El uso de la cannabis en el tratamiento de la fibromialgia: Una revisión integrativa de la literatura
DOI:
https://doi.org/10.33448/rsd-v14i3.48425Palabras clave:
Fibromialgia; Cannabis; Dolor Crónico.Resumen
Introducción. La fibromialgia se caracteriza por dolor nociplástico, alteraciones del sueño, astenia, cefalea y síntomas cognitivos. El sistema endocannabinoide parece desempeñar un papel crucial en su fisiopatología, y el uso de cannabis ha surgido como una alternativa terapéutica prometedora. Objetivo. Presentar un panorama descriptivo sobre estudios que analizan los beneficios del uso de cannabis en el tratamiento de la fibromialgia, sus objetivos terapéuticos y sus aspectos culturales y sociales. Metodología. Se realizó una revisión integrativa basada en la búsqueda de publicaciones en las bases de datos PubMed y SciELO (2020-2024). Se identificaron 2,851 artículos, de los cuales 120 cumplieron los criterios de inclusión, y 27 fueron seleccionados para análisis cualitativo y de contenido. Resultados. Los estudios fueron clasificados en tres categorías: “mejora sintomatológica”, “efectos adversos del cannabis” y “seguridad terapéutica”. Se destacó la dificultad de establecer una dosis terapéutica óptima debido a la falta de estudios más robustos. Sin embargo, la mayoría de los estudios señalaron una mejora en los síntomas. La seguridad del uso del cannabis depende de la proporción de CBD y THC. Conclusión. Se observó una predominancia de estudios que evidencian la mejora sintomatológica y la seguridad del uso de cannabis y cannabinoides, con correlación positiva con la intensidad del dolor, otros síntomas y el tratamiento farmacológico de la fibromialgia.
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Aizpurua-Olaizola, O., Elezgarai, I., Rico-Barrio, I., Zarandona, I., Etxebarria, N., & Usobiaga, A. (2017). Targeting the endocannabinoid system: future therapeutic strategies. Drug discovery today, 22(1), 105–110. https://doi.org/10.1016/j.drudis.2016.08.005.
Alves, P. F. S., & Moraes, F. C. (2020). Uso da cannabis no tratamento da fibromialgia. Revista Científica Eletrônica de Ciências Aplicadas da Fait, 2, 1-14.
Andrade, A., Steffens, R. de A. K., Grisard, F., Liz, C. M. de ., Brandt, R., Coimbra, D. R., & Bevilacqua, G. G.. (2023). Strength training in patients with fibromyalgia: a feasibility study. Revista Brasileira de Medicina do Esporte, 29, e176543. https://doi.org/10.1590/1517-869220232901176543.
Argueta, D. A., Ventura, C. M., Kiven, S., Sagi, V., & Gupta, K. (2020). A Balanced Approach for Cannabidiol Use in Chronic Pain. Frontiers in pharmacology, 11, 561. https://doi.org/10.3389/fphar.2020.00561
Arnold, J. C., Nation, T., & McGregor, I. S. (2020). Prescribing medicinal cannabis. Australian prescriber, 43(5), 152–159. https://doi.org/10.18773/austprescr.2020.052
Barros, S. O, Nunes Valadares, M., Oliveira dos Santos , J., Mairesse Ramos , E. H., & Mesquita Couto , F. (2023). Manejo Clínico da Fibromialgia: Terapias Farmacológicas e Não Farmacológicas para Alívio dos Sintomas. Brazilian Journal of Implantology and Health Sciences, 5(5), 5665–5680. https://doi.org/10.36557/2674-8169.2023v5n5p5665-5680.
Bell, A. D., MacCallum, C. A., Margolese, S., Walsh, Z., Wright, P., Daeninck, P. J., Mandarino, E., Lacasse, G., Jagpaul Kaur Deol, Lauren de Freitas, Michelle St Pierre, Belle-Isle, L., Gagnon, M., Bevan, S., Sanchez, T., Arlt, S., Monahan-Ellison, M., O’Hara, J., Boivin, M., & Costiniuk, C. T. (2023). Clinical Practice Guidelines for Cannabis and Cannabinoid-Based Medicines in the Management of Chronic Pain and Co-Occurring Conditions. https://doi.org/10.1089/can.2021.0156.
