O potencial efeito do resveratrol no tratamento da endometriose
DOI:
https://doi.org/10.33448/rsd-v11i8.31262Palavras-chave:
Endometriose; Resveratrol; Polifenóis; Endométrio; Compostos Fenólicos; Doenças ginecológicas.Resumo
A endometriose é uma desordem ginecológica caracterizada pela presença de tecido endometrial fora da cavidade uterina relacionado com predisposição genética, dependência de estrogênio, resistência à progesterona e inflamação. A teoria da menstruação retrógrada, formulada por Sampson, é a etiologia cientificamente mais aceitável devido mecanismos semelhantes que ocorreram em mulheres saudáveis. Entretanto, diversas outras teorias foram levantadas com diferentes focos fisiopatológicos. A patogênese da doença contribui para um desequilíbrio imunológico, culminando no aumento da expressão de mediadores inflamatórios, angiogênicos e alterações em diversas vias metabólicas. O resveratrol é um polifenol que tem sido amplamente estudado pelos seus benefícios no controle de mediadores inflamatórios. Nesta revisão, nós resumimos os achados mais recentes que interligam os efeitos do resveratrol e possíveis melhorias na sintomatologia da doença alvo. Estudos experimentais e in vitro mostraram resultados benéficos quando avaliados em modelos endometrióticos. No entanto, os mesmos resultados não foram obtidos em humanos, especialmente quando avaliaram os limiares de dor antes e depois da suplementação do resveratrol. Em conclusão, os resultados para a prática clínica ainda são inconclusivos.
Referências
Ahn, S. H., Monsanto, S. P., Miller, C., Singh, S. S., Thomas, R., & Tayade, C. (2015). Pathophysiology and immune dysfunction in endometriosis. BioMed research international, 2015.
Amaya, S. C., Savaris, R. F., Filipovic, C. J., Wise, J. D., Hestermann, E., Young, S. L., & Lessey, B. A. (2014). Resveratrol and endometrium: a closer look at an active ingredient of red wine using in vivo and in vitro models. Reproductive sciences, 21(11), 1362-1369.
Arablou, T., Aryaeian, N., Khodaverdi, S., Kolahdouz-Mohammadi, R., Moradi, Z., Rashidi, N., & Delbandi, A. A. (2021). The effects of resveratrol on the expression of VEGF, TGF-β, and MMP-9 in endometrial stromal cells of women with endometriosis. Scientific reports, 11(1), 1-12.
Aredo, J. V., Heyrana, K. J., Karp, B. I., Shah, J. P., & Stratton, P. (2017). Relating Chronic Pelvic Pain and Endometriosis to Signs of Sensitization and Myofascial Pain and Dysfunction. Seminars in reproductive medicine, 35(1), 88–97.
Bahat, P. Y., Ayhan, I., Ozdemir, E. U., Inceboz, Ü., & Oral, E. (2022). Dietary supplements for treatment of endometriosis: A review. Acta Bio Medica: Atenei Parmensis, 93(1).
Bahrami, A., Ayen, E., Razi, M., & Behfar, M. (2021). Effects of atorvastatin and resveratrol against the experimental endometriosis; evidence for glucose and monocarboxylate transporters, neoangiogenesis. Life Sciences, 272, 119230.
Bartiromo, L., Schimberni, M., Villanacci, R., Ottolina, J., Dolci, C., Salmeri, N., Viganò, P. & Candiani, M. (2021). Endometriosis and Phytoestrogens: Friends or Foes? A Systematic Review. Nutrients, 13(8), 2532.
Bulun, S. E., Yilmaz, B. D., Sison, C., Miyazaki, K., Bernardi, L., Liu, S., Kohlmeier, A., Yin, P., Milad, M., & Wei, J. (2019). Endometriosis. Endocrine reviews, 40(4), 1048–1079.
Burney, R. O., & Giudice, L. C. (2012). Pathogenesis and pathophysiology of endometriosis. Fertility and sterility, 98(3), 511-519.
Cai, X., Liu, M., Zhang, B., Zhao, S. J., & Jiang, S. W. (2021). Phytoestrogens for the Management of Endometriosis: Findings and Issues. Pharmaceuticals, 14(6), 569.
