The role of oxidative stress in Crohn's disease: A narrative review
DOI:
https://doi.org/10.33448/rsd-v10i4.14445Keywords:
Inflammatory Bowel Diseases; Antioxidants; Vitamins; Minerals.Abstract
Crohn's disease (DC) is part of a set of inflammatory disorders of the gastrointestinal tract of varied symptoms and chronic character. Evidence has shown an association between oxidative stress and DC. Therefore, different biomarkers are being studied, but there is still no consensus. This study aimed to compile the most recent studies on the oxidant/antioxidant balance in DC in active and in remission patients. Among the biomarkers, those related to lipid peroxidation were the most studied in DC. It was observed that, even with the disease under control, remissive patients continue to present high levels of oxidative stress (oxidative damage to lipids and proteins) and alterations in their antioxidant defenses (GPx and catalase activities). Moreover, plasmatic levels of selenium, a mineral with important antioxidant action, were found to be decreased in patients, regardless of the disease’s stage. These findings demonstrate the need to monitor the oxidative stress and antioxidant defense biomarkers in DC patients, especially in periods of remission, when the patient does not have symptoms but maintains latent oxidative-inflammatory changes. The data discussed here may contribute to the design and development of new approaches for patients with DC.
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