Effects of radiotherapy on the oral conditions of cancer patients

Authors

DOI:

https://doi.org/10.33448/rsd-v11i9.32452

Keywords:

Dental Surgeons; Oral Cancer; Radiotherapy; Health education.

Abstract

Malignant head and neck tumors comprise several types of cancer, including primarily squamous cell carcinoma and tumors of the nasal cavity, sinuses, salivary glands, pharynx, and larynx. HANC survival rates vary depending on the tumor site. Five-year survival rates range from 27.8% for hypopharyngeal cancer to 67.0% for salivary gland cancer. In this context, this article aimed to review the literature on the effects of radiotherapy on the oral conditions of cancer patients and to address oral management strategies for head and neck radiotherapy. For the construction of this article, a bibliographic survey was carried out in the databases SciVerse Scopus, Scientific Electronic Library Online (Scielo), U.S. National Library of Medicine (PUBMED) and ScienceDirect, using the Mendeley reference manager. The articles were collected from February to July 2022 and covered between the years 2015 to 2022. The results of this research reveal four main manifestations in the oral region from head and neck radiotherapy, namely xerostomia, oral mucositis, osteoradionecrosis and trismus. Considering the high incidences of PPC, it is extremely important that health professionals are familiar with the complications arising from cancer treatments.

References

Agarwal, P., Shiva Kumar, H. R., & Rai, K. K. (2016). Trismus in oral cancer patients undergoing surgery and radiotherapy. Journal of Oral Biology and Craniofacial Research, 6, S9–S13. https://doi.org/https://doi.org/10.1016/j.jobcr.2016.10.004

Binda, N. C., Binda, A. L. C., Rodrigues, S. de A., Loures, L. L. da S., Sá, A. C. S. F. de, Silva, J. V. L., Franco, A. G., Borba, T. O. da S., Magalhães, P. Í. B. M. de A., Araújo, E. L. da S. F. de, Souza, H. Y. M. S. de, Barbosa, R. L. S., Savi, F. da R., Reis, J. L., Ramalho, M. A., Fernandes, C. da S., & Sátiro, V. D. de S. (2021). Manifestações orais decorrentes da radioterapia de cabeça e pescoço. In Research, Society and Development. 10(12), e411101220519. https://doi.org/10.33448/rsd-v10i12.20519

Coelho, L. H. M., Silva, C. L. A., Pedra, R. C., Rosado, L. P. L., Verner, F. S., & Aquino, S. N. (2021). Probability of oral complications of radiotherapy and chemotherapy for head and neck cancer. General Dentistry, 69(4), 70–74.

Davies, A. N., & Thompson, J. (2015). Parasympathomimetic drugs for the treatment of salivary gland dysfunction due to radiotherapy. Cochrane Database of Systematic Reviews, 2015(10). https://doi.org/10.1002/14651858.CD003782.pub3

Davis, D. D., Hanley, M. E., & Cooper, J. S. (2022). Osteoradionecrosis.

Elting, L. S., Cooksley, C. D., Chambers, M. S., & Garden, A. S. (2007). Risk, outcomes, and costs of radiation-induced oral mucositis among patients with head-and-neck malignancies. International Journal of Radiation Oncology, Biology, Physics, 68(4), 1110–1120. https://doi.org/10.1016/j.ijrobp.2007.01.053

Ferretti, G. A., Raybould, T. P., Brown, A. T., Macdonald, J. S., Greenwood, M., Maruyama, Y., Geil, J., Lillich, T. T., & Ash, R. C. (1990). Chlorhexidine prophylaxis for chemotherapy- and radiotherapy-induced stomatitis: a randomized double-blind trial. Oral Surgery, Oral Medicine, and Oral Pathology, 69(3), 331–338. https://doi.org/10.1016/0030-4220(90)90295-4

Frankart, A. J., Frankart, M. J., Cervenka, B., Tang, A. L., Krishnan, D. G., & Takiar, V. (2021). Osteoradionecrosis: Exposing the Evidence Not the Bone. International Journal of Radiation Oncology*Biology*Physics, 109(5), 1206–1218. https://doi.org/https://doi.org/10.1016/j.ijrobp.2020.12.043

Gunn, L., Gilbert, J., Nenclares, P., Soliman, H., Newbold, K., Bhide, S., Wong, K. H., Harrington, K., & Nutting, C. (2021). Taste dysfunction following radiotherapy to the head and neck: A systematic review. Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology, 157, 130–140. https://doi.org/10.1016/j.radonc.2021.01.021

