Caatinga: celeiro de antioxidantes e bioativos nutracêuticos

Autores

DOI:

https://doi.org/10.33448/rsd-v11i11.33442

Palavras-chave:

Bioprospecção; Inflamação; EROs; Medicina popular; Compostos naturais; Câncer.

Resumo

A Caatinga, exclusivamente brasileira, é composta por plantas adaptadas às condições climáticas específicas presentes nesta região. Os recursos naturais neste domínio fitogeográfico são usados pelas comunidades locais como fonte de alimentos, desenvolvimento da economia regional e medicina tradicional. A medicina popular é aplicada como uma tradição local através da fração das plantas, como raízes, folhas e frutos, para tratar inflamações, tumores, doenças metabólicas ou degenerativas. Embora o processo tecnológico industrial farmacêutico apresente um desenvolvimento exponencial em benefícios para a saúde humana, a busca por novos tratamentos, naturais e alternativas atreladas à significativa conscientização das populações sobre a medicina popular e seus compostos naturais não são vastas. Desta forma, a presente revisão teve como objetivo realizar a pesquisa sistemática considerando 26 espécies endêmicas da Caatinga e seu potencial biológico mais significativo. Como resultado, observou-se que há mais estudos com as atividades antioxidante e imunomoduladora. O conhecimento prévio mostra a relação entre o acúmulo de espécies reativas de oxigênio (ROS) e o desenvolvimento de diferentes doenças imunológicas. Com esta revisão, propomos contribuir com o potencial biotecnológico da Caatinga para a saúde da ciência.

Referências

Abdel-Aty, A. M., Hamed, M. B., Salama, W. H., Ali, M. M., Fahmy, A. S., & Mohamed, S. A. (2019). Ficus carica, Ficus sycomorus and Euphorbia tirucalli latex extracts: Phytochemical screening, antioxidant and cytotoxic properties. Biocatalysis and Agricultural Biotechnology, 20(April), 101199. https://doi.org/10.1016/j.bcab.2019.101199

Abdolahi, M., Jafarieh, A., Sarraf, P., Sedighiyan, M., Yousefi, A., Tafakhori, A., Abdollahi, H., Salehinia, F., & Djalali, M. (2019). The Neuromodulatory Effects of ω-3 Fatty Acids and Nano-Curcumin on the COX-2/ iNOS Network in Migraines: A Clinical Trial Study from Gene Expression to Clinical Symptoms. Endocrine, Metabolic & Immune Disorders - Drug Targets, 19(6), 874–884. https://doi.org/10.2174/1871530319666190212170140

Agita, A., & Thaha, M. (2017). Agita A., Alsagaff M.T. Inflammation, Immunity, and Hypertension. Acta. Med. Indones. 2017; 49:158–165. Acta Medica Indonesiana, 49(2), 158–165.

Aini, A. S. N., Merrina, A., Stanslas, J., & Sreeramana, S. (2008). Cytotoxic Potential on Breast Cancer Cells Using Selected Forest Species Found in Malaysia. International Journal of Cancer Research, 4(3), 103–109. https://doi.org/10.3923/ijcr.2008.103.109

Amorim, M., Pereira, J. O., Silva, L. B., Ormenese, R. C. S. C., Pacheco, M. T. B., & Pintado, M. (2018). Use of whey peptide fraction in coated cashew nut as functional ingredient and salt replacer. LWT - Food Science and Technology, 92, 204–211. https://doi.org/10.1016/j.lwt.2017.12.075

Anjos, M. N. V., de Araújo-Neto, L. N., Buonafina, M. D. S., Neves, R. P., de Souza, E. R., Bezerra, I. C. F., Ferreira, M. R. A., Soares, L. A. L., Coutinho, H. D. M., Martins, N., da Silva, M. V., & Correia, M. T. dos S. (2020). Ocotea glomerata (Nees) mez extract and fractions: Chemical characterization, anti-Candida activity and related mechanism of action. Antibiotics, 9(7), 1–12. https://doi.org/10.3390/antibiotics9070394

Ansari, M. Y., Ahmad, N., & Haqqi, T. M. (2020). Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols. In Biomedicine and Pharmacotherapy (Vol. 129). Elsevier Masson SAS. https://doi.org/10.1016/j.biopha.2020.110452

Aumeeruddy-Elalfi, Z., Gurib-Fakim, A., & Mahomoodally, F. (2015). Antimicrobial, antibiotic potentiating activity and phytochemical profile of essential oils from exotic and endemic medicinal plants of Mauritius. Industrial Crops and Products, 71, 197–204. https://doi.org/10.1016/j.indcrop.2015.03.058