Berger, A. A., Keefe, J., Winnick, A., Gilbert, E., Eskander, J. P., Yazdi, C., Kaye, A. D., Viswanath, O., & Urits, I. (2020). Cannabis and cannabidiol (CBD) for the treatment of fibromyalgia. Best practice & research. Clinical anaesthesiology, 34(3), 617–631. https://doi.org/10.1016/j.bpa.2020.08.010.
Berl, V., Hurd, Y. L., Lipshutz, B. H., Roggen, M., Mathur, E. J., & Evans, M. (2022). A randomized, triple-blind, comparator-controlled parallel study investigating the pharmacokinetics of cannabidiol and tetrahydrocannabinol in a novel delivery system, solutech, in association with cannabis use history. Cannabis and cannabinoid research, 7(6), 777-789. https://doi.org/10.1089/can.2021.0176
Berwick, R., Barker, C., Goebel, A., & guideline development group (2022). The diagnosis of fibromyalgia syndrome. Clinical medicine (London, England), 22(6), 570–574. https://doi.org/10.7861/clinmed.2022-0402
Bettstetter, H., & Schäfer, A. (2024). Tetrahydrocannabinol (THC) bei Patienten mit Fibromyalgiesyndrom (FMS) : Retrospektive Untersuchung zu Veränderungen von Schmerz, psychometrischen Variablen und Analgetikaverbrauch im Verlauf einer interdisziplinären multimodalen stationären Schmerztherapie (IMST) [Tetrahydrocannabinol (THC) in patients with fibromyalgia syndrome (FMS) : A retrospective study of changes in pain, psychometric variables, and analgesic consumption during inpatient interdisciplinary multimodal pain therapy (IMPT)]. Schmerz (Berlin, Germany), 38(4), 259–266. https://doi.org/10.1007/s00482-023-00727-4
Bilbao, A., & Spanagel, R. (2022). Medical cannabinoids: a pharmacology-based systematic review and meta-analysis for all relevant medical indications. BMC medicine, 20(1), 259. https://doi.org/10.1186/s12916-022-02459-1
Bockmann, E. C., Brito, R., Madeira, L. F., da Silva Sampaio, L., Melo Reis, R. A., França, G. R., & Calaza, K. D. C. (2023). The Role of Cannabinoids in CNS Development: Focus on Proliferation and Cell Death. Cellular and molecular neurobiology, 43(4), 1469–1485. https://doi.org/10.1007/s10571-022-01263-y.
Boehnke, K. F., Gagnier, J. J., Matallana, L., & Williams, D. A. (2021). Cannabidiol Use for Fibromyalgia: Prevalence of Use and Perceptions of Effectiveness in a Large Online Survey. The journal of pain, 22(5), 556–566. https://doi.org/10.1016/j.jpain.2020.12.001
Botea, M. O., Lukas Andereggen, Urman, R. D., Luedi, M. M., & Romero, C. S. (2024). Cannabinoids for Acute Pain Management: Approaches and Rationale. Current Pain and Headache Reports. https://doi.org/10.1007/s11916-024-01252-4
Bourke, S. L., Schlag, A. K., O'Sullivan, S. E., Nutt, D. J., & Finn, D. P. (2022). Cannabinoids and the endocannabinoid system in fibromyalgia: A review of preclinical and clinical research. Pharmacology & therapeutics, 240, 108216. https://doi.org/10.1016/j.pharmthera.2022.108216
Brucki, S. M. D., Adoni, T., Almeida, C. M. O., Andrade, D. C., Anghinah, R., Barbosa, L. M., Bazan, R., Carvalho, A. A. S., Carvalho, W., Christo, P. P., Coletta, M. D., Conforto, A. B., Correa-Neto, Y., Engelhardt, E., França Junior, M. C., Franco, C., VON Glehn, F., Gomes, H. R., Houly, C. G. B., Kaup, A. O., … Prado, G. (2021). Cannabinoids in Neurology - Position paper from Scientific Departments from Brazilian Academy of Neurology. Arquivos de neuro-psiquiatria, 79(4), 354–369. https://doi.org/10.1590/0004-282X-ANP-2020-0432
Cavalcante, Lívia Teixeira Canuto, & Oliveira, Adélia Augusta Souto de. (2020). Métodos de revisão bibliográfica nos estudos científicos. Psicologia em Revista, 26(1), 83-102. https://doi.org/10.5752/P.1678-9563.2020v26n1p82-100
Cásedas, G., Yarza-Sancho, M., & López, V. (2024). Cannabidiol (CBD): A Systematic Review of Clinical and Preclinical Evidence in the Treatment of Pain. Pharmaceuticals (Basel, Switzerland), 17(11), 1438. https://doi.org/10.3390/ph17111438.
