Efeito da terapia antibiótica no período pós-operatório de cirurgias de terceiros molares: um estudo de boca dividida, randomizado e controlado

Autores

DOI:

https://doi.org/10.33448/rsd-v11i8.31236

Palavras-chave:

Dente serotino; Cirurgia bucal; Edema; Trismo.

Resumo

Objetivo: O objetivo deste ensaio clínico randomizado foi avaliar o período pós-operatório de 32 terceiros molares, semi-inclusos ou inclusos, em uma boca dividida, de pacientes da Universidade Estadual Paulista. Material e Métodos: Os dentes foram divididos em dois grupos, no grupo teste tratamento medicamentoso com Amoxicilina 500 mg, Dexametasona 4 mg e Dipirona 500 mg e no grupo controle pacientes receberam tratamento com Dexametasona 4 mg e Dipirona 500 mg. Os parâmetros utilizados foram edema, trismo e dor, medidos antes e depois da operação, onde os benefícios da antibioticoterapia foram avaliados. Para comparar os dados, foi utilizada uma escala analógica de dor, o método de Ustün, e régua milimetrada, sendo submetida ao teste T de Student. Resultados: Tanto os grupos teste como controle apresentaram valores semelhantes, sem diferença estatisticamente significativa na incidência de complicações pós-operatórias, assim como na presença de edema, dor e trismo mais pronunciado entre os grupos analisados no estudo. Conclusões: Em vista dos resultados estatísticos obtidos, não foi possível afirmar que o uso de antibioticoterapia foi benéfico quando relacionado a edema, trismo e dor.

Referências

Aravena, P. C., Yatabe, K., Jerez, A., Monardes, H., Groppo, F. C., & Benso, B. (2019). Assessment of the bioavailability of an antibiotic prophylactic protocol in patients undergoing third molar surgery. International Journal of Oral and Maxillofacial Surgery, 48(11), 1470–1474. https://doi.org/10.1016/j.ijom.2019.04.006

Arora, A., Roychoudhury, A., Bhutia, O., Pandey, S., Singh, S., & Das, B. K. (2014). Antibiotics in third molar extraction; are they really necessary: A non-inferiority randomized controlled trial. National Journal of Maxillofacial Surgery, 5(2), 166–171. https://doi.org/10.4103/0975-5950.154821

Bezerra, T. P., Studart-Soares, E. C., Scaparo, H. C., Pita-Neto, I. C., Batista, S. H. B., & Fonteles, C. S. R. (2011). Prophylaxis versus placebo treatment for infective and inflammatory complications of surgical third molar removal: a split-mouth, double-blind, controlled, clinical trial with amoxicillin (500 mg). Journal of Oral and Maxillofacial Surgery: Official Journal of the American Association of Oral and Maxillofacial Surgeons, 69(11), e333-9. https://doi.org/10.1016/j.joms.2011.03.055

Cervino, G., Cicciù, M., Biondi, A., Bocchieri, S., Herford, A. S., Laino, L., & Fiorillo, L. (2019). Antibiotic Prophylaxis on Third Molar Extraction: Systematic Review of Recent Data. Antibiotics (Basel, Switzerland), 8(2). https://doi.org/10.3390/antibiotics8020053

Colombini, B. L., Modena, K. C. S., Calvo, A. M., Sakai, V. T., Giglio, F. P. M., Dionísio, T. J., Trindade, A. S., Lauris, J. R. P., & Santos, C. F. (2006). Articaine and mepivacaine efficacy in postoperative analgesia for lower third molar removal: a double-blind, randomized, crossover study. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontology, 102(2), 169–174. https://doi.org/10.1016/j.tripleo.2005.09.003

Estrela, C. (2018). Metodologia Científica: Ciência, Ensino e Pesquisa (3a ed.). Artes Médicas, 120-122.

George, R., & Kavyashree, G. (2017). Effect of four mouth rinses on microhardness of esthetic restorative material: An in vitro Study. Journal of International Oral Health, 9(2), 55–59. https://doi.org/10.4103/jioh.jioh_21_16

Izuzquiza, I., Jamtøy, K. A., Fossland, N. P., Martínez-Padilla, I., Falahat, F., Alou, L., Prieto, J., & Gómez-Lus, M. L. (2017). [Is it necessary to prescribe antibiotics in impacted third molar surgical removal?: comparative study between prescribing patterns]. Revista espanola de quimioterapia: publicacion oficial de la Sociedad Espanola de Quimioterapia, 30(1), 34–39.