Ávila, R. I. de, Mattos Alvarenga, C. B., Ávila, P. H. M. de, Moreira, R. C., Arruda, A. F., Fernandes, T. de O., Rodrigues, B. dos S., Andrade, W. M., Batista, A. C., Paula, J. R. de, & Valadares, M. C. (2016a). Eugenia dysenterica DC. (Myrtaceae) exerts chemopreventive effects against hexavalent chromium-induced damage in vitro and in vivo. Pharmaceutical Biology, 54(11), 2652–2663. https://doi.org/10.1080/13880209.2016.1178306

Ávila, R. I. de, Mattos Alvarenga, C. B., Ávila, P. H. M. de, Moreira, R. C., Arruda, A. F., Fernandes, T. de O., Rodrigues, B. dos S., Andrade, W. M., Batista, A. C., Paula, J. R. de, & Valadares, M. C. (2016b). Eugenia dysenterica DC. (Myrtaceae) exerts chemopreventive effects against hexavalent chromium-induced damage in vitro and in vivo. Pharmaceutical Biology, 54(11), 2652–2663. https://doi.org/10.1080/13880209.2016.1178306

Awakan, O. J., Malomo, S. O., Adejare, A. A., Igunnu, A., Atolani, O., Adebayo, A. H., & Owoyele, B. V. (2018). Anti-inflammatory and bronchodilatory constituents of leaf extracts of Anacardium occidentale L. in animal models. Journal of Integrative Medicine, 16(1), 62–70. https://doi.org/10.1016/j.joim.2017.12.009

Barros, A. B., Moura, A. F., Silva, D. A., Oliveira, T. M., Barreto, F. S., Ribeiro, W. L. C., Alves, A. P. N. N., Araújo, A. J., Moraes Filho, M. O., Iles, B., Medeiros, J. V. R., & Marinho-Filho, J. D. B. (2020). Evaluation of antitumor potential of cashew gum extracted from Anacardium occidentale Linn. International Journal of Biological Macromolecules, 154(2020), 319–328. https://doi.org/10.1016/j.ijbiomac.2020.03.096

Belcaro, G., Saggino, A., Cornelli, U., Luzzi, R., Dugall, M., Hosoi, M., Feragalli, B., & Cesarone, M. R. (2018). Improvement in mood, oxidative stress, fatigue, and insomnia following supplementary management with Robuvit®. Journal of Neurosurgical Sciences, 62(4), 423–427. https://doi.org/10.23736/S0390-5616.18.04384-9

Bent, R., Moll, L., Grabbe, S., & Bros, M. (2018). Interleukin-1 beta—A friend or foe in malignancies? International Journal of Molecular Sciences, 19(8). https://doi.org/10.3390/ijms19082155

Bezerra Filho, C. M., da Silva, L. C. N., da Silva, M. V., Løbner-Olesen, A., Struve, C., Krogfelt, K. A., Correia, M. T. dos S., & Vilela Oliva, M. L. (2020). Antimicrobial and Antivirulence Action of Eugenia brejoensis Essential Oil in vitro and in vivo Invertebrate Models. Frontiers in Microbiology, 11(March), 1–11. https://doi.org/10.3389/fmicb.2020.00424

Bitencourt, M. A. O., Torres-Rêgo, M., de Souza Lima, M. C. J., Furtado, A. A., de Azevedo, E. P., do Egito, E. S. T., da Silva-Júnior, A. A., Zucolotto, S. M., & Fernandes-Pedrosa, M. de F. (2019). Protective effect of aqueous extract, fractions and phenolic compounds of Hancornia speciosa fruits on the inflammatory damage in the lungs of mice induced by Tityus serrulatus envenomation. Toxicon, 164, 1–9. https://doi.org/10.1016/j.toxicon.2019.03.018

Blanco-Vaca, F., Cedó, L., & Julve, J. (2018). Phytosterols in Cancer: From Molecular Mechanisms to Preventive and Therapeutic Potentials. Current Medicinal Chemistry, 26(37), 6735–6749. https://doi.org/10.2174/0929867325666180607093111

Bodoira, R., Rossi, Y., Montenegro, M., Maestri, D., & Velez, A. (2017). Extraction of antioxidant polyphenolic compounds from peanut skin using water-ethanol at high pressure and temperature conditions. Journal of Supercritical Fluids, 128, 57–65. https://doi.org/10.1016/j.supflu.2017.05.011

Borges, J. (2021). Cashew tree (Anacardium occidentale): Possible applications in dermatology. Clinics in Dermatology, xxxx, 2020–2022. https://doi.org/10.1016/j.clindermatol.2020.11.014

