Influence of vitamin D deficiency on intestinal dysbiosis: A systematic review
DOI:
https://doi.org/10.33448/rsd-v10i9.16596Keywords:
Dysbiosis; Vitamin D deficiency; Gastrointestinal microbiome.Abstract
The intestinal microbiota influences important local and systemic processes for the organism, having in its composition probiotic bacteria that assist in the beneficial processes and commensal bacteria, which often cause infections. The aim of this article is to analyze the existence of a relationship between the prevalence of pathogenic bacteria and intestinal inflammation when plasma levels are deficient in vitamin D. For this, a literature review was carried out with a systematic search in order to capture the current information. on the topic, in order to contribute to the clinical direction. As a result of the analysis, it was found that vitamin D sufficiency favors the presence of probiotics and intestinal barrier integrity, and that deficiency is associated with the prevalence of pathobionts and intestinal inflammation. Therefore, maintaining sufficient serum levels of vitamin D favors intestinal health, enabling an enterotype dominated by probiotics, decreasing inflammatory markers and protecting the integrity of the intestinal barrier.
References
Assa, A., Vong, L., Pinnell, LJ, Rautava, J., Avitzur, N., Johnson-Henry, KC, & Sherman, PM (2015). A deficiência de vitamina D predispõe à disfunção da barreira induzida por Escherichia coli invasiva aderente e lesão experimental do cólon. Doenças inflamatórias do intestino , 21 (2), 297-306.
Assa, A., Vong, L., Pinnell, L. J., Avitzur, N., Johnson-Henry, K. C., & Sherman, P. M. (2014). Vitamin D deficiency promotes epithelial barrier dysfunction and intestinal inflammation. The Journal of infectious diseases, 210(8), 1296-1305.
Científico, C., & de Paula, L. C. P. Hipovitaminose D em pediatria: recomendações para o diagnóstico, tratamento e prevenção.
Chen, D., Li, Y., Sun, H., Xiao, M., Zhang, R. L., Qiu, L., ... & Qian, J. M. (2020). Correlation between Vitamin D Status and Gut Microbiota in Patients with Inflammatory Bowel Disease. Zhongguo yi xue ke xue Yuan xue bao. Acta Academiae Medicinae Sinicae, 42(6), 740-748.
Claudio Gonçalves de Castro, L. (2011). O sistema endocrinológico vitamina D The vitamin D endocrine system. In Arq Bras Endocrinol Metab (Vol. 55, Issue 8).
de Oliveira, G. L. V., Leite, A. Z., Higuchi, B. S., Gonzaga, M. I., & Mariano, V. S. (2017). Intestinal dysbiosis and probiotic applications in autoimmune diseases. In Immunology (Vol. 152, Issue 1, pp. 1–12). Blackwell Publishing Ltd. https://doi.org/10.1111/imm.12765
Dos Santos Moraes, M., Peres Dos Santos Oliveira, L., Carvalho Furtado, C. De, & Gaspar Gonzalez, F. (2017). Efeitos funcionais dos probióticos com ênfase na atuação do kefir no tratamento da disbiose intestinal resumo functional effects os probiotics with emphasis on kefir’s action in the treatment of intestinal disbiosis. In revista unilus ensino e pesquisa v (vol. 37). Http://revista.lusiada.br/index.php/ruep
Estrela, C. (2018). Metodologia científica: ciência, ensino, pesquisa. Artes Médicas.
Garg, M., Hendy, P., Ding, J. N., Shaw, S., Hold, G., & Hart, A. (2018). The effect of vitamin D on intestinal inflammation and faecal microbiota in patients with ulcerative colitis. Journal of Crohn's and Colitis, 12(8), 963-972.
Gominak, S. C. (2016). Vitamin D deficiency changes the intestinal microbiome reducing B vitamin production in the gut. The resulting lack of pantothenic acid adversely affects the immune system, producing a “pro-inflammatory” state associated with atherosclerosis and autoimmunity. Medical hypotheses, 94, 103-107.
Jin, D., Wu, S., Zhang, Y. G., Lu, R., Xia, Y., Dong, H., & Sun, J. (2015). Lack of vitamin D receptor causes dysbiosis and changes the functions of the murine intestinal microbiome. Clinical therapeutics, 37(5), 996-1009.
Kanhere, M., He, J., Chassaing, B., Ziegler, TR, Alvarez, JA, Ivie, EA, ... & Tangpricha, V. (2018). A suplementação de vitamina D3 em bolus semanal tem impacto sobre a microbiota intestinal e das vias aéreas em adultos com fibrose cística: um ensaio clínico duplo-cego, randomizado e controlado por placebo. The Journal of Clinical Endocrinology & Metabolism , 103 (2), 564-574.
