Mecanismos da obesidade e importância dos compostos bioativos de frutas em sua regulação – uma revisão narrativa

Autores

DOI:

https://doi.org/10.33448/rsd-v11i4.27153

Palavras-chave:

Obesidade; Biomarcadores; Fitoquímicos; Frutas; Compostos bioativos.

Resumo

Uma dieta equilibrada é essencial no controle da obesidade. As frutas destacam-se pela presença de variados compostos bioativos, que representam ferramentas promissoras na prevenção e tratamento de diversas patologias. Na obesidade, fitoquímicos presentes nas frutas são relacionados a diferentes mecanismos de ação importantes, como atividade antioxidante e anti-inflamatória. Esta revisão narrativa visa entender as principais alterações fisiológicas da obesidade e os efeitos dos compostos bioativos de frutas sobre elas, identificando as substâncias mais conhecidas e seus prováveis mecanismos de ação sobre os principais biomarcadores. A pesquisa foi realizada nas bases de dados Google Acadêmico, Scielo, Pubmed e Science Direct, considerando revisões publicadas a partir de 2015 e estudos experimentais a partir de 2010. As citocinas inflamatórias e adipocinas são consideradas biomarcadores primários da obesidade, sendo considerados atualmente também a resistência insulínica, a menor tolerância à glicose, estresse oxidativo, microbiota intestinal, nutrientes e microRNAs. Três grupos de frutas destacaram-se por seus efeitos: as frutas cítricas, “berries” e frutas tropicais, fontes principalmente de flavonoides, antocianinas e carotenoides. Resultados experimentais apontam que as frutas e seus compostos podem auxiliar na prevenção e tratamento da obesidade através da regulação de citocinas inflamatórias e adipocinas envolvidas nos mecanismos desta doença, bem como propriedades antioxidantes e modulação da lipogênese. Mais estudos clínicos são necessários para entender sobre os mecanismos bioquímicos envolvidos, a fim de favorecer não só a produção de suplementos específicos como também a melhor prescrição clínica dietética.

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12/03/2022

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MARTINEZ , R. M. .; ALMEIDA, C. de O. R. P. de .; LIMA , T. P. B.; FIGUEIREDO , M. S. .; TEODORO, A. J. Mecanismos da obesidade e importância dos compostos bioativos de frutas em sua regulação – uma revisão narrativa. Research, Society and Development, [S. l.], v. 11, n. 4, p. e11411427153, 2022. DOI: 10.33448/rsd-v11i4.27153. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/27153. Acesso em: 22 nov. 2024.

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v. 11 n. 4

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Ciências da Saúde

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Copyright (c) 2022 Raquel Martins Martinez ; Carolina de Oliveira Ramos Petra de Almeida; Thuane Passos Barbosa Lima ; Mariana Sarto Figueiredo ; Anderson Junger Teodoro

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