Braga, F. C., Ojeda, M., Perdomo, R. T., de Albuquerque, S., Rafique, J., de Lima, D. P., & Beatriz, A. (2021a). Synthesis of cardanol-based 1,2,3-triazoles as potential green agents against neoplastic cells. Sustainable Chemistry and Pharmacy, 20(February), 2–7. https://doi.org/10.1016/j.scp.2021.100408

Braga, F. C., Ojeda, M., Perdomo, R. T., de Albuquerque, S., Rafique, J., de Lima, D. P., & Beatriz, A. (2021b). Synthesis of cardanol-based 1,2,3-triazoles as potential green agents against neoplastic cells. Sustainable Chemistry and Pharmacy, 20(February), 2–7. https://doi.org/10.1016/j.scp.2021.100408

Cardoso, L. de M., Martino, H. S. D., Moreira, A. V. B., Ribeiro, S. M. R., & Pinheiro-Sant’Ana, H. M. (2011). Cagaita (Eugenia dysenterica DC.) of the Cerrado of Minas Gerais, Brazil: Physical and chemical characterization, carotenoids and vitamins. Food Research International, 44(7), 2151–2154. https://doi.org/10.1016/j.foodres.2011.03.005

Carvalho, D. V., Santos, F. A., de Lima, R. P., Viana, A. F. S. C., Fonseca, S. G. C., Nunes, P. I. G., de Melo, T. S., Gallão, M. I., & de Brito, E. S. (2018). Influence of low molecular weight compounds associated to cashew (Anacardium occidentale L.) fiber on lipid metabolism, glycemia and insulinemia of normal mice. Bioactive Carbohydrates and Dietary Fibre, 13(July), 1–6. https://doi.org/10.1016/j.bcdf.2017.12.001

Catelan, T. B. S., Santos Radai, J. A., Leitão, M. M., Branquinho, L. S., Vasconcelos, P. C. de P., Heredia-Vieira, S. C., Kassuya, C. A. L., & Cardoso, C. A. L. (2018). Evaluation of the toxicity and anti-inflammatory activities of the infusion of leaves of Campomanesia guazumifolia (Cambess.) O. Berg. Journal of Ethnopharmacology, 226, 132–142. https://doi.org/10.1016/j.jep.2018.08.015

Chen, C. Y., Kao, C. L., & Liu, C. M. (2018). The cancer prevention, anti-inflammatory and anti-oxidation of bioactive phytochemicals targeting the TLR4 signaling pathway. International Journal of Molecular Sciences, 19(9). https://doi.org/10.3390/ijms19092729

Ciocoiu, M., Mirón, A., Mares, L., Tutunaru, D., Pohaci, C., Groza, M., & Badescu, M. (2009). The effects of Sambucus nigra polyphenols on oxidative stress and metabolic disorders in experimental diabetes mellitus. Journal of Physiology and Biochemistry, 65(3), 297–304. https://doi.org/10.1007/BF03180582

Cordeiro, B. M. P. C., Carvalho Junior, A. R., Santos, J. R. A., Araújo, A. D., Silva, A. G., Correia, M. T. S., Silva, M. V., Napoleão, T. H., Silva, L. C. N., Santos, N. D. L., & Paiva, P. M. G. (2020). Anticryptococcal activity of hexane extract from Spondias tuberosa Arruda and associated cellular events. Journal de Mycologie Medicale, 30(2). https://doi.org/10.1016/j.mycmed.2020.100965

Cossetin, J. F., da Silva Brum, E., Casoti, R., Camponogara, C., Dornelles, R. C., Maziero, M., Tatiane de David Antoniazzi, C., Guex, C. G., Ramos, A. P., Pintos, F. G., Engelmann, A. M., Melazzo de Andrade, C., Manfron, M. P., Oliveira, S. M., de Freitas Bauermann, L., Sagrillo, M. R., Machado, A. K., Soares Santos, A. R., & Trevisan, G. (2019). Peanut leaf extract has antioxidant and anti-inflammatory activity but no acute toxic effects. Regulatory Toxicology and Pharmacology, 107, 104407. https://doi.org/10.1016/j.yrtph.2019.104407

