Marcadores de laboratorio y hallazgos de imágenes del síndrome respiratorio agudo grave causado por el nuevo coronavirus (SARS-CoV-2): ¿qué podemos encontrar?

Autores/as

DOI:

https://doi.org/10.33448/rsd-v9i8.6399

Palabras clave:

COVID-19; Marcadores de laboratório; Resultados de imagen; Síndrome respiratório.

Resumen

COVID-19 es una enfermedad infecciosa emergente que representa una amenaza significativa para La salud pública en todo el mundo. Esto indica La necesidad de cumplir con las políticas públicas de medidas preventivas, de control y de diagnóstico rápido y preciso como parte de las medidas para contener el avance de la pandemia. Este estúdio tuvo como objetivo analizar los principal es hallazgos de laboratório del síndrome respiratorio causado por El nuevo coronavirus SARS- COV-2 por medio de una revisión narrativa de la literatura. La técnica para detectar ARN viral del coronavirus se describió como la metodología principal utilizada para el diagnóstico clínico. Entre los hallazgos de laboratorio, se verificaron los valores de linfocitopenia, disminución de hemoglobina y albúmina sérica, aumento de la lactato deshidrogenasa (LDH) y la proteína C reactiva (PCR), aumento de la velocidad de sedimentación globular (VSG). El dímero D se ha relacionado com un mal pronóstico en pacientes críticos. Em el contexto actual, lãs pruebas de laboratório pueden contribuir a la identificación temprana de signos de gravedad y mal pronóstico del síndrome respiratorio causado por el nuevo SARS-CoV-2.

Biografía del autor/a

Maikiane Aparecida Nascimento, Dr. Anuar Auad State Hospital for Tropical Diseases and Dr. Giovanni Cysneiros State Public Health Laboratory

Currently, resident of the Multiprofessional Residency Program of the Goiás State Secretariat, located at the Hospital de Tropical Diseases Dr. Anuar Auad, working in the field of infectious diseases and at the State Public Health Laboratory Dr. Giovanni Cysneiros (LACEN / GO). Graduated in Biomedicine (2018) from the University of Oeste Paulista (UNOESTE), previously undertook Sandwich graduation at the Faculty of Pharmacy of the University of Porto - Portugal by the Santander Universidades - Ibero-American mobility scholarships program. Research lines: Microbiology, Clinical Mycology, tropical diseases, infectious diseases.

Savyla Franciele Soares Silva, Dr. Anuar Auad State Hospital for Tropical Diseases and Dr. Giovanni Cysneiros State Public Health Laboratory

Currently, resident of the Multiprofessional Residency Program of the Goiás State Secretariat, located at the Hospital de Tropical Diseases Dr. Anuar Auad, working in the field of infectious diseases and at the State Public Health Laboratory Dr. Giovanni Cysneiros (LACEN / GO). Graduated in Biomedicine.

Camila Aparecida Nunes de Albuquerque, Dr. Anuar Auad State Hospital for Tropical Diseases and Dr. Giovanni Cysneiros State Public Health Laboratory

Currently, resident of the Multiprofessional Residency Program of the Goiás State Secretariat, located at the Hospital de Tropical Diseases Dr. Anuar Auad, working in the field of infectious diseases and at the State Public Health Laboratory Dr. Giovanni Cysneiros (LACEN / GO). Graduated in Biomedicine.

Rosana Brambilla Ederli, Paulista State University

Undergraduate student in Physiotherapy at Universidade Estadual Paulista (UNESP).

Elorraine Coutinho Mathias Santos, University of Oeste Paulista

Graduated in Pharmacy from UNOESTE (2018). Has experience in Commercial Pharmacy, Hospital and Laboratory, during the curricular and extra curricular internship. Acting mainly on the following topics: Over-the-counter service, training at SNGPC, making standard operating procedure, dispensing medications, dispensing psychotropic medications, injecting application, blood pressure measurement, capillary blood glucose test and dispensing with a focus on clinical pharmacy. In the hospital area, training in a computerized system for dispensing medicines, training in the unit dose system, discussion and interpretation of prescriptions. In the laboratory area, blood collection, testing to aid in the diagnosis of diseases and handling of laboratory equipment.

João Pedro Brambilla Ederli, University of Oeste Paulista

Biomedical from the Faculty of Biomedicine of the University of Oeste Paulista (UNOESTE), qualified in Clinical Pathology (Clinical Analysis) and Imaging (Diagnostic Imaging). Has scientific initiation in the area of Clinical Microbiology with a focus on multidrug resistance of microorganisms. He served as monitor of the General Pathology discipline in the Nursing course.