Chantalat, E., Valera, M. C., Vaysse, C., Noirrit, E., Rusidze, M., Weyl, A., Vergriete, K., Buscail, E., Lluel, P., Fontaine, C., Arnal, J.F. & Lenfant, F. (2020). Estrogen receptors and endometriosis. International journal of molecular sciences, 21(8), 2815.
Chen, F. Y., Wang, X., Tang, R. Y., Guo, Z. X., Deng, Y. Z. J., & Yu, Q. (2019). New therapeutic approaches for endometriosis besides hormonal therapy. Chinese medical journal, 132(24), 2984-2993.
Chen, Z., Wang, C., Lin, C., Zhang, L., Zheng, H., Zhou, Y., Li, X., Li, C., Zhang, X. & Yang, X.. (2021). Lipidomic Alterations and PPARα Activation Induced by Resveratrol Lead to Reduction in Lesion Size in Endometriosis Models. Oxidative medicine and cellular longevity, 2021.
Culley, L., Law, C., Hudson, N., Denny, E., Mitchell, H., Baumgarten, M., & Raine-Fenning, N. (2013). The social and psychological impact of endometriosis on women's lives: a critical narrative review. Human reproduction update, 19(6), 625-639.
Coxon, L., Horne, A. W., & Vincent, K. (2018). Pathophysiology of endometriosis-associated pain: A review of pelvic and central nervous system mechanisms. Best Practice & Research Clinical Obstetrics & Gynaecology, 51, 53-67.
Dragan, S., Șerban, M. C., Damian, G., Buleu, F., Valcovici, M., & Christodorescu, R. (2020). Dietary patterns and interventions to alleviate chronic pain. Nutrients, 12(9), 2510.
Dull, A. M., Moga, M. A., Dimienescu, O. G., Sechel, G., Burtea, V., & Anastasiu, C. V. (2019). Therapeutic approaches of resveratrol on endometriosis via anti-inflammatory and anti-angiogenic pathways. Molecules, 24(4), 667.
Ergenoğlu, A. M., Yeniel, A. Ö., Erbaş, O., Aktuğ, H., Yildirim, N., Ulukuş, M., & Taskiran, D. (2013). Regression of endometrial implants by resveratrol in an experimentally induced endometriosis model in rats. Reproductive sciences, 20(10), 1230-1236.
Estes, S. J., Soliman, A. M., Yang, H., Wang, J., & Freimark, J. (2020). A longitudinal assessment of the impact of endometriosis on patients’ salary growth and risk of leaving the workforce. Advances in Therapy, 37(5), 2144-2158.
Galiniak, S., Aebisher, D., & Bartusik-Aebisher, D. (2019). Health benefits of resveratrol administration. Acta biochimica polonica, 66(1), 13-21.
Gambini, J., Inglés, M., Olaso, G., Lopez-Grueso, R., Bonet-Costa, V., Gimeno-Mallench, L., Mas-Bargues, C., Abdelaziz, K.M., Gomez-Cabrera, M.C., Vina, J. & Borras, C. (2015). Properties of resveratrol: in vitro and in vivo studies about metabolism, bioavailability, and biological effects in animal models and humans. Oxidative medicine and cellular longevity, 2015.
Gołąbek, A., Kowalska, K., & Olejnik, A. (2021). Polyphenols as a Diet Therapy Concept for Endometriosis—Current Opinion and Future Perspectives. Nutrients, 13(4), 1347.
Gombart, A. F., Pierre, A., & Maggini, S. (2020). A review of micronutrients and the immune system–working in harmony to reduce the risk of infection. Nutrients, 12(1), 236.
Halpern, G., Schor, E., & Kopelman, A. (2015). Nutritional aspects related to endometriosis. Revista da Associação Médica Brasileira, 61, 519-523.
Haydardedeoglu, B., & Zeyneloglu, H. B. (2015). The impact of endometriosis on fertility. Women's health, 11(5), 619-623.
Huijs, E., & Nap, A. (2020). The effects of nutrients on symptoms in women with endometriosis: a systematic review. Reproductive BioMedicine Online, 41(2), 317-328.
Hung, S. W., Zhang, R., Tan, Z., Chung, J. P. W., Zhang, T., & Wang, C. C. (2021). Pharmaceuticals targeting signaling pathways of endometriosis as potential new medical treatment: A review. Medicinal research reviews, 41(4), 2489-2564.
