Decanoato de nandrolona reduz os efeitos positivos do treinamento resistido na cognição, comportamento ansioso, e morfologia hipocampal de ratos
DOI:
https://doi.org/10.33448/rsd-v11i8.30600Palavras-chave:
Memória; Testosterona; Exercício físico; Hipertrofia; Comportamento.Resumo
Os EAA tornaram-se populares entre atletas competitivos e a população em geral para fins recreativos e de desempenho. O uso indiscriminado de EAAs ocorrem em doses suprafisiológicas e afetam negativamente a cognição. Além disso, o abuso de decanoato de nandrolona (DECA) pode reduzir os efeitos benéficos do treino de resistência (TR) na saúde. Objetivo: Pretendíamos investigar se a administração de DECA em doses suprafisiológicas interfere com os efeitos positivos da TR no comportamento, memória e morfologia dos neurónios no hipocampo dos ratos. Materiais e Métodos: Os ratos foram distribuídos aleatoriamente em quatro grupos (N= 12): Controle (C); DECA (D); Treinado (T) Treinado+DECA (TD). A EAA DECA foi administrada em doses suprafisiológicas diárias de 15mg/kg durante as 8 semanas do protocolo TR. Todos os grupos realizaram um teste de carga máxima antes e depois do protocolo TR; o comportamento ansioso e os testes de memória foram realizados, e depois, os ratos foram eutanasiados para análises morfológicas do hipocampo. O DECA produziu um efeito ansiogênico, agravou a cognição e reduziu a espessura da camada granulado da DG no hipocampo. Além disso, a DECA reduziu os efeitos positivos do TR na cognição e nos neurónios da GD. Este é o primeiro estudo que mostra que as doses suprafarmacológicas do DECA reduzem os efeitos positivos do TR na memória e a espessura da camada granular da GD.
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