Citas

Al-Hanawi, M. K., Angawi, K., Qattan, A., & Kattan, W. (2020). Knowledge, Attitude, and Practice Toward COVID-19 Among the Public in the Kingdom of Saudi Arabia: A Cross-Sectional Study. Front Public Health, 8 (217), 1-10. doi:10.3389/fpubh.2020.00217

Asadi-Pooya, A. A., & Simani, L. (2020). Central nervous system manifestations of COVID-19: A systematic review. Journal of the Neurological Sciences, 413, 1-5. doi:10.1016/j.jns.2020.116832

ABC Med. (2016). Liver tests or liver function tests. Retrieved July 6, 2020, from https://www.abc.med.br/p/exames-e-procedimentos/1274018/exames-do-figado-ou-provas-de-funcao-hepatica.htm

Bahia, C. A., Guimarães, R. M., & Asmus, C. I., (2020). Changes in hepatic markers from environmental exposure to organochlorines in Brazil. Instituto de Estudos em Saúde Coletiva (IESC), 22 (2): 133-41. doi:10.1590/1414-462X201400020005

Brazilian Ministry of Health. (2020). Accuracy of diagnostic tests recorded for COVID-19. Retrieved July 6, 2020, from

http://portalarquivos2.saude.gov.br/images/pdf/2020/June/02/AcuraciaDiagnostico-COVID19-atualizacaoC.pdf

Carvalho, A., Alqusairi, R., Adams, A., Paul, M., Kothari, N., Peters, S., et al. (2020). SARS-CoV-2 Gastrointestinal Infection Causing Hemorrhagic Colitis: Implications for Detection and Transmission of COVID-19 Disease. Am J Gastroenterol, 115, 942–946. doi:10.14309/ajg.0000000000000667

Cavezzi, A., Troiani E. & Corrao, S. (2020). COVID-19: hemoglobin, iron, and hypoxia beyond inflammation. A narrative review. Clinics and Practice, 10 (28), 24-30. doi:10.4081%2Fcp.2020.1271

Cevik, M., Bamford, C. G. G., & Ho, A. (2020). COVID-19 pandemic a focused review for clinicians. Clinical Microbiology and Infection, 26, 842-847. doi:10.1016/j.cmi.2020.04.023

Chan, J. F., Yip, C. C., Kai-Wang, To, K. K., Tang, T. H., Wong, S. C., Leung, K., et al. (2020). Improved Molecular Diagnosis of COVID-19 by the Novel, Highly Sensitive and Specific COVID-19-RdRp/Hel Real-Time Reverse Transcription-PCR Assay Validated In Vitro and with Clinical Specimens. Journal of Microbiology, 58 (95), 1-10. doi:10.1128/JCM.00310-20

Chate, R. C., Fonseca, E. K., Steps, R. D., Teles, G. B. Shoji, H., & Szarf, G. (2020). Tomographic presentation of a lung infection at COVID-19: the initial Brazilian experience. J Bras Pneumol, 46 (2), 1-4. doi:10.36416/1806-3756/e20200121

Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., et al. (2020). Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study. Lancet. 395, 507–13. doi:10.1016/S0140-6736(20)30211-7

Chen, L., Liu, H. G., Liu, W., Liu, J., Liu, K., Shang, J., Deng, Y., & Wei, S. (2020). Analysis of Clinical Features of 29 Patients With 2019 novel Coronavirus Pneumonia. Chinese Journal of Tuberculosis and Respiratory Diseases, 6 (43), 1-10. doi:10.3760/cma.j.issn.1001-0939.2020.0005

Craver, R., Huber, S., Sandomirsky, M., McKenna, D., Schieffelin, J., & Finger, L. (2020). Fatal Eosinophilic Myocarditis in a Healthy 17-Year-Old Male with SevereAcute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2c). Fetal and Pediatric Pathology, 39 (3), 263–268. doi.org/10.1080/15513815.2020.1761491

Dhama, K., Patel, S. K., Pathak, M., Yatoo, M. I., Tiwari, R., Malik, Y.S., et al. (2020). An update on SARS-CoV-2/COVID-19 with particular reference to its clinical pathology, pathogenesis, immunopathology, and mitigation strategies. Travel Medicine and Infectious Disease, doi:10.1016/j.tmaid.2020.101755.