Costa, W. K., Oliveira, J. R. S. de, Oliveira, A. M. de, Santos, I. B. da S., Cunha, R. X. da, Freitas, A. F. S. de, Silva, J. W. L. M. da, Silva, V. B. G., Aguiar, J. C. R. de O. F. de, Silva, A. G. da, Navarro, D. M. do A. F., Lima, V. L. de M., & Silva, M. V. da. (2020). Essential oil from Eugenia stipitata McVaugh leaves has antinociceptive, anti-inflammatory and antipyretic activities without showing toxicity in mice. Industrial Crops and Products, 144(August 2019), 112059. https://doi.org/10.1016/j.indcrop.2019.112059

da Rocha, P. D. S., Paula, V. M. B., Olinto, S. C. F., Dos Santos, E. L., Souza, K. de P., & Estevinho, L. M. (2020a). Diversity, chemical constituents and biological activities of endophytic fungi isolated from Schinus terebinthifolius raddi. Microorganisms, 8(6), 1–13. https://doi.org/10.3390/microorganisms8060859

da Rocha, P. D. S., Paula, V. M. B., Olinto, S. C. F., Dos Santos, E. L., Souza, K. de P., & Estevinho, L. M. (2020b). Diversity, chemical constituents and biological activities of endophytic fungi isolated from Schinus terebinthifolius raddi. Microorganisms, 8(6), 1–13. https://doi.org/10.3390/microorganisms8060859

da Silva Barbosa, D. C., Holanda, V. N., de Assis, C. R. D., de Oliveira Farias de Aguiar, J. C. R., doNascimento, P. H., da Silva, W. V., do Amaral Ferraz Navarro, D. M., Silva, M. V. da, de Menezes Lima, V. L., & dos Santos Correia, M. T. (2020a). Chemical composition and acetylcholinesterase inhibitory potential, in silico, of Myrciaria floribunda (H. West ex Willd.) O. Berg fruit peel essential oil. Industrial Crops and Products, 151(November 2019), 112372. https://doi.org/10.1016/j.indcrop.2020.112372

da Silva Barbosa, D. C., Holanda, V. N., de Assis, C. R. D., de Oliveira Farias de Aguiar, J. C. R., doNascimento, P. H., da Silva, W. V., do Amaral Ferraz Navarro, D. M., Silva, M. V. da, de Menezes Lima, V. L., & dos Santos Correia, M. T. (2020b). Chemical composition and acetylcholinesterase inhibitory potential, in silico, of Myrciaria floribunda (H. West ex Willd.) O. Berg fruit peel essential oil. Industrial Crops and Products, 151, 112372. https://doi.org/10.1016/j.indcrop.2020.112372

da Silva Brito, S. S., Silva, F., Malheiro, R., Baptista, P., & Pereira, J. A. (2018). Croton argyrophyllus Kunth and Croton heliotropiifolius Kunth: Phytochemical characterization and bioactive properties. Industrial Crops and Products, 113, 308–315. https://doi.org/10.1016/j.indcrop.2018.01.044

da Silva, G. C., de Veras, B. O., de Assis, C. R. D., Navarro, D. M. do A. F., Diniz, D. L. V., Brayner dos Santos, F. A., de Aguiar, J. C. R. de O. F., da Silva, M. V., & dos Santos Correia, M. T. (2020). Chemical composition, antimicrobial activity and synergistic effects with conventional antibiotics under clinical isolates by essential oil of Hymenaea rubriflora Ducke (FABACEAE). Natural Product Research, 0(0), 1–5. https://doi.org/10.1080/14786419.2020.1729150

da Silva, J. M. C., & Lacher, T. E. (2020). Caatinga—South America. In Encyclopedia of the World’s Biomes. Elsevier Inc. https://doi.org/10.1016/b978-0-12-409548-9.11984-0

Da Silva, S. M. M., Costa, C. R. R., Gelfuso, G. M., Guerra, E. N. S., De Medeiros Nóbrega, Y. K., Gomes, S. M., Pic-Taylor, A., Fonseca-Bazzo, Y. M., Silveira, D., & De Oliveira Magalhães, P. (2019a). Wound healing effect of essential oil extracted from eugenia dysenterica DC (Myrtaceae) leaves. Molecules, 24(1). https://doi.org/10.3390/molecules24010002

Da Silva, S. M. M., Costa, C. R. R., Gelfuso, G. M., Guerra, E. N. S., De Medeiros Nóbrega, Y. K., Gomes, S. M., Pic-Taylor, A., Fonseca-Bazzo, Y. M., Silveira, D., & De Oliveira Magalhães, P. (2019b). Wound healing effect of essential oil extracted from eugenia dysenterica DC (Myrtaceae) leaves. Molecules, 24(1). https://doi.org/10.3390/molecules24010002

D’abadia, P. L., Bailão, E. F. L. C., Lino Júnior, R. S., Oliveira, M. G., Silva, V. B., Oliveira, L. A. R., Conceição, E. C., Melo-Reis, P. R., Luiborges, L., Gonçalves, P. J., & Almeida, L. M. (2020). Hancornia speciosa serum fraction latex stimulates the angiogenesis and extracellular matrix remodeling processes. Anais Da Academia Brasileira de Ciencias, 92(2), 1–17. https://doi.org/10.1590/0001-3765202020190107

