HTLV-1: fatores genéticos e epigenéticos associados ao desenvolvimento de leucemia/linfoma de células t do adulto
DOI:
https://doi.org/10.33448/rsd-v11i7.29781Palavras-chave:
HTLV-1; Oncoproteínas; Epigenética.Resumo
Objetivo: Identificar possíveis fatores genéticos e epigenéticos associados ao desenvolvimento da leucemia/linfoma de células T do adulto. Metodologia: Trata-se de trabalho baseado na revisão integrativa da literatura. A busca por artigos foi realizada mediante o uso dos descritores indexados no DeCS (Descritores em Ciências de saúde) e MeSH (Medical Subject Headings), foram incluídos artigos publicados nos últimos 5 anos. Resultados e Discussão: O processo de carcinogênese que culmina na progressão a ATLL possui várias fases em um longo período de tempo. O início do processo neoplásico está relacionado à expressão da oncoproteína viral Tax, que induz a replicação e início do processo de expansão clonal. A oncoproteína HBZ e o RNA HBZ são continuamente transcritos nas células neoplásicas e influenciam no processo de proliferação celular e persistência viral. Além de fatores genéticos que geralmente são mediadas pelas proteínas Tax e HBZ também é necessário alterações epigenéticas, como a acetilação de histonas e metilação do DNA. Conclusão: conclui-se então que fatores genéticos como o Tax, HBZ, FYN, PLCG1, CD247, DLG1, VAV1, ERC1, PRKCQ, CARD11, RELA, IKBKB, TET1, TET2, MLL2, MLL3 DNMT1 e IRF4. E vias epigenéticas que atuam na metilação do DNA e na acetilação de histonas estão envolvidos no processo de carcinogênese mediado pelo HTLV-1.
Referências
Akbarin, M. M., Shirdel, A., Bari, A., Mohaddes, S. T., Rafatpanah, H., Karimani, E. G., Etminani, K., Golabpour, A., & Torshizi, R. (2017). Evaluation of the role of TAX, HBZ, and HTLV-1 proviral load on the survival of ATLL patients. Blood research, 52(2), 106–111. https://doi.org/10.5045/br.2017.52.2.106
Alessio, L., Minichini, C., Starace, M., Occhiello, L., Caroprese, M., Di Caprio, G., Sagnelli, C., Gualdieri, L., Pisaturo, M., Onorato, L., Scotto, G., Macera, M., De Pascalis, S., Sagnelli, E., & Coppola, N. (2018). Low prevalence of HTLV1/2 infection in a population of immigrants living in southern Italy. PLoS neglected tropical diseases, 12(6), e0006601. https://doi.org/10.1371/journal.pntd.0006601
Alvarez, C., Gotuzzo, E., Vandamme, A. M., & Verdonck, K. (2016). Family Aggregation of Human T-Lymphotropic Virus 1-Associated Diseases: A Systematic Review. Frontiers in microbiology, 7, 1674. https://doi.org/10.3389/fmicb.2016.01674
Bangham C. (2018). Human T Cell Leukemia Virus Type 1: Persistence and Pathogenesis. Annual review of immunology, 36, 43–71. https://doi.org/10.1146/annurev-immunol-042617-053222
Bangham, C., & Matsuoka, M. (2017). Human T-cell leukaemia virus type 1: parasitism and pathogenesis. Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 372(1732), 20160272. https://doi.org/10.1098/rstb.2016.0272
Cheng, W., Zheng, T., Wang, Y., Cai, K., Wu, W., Zhao, T., & Xu, R. (2019). Activation of Notch1 signaling by HTLV-1 Tax promotes proliferation of adult T-cell leukemia cells. Biochemical and biophysical research communications, 512(3), 598–603. https://doi.org/10.1016/j.bbrc.2019.03.094
Cook, L. B., Fuji, S., Hermine, O., Bazarbachi, A., Ramos, J. C., Ratner, L., Horwitz, S., Fields, P., Tanase, A., Bumbea, H., Cwynarski, K., Taylor, G., Waldmann, T. A., Bittencourt, A., Marcais, A., Suarez, F., Sibon, D., Phillips, A., Lunning, M., Farid, R., … Watanabe, T. (2019). Revised Adult T-Cell Leukemia-Lymphoma International Consensus Meeting Report. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 37(8), 677–687. https://doi.org/10.1200/JCO.18.00501
Futsch, N., Mahieux, R., & Dutartre, H. (2017). HTLV-1, the Other Pathogenic Yet Neglected Human Retrovirus: From Transmission to Therapeutic Treatment. Viruses, 10(1), 1. https://doi.org/10.3390/v10010001
Gazon, H., Belrose, G., Terol, M., Meniane, J. C., Mesnard, J. M., Césaire, R., & Peloponese, J. M., Jr (2016). Impaired expression of DICER and some microRNAs in HBZ expressing cells from acute adult T-cell leukemia patients. Oncotarget, 7(21), 30258–30275. https://doi.org/10.18632/oncotarget.7162
Giam, C. Z., & Semmes, O. J. (2016). HTLV-1 Infection and Adult T-Cell Leukemia/Lymphoma-A Tale of Two Proteins: Tax and HBZ. Viruses, 8(6), 161. https://doi.org/10.3390/v8060161
Harrod R. (2019). Silencers of HTLV-1 and HTLV-2: the pX-encoded latency-maintenance factors. Retrovirology, 16(1), 25. https://doi.org/10.1186/s12977-019-0487-9
Hartl, D. L., & Clark, A. G. (2010). Princípios de Genética de Populações-4. Artmed Editora.