Farias, L.P. G., Fonseca, E. K. N., Strabelli, D. G., Loureiro, B. M., Neves, I. S., & Rodrigues, T. P. (2020). Imaging findings in COVID-19 pneumonia. Clinics, 27, 1-8. doi:10.6061/clinics/2020/e2027

Gao, Y., Li, T., Hang, M., Li, X., Wu, D., Xu, X., et al. (2020). Diagnostic utility of clinical laboratory data determinations for patients with the severe COVID-19. J Med Virol., 92, 791–796. doi:10.1002/jmv.25770

Guan, W., Ni, Z., Hu, Y., Liang, W., et al. (2020). Clinical Characteristics of Coronavirus Disease 2019 in China, N. Engl. J. Med., 382, 1708-1720. doi:10.1056/NEJMoa2002032

Heneka, M. T, Golenbock, D., Latz, E., Morgan, D., & Brown, R. (2020). Immediate and long-term consequences of COVID-19 infections for the development of neurological disease. Alzheimer's Research & Therapy, 12 (69), 1-3. doi:10.1186/s13195-020-00640-3

Huang, C., Wang, Y. Li, X., Ren, L., Zao, J., Hu, J., et al. (2020). Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet, 395, 497–506. doi: 10.1016/S0140-6736(20)30183-5

Hunt, M. (2020). Main events involved in replication. Retrieved July 6, 2020, from https://www.microbiologybook.org/Portuguese/virol-port-chapter2.htm#:~:text=Many%20virus%20induce%20apoptosis%20(death,and%20o%20missing%20da%20infec%C3%A7%C3%A3o

Johns Hopkins. (2020). COVID-19 Dashboard by the Center for Systems Science and Engineering (CSSE) at Johns Hopkins. Retrieved July 6, 2020, from https://www.worldometers.info/coronavirus/

Lippi, G., & Mattiuzzi, C. (2020). Hemoglobin value may be decreased in patients with severe coronavirus disease 2019. Hematol Transfus Cell Ther, 42, 116-117. doi:10.1016/j.htct.2020.03.001

Matushek, S. M. (2020). Evaluation of the EUROIMMUN Anti-SARS-CoV-2 ELISA Assay for detection of IgA and IgG antibodies. Retrieved July 6, 2020, from https://www.biorxiv.org/content/10.1101/2020.05.11.089862v1.full.pdf

Moreira, B. L., Brotto, M. A., & Marchiori, E. (2020). Chest radiography and computed tomography findings from a Brazilian patient with COVID-19 pneumonia. Journal of the Brazilian Society of Tropical Medicine, 53, 1-2. doi:10.1590/0037-8682-0134-2020

Moreira, B. L., Santana, P. R., Zanetti, G., & Marchiori, E. (2020). COVID-19 and acute pulmonary embolism: what should be considered to indicate a computed tomography pulmonary angiography scan? Journal of the Brazilian Society of Tropical Medicine, 53,1-2. doi:10.1590/0037-8682-0267-2020

Muniz, B. C., Milito, M. A., & Marchiori, E. (2020). COVID-19 - Computed tomography findings in two patients in Petrópolis, Rio de Janeiro, Brazil. Journal of the Brazilian Society of Tropical Medicine, 53, 1. doi:10.1590/0037-8682-0147-2020

Needham, E. J., Chou, S. H.., Coles, A. J., & Menon, D. K. Neurological Implications of COVID-19 Infections. Neurocritical care society, 1 , 1-5. doi: 10.1007/s12028-020-00978-4

Novara, E., Molinaro, E., BenedettI, I., Bonometti, R., Lauritano, E. C., &. Boverio, R. (2020). Severe acute dried gangrene in COVID-19 infection: a case report. European Review for Medical and Pharmacological Sciences, 24, 1-3. doi:10.26355/eurrev_202005_21369

Novi, G. Rossi, T., Pedemonte, E., Saitta, L., Rolla, C., Roccatagliata, L., et al. (2020). Acute disseminated encephalomyelitis after SARS-CoV-2 infection. Neurol Neuroimmunol Neuroinflamm, 7, 1-4. doi:10.1212/NXI.0000000000000797

Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). Methodology of cientific research. [e-Book]. Retrieved July 6, 2020, from https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1

Ramaswamya, S. R., & Govindarajanb, R. (2020). COVID-19 in Refractory Myasthenia Gravis- A Case Report of Successful Outcome. Journal of Neuromuscular Diseases, 7, 1-4. doi:10.3233/jnd-200520