De Almeida, L. M., Nogueira, C. A., Borges, P. P., Do Prado, A. D. L., & Gonçalves, P. J. (2016). State Of The Art Of Scientific Literature On Hancornia Speciosa: Trends And Gaps. Revista Brasileira de Fruticultura, 38(4). https://doi.org/10.1590/0100-29452016869

de Araújo, F. F., de Paulo Farias, D., Neri-Numa, I. A., Dias-Audibert, F. L., Delafiori, J., de Souza, F. G., Catharino, R. R., do Sacramento, C. K., & Pastore, G. M. (2021). Influence of high-intensity ultrasound on color, chemical composition and antioxidant properties of araçá-boi pulp. Food Chemistry, 338, 127747. https://doi.org/10.1016/j.foodchem.2020.127747

de Araújo, J. S. C., de Castilho, A. R. F., Lira, A. B., Pereira, A. V., de Azevêdo, T. K. B., de Brito Costa, E. M. de M., Pereira, M. do S. V., Pessoa, H. F. L., & Pereira, J. V. (2018). Antibacterial activity against cariogenic bacteria and cytotoxic and genotoxic potential of Anacardium occidentale L. and Anadenanthera macrocarpa (Benth.) Brenan extracts. Archives of Oral Biology, 85(May 2017), 113–119. https://doi.org/10.1016/j.archoralbio.2017.10.008

de Araújo Rodrigues, P., de Morais, S. M., Aguiar, L. A., Vila-Nova, N. S., & Benjamin, S. R. (2019). Effect of Byrsonima sericea DC. leaf extracts on mice gastrointestinal tract. Toxicology Reports, 6, 1182–1187. https://doi.org/10.1016/j.toxrep.2019.10.018

de Azevedo, M. M. L., Cascaes, M. M., Guilhon, G. M. S. P., Andrade, E. H. A., Zoghbi, M. das G. B., da Silva, J. K. R., Santos, L. S., & da Silva, S. H. M. (2019). Lupane triterpenoids, antioxidant potential and antimicrobial activity of Myrciaria floribunda (H. West ex Willd.) O. Berg. Natural Product Research, 33(4), 506–515. https://doi.org/10.1080/14786419.2017.1402311

de Lavor, É. M., Leal, A. E. B. P., Fernandes, A. W. C., Ribeiro, F. P. R. de A., Barbosa, J. de M., Gama e Silva, M., Teles, R. B. de A., Oliveira, L. F. da S., Silva, J. C., Rolim, L. A., de Menezes, I. R. A., & Almeida, J. R. G. da S. (2018). Ethanolic extract of the aerial parts of Passiflora cincinnata Mast. (Passifloraceae) reduces nociceptive and inflammatory events in mice. Phytomedicine, 47, 58–68. https://doi.org/10.1016/j.phymed.2018.04.052

de Lima, M. de F. R., Cavalcante, L. A., Costa, E. C. T. de A., de Veras, B. O., da Silva, M. V., Cavalcanti, L. N., & Araújo, R. M. (2021). Bioactivity flavonoids from roots of Euphorbia tirucalli L. Phytochemistry Letters, 41(January), 186–192. https://doi.org/10.1016/j.phytol.2020.10.017

de Moura Barbosa, H., Amaral, D., do Nascimento, J. N., Machado, D. C., de Sousa Araújo, T. A., de Albuquerque, U. P., Guedes da Silva Almeida, J. R., Rolim, L. A., Lopes, N. P., Gomes, D. A., & Lira, E. C. (2018). Spondias tuberosa inner bark extract exert antidiabetic effects in streptozotocin-induced diabetic rats. Journal of Ethnopharmacology, 227, 248–257. https://doi.org/10.1016/j.jep.2018.08.038

de Oliveira Silva Ribeiro, F., de França Dourado, F., Silva, M. F. S., Brito, L. M., Pessoa, C., de Lima, L. R. M., de Paula, R. C. M., de Souza de Almeida Leite, J. R., de Araújo, A. R., & da Silva, D. A. (2020). Anti-proliferative profile of Anacardium occidentale polysaccharide and characterization by AFM. International Journal of Biological Macromolecules, 156, 981–987. https://doi.org/10.1016/j.ijbiomac.2020.03.145

de Oliveira Yamashita, F., Torres-Rêgo, M., dos Santos Gomes, J. A., Félix-Silva, J., Ramos Passos, J. G., de Santis Ferreira, L., da Silva-Júnior, A. A., Zucolotto, S. M., & Fernandes-Pedrosa, M. de F. (2020). Mangaba (Hancornia speciosa Gomes) fruit juice decreases acute pulmonary edema induced by Tityus serrulatus venom: Potential application for auxiliary treatment of scorpion stings. Toxicon, 179, 42–52. https://doi.org/10.1016/j.toxicon.2020.02.025