Jurkiewicz-Przondziono, J., Lemm, M., Kwiatkowska-Pamuła, A., Ziółko, E., & Wójtowicz, M. K. (2017). Influence of diet on the risk of developing endometriosis. Ginekologia polska, 88(2), 96-102.
Kaponis, A., Iwabe, T., Taniguchi, F., Ito, M., Deura, I., Decavalas, G., Terakawa, N. & Harada, T. (2012). The role of NF-kappaB in endometriosis. Front Biosci (Schol Ed), 4, 1213-1234.
Karlsson, J. V., Patel, H., & Premberg, A. (2020). Experiences of health after dietary changes in endometriosis: a qualitative interview study. BMJ open, 10(2), e032321.
Kolahdouz-Mohammadi, R. & Arablou, T. (2017). Resveratrol and endometriosis: In vitro and animal studies and underlying mechanisms. Biomedicine & Pharmacotherapy, 91, 220-228.
Kolahdouz-Mohammadi, R., Delbandi, A. A., Khodaverdi, S., Arefi, S., Arablou, T., & Shidfar, F. (2020). The effects of resveratrol treatment on Bcl-2 and bax gene expression in endometriotic compared with non-endometriotic stromal cells. Iranian Journal of Public Health, 49(8), 1546.
Kolahdouz‐Mohammadi, R., Shidfar, F., Khodaverdi, S., Arablou, T., Heidari, S., Rashidi, N., & Delbandi, A. A. (2021). Resveratrol treatment reduces expression of MCP‐1, IL‐6, IL‐8 and RANTES in endometriotic stromal cells. Journal of Cellular and Molecular Medicine, 25(2), 1116-1127.
Koninckx, P. R., Fernandes, R., Ussia, A., Schindler, L., Wattiez, A., Al-Suwaidi, S., Amro, B., Al-Maamari, B., Hakim, Z. & Tahlak, M. (2021). Pathogenesis based Diagnosis and Treatment of endometriosis. Frontiers in endocrinology, 1522.
Kong, X., Xu, X., Zhou, L., Zhu, M., Yao, S., Ding, Y., Liu, T., Wang, Y., Li, R., Tang, X., Ling, L., Wu, J., Zhu, X., Gu, Y. & Zhou, H. (2020). MTA1, a target of resveratrol, promotes epithelial-mesenchymal transition of endometriosis via ZEB2. Molecular Therapy-Methods & Clinical Development, 19, 295-306.
Koushki, M., Lakzaei, M., Khodabandehloo, H., Hosseini, H., Meshkani, R., & Panahi, G. (2020). Therapeutic effect of resveratrol supplementation on oxidative stress: a systematic review and meta-analysis of randomised controlled trials. Postgraduate Medical Journal, 96(1134), 197-205.
Laganà, A. S., Garzon, S., Götte, M., Viganò, P., Franchi, M., Ghezzi, F., & Martin, D. C. (2019). The pathogenesis of endometriosis: molecular and cell biology insights. International journal of molecular sciences, 20(22), 5615.
Malaguarnera, L. (2019). Influence of resveratrol on the immune response. Nutrients, 11(5), 946.
Margină, D., Ungurianu, A., Purdel, C., Tsoukalas, D., Sarandi, E., Thanasoula, M., Tekos, F., Mesnage, R., Kouretas, D., & Tsatsakis, A. (2020). Chronic inflammation in the context of everyday life: dietary changes as mitigating factors. International Journal of Environmental Research and Public Health, 17(11), 4135.
Marquardt, R. M., Kim, T. H., Shin, J. H., & Jeong, J. W. (2019). Progesterone and estrogen signaling in the endometrium: what goes wrong in endometriosis?. International journal of molecular sciences, 20(15), 3822.
Meresman, G. F., Götte, M., & Laschke, M. W. (2021). Plants as source of new therapies for endometriosis: a review of preclinical and clinical studies. Human Reproduction Update, 27(2), 367-392.
Mikhaleva, L. M., Radzinsky, V. E., Orazov, M. R., Khovanskaya, T. N., Sorokina, A. V., Mikhalev, S. A., Volkova, S. V., Shustova, A. V., Mikhalev, S. A., Volkova, S. V., Shustova, V. B. & Sinelnikov, M. Y. (2021). Current knowledge on endometriosis etiology: a systematic review of literature. International Journal of Women's Health, 13, 525.