Campos, R. M. P., Aguiar, A. F. L., Paes-Colli, Y., Trindade, P. M. P., Ferreira, B. K., Melo Reis, R. A., & Sampaio, L. S. (2021). Cannabinoid Therapeutics in Chronic Neuropathic Pain: From Animal Research to Human Treatment. Frontiers in physiology, 12, 785176. https://doi.org/10.3389/fphys.2021.785176
Carvalho, J. F., Ribeiro, M. F. L. D. S., & Skare, T. (2024). Cannabis therapy in rheumatological diseases: A systematic review. Northern clinics of Istanbul, 11(4), 361–366. https://doi.org/10.14744/nci.2023.43669.
Chaves, C., Bittencourt, P. C. T., & Pelegrini, A. (2020). Ingestion of a THC-Rich Cannabis Oil in People with Fibromyalgia: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial. Pain medicine (Malden, Mass.), 21(10), 2212–2218. https://doi.org/10.1093/pm/pnaa303
Clifford-Faugère, G., Nguena Nguefack, H. L., Godbout-Parent, M., Diallo, M. A., Guénette, L., Pagé, M. G., Choinière, M., Beaudoin, S., Boulanger, A., Pinard, A. M., Lussier, D., De Grandpré, P., Deslauriers, S., & Lacasse, A. (2023). Pain Medications Used by Persons Living With Fibromyalgia: A Comparison Between the Profile of a Quebec Sample and Clinical Practice Guidelines. Canadian journal of pain = Revue canadienne de la douleur, 7(2), 2252037. https://doi.org/10.1080/24740527.2023.2252037.
Dizner-Golab, A., Lisowska, B., & Kosson, D. (2023). Fibromyalgia - etiology, diagnosis and treatment including perioperative management in patients with fibromyalgia. Reumatologia, 61(2), 137–148. https://doi.org/10.5114/reum/163094
Dumont, M. F.; Dias, R. S.; Veiga, R. M. P.; Araujo, I. M. C. S. et al. (2024). Manejo da fibromialgia: uma revisão de literatura. Brazilian Journal of Implantology and Health Sciences, 6(9), 31–40. https://doi.org/10.36557/2674-8169.2024v6n9p31-40
Ergisi, M., Erridge, S., Harris, M., Kawka, M., Nimalan, D., Salazar, O., Loupasaki, K., Ali, R., Holvey, C., Coomber, R., Usmani, A., Sajad, M., Beri, S., Hoare, J., Khan, S. A., Weatherall, M. W., Platt, M., Rucker, J. J., & Sodergren, M. H. (2023). An Updated Analysis of Clinical Outcome Measures Across Patients From the UK Medical Cannabis Registry. Cannabis and cannabinoid research, 8(3), 557–566. https://doi.org/10.1089/can.2021.0145.
Esposito, M., & Piazza, L. (2022). Ultrasound-assisted extraction of oil from hempseed (Cannabis sativa L.): Part 1. Journal of the science of food and agriculture, 102(2), 732–739. https://doi.org/10.1002/jsfa.11404
Fitzcharles, M. A., Petzke, F., Tölle, T. R., & Häuser, W. (2021). Cannabis-Based Medicines and Medical Cannabis in the Treatment of Nociplastic Pain. Drugs, 81(18), 2103–2116. https://doi.org/10.1007/s40265-021-01602-1.
Freitas, H. R., Isaac, A. R., Malcher-Lopes, R., Diaz, B. L., Trevenzoli, I. H., & Melo Reis, R. A. (2018). Polyunsaturated fatty acids and endocannabinoids in health and disease. Nutritional neuroscience, 21(10), 695–714. https://doi.org/10.1080/1028415X.2017.1347373.
García Rodríguez, D. F., & Abud Mendoza, C. (2020). Physiopathology of fibromyalgia. Fisiopatología de la fibromialgia. Reumatologia clinica, 16(3), 191–194. https://doi.org/10.1016/j.reuma.2020.02.003
Giardina, A., Palmieri, R., Ponticelli, M., Antonelli, C., Carlucci, V., Colangelo, M., Benedetto, N., Di Fazio, A., & Milella, L. (2024). Is a Low Dosage of Medical Cannabis Effective for Treating Pain Related to Fibromyalgia? A Pilot Study and Systematic Review. Journal of clinical medicine, 13(14), 4088. https://doi.org/10.3390/jcm13144088
Giorgi, V., Bongiovanni, S., Atzeni, F., Marotto, D., Salaffi, F., & Sarzi-Puttini, P. (2020). Adding medical cannabis to standard analgesic treatment for fibromyalgia: a prospective observational study. Clinical and experimental rheumatology, 38 Suppl 123(1), 53–59.