Ichikawa, T., Nakahata, S., Fujii, M., Iha, H., Shimoda, K., & Morishita, K. (2019). The regulation of NDRG2 expression during ATLL development after HTLV-1 infection. Biochimica et biophysica acta. Molecular basis of disease, 1865(10), 2633–2646. https://doi.org/10.1016/j.bbadis.2019.07.001
Kannagi, M., Hasegawa, A., Nagano, Y., Kimpara, S., & Suehiro, Y. (2019). Impact of host immunity on HTLV-1 pathogenesis: potential of Tax-targeted immunotherapy against ATL. Retrovirology, 16(1), 23. https://doi.org/10.1186/s12977-019-0484-z
Kanzaki L. (2018). HTLV-1: A real pathogen or a runaway guest of a diseased cell?. Journal of biosciences, 43(4), 785–795.
Kataoka, K., Nagata, Y., Kitanaka, A., Shiraishi, Y., Shimamura, T., Yasunaga, J., Totoki, Y., Chiba, K., Sato-Otsubo, A., Nagae, G., Ishii, R., Muto, S., Kotani, S., Watatani, Y., Takeda, J., Sanada, M., Tanaka, H., Suzuki, H., Sato, Y., Shiozawa, Y., … Ogawa, S. (2015). Integrated molecular analysis of adult T cell leukemia/lymphoma. Nature genetics, 47(11), 1304–1315. https://doi.org/10.1038/ng.3415
Kataoka, K., Iwanaga, M., Yasunaga, J. I., Nagata, Y., Kitanaka, A., Kameda, T., Yoshimitsu, M., Shiraishi, Y., Sato-Otsubo, A., Sanada, M., Chiba, K., Tanaka, H., Ochi, Y., Aoki, K., Suzuki, H., Shiozawa, Y., Yoshizato, T., Sato, Y., Yoshida, K., Nosaka, K., … Ogawa, S. (2018). Prognostic relevance of integrated genetic profiling in adult T-cell leukemia/lymphoma. Blood, 131(2), 215–225. https://doi.org/10.1182/blood-2017-01-761874
Lyngdoh, D. L., Shukla, H., Sonkar, A., Anupam, R., & Tripathi, T. (2019). Portrait of the Intrinsically Disordered Side of the HTLV-1 Proteome. ACS omega, 4(6), 10003–10018. https://doi.org/10.1021/acsomega.9b01017
Mahgoub, M., Yasunaga, J. I., Iwami, S., Nakaoka, S., Koizumi, Y., Shimura, K., & Matsuoka, M. (2018). Sporadic on/off switching of HTLV-1 Tax expression is crucial to maintain the whole population of virus-induced leukemic cells. Proceedings of the National Academy of Sciences of the United States of America, 115(6), E1269–E1278. https://doi.org/10.1073/pnas.1715724115
Malpica, L., Pimentel, A., Reis, I. M., Gotuzzo, E., Lekakis, L., Komanduri, K., Harrington, T., Barber, G. N., & Ramos, J. C. (2018). Epidemiology, clinical features, and outcome of HTLV-1-related ATLL in an area of prevalence in the United States. Blood advances, 2(6), 607–620. https://doi.org/10.1182/bloodadvances.2017011106
Martinez, M. P., Al-Saleem, J., & Green, P. L. (2019). Comparative virology of HTLV-1 and HTLV-2. Retrovirology, 16(1), 21. https://doi.org/10.1186/s12977-019-0483-0
Matsuoka, M., & Mesnard, J. M. (2020). HTLV-1 bZIP factor: the key viral gene for pathogenesis. Retrovirology, 17(1), 2. https://doi.org/10.1186/s12977-020-0511-0
Mehta-Shah, N., Ratner, L., & Horwitz, S. M. (2017). Adult T-Cell Leukemia/Lymphoma. Journal of oncology practice, 13(8), 487–492. https://doi.org/10.1200/JOP.2017.021907