Missmer, S. A., Tu, F. F., Agarwal, S. K., Chapron, C., Soliman, A. M., Chiuve, S., Eichner, S., Flores-Caldera, I., Horne, A., Kimball, A. B., Laufer, M. R., Leyland, N., Singh, S. S., Taylor, H. S. & As-Sanie, S. (2021). Impact of endometriosis on life-course potential: a narrative review. International Journal of General Medicine, 14, 9.
Nirgianakis, K., Egger, K., Kalaitzopoulos, D. R., Lanz, S., Bally, L., & Mueller, M. D. (2021). Effectiveness of dietary interventions in the treatment of endometriosis: a systematic review. Reproductive sciences, 1-17.
Novakovic, R., Rajkovic, J., Gostimirovic, M., Gojkovic-Bukarica, L., & Radunovic, N. (2022). Resveratrol and Reproductive Health. Life, 12(2), 294.
Ochiai, A., & Kuroda, K. (2020). Preconception resveratrol intake against infertility: Friend or foe?. Reproductive medicine and biology, 19(2), 107-113.
Parasar, P., Ozcan, P., & Terry, K. L. (2017). Endometriosis: epidemiology, diagnosis and clinical management. Current obstetrics and gynecology reports, 6(1), 34-41.
Parazzini, F., Viganò, P., Candiani, M., & Fedele, L. (2013). Diet and endometriosis risk: a literature review. Reproductive Biomedicine Online, 26(4), 323-336.
Piccinato, C. A., Neme, R. M., Torres, N., Sanches, L. R., Cruz Derogis, P. B., Brudniewski, H. F., Silva, J C. R, & Ferriani, R. A. (2016). Increased expression of CYP1A1 and CYP1B1 in ovarian/peritoneal endometriotic lesions. Reproduction, 151(6), 683-692.
Ricci, A. G., Olivares, C. N., Bilotas, M. A., Baston, J. I., Singla, J. J., Meresman, G. F., & Barañao, R. I. (2013). Natural therapies assessment for the treatment of endometriosis. Human reproduction, 28(1), 178-188.
Ricker, M. A., & Haas, W. C. (2017). Anti‐inflammatory diet in clinical practice: a review. Nutrition in Clinical Practice, 32(3), 318-325.
Rocha, A. L. L., Reis, F. M., & Taylor, R. N. (2013). Angiogenesis and endometriosis. Obstetrics and gynecology international, 2013.
Rogers‑Broadway, K. R., Kumar, J., Sisu, C., Wander, G., Mazey, E., Jeyaneethi, J., Pados, G., Tsolakidis, D., Eleftherios K., Grunt, T., Hall, M., Chatterjee, J. & Karteris, E. (2019). Differential expression of mTOR components in endometriosis and ovarian cancer: Effects of rapalogues and dual kinase inhibitors on mTORC1 and mTORC2 stoichiometry. International journal of molecular medicine, 43(1), 47-56.
Rondanelli, M., Faliva, M. A., Miccono, A., Naso, M., Nichetti, M., Riva, A., Guerriero, F., De Gregori, M., Peroni, G. & Perna, S. (2018). Food pyramid for subjects with chronic pain: foods and dietary constituents as anti-inflammatory and antioxidant agents. Nutrition research reviews, 31(1), 131-151.
Rudzitis-Auth, J., Menger, M. D., & Laschke, M. W. (2013). Resveratrol is a potent inhibitor of vascularization and cell proliferation in experimental endometriosis. Human reproduction, 28(5), 1339-1347.
Saeed, F., Nadeem, M., Ahmed, R. S., Tahir Nadeem, M., Arshad, M. S., & Ullah, A. (2016). Studying the impact of nutritional immunology underlying the modulation of immune responses by nutritional compounds–a review. Food and agricultural immunology, 27(2), 205-229.
Scutiero, G., Iannone, P., Bernardi, G., Bonaccorsi, G., Spadaro, S., Volta, C. A., Greco, P. & Nappi, L. (2017). Oxidative stress and endometriosis: a systematic review of the literature. Oxidative medicine and cellular longevity, 2017.
Sevilla, I. Ñ., Linde, F. M., Sánchez, M. D. P. M., Arense, J. J., Torroba, A., Díaz, A. N., & Ferrer, M. L. S. (2019). Prognostic importance of atypical endometriosis with architectural hyperplasia versus cytologic atypia in endometriosis-associated ovarian cancer. Journal of gynecologic oncology, 30(4).
