Agentes fitoterápicos no controle da ansiedade em odontologia: uma revisão de literatura
DOI:
https://doi.org/10.33448/rsd-v10i16.23528Palavras-chave:
Ansiedade ao Tratamento Odontológico; Fitoterapia; Odontologia.Resumo
O objetivo deste trabalho é revisar a literatura acerca do uso de fitoterápicos no controle da ansiedade odontológica. Para tanto, foram pesquisados artigos nas bases de dados ScienceDirect, Pubmed and The Cochrane Library. 57 artigos foram incluídos neste estudo. As evidências da pesquisa apontam a Valeriana officinalis e Passiflora incarnata como os fitoterápicos mais estudados para o controle da ansiedade, inclusive são investigados seus efeitos adversos. Estudos comprovam a relativa segurança no uso desses medicamentos, bem como sua eficácia, baixo custo, menor concentração de princípios ativos com melhores efeitos e menores efeitos colaterais quando comparados aos benzodiazepínicos. O uso dessas plantas medicinais requerem maiores esclarecimentos quanto à sua real eficácia, dosagem correta e efeitos colaterais na sedação consciente em Odontologia.
Referências
Ahmadi, M., Khalili, H., Abbasian, L., & Ghaeli, P. (2017). Effect of Valerian in Preventing Neuropsychiatric Adverse Effects of Efavirenz in HIV-Positive Patients: A Pilot Randomized, Placebo-Controlled Clinical Trial. The Annals of pharmacotherapy, 51(6), 457–464.
Akhondzadeh, S., Naghavi, H. R., Vazirian, M., Shayeganpour, A., Rashidi, H., & Khani, M. (2001). Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. Journal of clinical pharmacy and therapeutics, 26(5), 363–367.
Andreatini, R., & Leite, J. R. (1994). Effect of valepotriates on the behavior of rats in the elevated plus-maze during diazepam withdrawal. European journal of pharmacology, 260(2-3), 233–235.
Araújo, J. O., Motta, R., Bergamaschi, C. C., Guimarães, C. C., Ramacciato, J. C., de Andrade, N. K., Fiqueiró, M. F., & Lopes, L. C. (2018). Effectiveness and safety of oral sedation in adult patients undergoing dental procedures: protocol for a systematic review. BMJ open, 8(1), 176-181.
Aslanargun, P., Cuvas, O., Dikmen, B., Aslan, E., & Yuksel, M. U. (2012). Passiflora incarnata Linneaus as an anxiolytic before spinal anesthesia. Journal of anesthesia, 26(1), 39–44.
Baek, J. H., Nierenberg, A. A., & Kinrys, G. (2014). Clinical applications of herbal medicines for anxiety and insomnia; targeting patients with bipolar disorder. The Australian and New Zealand journal of psychiatry, 48(8), 705–715.
Baldwin, D. S., & Polkinghorn, C. (2005). Evidence-based pharmacotherapy of Generalized Anxiety Disorder. The international journal of neuropsychopharmacology, 8(2), 293–302.
Becker, A., Felgentreff, F., Schröder, H., Meier, B., & Brattström, A. (2014). The anxiolytic effects of a Valerian extract is based on valerenic acid. BMC complementary and alternative medicine, 14, 267.
Behboodi Moghadam, Z., Rezaei, E., Shirood Gholami, R., Kheirkhah, M., & Haghani, H. (2016). The effect of Valerian root extract on the severity of pre menstrual syndrome symptoms. Journal of traditional and complementary medicine, 6(3), 309–315.
Bos, R., Hendriks, H., Scheffer, J. J., & Woerdenbag, H. J. (1998). Cytotoxic potential of valerian constituents and valerian tinctures. Phytomedicine : international journal of phytotherapy and phytopharmacology, 5(3), 219–225.
Carlini E. A. (2003). Plants and the central nervous system. Pharmacology, biochemistry, and behavior, 75(3), 501–512.
da Cunha, R. S., Amorim, K. S., Gercina, A. C., de Oliveira, A., Dos Santos Menezes, L., Groppo, F. C., & Souza, L. (2021). Herbal medicines as anxiolytics prior to third molar surgical extraction. A randomized controlled clinical trial. Clinical oral investigations, 25(3), 1579–1586.
Dantas, L. P., de Oliveira-Ribeiro, A., de Almeida-Souza, L. M., & Groppo, F. C. (2017). Effects of passiflora incarnata and midazolam for control of anxiety in patients undergoing dental extraction. Medicina oral, patologia oral y cirugia bucal, 22(1), 95–101.
Dhawan, K., Kumar, S., & Sharma, A. (2001). Anti-anxiety studies on extracts of Passiflora incarnata Linneaus. Journal of ethnopharmacology, 78(2-3), 165–170.
Deogade, S. C., & Suresan, V. (2016). Psychometric assessment of anxiety with the Modified Dental Anxiety Scale among central Indian adults seeking oral health care to a dental school. Industrial psychiatry journal, 25(2), 202–209.
Facco, E., & Zanette, G. (2017). The Odyssey of Dental Anxiety: From Prehistory to the Present. A Narrative Review. Frontiers in psychology, 8, 1155.