Karm, M. H., Park, F. D., Kang, M., Kim, H. J., Kang, J. W., Kim, S., Kim, Y. D., Kim, C. H., Seo, K. S., Kwon, K. H., Kim, C. H., Lee, J. W., Hong, S. W., Lim, M. H., Nam, S. K., & Cho, J. M. (2017). Comparison of the efficacy and safety of 2% lidocaine HCl with different epinephrine concentration for local anesthesia in participants undergoing surgical extraction of impacted mandibular third molars. Medicine (United States), 96(21). https://doi.org/10.1097/MD.0000000000006753

Lee, J. Y., Do, H. S., Lim, J. H., Jang, H. S., Rim, J. S., Kwon, J. J., & Lee, E. S. (2014). Correlation of antibiotic prophylaxis and difficulty of extraction with postoperative inflammatory complications in the lower third molar surgery. The British Journal of Oral & Maxillofacial Surgery, 52(1), 54–57. https://doi.org/10.1016/j.bjoms.2013.08.010

López-Cedrún, J. L., Pijoan, J. I., Fernández, S., Santamaria, J., & Hernandez, G. (2011). Efficacy of amoxicillin treatment in preventing postoperative complications in patients undergoing third molar surgery: a prospective, randomized, double-blind controlled study. Journal of Oral and Maxillofacial Surgery: Official Journal of the American Association of Oral and Maxillofacial Surgeons, 69(6), e5-14. https://doi.org/10.1016/j.joms.2011.01.019

Maxwell, C. (1978). Sensitivity and accuracy of the visual analogue scale: a psycho-physical classroom experiment. British Journal of Clinical Pharmacology, 6(1), 15–24. https://doi.org/10.1111/j.1365-2125.1978.tb01676.x

McCarthy, C., Warren, E., & Sleeman, D. (2018). Comparison of anaesthetic regime in patients undergoing third molar extraction. Oral Surgery, 11(1), 33–40. https://doi.org/10.1111/ors.12297

Menon, R. K., Kar Yan, L., Gopinath, D., & Botelho, M. G. (2019). Is there a need for postoperative antibiotics after third molar surgery? A 5-year retrospective study. Journal of Investigative and Clinical Dentistry, 10(4), e12460. https://doi.org/10.1111/jicd.12460

Milani, B. A., Bauer, H. C., Sampaio-Filho, H., Horliana, A. C. R. T., Perez, F. E. G., Tortamano, I. P., & Jorge, W. A. (2015). Antibiotic therapy in fully impacted lower third molar surgery: randomized three-arm, double-blind, controlled trial. Oral and Maxillofacial Surgery, 19(4), 341–346. https://doi.org/10.1007/s10006-015-0521-6

Moher, D., Hopewell, S., Schulz, K. F., Montori, V., Gøtzsche, P. C., Devereaux, P. J., Elbourne, D., Egger, M., & Altman, D. G. (2012). CONSORT 2010 explanation and elaboration: updated guidelines for reporting parallel group randomised trials. International Journal of Surgery (London, England), 10(1), 28–55. https://doi.org/10.1016/j.ijsu.2011.10.001

Pell, G. J., & Gregory, B. T. (1933). Impacted mandibular third molars: classification and modified techniques for removal. Dent Digest, 39, 330-338.

Poeschl, P. W., Eckel, D., & Poeschl, E. (2004). Postoperative prophylactic antibiotic treatment in third molar surgery--a necessity? Journal of Oral and Maxillofacial Surgery: Official Journal of the American Association of Oral and Maxillofacial Surgeons, 62(1), 3–8; discussion 9. https://doi.org/10.1016/j.joms.2003.05.004

Reiland, M. D., Ettinger, K. S., Lohse, C. M., & Viozzi, C. F. (2017). Does Administration of Oral Versus Intravenous Antibiotics for Third Molar Removal Have an Effect on the Incidence of Alveolar Osteitis or Postoperative Surgical Site Infections? Journal of Oral and Maxillofacial Surgery: Official Journal of the American Association of Oral and Maxillofacial Surgeons, 75(9), 1801–1808. https://doi.org/10.1016/j.joms.2017.03.038

Ustün, Y., Erdogan, O., Esen, E., & Karsli, E. D. (2003). Comparison of the effects of 2 doses of methylprednisolone on pain, swelling, and trismus after third molar surgery. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics, 96(5), 535–539. https://doi.org/10.1016/S1079210403004645

Winter, G. B. (1926). Principles of exodontia as applied to the impacted mandibular third molar: A complete treatise on the operative technic with clinical diagnoses and radiographic interpretations. St. Louis, Mo: American medical Book Company.

Yoshida, H., Matsuda, S., Aratani, T., Tsukamoto, H., Yoshimura, H., Sano, K., & Iwasaki, H. (2020). Collaboration with an infection control team promoted appropriate antibiotic use for third molar extraction at a Japanese hospital. Journal of Infection and Chemotherapy: Official Journal of the Japan Society of Chemotherapy, 26(6), 531–534. https://doi.org/10.1016/j.jiac.2020.01.003

Downloads

Publicado

30/06/2022

Como Citar

OLIVEIRA, I. J. M.; BOTTURE, S. S. .; SATO, F. R. L. .; RALDI, F. V. .; SILVA, L. A. de A. .; MORAES, M. B. de . Efeito da terapia antibiótica no período pós-operatório de cirurgias de terceiros molares: um estudo de boca dividida, randomizado e controlado. Research, Society and Development, [S. l.], v. 11, n. 8, p. e57211831236, 2022. DOI: 10.33448/rsd-v11i8.31236. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/31236. Acesso em: 25 nov. 2024.

Edição

Seção

Ciências da Saúde