Ensaio aleatório - Reutilização de Ivermectina para tratamento COVID-19 de pacientes ambulatórios com doença leve em centros primários de saúde

Autores

DOI:

https://doi.org/10.33448/rsd-v11i8.30844

Palavras-chave:

COVID-19; Ivermectina; Assistência Ambulatorial; Reposicionamento de medicamentos; Atenção Primária à Saúde.

Resumo

Objetivo: avaliar a intervenção terapêutica com Ivermectina em pacientes ambulatoriais com doença leve de COVID-19, para aumentar a alta médica e prevenir a progressão para doença moderada ou grave.  Métodos: Ensaio Randomizado, n= 254. Os sujeitos foram divididos em grupo experimental (GE: n= 110) e grupo controle (GC: n= 144).  O GE recebeu Ivermectina oral 0,6 mg/kg de peso em duas doses.  Todos os participantes realizarão exame físico COVID-19 e diagnosticados com RT-PCR negativo no início e no final do protocolo.  As diferenças entre as variáveis ​​foram determinadas pelo teste Qui-quadrado (p<0,05).  O risco de contágio (Odds Ratio) foi calculado por meio do software STATA.  Resultados: Ambos os grupos foram semelhantes em idade, sexo e comorbidades.  Uma redução significativa no percentual de participantes com sintomas (PPS) foi observada no GE e GC quando a avaliação clínica dos sintomas foi realizada do 5º ao 9º (p= 0,0005).  Quando a avaliação clínica foi realizada do 10º ao 14º dia não houve diferença significativa.  Foi observada Maior proporção de alta médica no GE (98,2%) vs. GC (86,1%) (p= 0,0007).  O GE apresentou 8 vezes mais chance de receber alta médica do que o GC (OR 8,71, IC 95%: 1,99 – 38,12, p= 0,004).  O efeito do tratamento com Ivermectina para obter alta médica da assistência ambulatorial foi analisado pela regressão logística.  Então, a chance de obter alta médica foi independente das variáveis ​​sexo, idade e comorbidades.  Conclusão: Este trabalho apoia a eficácia potencial da Ivermectina na assistência ambulatorial com COVID-19 leve como uma intervenção potencialmente útil de saúde pública.

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21/06/2022

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CHAHLA, R. E.; RUIZ, L. M. .; MENA, T. .; BREPE, Y.; TERRANOVA, P.; ORTEGA, E. S.; BARRENECHEA, G. G.; GOROSO, D. G.; PERAL DE BRUNO, M. de los Ángeles. Ensaio aleatório - Reutilização de Ivermectina para tratamento COVID-19 de pacientes ambulatórios com doença leve em centros primários de saúde. Research, Society and Development, [S. l.], v. 11, n. 8, p. e35511830844, 2022. DOI: 10.33448/rsd-v11i8.30844. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/30844. Acesso em: 21 dez. 2024.

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Ciências da Saúde