Lipid profile and blood glucose in patients with Diabetes Mellitus treated with Cinnamon - Systematic Review and Meta-analysis with randomized clinical research
DOI:
https://doi.org/10.33448/rsd-v10i9.18203Keywords:
Type 2 diabetes mellitus; Cinnamon; Blood glucose; Lipid profiles.Abstract
This study aimed to measure the efficiency of cinnamon in patients with Type 2 Diabetes Mellitus (DM2), comparing fasting plasma glucose averages and lipid profiles with a placebo group through a meta-analysis. Four databases were the source of the research to find the articles used, including: Medline / PubMed, LILACS and NCBI. 11 randomized clinical trials that evaluated cinnamon on glycemic and lipid parameters were included in this study. Meta-analysis was performed with the aid of the STATA® 16.0 software, which determined the difference in glucose means and lipid profiles compared to a placebo group. Cinnamon at concentrations of 250 mg twice a day decreased blood glucose with MD = -0.25 (95%CI = - 0.36 to -0.14; p<0.00001) and in the intervention with 2 g 3 times a day with MD = -5.60 (95%CI = -6.98 to -4.22; p<0.00001). Total cholesterol was significant with 2 g 3 times a day with MD = 0.98 (95%CI = -1.27 to -0.69), followed by LDL-cholesterol MD = 0.64 (95%CI = 0.88 to 0.40; p<0.00001), and HDL-cholesterol with 500 mg 3 times daily with MD = 0.12 (95%CI = 0.05 to 0.19). High-dose supplementation of cinnamon can reduce glucose and lipid profiles in patients with DM2. This supporting treatment can be useful when added to the diet plan of patients with DM2.
Author Biographies
Lucas Cândido Gonçalves, Federal University of Goiás,
Graduated in Biomedicine from Universidade Paulista - UNIP, Master's Student at Federal University of Goiás - UFG by the Health Sciences program, Post-Graduate Student in Hematology at Faculdade Única, Post-Graduate Student in Clinical Analysis and Microbiology at Faculty FAVENI. Completed internship in the laboratory of clinical analysis in the dependencies of the legislative assembly of the state of Goiás - ALEGO. He also completed an internship and multidisciplinary monitoring (Biochemistry, Hematology, Immunology, parasitology, microbiology and body fluids) at the University of São Paulo - UNIP.
Paulo Alex Neves da Silva, Federal University of Goiás
Graduated in Biological Sciences from Centro Universitário São Lucas (2012), specialization in clinical microbiology (2016), specialization in sanitation and environmental health (2020), master's degree in biology of the host parasite relationship (immunology) (2017). Doctoral student in Health Sciences (microbiology) by FM/UFG. He is currently a clinical pathologist in an urgent/emergency laboratory and a university professor, teaching courses in the health area. He has experience in the field of Immunology, working mainly in humoral immunity against Zika virus infection; clinical and environmental microbiology, working mainly in the department of biotechnology, bacteriology and virology; hematology, hormones, biochemistry and uranalysis. Currently developing research in the field of virology: Research on arboviruses (ChikV, DenV and Zikv) of medical interest and New coronavirus, which causes COVID-19. Member of the Biotechnology Laboratory for Microorganisms (LBMIC).
Lilian Carla Carneiro, Federal University of Goiás
Degree in Biological Sciences Medical-biomedicine modality from the Pontifical Catholic University of Goiás (2000), Master's in Biochemistry and Molecular Biology from the Federal University of Goiás (2004), Ph.D. in Cellular and Molecular Biology from the Federal University of Goiás (2010), post- PhD in Molecular and Imaging Diagnosis of Infectious and Parasitic Diseases from UFCSPA (2013). Professor at PUC-GO (2002), professor at the State University of Goiás (2003 to 2012), researcher at the Molecular Biology Institute of Paraná (2013 to 2015). I am currently a professor at the Federal University of Goiás. I have experience in the area of microbiology, with an emphasis on molecular biology applications, working mainly on the following topics: microbiological analysis, microorganism biotechnology and biotechnology applied to public health.