Giossi, R., Carrara, F., Padroni, M., Bilancio, M. C., Mazzari, M., Enisci, S., ... & Fornasari, D. (2022). Systematic review and meta-analysis seem to indicate that cannabinoids for chronic primary pain treatment have limited benefit. Pain and Therapy, 11(4), 1341-1358. https://doi.org/10.1007/s40122-022-00434-5
Gonen, T., & Amital, H. (2020). Cannabis and Cannabinoids in the Treatment of Rheumatic Diseases. Rambam Maimonides medical journal, 11(1), e0007. https://doi.org/10.5041/RMMJ.10389
Hershkovich, O., Hayun, Y., Oscar, N., Shtein, A., & Lotan, R. (2023). The role of cannabis in treatment-resistant fibromyalgia women. Pain practice : the official journal of World Institute of Pain, 23(2), 180–184. https://doi.org/10.1111/papr.13179
Isaac, A. R., Velasco, P. C., Fraga, K. Y. D., Tavares-do-Carmo, M. D. G., Campos, R. M. P., Iannotti, F. A., Verde, R., Martins, D. B. G., Santos, T. A., Ferreira, B. K., Mello, F. G., Di Marzo, V., Andrade-da-Costa, B. L. D. S., & Melo Reis, R. A. (2021). Maternal omega-3 intake differentially affects the endocannabinoid system in the progeny`s neocortex and hippocampus: Impact on synaptic markers. The Journal of nutritional biochemistry, 96, 108782. https://doi.org/10.1016/j.jnutbio.2021.108782
Jacob, M. T. R. J., & Milani, B. J. (2023). Retrograde inhibition of hyperactive central pathways in nociplastic pain. Brjp, 6, 120–125. https://doi.org/10.5935/2595-0118.20230029-en.
Jain, N., & Moorthy, A. (2022). Cannabinoids in rheumatology: Friend, foe or a bystander?. Musculoskeletal care, 20(2), 416–428. https://doi.org/10.1002/msc.1636
Khurshid, H., Qureshi, I. A., Jahan, N., Went, T. R., Sultan, W., Sapkota, A., & Alfonso, M. (2021). A Systematic Review of Fibromyalgia and Recent Advancements in Treatment: Is Medicinal Cannabis a New Hope?. Cureus, 13(8), e17332. https://doi.org/10.7759/cureus.17332.
Latorraca, C. de O. C., Pacheco, R. L., Martimbianco, A. L. C., Pachito, D. V., & Riera, R. (2018). What do Cochrane systematic reviews say about the use of cannabinoids in clinical practice?. Sao Paulo Medical Journal, 136(5), 472–478. https://doi.org/10.1590/1516-3180.2018.0313210818.
Le, K., Le, R., Nguyen, J., Hua, J., & Munday, S. (2024). The Role of Medicinal Cannabis as an Emerging Therapy for Opioid Use Disorder. Pain and Therapy. https://doi.org/10.1007/s40122-024-00599-1.
Lopera, V., Restrepo, J. C., & Amariles, P. (2024). Effectiveness and safety of cannabis-based products for medical use in patients with fibromyalgia syndrome: A systematic review. Exploratory research in clinical and social pharmacy, 16, 100524. https://doi.org/10.1016/j.rcsop.2024.100524.
Maffei M. E. (2020). Fibromyalgia: Recent Advances in Diagnosis, Classification, Pharmacotherapy and Alternative Remedies. International journal of molecular sciences, 21(21), 7877. https://doi.org/10.3390/ijms21217877
Manojlović, D., & Kopše, E. I. (2023). The effectiveness of aerobic exercise for pain management in patients with fibromyalgia. European journal of translational myology, 33(3), 11423. https://doi.org/10.4081/ejtm.2023.1142.
Martinez Naya, N., Kelly, J., Corna, G., Golino, M., Polizio, A. H., Abbate, A., Toldo, S., & Mezzaroma, E. (2024). An Overview of Cannabidiol as a Multifunctional Drug: Pharmacokinetics and Cellular Effects. Molecules (Basel, Switzerland), 29(2), 473. https://doi.org/10.3390/molecules29020473.