Rodriguez-Morales, A., Cardona-Ospinaa, J. A., Gutiérrez-Ocampo, E., Villamizar- Peña, R., Holguin-Rivera, Y., Escalera-Antezana, J. P., et al. (2020). Clinical, laboratory and imaging features of COVID-19: a systematic review and meta-analysis. Travel Med. Infect Dis, 34, 1-14. doi:10.1016/j.tmaid.2020.101623

Rosa, M. E., Matos, M. J., Furtado, R. S., Brito, V. M., Amaral, L. T., Beraldo, G. L., et al. (2020). COVID-19 findings identified in chest computed tomography: pictorial assay. Einstein, 18, 1-6. doi:10.31744/einstein_journal/2020RW5741

Tahamtan, A., & Ardebili, A. (2020). Real-time RT-PCR in COVID-19 detection: issues affecting the results. Expert Review of Molecular Diagnostics, 20 (5), 1-2. doi:10.1080%2F14737159.2020.1757437

Traugot, M., Aberle, S. W., Aberle, J. W., Griebler, H., Karolyi, M., Pawelka, E., et al. (2020). Performance of Severe Acute Respiratory Syndrome Coronavirus 2 Antibody Assays in Different Stages of Infection: Comparison of Commercial Enzyme-Linked Immunosorbent Assays and Rapid Tests. The Journal of Infectious Diseases, 222, 362-66. doi:10.1093/infdis/jiaa305

Toscano, G., Palmerini, F., Ravaglia, S., et al. (2020). Guillain–Barré Syndrome Associated with SARS-CoV-2. The New England journal of medicine, 2020, 1-3. doi:10.1056/NEJMc2009191

Ucpinar, B.A., Sahin, C., & Yanc, Y. (2020). Spontaneous pneumothorax and subcutaneous emphysema in COVID-19 patient: Case report. Journal of Infection and Public Health, 13(6), 887-889. doi:10.1016/j.jiph.2020.05.012

Velavana, T., & Meyer, C. G. (2020). Mild Versus Severe COVID-19: Laboratory Markers. International Journal of Infectious Diseases, 95, 304–307. doi:10.1016%2Fj.ijid.2020.04.061

Xu, Y., Gu, K., Quian, Y., & Tang, J. (2020). Relationship Between D-dimer Concentration and Inflammatory Factors or Organ Function in Patients With Coronavirus Disease 2019. Chinese Journal of Tuberculosis and Respiratory Diseases, 32 (5), 559-563. doi:10.3760/cma.j.cn121430-20200414-00518

Wang, W., Tang, J., & Wei, F. (2020). Updated understanding of the outbreak of 2019 novel coronavirus (2019-nCoV) in Wuhan, China, J. Med. Virol. 92, 441–447. doi:10.1002/jmv.25689

Zhang, L., Wang, B., Zhou, J., Kirkpatrick, J., Xie, M., & Johri, A. M. (2020). Bedside Focused Cardiac Ultrasound in COVID-19 from the Wuhan Epicenter: The Role of Cardiac Point-of-Care Ultrasound, Limited Transthoracic Echocardiography, and Critical Care Echocardiography. Journal of the American Society of Echocardiography, 33 (6), 667-82. doi:10.1016%2Fj.echo.2020.04.004

Zhu, N., Zhang, N., Wang, W., Li, X., Yang, B., Song, J., et al. (2020). A novel coronavirus from patients with pneumonia in China, 2019. N Engl J Med., 382 (8), 727- 33. doi:10.1056/NEJMoa2001017

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Publicado

20/07/2020

Cómo citar

NASCIMENTO, M. A.; SILVA, S. F. S.; ALBUQUERQUE, C. A. N. de; EDERLI, R. B.; SANTOS, E. C. M.; EDERLI, J. P. B. Marcadores de laboratorio y hallazgos de imágenes del síndrome respiratorio agudo grave causado por el nuevo coronavirus (SARS-CoV-2): ¿qué podemos encontrar?. Research, Society and Development, [S. l.], v. 9, n. 8, p. e673986399, 2020. DOI: 10.33448/rsd-v9i8.6399. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/6399. Acesso em: 8 ene. 2025.

Número

Vol. 9 Núm. 8

Sección

Ciencias de la salud

Licencia

Derechos de autor 2020 Maikiane Aparecida Nascimento, Savyla Franciele Soares Silva, Camila Aparecida Nunes de Albuquerque, Rosana Brambilla Ederli, Elorraine Coutinho Mathias Santos, João Pedro Brambilla Ederli

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