de Oliveira-Júnior, R. G., Alves Ferraz, C. A., Pontes, M. C., Cavalcante, N. B., da Cruz Araújo, E. C., de Oliveira, A. P., Picot, L., Rolim, L. A., & da Silva Almeida, J. R. G. (2018). Antibacterial activity of terpenoids isolated from Cnidoscolus quercifolius Pohl (Euphorbiaceae), a Brazilian medicinal plant from Caatinga biome. European Journal of Integrative Medicine, 24, 30–34. https://doi.org/10.1016/j.eujim.2018.10.011

de Sousa, E. R. B., Camilo, Y. M. V., & Vera, R. (2018). Cagaita— Eugenia dysenterica. Exotic Fruits, 77–83. https://doi.org/10.1016/b978-0-12-803138-4.00011-3

de Souza, L. S., Puziol, L. C., Tosta, C. L., Bittencourt, M. L. F., Ardisson, J. S., Kitagawa, R. R., Filgueiras, P. R., & Kuster, R. M. (2019). Analytical methods to access the chemical composition of an Euphorbia tirucalli anticancer latex from traditional Brazilian medicine. Journal of Ethnopharmacology, 237(January), 255–265. https://doi.org/10.1016/j.jep.2019.03.041

de Souza, M. Q., Teotônio, I. M. S. N., de Almeida, F. C., Heyn, G. S., Alves, P. S., Romeiro, L. A. S., Pratesi, R., de Medeiros Nóbrega, Y. K., & Pratesi, C. B. (2018a). Molecular evaluation of anti-inflammatory activity of phenolic lipid extracted from cashew nut shell liquid (CNSL). BMC Complementary and Alternative Medicine, 18(1), 1–11. https://doi.org/10.1186/s12906-018-2247-0

de Souza, M. Q., Teotônio, I. M. S. N., de Almeida, F. C., Heyn, G. S., Alves, P. S., Romeiro, L. A. S., Pratesi, R., de Medeiros Nóbrega, Y. K., & Pratesi, C. B. (2018b). Molecular evaluation of anti-inflammatory activity of phenolic lipid extracted from cashew nut shell liquid (CNSL). BMC Complementary and Alternative Medicine, 18(1), 1–11. https://doi.org/10.1186/s12906-018-2247-0

de Souza, R. O., de Assis Dias Alves, G., Aguillera, A. L. S., Rogez, H., & Fonseca, M. J. V. (2018). Photochemoprotective effect of a fraction of a partially purified extract of Byrsonima crassifolia leaves against UVB-induced oxidative stress in fibroblasts and hairless mice. Journal of Photochemistry and Photobiology B: Biology, 178, 53–60. https://doi.org/10.1016/j.jphotobiol.2017.10.033

de Souza Silva, G., da Silva Campelo Borges, G., Pinho da Costa Castro, C. D., de Tarso Aidar, S., Telles Biasoto Marques, A., Tonetto de Freitas, S., Poloni Rybka, A. C., & Cardarelli, H. R. (2020). Physicochemical quality, bioactive compounds and in vitro antioxidant activity of a new variety of passion fruit cv. BRS Sertão Forte (Passiflora cincinnata Mast.) from Brazilian Semiarid region. Scientia Horticulturae, 272, 109595. https://doi.org/10.1016/j.scienta.2020.109595

de Veras, B. O., de Oliveira, J. R. S., de Menezes Lima, V. L., do Amaral Ferraz Navarro, D. M., de Oliveira Farias de Aguiar, J. C. R., de Medeiros Moura, G. M., da Silva, J. W., de Assis, C. R. D., Gorlach-Lira, K., de Assis, P. A. C., de Souza Barbosa, J. I., de Melo, M. R. C. S., de Oliveira, M. B. M., da Silva, M. V., & de Souza Lopes, A. C. (2021). The essential oil of the leaves of Verbesina macrophylla (Cass.) S.F.Blake has antimicrobial, anti-inflammatory and antipyretic activities and is toxicologically safe. Journal of Ethnopharmacology, 265, 113248. https://doi.org/10.1016/j.jep.2020.113248

do Nascimento, K. F., Moreira, F. M. F., Alencar Santos, J., Kassuya, C. A. L., Croda, J. H. R., Cardoso, C. A. L., Vieira, M. do C., Góis Ruiz, A. L. T., Ann Foglio, M., de Carvalho, J. E., & Formagio, A. S. N. (2018). Antioxidant, anti-inflammatory, antiproliferative and antimycobacterial activities of the essential oil of Psidium guineense Sw. and spathulenol. Journal of Ethnopharmacology, 210, 351–358. https://doi.org/10.1016/j.jep.2017.08.030