Fajemiroye, J. O., da Silva, D. M., de Oliveira, D. R., & Costa, E. A. (2016). Treatment of anxiety and depression: medicinal plants in retrospect. Fundamental & clinical pharmacology, 30(3), 198–215.
Farah, G. J., Ferreira, G. Z., Danieletto-Zanna, C. F., Luppi, C. R., & Jacomacci, W. P. (2019). Assessment of Valeriana officinalis l. (Valerian) for Conscious Sedation of Patients During the Extraction of Impacted Mandibular Third Molars: A Randomized, Split-Mouth, Double-Blind, Crossover Study. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 77(9), 1796–17968.
Fernández-San-Martín, M. I., Masa-Font, R., Palacios-Soler, L., Sancho-Gómez, P., Calbó-Caldentey, C., & Flores-Mateo, G. (2010). Effectiveness of Valerian on insomnia: a meta-analysis of randomized placebo-controlled trials. Sleep medicine, 11(6), 505–511.
Gharib, M., Samani, L. N., Panah, Z. E., Naseri, M., Bahrani, N., & Kiani, K. (2015). The effect of valeric on anxiety severity in women undergoing hysterosalpingography. Global journal of health science, 7(3), 358–363.
Gordon, D., Heimberg, R. G., Tellez, M., & Ismail, A. I. (2013). A critical review of approaches to the treatment of dental anxiety in adults. Journal of anxiety disorders, 27(4), 365–378.
Groppo, F. C., Bergamaschi, C., Cogo, K., Franz-Montan, M., Motta, R. H., & de Andrade, E. D. (2008). Use of phytotherapy in dentistry. Phytotherapy research : PTR, 22(8), 993–998.
Grundmann, O., Wang, J., McGregor, G. P., & Butterweck, V. (2008). Anxiolytic activity of a phytochemically characterized Passiflora incarnata extract is mediated via the GABAergic system. Planta medica, 74(15), 1769–1773.
Hadley, S., & Petry, J. J. (2003). Valerian. American family physician, 67(8), 1755–1758.
Hendriks, H., Bos, R., Woerdenbag, H. J., & Koster, A. S. (1985). Central nervous depressant activity of valerenic Acid in the mouse. Planta medica, 51(1), 28–31.
Jamieson, D. D., & Duffield, P. H. (1990). The antinociceptive actions of kava components in mice. Clinical and experimental pharmacology & physiology, 17(7), 495–507.
Jung, H. Y., Yoo, D. Y., Nam, S. M., Kim, J. W., Choi, J. H., Yoo, M., Lee, S., Yoon, Y. S., & Hwang, I. K. (2015). Valerenic Acid Protects Against Physical and Psychological Stress by Reducing the Turnover of Serotonin and Norepinephrine in Mouse Hippocampus-Amygdala Region. Journal of medicinal food, 18(12), 1333–1339.
Kaviani, N., Tavakoli, M., Tabanmehr, M., & Havaei, R. (2013). The efficacy of passiflora incarnata linnaeus in reducing dental anxiety in patients undergoing periodontal treatment. Journal of dentistry (Shiraz, Iran), 14(2), 68–72.
Kinrys, G., Coleman, E., & Rothstein, E. (2009). Natural remedies for anxiety disorders: potential use and clinical applications. Depression and anxiety, 26(3), 259–265.
Leuschner, J., Müller, J., & Rudmann, M. (1993). Characterisation of the central nervous depressant activity of a commercially available valerian root extract. Arzneimittel-Forschung, 43(6), 638–641.
Liu, L., Liu, C., Wang, Y., Wang, P., Li, Y., & Li, B. (2015). Herbal Medicine for Anxiety, Depression and Insomnia. Current neuropharmacology, 13(4), 481–493.
Loeffler P. M. (1992). Oral benzodiazepines and conscious sedation: a review. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons, 50(9), 989–997.
Movafegh, A., Alizadeh, R., Hajimohamadi, F., Esfehani, F., & Nejatfar, M. (2008). Preoperative oral Passiflora incarnata reduces anxiety in ambulatory surgery patients: a double-blind, placebo-controlled study. Anesthesia and analgesia, 106(6), 1728–1732.
Manayi, A., Nabavi, S. M., Daglia, M., & Jafari, S. (2016). Natural terpenoids as a promising source for modulation of GABAergic system and treatment of neurological diseases. Pharmacological reports : PR, 68(4), 671–679.
Mancuso, C. E., Tanzi, M. G., & Gabay, M. (2004). Paradoxical reactions to benzodiazepines: literature review and treatment options. Pharmacotherapy, 24(9), 1177–1185.
Miroddi, M., Calapai, G., Navarra, M., Minciullo, P. L., & Gangemi, S. (2013). Passiflora incarnata L.: ethnopharmacology, clinical application, safety and evaluation of clinical trials. Journal of ethnopharmacology, 150(3), 791–804.
Murphy, K., Kubin, Z. J., Shepherd, J. N., & Ettinger, R. H. (2010). Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats. Phytomedicine : international journal of phytotherapy and phytopharmacology, 17(8-9), 674–678.