José Arthur Silva e Sousa, National Institute of Courses (INCURSOS)
Biomedical from Universidade Paulista -UNIP (2020). Determined person, has excellent ability to develop teamwork, in addition to being proactive and organized. These and other characteristics made José Arthur achieve excellent results as a student in the biomedicine course. Postgraduate, Lato Sensu modality, in Microbiology Applied to the Clinical Laboratory. Currently, as a biomedical professional, he works at the JC Laboratory of Clinical Analysis, LTDA - BIOMED. As a professional, he seeks to promote the exercise of knowledge and skills acquired in the area of biomedical practice; acquire relationships with professionals in the respective area, aiming at obtaining and assimilating experiences; the development of knowledge and creativity with a view to professional growth. And, as a research scientist, he performs statistical analyzes related to the great area of health and biology, mainly with descriptive data modeling to carry out meta-analyses. Available and flexible to schedules and changes. #Opentowork
Fábio Silvestre Ataídes, Universidade Paulista
Graduated in Biomedicine from the Catholic University of Goiás (1999) and specialization in Microbiology from the Federal University of Goiás (2007). Master with the project "Isolation, identification and in vitro susceptibility causing onychomycosis" completed in 02/2010 and Ph.D. with the project "Molecular identification, virulence and susceptibility to antifungal agents of Candida parapsilosis complex species" completed in 08/2014, both attended at Federal University of Goiás for the Postgraduate Program in Tropical Medicine and Public Health in the area of Microbiology. He is currently a professor at the Pontifical Catholic University of Goiás and Paulista University Campus Flamboyant. At Centro Universitário de Goiânia - UNICEUG he is a professor, Assistant Coordinator of the Biomedicine course and Member of the Institutional Committee of the Scientific and Technological Initiation Program. Has practical and theoretical experience in the field of Microbiology, with an emphasis on Mycology.
Xisto Sena Passos, Universidade Paulista
Graduated in Bachelor's Degree in Biology from the Pontifical Catholic University of Goiás (1984), Specialization in Microbiology (2000), Master's Degree in Tropical Medicine from the Federal University of Goiás (2002) and Doctorate in Tropical Medicine from the Federal University of Goiás (2007 ). He is currently a professor at the Universidade Paulista of Courses: Biology, Biomedicine, Physical Education, Nursing, Physiotherapy and Nutrition. Having experience in General Biology, with an emphasis on Cytology, Histology, Biostatistics and Final Course Paper.
Antonio Márcio Teodoro Cordeiro Silva, Pontifical Catholic University of Goiás
Graduated in Biomedicine from the Pontifical Catholic University of Goiás (1999), Master's in Genetics from the Federal University of Goiás (2003) and Ph.D. in Cellular and Molecular Biology from the Federal University of Goiás (2009). He is currently an adjunct professor at the Pontifical Catholic University of Goiás (PUC Goiás), in the undergraduate course, in the Medicine Course (Citology and Genetics), and in the Graduate Program, where he teaches and advises students, in the Master's Degree in Environmental Sciences and Health (MCAS ). He is a member of the Research Ethics Committee (CEP) of the Pontifical Catholic University of Goiás (PUC Goiás). He is Associate Editor of the Revista Estudos - Vida e Saúde (REVS, ISSN 1983-781X) of the Pontifical Catholic University of Goiás. At PUC Goiás, he develops research in the areas of genetics, molecular biology and epidemiology, with an emphasis on molecular, human and medical genetics , acting on the following topics: oncology, molecular biology, biostatistics (meta-analysis) and epidemiology.
Yara Lúcia Marques Maia, Universidade Paulista
Graduated in Pharmacy and Biochemistry from the Federal University of Goiás (1984), Master in Environmental Sciences and Health from the Catholic University of Goiás (2004), specialization in Business Management from Fundação Getúlio Vargas (2002) and Hospital Administration and Business in Health from the University State of Goiás (2001). She is currently a professor at Faculdade Estácio de Sá de Goiás and at Universidade Paulista - UNIP Campus Flamboyant; Professor of Postgraduate Studies at PUC-GO, Faculdade Osvaldo Cruz and UNIUBE (IEPG) and technical-scientific consultant. He has experience in translating scientific articles, preparing healthcare companies for accreditation, organizing courses and conferences, and providing courses in the healthcare area.
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Copyright (c) 2021 Antônio Guilherme Sousa Silva; Lucas Cândido Gonçalves; Paulo Alex Neves da Silva; Lilian Carla Carneiro; José Arthur Silva e Sousa; Fábio Silvestre Ataídes; Xisto Sena Passos; Antonio Márcio Teodoro Cordeiro Silva; Yara Lúcia Marques Maia
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