Silva, D. M., Gross, L. A., Neto, E. D. P. G., Lessey, B. A., & Savaris, R. F. (2017). The use of resveratrol as an adjuvant treatment of pain in endometriosis: a randomized clinical trial. Journal of the Endocrine Society, 1(4), 359-369.
Smolarz, B., Szyłło, K., & Romanowicz, H. (2021). Endometriosis: Epidemiology, Classification, Pathogenesis, Treatment and Genetics (Review of Literature). International Journal of Molecular Sciences, 22(19), 10554.
Taguchi, A., Wada‐Hiraike, O., Kawana, K., Koga, K., Yamashita, A., Shirane, A., Urata, Y., Kozuma, S., Osuga, Y. & Fujii, T. (2014). Resveratrol suppresses inflammatory responses in endometrial stromal cells derived from endometriosis: a possible role of the sirtuin 1 pathway. Journal of Obstetrics and Gynaecology Research, 40(3), 770-778.
Tennfjord, M. K., Gabrielsen, R., & Tellum, T. (2021). Effect of physical activity and exercise on endometriosis-associated symptoms: a systematic review. BMC women's health, 21(1), 1-10.
Vercellini, P., Viganò, P., Somigliana, E., & Fedele, L. (2014). Endometriosis: pathogenesis and treatment. Nature Reviews Endocrinology, 10(5), 261-275.
Villanueva, J. A., Sokalska, A., Cress, A. B., Ortega, I., Bruner-Tran, K. L., Osteen, K. G., & Duleba, A. J. (2013). Resveratrol potentiates effect of simvastatin on inhibition of mevalonate pathway in human endometrial stromal cells. The Journal of Clinical Endocrinology & Metabolism, 98(3), E455-E462.
Wang, C., Chen, Z., Zhao, X., Lin, C., Hong, S., Lou, Y., Shi, X., Zhao, M., Yang, X., Guan, M. & Xi, Y. (2021). Transcriptome-Based Analysis Reveals Therapeutic Effects of Resveratrol on Endometriosis in aRat Model. Drug Design, Development and Therapy, 15, 4141.
Wang, Y., Nicholes, K., & Shih, I. M. (2020). The origin and pathogenesis of endometriosis. Annual Review of Pathology: Mechanisms of Disease, 15, 71-95.
Warzecha, D., Szymusik, I., Wielgos, M., & Pietrzak, B. (2020). The impact of endometriosis on the quality of life and the incidence of depression—A cohort study. International Journal of Environmental Research and Public Health, 17(10), 3641.
Yavuz, S., Aydin, N. E., Celik, O., Yilmaz, E. R. C. A. N., Ozerol, E. & Tanbek, K. E. V. S. E. R. (2014). Resveratrol successfully treats experimental endometriosis through modulation of oxidative stress and lipid peroxidation. Journal of Cancer Research and Therapeutics, 10(2), 324.
Zhang, J., Wang, H., Meng, Q., Chen, J., Wang, J., & Huang, S. (2018). Expression of MTA1 in endometriosis and its relationship to the recurrence. Medicine, 97(35).
Zondervan, K. T., Becker, C. M. & Missmer, S. A. (2020). Endometriosis. N Engl J Med, 382, 1244-56.
Downloads
Publicado
Como Citar
Edição
Seção
Licença
Copyright (c) 2022 Silvia Neide da Silva Uchoa; Larissa Lima Figueira; Daniela de Araújo Medeiros Dias
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.
Autores que publicam nesta revista concordam com os seguintes termos:
1) Autores mantém os direitos autorais e concedem à revista o direito de primeira publicação, com o trabalho simultaneamente licenciado sob a Licença Creative Commons Attribution que permite o compartilhamento do trabalho com reconhecimento da autoria e publicação inicial nesta revista.
2) Autores têm autorização para assumir contratos adicionais separadamente, para distribuição não-exclusiva da versão do trabalho publicada nesta revista (ex.: publicar em repositório institucional ou como capítulo de livro), com reconhecimento de autoria e publicação inicial nesta revista.
3) Autores têm permissão e são estimulados a publicar e distribuir seu trabalho online (ex.: em repositórios institucionais ou na sua página pessoal) a qualquer ponto antes ou durante o processo editorial, já que isso pode gerar alterações produtivas, bem como aumentar o impacto e a citação do trabalho publicado.