Ouzzani, M., Hammady, H., Fedorowicz, Z., & Elmagarmid, A. (2016). Rayyan-a web and mobile app for systematic reviews. Syst Rev, 5(1), 210. https://doi.org/10.1186/s13643-016-0384-4.
Pakseresht, S., Boostani, H., & Sayyah, M. (2011). Extract of valerian root (Valeriana officinalis L.) vs. placebo in treatment of obsessive-compulsive disorder: a randomized double-blind study. Journal of complementary & integrative medicine, 8, /j/jcim.2011.8.issue-1/1553-3840.1465/1553-3840.1465.xml.
Pereira, R. P., Fachinetto, R., de Souza Prestes, A., Wagner, C., Sudati, J. H., Boligon, A. A., Athayde, M. L., Morsch, V. M., & Rocha, J. B. (2011). Valeriana officinalis ameliorates vacuous chewing movements induced by reserpine in rats. Journal of neural transmission (Vienna, Austria : 1996), 118(11), 1547–1557.
Pinheiro, M. L., Alcântara, C. E., de Moraes, M., & de Andrade, E. D. (2014). Valeriana officinalis L. for conscious sedation of patients submitted to impacted lower third molar surgery: A randomized, double-blind, placebo-controlled split-mouth study. Journal of pharmacy & bioallied sciences, 6(2), 109–114.
Pittler, M. H., & Ernst, E. (2003). Kava extract for treating anxiety. The Cochrane database of systematic reviews, (1), CD003383.
Ricigliano, V., Kumar, S., Kinison, S., Brooks, C., Nybo, S. E., Chappell, J., & Howarth, D. G. (2016). Regulation of sesquiterpenoid metabolism in recombinant and elicited Valeriana officinalis hairy roots. Phytochemistry, 125, 43–53.
Sarris, J., Byrne, G. J., Bousman, C. A., Cribb, L., Savage, K. M., Holmes, O., Murphy, J., Macdonald, P., Short, A., Nazareth, S., Jennings, E., Thomas, S. R., Ogden, E., Chamoli, S., Scholey, A., & Stough, C. (2020). Kava for generalised anxiety disorder: A 16-week double-blind, randomised, placebo-controlled study. The Australian and New Zealand journal of psychiatry, 54(3), 288–297.
Sarris, J., McIntyre, E., & Camfield, D. A. (2013). Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence. CNS drugs, 27(4), 301–319.
Sarris, J., Panossian, A., Schweitzer, I., Stough, C., & Scholey, A. (2011). Herbal medicine for depression, anxiety and insomnia: a review of psychopharmacology and clinical evidence. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology, 21(12), 841–860.
Schunck, R., Macedo, I. C., Laste, G., de Souza, A., Valle, M., Salomón, J., Nunes, E. A., Campos, A., Gnoatto, S., Bergold, A. M., Konrath, E. L., Dallegrave, E., Arbo, M. D., Torres, I., & Leal, M. B. (2017). Standardized Passiflora incarnata L. Extract Reverts the Analgesia Induced by Alcohol Withdrawal in Rats. Phytotherapy research : PTR, 31(8), 1199–1208.
Singh, Y. N., & Singh, N. N. (2002). Therapeutic potential of kava in the treatment of anxiety disorders. CNS drugs, 16(11), 731–743.
Thomas, K., Canedo, J., Perry, P. J., Doroudgar, S., Lopes, I., Chuang, H. M., & Bohnert, K. (2016). Effects of valerian on subjective sedation, field sobriety testing and driving simulator performance. Accident; analysis and prevention, 92, 240–244.
Trompetter, I., Krick, B., & Weiss, G. (2013). Herbal triplet in treatment of nervous agitation in children. Wiener medizinische Wochenschrift (1946), 163(3-4), 52–57.
Tzeng, Y. M., & Lee, M. J. (2015). Neuroprotective properties of kavalactones. Neural regeneration research, 10(6), 875–877.
Ugalde, M., Reza, V., González-Trujano, M. E., Avula, B., Khan, I. A., & Navarrete, A. (2005). Isobolographic analysis of the sedative interaction between six central nervous system depressant drugs and Valeriana edulis hydroalcoholic extract in mice. The Journal of pharmacy and pharmacology, 57(5), 631–639.
Vanhee, T., Mourali, S., Bottenberg, P., Jacquet, W., & Vanden Abbeele, A. (2020). Stimuli involved in dental anxiety: What are patients afraid of?: A descriptive study. International journal of paediatric dentistry, 30(3), 276–285.
Witte, S., Loew, D., & Gaus, W. (2005). Meta-analysis of the efficacy of the acetonic kava-kava extract WS1490 in patients with non-psychotic anxiety disorders. Phytotherapy research : PTR, 19(3), 183–188.
Yao, M., Ritchie, H. E., & Brown-Woodman, P. D. (2007). A developmental toxicity-screening test of valerian. Journal of ethnopharmacology, 113(2), 204–209.
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Copyright (c) 2021 Camila Soares Lopes; Suellen de Azevedo Moreira; Marcela de Come Ramos; Naiana Viana Viola
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