Donado-Pestana, C. M., dos Santos-Donado, P. R., Daza, L. D., Belchior, T., Festuccia, W. T., & Genovese, M. I. (2018a). Cagaita fruit (Eugenia dysenterica DC.) and obesity: Role of polyphenols on already established obesity. Food Research International, 103, 40–47. https://doi.org/10.1016/j.foodres.2017.10.011

Donado-Pestana, C. M., dos Santos-Donado, P. R., Daza, L. D., Belchior, T., Festuccia, W. T., & Genovese, M. I. (2018b). Cagaita fruit (Eugenia dysenterica DC.) and obesity: Role of polyphenols on already established obesity. Food Research International, 103, 40–47. https://doi.org/10.1016/j.foodres.2017.10.011

Dornas, W. C., De Oliveira, T. T., Dores, R. G. R., Fabres, M. H. A., & Nagem, T. J. (2009). Antidiabetic effects of the medicinal plants. Brazilian Journal of Pharmacognosy, 19(2 A), 488–500. https://doi.org/10.1590/S0102-695X2009000300024

dos Santos, A. L., Polidoro, A. dos S., Cardoso, C. A. L., Batistote, M., do Carmo Vieira, M., Jacques, R. A., & Caramão, E. B. (2019). GC×GC/qMS analyses of Campomanesia guazumifolia (Cambess.) O. Berg essential oils and their antioxidant and antimicrobial activity. Natural Product Research, 33(4), 593–597. https://doi.org/10.1080/14786419.2017.1399383

dos Santos da Rocha, P., de Araújo Boleti, A. P., do Carmo Vieira, M., Carollo, C. A., da Silva, D. B., Estevinho, L. M., dos Santos, E. L., & de Picoli Souza, K. (2019a). Microbiological quality, chemical profile as well as antioxidant and antidiabetic activities of Schinus terebinthifolius Raddi. Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology, 220(February), 36–46. https://doi.org/10.1016/j.cbpc.2019.02.007

dos Santos da Rocha, P., de Araújo Boleti, A. P., do Carmo Vieira, M., Carollo, C. A., da Silva, D. B., Estevinho, L. M., dos Santos, E. L., & de Picoli Souza, K. (2019b). Microbiological quality, chemical profile as well as antioxidant and antidiabetic activities of Schinus terebinthifolius Raddi. Comparative Biochemistry and Physiology Part - C: Toxicology and Pharmacology, 220, 36–46. https://doi.org/10.1016/j.cbpc.2019.02.007

Dos Santos, E., Radai, J. A. S., do Nascimento, K. F., Formagio, A. S. N., de Matos Balsalobre, N., Ziff, E. B., Castelon Konkiewitz, E., & Kassuya, C. A. L. (2020). Contribution of spathulenol to the anti-nociceptive effects of Psidium guineense. Nutritional Neuroscience. https://doi.org/10.1080/1028415X.2020.1815330

dos Santos, G. H. F., Amaral, A., & da Silva, E. B. (2018). Antibacterial activity of irradiated extracts of Anacardium occidentale L. on multiresistant strains of Staphylococcus aureus. Applied Radiation and Isotopes, 140, 327–332. https://doi.org/10.1016/j.apradiso.2018.07.035

Dos Santos, U. P., Tolentino, G. S., Morais, J. S., De Picoli Souza, K., Estevinho, L. M., & Dos Santos, E. L. (2018a). Physicochemical characterization, microbiological quality and safety, and pharmacological potential of Hancornia speciosa gomes. Oxidative Medicine and Cellular Longevity, 2018. https://doi.org/10.1155/2018/2976985

Dos Santos, U. P., Tolentino, G. S., Morais, J. S., De Picoli Souza, K., Estevinho, L. M., & Dos Santos, E. L. (2018b). Physicochemical characterization, microbiological quality and safety, and pharmacological potential of Hancornia speciosa gomes. Oxidative Medicine and Cellular Longevity, 2018. https://doi.org/10.1155/2018/2976985

Duong, T. H., Beniddir, M. A., Genta-Jouve, G., Nguyen, H. H., Nguyen, D. P., Nguyen, T. A. T., Mac, D. H., Boustie, J., Nguyen, K. P. P., Chavasiri, W., & Le Pogam, P. (2019). Further terpenoids from Euphorbia tirucalli. Fitoterapia, 135(April), 44–51. https://doi.org/10.1016/j.fitote.2019.04.001