Mayorga-Anaya, H. J., Torres-Ortiz, M. P., Flórez-Valencia, D. H., & Gomezese-Ribero, O. F. (2021). Efficacy of cannabinoids in fibromyalgia: a literature review. Colombian Journal of Anestesiology, 49(4), e302. Epub August 25, 2021. https://doi.org/10.5554/22562087.e980.
Mazza M. (2021). Medical cannabis for the treatment of fibromyalgia syndrome: a retrospective, open-label case series. Journal of cannabis research, 3(1), 4. https://doi.org/10.1186/s42238-021-00060-6.
Melo Reis, R. A., Isaac, A. R., Freitas, H. R., de Almeida, M. M., Schuck, P. F., Ferreira, G. C., Andrade-da-Costa, B. L. D. S., & Trevenzoli, I. H. (2021). Quality of Life and a Surveillant Endocannabinoid System. Frontiers in neuroscience, 15, 747229. https://doi.org/10.3389/fnins.2021.747229.
Melo Reis, R. A., et al., (2022). Phytocannabinoids and Cannabis-Based Products as Alternative Pharmacotherapy in Neurodegenerative Diseases: From Hypothesis to Clinical Practice. Frontiers in cellular neuroscience, 16, 917164. https://doi.org/10.3389/fncel.2022.917164.
Mick, G., & Douek, P. (2024). Clinical Benefits and Safety of Medical Cannabis Products: A Narrative Review on Natural Extracts. Pain and therapy, 13(5), 1063–1094. https://doi.org/10.1007/s40122-024-00643-0.
Miranda, M. L. F., Montemezzo, C. P., Zeni, P., & Lutinski, J. A. (2023). Influência da meditação sobre dor, qualidade do sono e qualidade de vida em pessoas com fibromialgia. Brazilian Journal of Implantology and Health Sciences, 5(4), 1926–1947.
https://doi.org/10.36557/2674-8169.2023v5n4p1926-1947.
Mlost, J., Bryk, M., & Starowicz, K. (2020). Cannabidiol for Pain Treatment: Focus on Pharmacology and Mechanism of Action. International journal of molecular sciences, 21(22), 8870. https://doi.org/10.3390/ijms21228870
Montagner, P., de Salas Quiroga, A., Ferreira, A. S., Duarte da Luz, B. M., Ruppelt, B. M., Schlechta Portella, C. F., Abdala, C. V. M., Tabach, R., Ghelman, R., Blesching, U., Perfeito, J. P. S., & Schveitzer, M. C. (2024). Charting the therapeutic landscape: a comprehensive evidence map on medical cannabis for health outcomes. Frontiers in pharmacology, 15, 1494492. https://doi.org/10.3389/fphar.2024.1494492.
Mozhi, A., & Arumugam, N. (2021). Effects of cognitive behavioral therapy in patients with fibromyalgia: a single blind, randomized controlled study. Revista Pesquisa Em Fisioterapia, 11(1), 41. https://doi.org/10.17267/2238-2704rpf.v11i1.3309.
Nachnani, R., Knehans, A., Vizinhos, J. D., Kocis, P. T., Lee, T., Tegeler, K., Trite, T., Raup-Konsavage, W. M., & Vrana, K. E. (2024). Revisão sistemática das interações droga-droga de delta-9-tetrahidrocanabinol, canabidiol e cannabis. Fronteiras em farmacologia, 15, 1282831. https://doi.org/10.3389/fphar.2024.1282831
O’Sullivan, S. E., Jensen, S. S., Kolli, A. R., Nikolajsen, G. N., Bruun, H. Z., & Hoeng, J. (2024). Strategies to Improve Cannabidiol Bioavailability and Drug Delivery. Pharmaceuticals, 17(2), 244. https://doi.org/10.3390/ph17020244
Pagano, C., Navarra, G., Coppola, L., Avilia, G., Bifulco, M., & Laezza, C. (2022). Cannabinoids: Therapeutic Use in Clinical Practice. International journal of molecular sciences, 23(6), 3344. https://doi.org/10.3390/ijms23063344
Paula, Juliane dos Anjos de. (2021). Uso de psicofármacos no tratamento da fibromialgia: uma revisão sistemática. Journal of Human Growth and Development, 31(2), 336-345. https://doi.org/10.36311/jhgd.v31.12228;
Petzke, F., Tölle, T., Fitzcharles, M. A., & Häuser, W. (2022). Cannabis-Based Medicines and Medical Cannabis for Chronic Neuropathic Pain. CNS drugs, 36(1), 31–44. https://doi.org/10.1007/s40263-021-00879-w
Raup-Konsavage, W. M., & Vrana, K. E. (2024). Systematic review of drug-drug interactions of delta-9-tetrahydrocannabinol, cannabidiol, and Cannabis. Frontiers in pharmacology, 15, 1282831. https://doi.org/10.3389/fphar.2024.1282831.