Hamilton, S. N., Tran, E., Ho, C., Berthelet, E., Wu, J., DeVries, K., LaPointe, V., Bowman, A., Lagman, M., & Olson, R. (2021). Patient-reported outcome measures in patients undergoing radiotherapy for head and neck cancer. Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer, 29(5), 2537–2547. https://doi.org/10.1007/s00520-020-05778-2

Haroun, K., & Coblens, O. M. (2019). Reconstruction of the mandible for osteoradionecrosis. Current Opinion in Otolaryngology & Head and Neck Surgery, 27(5), 401–406. https://doi.org/10.1097/MOO.0000000000000571

Kawashita, Y., Soutome, S., Umeda, M., & Saito, T. (2020). Oral management strategies for radiotherapy of head and neck cancer. Japanese Dental Science Review, 56(1), 62–67. https://doi.org/https://doi.org/10.1016/j.jdsr.2020.02.001

Kwon, Y. (2016). Mechanism-based management for mucositis: option for treating side effects without compromising the efficacy of cancer therapy. OncoTargets and Therapy, 9, 2007–2016. https://doi.org/10.2147/OTT.S96899

Lee, C. T., & Galloway, T. J. (2022). Pathogenesis and Amelioration of Radiation-Induced Oral Mucositis. Current Treatment Options in Oncology, 23(3), 311–324. https://doi.org/10.1007/s11864-022-00959-z

Leonetti, J. P., Weishaar, J. R., Gannon, D., Harmon, G. A., Block, A., & Anderson, D. E. (2020). Osteoradionecrosis of the skull base. Journal of Neuro-Oncology, 150(3), 477–482. https://doi.org/10.1007/s11060-020-03462-3

Li, E., & Trovato, J. A. (2012). New developments in management of oral mucositis in patients with head and neck cancer or receiving targeted anticancer therapies. American Journal of Health-System Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists, 69(12), 1031–1037. https://doi.org/10.2146/ajhp100531

Li, R., Su, L., Hua, Y., Ye, J.-R., Song, X.-R., Tian, J., Song, J.-H., & Hong, J.-S. (2021). Anxiety and depression status prior to radiotherapy in patients with nasopharyngeal carcinoma and its effect on acute radiation toxicities. European Journal of Cancer Care, 30(6), e13487. https://doi.org/10.1111/ecc.13487

Martins, A. F. L., Nogueira, T. E., Morais, M. O., Oton-Leite, A. F., Valadares, M. C., Batista, A. C., Freitas, N. M. A., Leles, C. R., & Mendonça, E. F. (2019). Effect of photobiomodulation on the severity of oral mucositis and molecular changes in head and neck cancer patients undergoing radiotherapy: a study protocol for a cost-effectiveness randomized clinical trial. Trials, 20(1), 97. https://doi.org/10.1186/s13063-019-3196-8

Moore, C., McLister, C., Cardwell, C., O’Neill, C., Donnelly, M., & McKenna, G. (2020). Dental caries following radiotherapy for head and neck cancer: A systematic review. Oral Oncology, 100, 104484. https://doi.org/https://doi.org/10.1016/j.oraloncology.2019.104484

Mortazavi, H., Shafiei, S., Sadr, S., & Safiaghdam, H. (2018). Drug-related Dysgeusia: A Systematic Review. Oral Health & Preventive Dentistry, 16(6), 499–507. https://doi.org/10.3290/j.ohpd.a41655

Muñoz-Corcuera, M., González-Nieto, A., & López-Pintor Muñoz, R. M. (2014). [Use of laser for the prevention and treatment of oral mucositis induced by radiotherapy and chemotherapy for head and neck cancer]. Medicina clinica, 143(4), 170–175. https://doi.org/10.1016/j.medcli.2013.09.017

Oladega, A., Mojdami, D., Hope, A., Watson, E., & Glogauer, M. (2021). The process of developing consensus guidelines by Dental Oncologists for pre-radiotherapy dental care in head and neck cancer patients using the modified Delphi technique. Journal of Evidence Based Dental Practice, 101620. https://doi.org/https://doi.org/10.1016/j.jebdp.2021.101620

Pereira, A., Shitsuka, D., Parreira, F., & Shitsuka, R. (2018). Método Qualitativo, Quantitativo ou Quali-Quanti. In Metodologia da Pesquisa Científica. https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1. Acesso em: 28 março 2020.