Mendes, F. C., M., de Ribamar Oliveira Lima, J., de Oliveira de Melo, B., de Maria Fernandes da Silva Pinto, C., Maia, H. S., Ferro, T., Monteiro, S. G., Stancioli, E., & Bomfim, M. (2020). Molecular detection of human T cell lymphotropic virus type 1 in pregnant women from Maranhão state, Brazil. Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology], 51(2), 637–645. https://doi.org/10.1007/s42770-020-00233-0
Mohanty, S., & Harhaj, E. W. (2020). Mechanisms of Oncogenesis by HTLV-1 Tax. Pathogens (Basel, Switzerland), 9(7), 543. https://doi.org/10.3390/pathogens9070543
Morais, M., Gato, C. M., Maciel, L. A., Lalwani, P., Costa, C. A., & Lalwani, J. (2017). Prevalence of Human T-lymphotropic virus type 1 and 2 among blood donors in Manaus, Amazonas State, Brazil. Revista do Instituto de Medicina Tropical de Sao Paulo, 59, e80. https://doi.org/10.1590/S1678-9946201759080
Naito, T., Ushirogawa, H., Fukushima, T., Tanaka, Y., & Saito, M. (2019). EOS, an Ikaros family zinc finger transcription factor, interacts with the HTLV-1 oncoprotein Tax and is downregulated in peripheral blood mononuclear cells of HTLV-1-infected individuals, irrespective of clinical statuses. Virology journal, 16(1), 160. https://doi.org/10.1186/s12985-019-1270-1
Oliveira, P. D., Farre, L., & Bittencourt, A. L. (2016). Adult T-cell leukemia/lymphoma. Revista da Associacao Medica Brasileira (1992), 62(7), 691–700. https://doi.org/10.1590/1806-9282.62.07.691
Phillips, A. A., & Harewood, J. (2018). Adult T Cell Leukemia-Lymphoma (ATL): State of the Art. Current hematologic malignancy reports, 13(4), 300–307. https://doi.org/10.1007/s11899-018-0458-6
Ratner L. (2020). Molecular biology of human T cell leukemia virus. Seminars in diagnostic pathology, 37(2), 104–109. https://doi.org/10.1053/j.semdp.2019.04.003
Rodríguez-Zúñiga, M. J., Cortez-Franco, F., & Qujiano-Gomero, E. (2017). Adult T-cell leukemia/lymphoma in a Peruvian hospital in human T-lymphotropic virus type 1 (HTLV-1) positive patients. International journal of dermatology, 56(5), 503–509. https://doi.org/10.1111/ijd.13567
Rowan, A. G., Dillon, R., Witkover, A., Melamed, A., Demontis, M. A., Gillet, N. A., Mun, L. J., Bangham, C., Cook, L. B., Fields, P. A., & Taylor, G. P. (2020). Evolution of retrovirus-infected premalignant T-cell clones prior to adult T-cell leukemia/lymphoma diagnosis. Blood, 135(23), 2023–2032. https://doi.org/10.1182/blood.2019002665
Rushing, A. W., Rushing, B., Hoang, K., Sanders, S. V., Péloponèse, J. M., Jr, Polakowski, N., & Lemasson, I. (2019). HTLV-1 basic leucine zipper factor protects cells from oxidative stress by upregulating expression of Heme Oxygenase I. PLoS pathogens, 15(6), e1007922. https://doi.org/10.1371/journal.ppat.1007922
Saito M. (2019). Association Between HTLV-1 Genotypes and Risk of HAM/TSP. Frontiers in microbiology, 10, 1101. https://doi.org/10.3389/fmicb.2019.01101
Shudofsky, A., & Giam, C. Z. (2019). Cells of adult T-cell leukemia evade HTLV-1 Tax/NF-κB hyperactivation-induced senescence. Blood advances, 3(4), 564–569. https://doi.org/10.1182/bloodadvances.2018029322
Sousa, L. M. M. S., Marques-Vieira, C. M. A., Severino, S. S., & Antunes, A. V. (2017). Metodologia de revisão integrativa da literatura em enfermagem.
