Alterações leucocitárias em pacientes com COVID-19 observadas em extensão de sangue periférico
DOI:
https://doi.org/10.33448/rsd-v10i11.19838Palavras-chave:
Coronavírus; Leucócitos; Hematologia; Infecção por SARS-CoV-2; Contagem de leucócitos.Resumo
O objetivo do estudo foi verificar as principais alterações na linhagem leucocitária causadas pela infecção pelo SARS-CoV-2, vírus de origem zoonótica responsável pela doença conhecida como COVID-19. O SARS-CoV-2 afeta vários sistemas, incluindo o sistema hematopoiético, o que ocasiona alterações nas linhagens dos leucócitos. Os pacientes infectados pelo vírus SARS-CoV-2 apresentavam alterações numéricas e morfológicas na linhagem de leucócitos, sendo mais significativo a linfopenia e a neutrofilia. Quanto à morfologia, foram observadas várias anomalias. Os linfócitos reativos plasmocitóides e os semelhantes às células de Downey foram observados com frequência. Monócitos displásicos e neutrófilos com hipolobulação, classificados como anomalia Pseudo Pelger-Huet adquirida, também estavam presentes. Essas anormalidades foram correlacionadas com maior chance de admissão na UTI e evolução para óbito. Houve correspondência entre a contagem normal de eosinófilos com a progressão positiva da doença, o que sugere que, a regeneração dos eosinófilos esteja relacionada com a recuperação da doença. Esse conjunto de alterações não foi observado em nenhuma outra pneumonia de origem viral. A contagem diferencial de leucócitos é um exame rápido e de fácil realização, que pode auxiliar a equipe médica na classificação de pacientes graves ou não graves, e fornecer direcionamento da evolução da doença.
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Copyright (c) 2021 Carolina Coradi; Suellen Laís Vicentino Vieira
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Autores que publicam nesta revista concordam com os seguintes termos:
1) Autores mantém os direitos autorais e concedem à revista o direito de primeira publicação, com o trabalho simultaneamente licenciado sob a Licença Creative Commons Attribution que permite o compartilhamento do trabalho com reconhecimento da autoria e publicação inicial nesta revista.
2) Autores têm autorização para assumir contratos adicionais separadamente, para distribuição não-exclusiva da versão do trabalho publicada nesta revista (ex.: publicar em repositório institucional ou como capítulo de livro), com reconhecimento de autoria e publicação inicial nesta revista.
3) Autores têm permissão e são estimulados a publicar e distribuir seu trabalho online (ex.: em repositórios institucionais ou na sua página pessoal) a qualquer ponto antes ou durante o processo editorial, já que isso pode gerar alterações produtivas, bem como aumentar o impacto e a citação do trabalho publicado.
