizations. With regard to sex and color, white women were the most affected. There were 152,891 deaths, most of which occurred in the southeastern region of the country. The average hospital stay rate was 22.9 days, the average hospital stay was R$ 1,754.75 and the total amount spent on Alzheimer's in the analyzed period was R$ 24,608,616.49. Conclusion: In short, it is possible to infer that Alzheimer's disease has a high incidence in Brazil, especially in the Southeast region. Female patients, white, aged 70 years or older are the most dependent. Despite being a disease of late onset in most cases, it causes damage to the quality of life of patients, as it causes impairment of higher cognitive functions, especially loss of memory of recent events.

References

Atri A. (2019). The Alzheimer's Disease Clinical Spectrum: Diagnosis and Management. The Medical clinics of North America, 103(2), 263–293. https://doi.org/10.1016/j.mcna.2018.10.009

Breijyeh, Z., & Karaman, R. (2020). Comprehensive Review on Alzheimer's Disease: Causes and Treatment. Molecules (Basel, Switzerland), 25(24), 5789. https://doi.org/10.3390/molecules25245789

Cummings, J. L., Tong, G., & Ballard, C. (2019). Treatment Combinations for Alzheimer's Disease: Current and Future Pharmacotherapy Options. Journal of Alzheimer's disease: JAD, 67(3), 779–794. https://doi.org/10.3233/JAD-180766

DATASUS (2023). Departamento de Informática do SUS. https://datasus.saude.gov.br/

Eratne, D., Loi, S. M., Farrand, S., Kelso, W., Velakoulis, D., & Looi, J. C. (2018). Alzheimer's disease: clinical update on epidemiology, pathophysiology and diagnosis. Australasian psychiatry: bulletin of Royal Australian and New Zealand College of Psychiatrists, 26(4), 347–357. https://doi.org/10.1177/1039856218762308

Erkkinen, M. G., Kim, M. O., & Geschwind, M. D. (2018). Clinical Neurology and Epidemiology of the Major Neurodegenerative Diseases. Cold Spring Harbor perspectives in biology, 10(4), a033118. https://doi.org/10.1101/cshperspect.a033118

Garre-Olmo J. (2018). Epidemiologia de la enfermedad de Alzheimer y otras demencias [Epidemiology of Alzheimer's disease and other dementias]. Revista de neurologia, 66(11), 377–386.

Grabher B. J. (2018). Effects of Alzheimer Disease on Patients and Their Family. Journal of nuclear medicine technology, 46(4), 335–340. https://doi.org/10.2967/jnmt.118.218057

Hodson R. (2018). Alzheimer's disease. Nature, 559(7715), S1. https://doi.org/10.1038/d41586-018-05717-6

Instituto Brasileiro de Geografia e Estatística. (2023). Projeção da população do Brasil e das Unidades da Federação. IBGE. https://www.ibge.gov.br/apps/populacao/projecao/index.html

Khan, S., Barve, K. H., & Kumar, M. S. (2020). Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer's Disease. Current neuropharmacology, 18(11), 1106–1125. https://doi.org/10.2174/1570159X18666200528142429

Kumar, A., Sidhu, J., Goyal, A., Tsao, J. W & Doerr, C. (2022). Doença de Alzheimer (Enfermagem). Em StatPearls. Publicação StatPearls.

Knapskog, AB, Engedal, K., Selbæk, G., & Øksengård, AR (2021). Alzheimers sykdom – diagnostikk og behandling [doença de Alzheimer – diagnóstico e tratamento]. Tidsskrift for den Norske laegeforening: tidsskrift for praktisk medicin, ny raekke, 141 (7), 10.4045/tidsskr.20.0919. https://doi.org/10.4045/tidsskr.20.0919

Knopman, D. S., Amieva, H., Petersen, R. C., Chételat, G., Holtzman, D. M., Hyman, B. T., Nixon, R. A., & Jones, D. T. (2021). Alzheimer disease. Nature reviews. Disease primers, 7(1), 33. https://doi.org/10.1038/s41572-021-00269-y

Marconi, A. & Lakatos, E. M. (2021). Fundamentos de Metodologia Científica. (9a ed.), Editora Atlas, 2021.

Morley, J. E., Farr, S. A., & Nguyen, A. D. (2018). Alzheimer Disease. Clinics in geriatric medicine, 34(4), 591–601. https://doi.org/10.1016/j.cger.2018.06.006

Tecalco-Cruz, A. C., Ramírez-Jarquín, J. O., Alvarez-Sánchez, M. E., & Zepeda-Cervantes, J. (2020). Epigenetic basis of Alzheimer disease. World journal of biological chemistry, 11(2), 62–75. https://doi.org/10.4331/wjbc.v11.i2.62

Tinetti, M. E., McAvay, G. J., Murphy, T. E., Gross, C. P., Lin, H., & Allore, H. G. (2012). Contribution of individual diseases to death in older adults with multiple diseases. Journal of the American Geriatrics Society, 60(8), 1448–1456. https://doi.org/10.1111/j.1532-5415.2012.04077.x

Wong W. (2020). Economic burden of Alzheimer disease and managed care considerations. The American journal of managed care, 26(8 Suppl), S177–S183. https://doi.org/10.37765/ajmc.2020.88482

Zhang, X. X., Tian, Y., Wang, Z. T., Ma, Y. H., Tan, L., & Yu, J. T. (2021). The Epidemiology of Alzheimer's Disease Modifiable Risk Factors and Prevention. The journal of prevention of Alzheimer's disease, 8(3), 313–321. https://doi.org/10.14283/jpad.2021.15

Downloads

Published

14/02/2023

How to Cite

ARAÚJO, S. R. M. .; CUNHA, E. R. .; MARQUES, I. L. .; PAIXÃO, S. A. .; DIAS, A. de F. G. .; SOUSA, P. M. de .; SOARES, N. de K. P. .; SOUSA, M. O. .; LOBATO, R. M. .; SOUZA, M. T. P. de . Alzheimer’s disease in Brazil: an epidemiological analysis between 2013 and 2022. Research, Society and Development, [S. l.], v. 12, n. 2, p. e29412240345, 2023. DOI: 10.33448/rsd-v12i2.40345. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/40345. Acesso em: 18 apr. 2024.

Issue

Vol. 12 No. 2

Section

Health Sciences

License

Copyright (c) 2023 Sandra Regina Machado Araújo; Euzite Rabelo Cunha; Iranete Lopes Marques; Simone Alves Paixão; Alice de Fátima Gomes Dias; Patrícia Martins de Sousa; Nayara de Kassya Pinheiro Soares; Maria Olivia Sousa; Rutileia Moura Lobato; Maria Tereza Pereira de Souza

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Authors who publish with this journal agree to the following terms:

1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.

2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.

3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.