Ribeiro, G. H., Chrun, E. S., Dutra, K. L., Daniel, F. I., & Grando, L. J. (2018). Osteonecrosis of the jaws: a review and update in etiology and treatment. Brazilian Journal of Otorhinolaryngology, 84(1), 102–108. https://doi.org/10.1016/j.bjorl.2017.05.008

Rivero, J. A., Shamji, O., & Kolokythas, A. (2017). Osteoradionecrosis: a review of pathophysiology, prevention and pharmacologic management using pentoxifylline, α-tocopherol, and clodronate. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 124(5), 464–471. https://doi.org/10.1016/j.oooo.2017.08.004

Scherpenhuizen, A., van Waes, A. M. A., Janssen, L. M., Van Cann, E. M., & Stegeman, I. (2015). The effect of exercise therapy in head and neck cancer patients in the treatment of radiotherapy-induced trismus: A systematic review. Oral Oncology, 51(8), 745–750. https://doi.org/https://doi.org/10.1016/j.oraloncology.2015.05.001

Sroussi, H. Y., Epstein, J. B., Bensadoun, R.-J., Saunders, D. P., Lalla, R. V, Migliorati, C. A., Heaivilin, N., & Zumsteg, Z. S. (2017). Common oral complications of head and neck cancer radiation therapy: mucositis, infections, saliva change, fibrosis, sensory dysfunctions, dental caries, periodontal disease, and osteoradionecrosis. Cancer Medicine, 6(12), 2918–2931. https://doi.org/10.1002/cam4.1221

Thakkar, J. P., & Lane, C. J. (2022). Hyposalivation and Xerostomia and Burning Mouth Syndrome: Medical Management. Oral and Maxillofacial Surgery Clinics of North America, 34(1), 135–146. https://doi.org/https://doi.org/10.1016/j.coms.2021.08.002

Vahidi, N., Lee, T. S., Daggumati, S., Shokri, T., Wang, W., & Ducic, Y. (2020). Osteoradionecrosis of the Midface and Mandible: Pathogenesis and Management. Seminars in Plastic Surgery, 34(4), 232–244. https://doi.org/10.1055/s-0040-1721759

Vélez, I., Tamara, L. A., & Mintz, S. (2004). Management of oral mucositis induced by chemotherapy and radiotherapy: an update. Quintessence International (Berlin, Germany : 1985), 35(2), 129–136.

Y, K., S, H., M, F., M, U., & T, S. (2014). Prophylactic bundle for radiation-induced oral mucositis in oral or oropharyngeal cancer patients. Journal of Cancer Research & Therapy, 2(1), 9–13. https://doi.org/10.14312/2052-4994.2014-2

Zhu, J., Zhang, H., Li, J., Zheng, X., Jia, X., Xie, Q., Zheng, L., Zhou, X., Wang, Y., & Xu, X. (2021). LiCl Promotes Recovery of Radiation-Induced Oral Mucositis and Dysgeusia. Journal of Dental Research, 100(7), 754–763. https://doi.org/10.1177/0022034521994756

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Published

18/07/2022

How to Cite

BOMFIM, R. M.; SANTANA, L. D. A. .; RODRIGUES , M. C.; CARNEIRO , G. K. M. .; ARAGÃO, F. A. A.; SANTOS, M. G. dos .; TORRE, M. V. A. D. .; NASCIMENTO NETO, E. V. do .; SILVA, A. C. R. da .; CARPINE, M. B. . Effects of radiotherapy on the oral conditions of cancer patients. Research, Society and Development, [S. l.], v. 11, n. 9, p. e55311932452, 2022. DOI: 10.33448/rsd-v11i9.32452. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/32452. Acesso em: 23 apr. 2024.

Issue

Vol. 11 No. 9

Section

Health Sciences

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Copyright (c) 2022 Rafael Meneses Bomfim; Larah Domingos Alves Santana; Marcelo Costa Rodrigues ; Grace Kelly Martins Carneiro ; Francisco Anderson Angelo Aragão; Müller Gomes dos Santos; Marcus Vinícius Alves Della Torre; Edvaldo Vieira do Nascimento Neto; Ana Carolina Resende da Silva; Maitê Bock Carpine

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