Sugata, K., Yasunaga, J., Kinosada, H., Mitobe, Y., Furuta, R., Mahgoub, M., Onishi, C., Nakashima, K., Ohshima, K., & Matsuoka, M. (2016). HTLV-1 Viral Factor HBZ Induces CCR4 to Promote T-cell Migration and Proliferation. Cancer research, 76(17), 5068–5079. https://doi.org/10.1158/0008-5472.CAN-16-0361
Takiuchi, Y., Kobayashi, M., Tada, K., Iwai, F., Sakurada, M., Hirabayashi, S., Nagata, K., Shirakawa, K., Shindo, K., Yasunaga, J. I., Murakawa, Y., Rajapakse, V., Pommier, Y., Matsuoka, M., & Takaori-Kondo, A. (2017). HTLV-1 bZIP factor suppresses TDP1 expression through inhibition of NRF-1 in adult T-cell leukemia. Scientific reports, 7(1), 12849. https://doi.org/10.1038/s41598-017-12924-0
Tanaka, A., & Matsuoka, M. (2018). HTLV-1 Alters T Cells for Viral Persistence and Transmission. Frontiers in microbiology, 9, 461. https://doi.org/10.3389/fmicb.2018.00461
Tarokhian, H., Rahimi, H., Mosavat, A., Shirdel, A., Rafatpanah, H., Akbarin, M. M., Bari, A., Ramezani, S., & Rezaee, S. A. (2018). HTLV-1-host interactions on the development of adult T cell leukemia/lymphoma: virus and host gene expressions. BMC cancer, 18(1), 1287. https://doi.org/10.1186/s12885-018-5209-5
Uchida, Y., Yoshimitsu, M., Hachiman, M., Kusano, S., Arima, N., Shima, K., Hayashida, M., Kamada, Y., Nakamura, D., Arai, A., Tanaka, Y., Hara, H., & Ishitsuka, K. (2021). RLTPR Q575E: A novel recurrent gain-of-function mutation in patients with adult T-cell leukemia/lymphoma. European journal of haematology, 106(2), 221–229. https://doi.org/10.1111/ejh.13540
Watanabe T. (2017). Adult T-cell leukemia: molecular basis for clonal expansion and transformation of HTLV-1-infected T cells. Blood, 129(9), 1071–1081. https://doi.org/10.1182/blood-2016-09-692574
Yamagishi, M., Fujikawa, D., Watanabe, T., & Uchimaru, K. (2018). HTLV-1-Mediated Epigenetic Pathway to Adult T-Cell Leukemia-Lymphoma. Frontiers in microbiology, 9, 1686. https://doi.org/10.3389/fmicb.2018.01686
Yamagishi, M., Hori, M., Fujikawa, D., Ohsugi, T., Honma, D., Adachi, N., Katano, H., Hishima, T., Kobayashi, S., Nakano, K., Nakashima, M., Iwanaga, M., Utsunomiya, A., Tanaka, Y., Okada, S., Tsukasaki, K., Tobinai, K., Araki, K., Watanabe, T., & Uchimaru, K. (2019). Targeting Excessive EZH1 and EZH2 Activities for Abnormal Histone Methylation and Transcription Network in Malignant Lymphomas. Cell reports, 29(8), 2321–2337.e7. https://doi.org/10.1016/j.celrep.2019.10.083
Yasunaga J. I. (2020). Strategies of Human T-Cell Leukemia Virus Type 1 for Persistent Infection: Implications for Leukemogenesis of Adult T-Cell Leukemia-Lymphoma. Frontiers in microbiology, 11, 979. https://doi.org/10.3389/fmicb.2020.00979
Yeh, C. H., Bellon, M., Pancewicz-Wojtkiewicz, J., & Nicot, C. (2016). Oncogenic mutations in the FBXW7 gene of adult T-cell leukemia patients. Proceedings of the National Academy of Sciences of the United States of America, 113(24), 6731–6736. https://doi.org/10.1073/pnas.1601537113
Zhang, L. L., Wei, J. Y., Wang, L., Huang, S. L., & Chen, J. L. (2017). Human T-cell lymphotropic virus type 1 and its oncogenesis. Acta pharmacologica Sinica, 38(8), 1093–1103. https://doi.org/10.1038/aps.2017.17
Zhang, L., Lu, Q., & Chang, C. (2020). Epigenetics in Health and Disease. Advances in experimental medicine and biology, 1253, 3–55. https://doi.org/10.1007/978-981-15-3449-2_1
Zhao T. (2016). The Role of HBZ in HTLV-1-Induced Oncogenesis. Viruses, 8(2), 34. https://doi.org/10.3390/v8020034
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Copyright (c) 2022 Gessica Hellen Silva dos Anjos; Klaudia Emanuela Ramos Tenório
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Autores que publicam nesta revista concordam com os seguintes termos:
1) Autores mantém os direitos autorais e concedem à revista o direito de primeira publicação, com o trabalho simultaneamente licenciado sob a Licença Creative Commons Attribution que permite o compartilhamento do trabalho com reconhecimento da autoria e publicação inicial nesta revista.
2) Autores têm autorização para assumir contratos adicionais separadamente, para distribuição não-exclusiva da versão do trabalho publicada nesta revista (ex.: publicar em repositório institucional ou como capítulo de livro), com reconhecimento de autoria e publicação inicial nesta revista.
3) Autores têm permissão e são estimulados a publicar e distribuir seu trabalho online (ex.: em repositórios institucionais ou na sua página pessoal) a qualquer ponto antes ou durante o processo editorial, já que isso pode gerar alterações produtivas, bem como aumentar o impacto e a citação do trabalho publicado.