Kong, J., Zhang, Z., Musch, M. W., Ning, G., Sun, J., Hart, J., ... & Li, Y. C. (2008). Novel role of the vitamin D receptor in maintaining the integrity of the intestinal mucosal barrier. American Journal of Physiology-Gastrointestinal and Liver Physiology, 294(1), G208-G216.
Marques, C., Dantas, A., Fragoso, T., & Duarte, Â. (2010). A importância dos níveis de vitamina D nas doenças autoimunes. https://www.scielo.br/j/rbr/a/5BcvSsQGhJPXXD8Q9Pzff8H/?lang=pt
Naderpoor, N., Mousa, A., Arango, L. F. G., Barrett, H. L., Nitert, M. D., & de Courten, B. (2019). Effect of vitamin D supplementation on faecal microbiota: A randomised clinical trial. Nutrients, 11(12). https://doi.org/10.3390/nu11122888
Nakaoka, K., Yamada, A., Noda, S., & Goseki-Sone, M. (2018). Vitamin D-restricted high-fat diet down-regulates expression of intestinal alkaline phosphatase isozymes in ovariectomized rats. Nutrition research, 53, 23-31.
Ooi, JH, Li, Y., Rogers, CJ, & Cantorna, MT (2013). A vitamina D regula o microbioma intestinal e protege camundongos da colite induzida por sulfato de sódio dextrana. The Journal of Nutrition , 143 (10), 1679-1686.
Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). Metodologia da pesquisa científica.
Robles-Vera, I., Callejo, M., Ramos, R., Duarte, J., & Perez-Vizcaino, F. (2019). Impact of vitamin D deficit on the rat gut microbiome. Nutrients, 11(11), 2564.
Schäffler, H., Herlemann, DP, Klinitzke, P., Berlin, P., Kreikemeyer, B., Jaster, R., & Lamprecht, G. (2018). A administração de vitamina D leva a uma mudança na composição bacteriana intestinal em pacientes com doença de Crohn, mas não em controles saudáveis. Journal of digestive disease , 19 (4), 225-234.
Singh, P., Rawat, A., Alwakeel, M., Sharif, E., & al Khodor, S. (2020). The potential role of vitamin D supplementation as a gut microbiota modifier in healthy individuals. Scientific Reports, 10(1).
Su, D., Nie, Y., Zhu, A., Chen, Z., Wu, P., Zhang, L., ... & Han, YP (2016). A sinalização da vitamina D por meio da indução de defensinas de células paneth mantém a microbiota intestinal e melhora os distúrbios metabólicos e a esteatose hepática em modelos animais. Fronteiras em fisiologia , 7 , 498.
Weiss, G. A., & Hennet, T. (2017). Mechanisms and consequences of intestinal dysbiosis. In Cellular and Molecular Life Sciences (Vol. 74, Issue 16, pp. 2959–2977). Birkhauser Verlag AG. https://doi.org/10.1007/s00018-017-2509-x
Wu, P., Zhang, R., Luo, M., Zhang, T., Pan, L., Xu, S., ... & Han, YP (2020). A 25-hidroxilação prejudicada da vitamina D na lesão hepática suprime as defensinas das células Paneth intestinais, levando à disbiose intestinal e fibrogênese hepática. American Journal of Physiology-Gastrointestinal and Liver Physiology , 319 (6), G685-G695.
Yatsunenko, T., Rey, F. E., Manary, M. J., Trehan, I., Dominguez-Bello, M. G., Contreras, M., Magris, M., Hidalgo, G., Baldassano, R. N., Anokhin, A. P., Heath, A. C., Warner, B., Reeder, J., Kuczynski, J., Caporaso, J. G., Lozupone, C. A., Lauber, C., Clemente, J. C., Knights, D., … Gordon, J. I. (2012). Human gut microbiome viewed across age and geography. In Nature (Vol. 486, Issue 7402, pp. 222–227). https://doi.org/10.1038/nature11053
Zhou, X., Chen, C., Zhong, Y. N., Zhao, F., Hao, Z., Xu, Y., ... & Yin, X. (2020). Effect and mechanism of vitamin D on the development of colorectal cancer based on intestinal flora disorder. Journal of gastroenterology and hepatology, 35(6), 1023-1031.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Ana Carolina Pereira de Araújo dos Anjos; Mirella Vidal Félix de Andrade; Ana Caroline Maia Santos; Daniela Machado Bezerra; Manoel Aguiar Fenelon Júnior ; Joilson Ramos de Jesus
This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