Rodrigues, K. da S., da Silva, A. A., da Silva, N. D., & Cavalcanti, Élida B. V. S. (2022). Uma abordagem multidisciplinar não-farmacológica e farmacológica para o tratamento de fibromialgia: uma revisão bibliográfica. Europub Journal of Health Research, 3(4 Edição Especial), 314–319. https://ojs.europubpublications.com/ojs/index.php/ejhr/article/view/215.
Safi, K., Sobieraj, J., Michał Błaszkiewicz, Żyła, J., Salata, B., & Tomasz Dzierżanowski. (2024). Tetrahydrocannabinol and Cannabidiol for Pain Treatment—An Update on the Evidence. Biomedicines, 12(2), 307–307. https://doi.org/10.3390/biomedicines12020307.
Scublinsky, D., Kirmayr , K., Ink, M., Ibelli, F., Graf , C., Lanza, R., González Negri, M. R., & Damin, C. (2020). Uso y prescripción de cannabis medicinal por reumatólogos en Argentina. Revista Argentina De Reumatología, 31(4), 8 - 12. https://doi.org/10.47196/rar.v31i4.381.
Snyder, H. (2019). Literature review as a research methodology: An overview and guidelines. Journal of business research, 104, 333-339.
Sousa, A. M., Slullitel, A., & Serra, T. S. (2023). Gaps in our knowledge and future research on the endocannabinoid system and the painful phenomenon. Brjp, 6, 97–102. https://doi.org/10.5935/2595-0118.20230025-en.
Sousa, A. M., Slullitel, A., & Serra, T. S. (2023). Gaps in our knowledge and future research on the endocannabinoid system and the painful phenomenon. Brjp, 6, 97–102. https://doi.org/10.5935/2595-0118.20230025-en.
Souza, R. G. de, Trajano, L. A. da S. N., & Fontes, I. A. (2024). Benefícios do treinamento resistido no tratamento de pacientes com fibromialgia: uma revisão de literatura. Revista Pró-UniverSUS, 15(3), 143–147. https://doi.org/10.21727/rpu.v15i3.4539.
Sridharan, S., Erridge, S., Holvey, C., Coomber, R., Holden, W., Rucker, J. J., Platt, M., & Sodergren, M. H. (2024). Comparison of Cannabis-Based Medicinal Product Formulations for Fibromyalgia: A Cohort Study. Journal of pain & palliative care pharmacotherapy, 1–14. Advance online publication. https://doi.org/10.1080/15360288.2024.2414073.
Strand, N. H., Maloney, J., Kraus, M., Wie, C., Turkiewicz, M., Gomez, D. A., Adeleye, O., & Harbell, M. W. (2023). Cannabis for the Treatment of Fibromyalgia: A Systematic Review. Biomedicines, 11(6), 1621. https://doi.org/10.3390/biomedicines11061621
Trevenzoli, I. H. et al., (2021). Quality of Life and a Surveillant Endocannabinoid System. Frontiers in neuroscience, 15, 747229. https://doi.org/10.3389/fnins.2021.747229.
Velayudhan, L., Pisani, S., Dugonjic, M., McGoohan, K., & Bhattacharyya, S. (2024). Eventos adversos causados por canabinoides em adultos de meia-idade e idosos para todas as indicações: uma meta-análise da diferença de taxa de incidência. Idade e envelhecimento, 53(11), afae261. https://doi.org/10.1093/ageing/afae261.
Wang, C., Erridge, S., Holvey, C., Coomber, R., Usmani, A., Sajad, M., Guru, R., Holden, W., Rucker, J. J., Platt, M. W., & Sodergren, M. H. (2023). Assessment of clinical outcomes in patients with fibromyalgia: Analysis from the UK Medical Cannabis Registry. Brain and behavior, 13(7), e3072. https://doi.org/10.1002/brb3.3072.
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