Dutra, R. L. T., Dantas, A. M., Marques, D. de A., Batista, J. D. F., Meireles, B. R. L. de A., de Magalhães Cordeiro, Â. M. T., Magnani, M., & Borges, G. da S. C. (2017a). Bioaccessibility and antioxidant activity of phenolic compounds in frozen pulps of Brazilian exotic fruits exposed to simulated gastrointestinal conditions. Food Research International, 100, 650–657. https://doi.org/10.1016/j.foodres.2017.07.047

Dutra, R. L. T., Dantas, A. M., Marques, D. de A., Batista, J. D. F., Meireles, B. R. L. de A., de Magalhães Cordeiro, Â. M. T., Magnani, M., & Borges, G. da S. C. (2017b). Bioaccessibility and antioxidant activity of phenolic compounds in frozen pulps of Brazilian exotic fruits exposed to simulated gastrointestinal conditions. Food Research International, 100, 650–657. https://doi.org/10.1016/j.foodres.2017.07.047

Eming, S. A., Wynn, T. A., & Martin, P. (2017). Inflammation and metabolism in tissue repair and regeneration. Science, 356(6342), 1026–1030. https://doi.org/10.1126/science.aam7928

Estevão, L. R. M., Simões, R. S., Cassini-Vieira, P., Canesso, M. C. C., Barcelos, L. da S., Rachid, M. A., da Câmara, C. A. G., & Evêncio-Neto, J. (2017). Schinus terebinthifolius raddi (aroeira) leaves oil attenuates inflammatory responses in cutaneous wound healing in mice. Acta Cirurgica Brasileira, 32(9), 726–735. https://doi.org/10.1590/s0102-865020170090000005

Eungsuwan, N., Chayjarung, P., Pankam, J., Pilaisangsuree, V., Wongshaya, P., Kongbangkerd, A., Sriphannam, C., & Limmongkon, A. (2021a). Production and antimicrobial activity of trans-resveratrol, trans-arachidin-1 and trans-arachidin-3 from elicited peanut hairy root cultures in shake flasks compared with bioreactors. Journal of Biotechnology, 326, 28–36. https://doi.org/10.1016/j.jbiotec.2020.12.006

Eungsuwan, N., Chayjarung, P., Pankam, J., Pilaisangsuree, V., Wongshaya, P., Kongbangkerd, A., Sriphannam, C., & Limmongkon, A. (2021b). Production and antimicrobial activity of trans-resveratrol, trans-arachidin-1 and trans-arachidin-3 from elicited peanut hairy root cultures in shake flasks compared with bioreactors. Journal of Biotechnology, 326, 28–36. https://doi.org/10.1016/j.jbiotec.2020.12.006

Farinha, J. B., Ramis, T. R., Vieira, A. F., Macedo, R. C. O., Rodrigues-Krause, J., Boeno, F. P., Schroeder, H. T., Müller, C. H., Boff, W., Krause, M., De Bittencourt, P. I. H., & Reischak-Oliveira, A. (2018). Glycemic, inflammatory and oxidative stress responses to different high-intensity training protocols in type 1 diabetes: A randomized clinical trial. Journal of Diabetes and Its Complications, 32(12), 1124–1132. https://doi.org/10.1016/j.jdiacomp.2018.09.008

Feriani, A., Tir, M., Arafah, M., Gómez-Caravaca, A. M., Contreras, M. del M., Nahdi, S., Taamalli, A., Allagui, M. S., Alwasel, S., Segura-Carretero, A., Harrath, A. H., & Tlili, N. (2021). Schinus terebinthifolius fruits intake ameliorates metabolic disorders, inflammation, oxidative stress, and related vascular dysfunction, in atherogenic diet-induced obese rats. Insight of their chemical characterization using HPLC-ESI-QTOF-MS/MS. Journal of Ethnopharmacology, 269. https://doi.org/10.1016/j.jep.2020.113701

Feriani, A., Tir, M., Hamed, M., Sila, A., Nahdi, S., Alwasel, S., Harrath, A. H., & Tlili, N. (2020a). Multidirectional insights on polysaccharides from Schinus terebinthifolius and Schinus molle fruits: Physicochemical and functional profiles, in vitro antioxidant, anti-genotoxicity, antidiabetic, and antihemolytic capacities, and in vivo anti-inflammatory and anti-nociceptive properties. International Journal of Biological Macromolecules, 165(Pt B), 2576–2587. https://doi.org/10.1016/j.ijbiomac.2020.10.123

Feriani, A., Tir, M., Hamed, M., Sila, A., Nahdi, S., Alwasel, S., Harrath, A. H., & Tlili, N. (2020b). Multidirectional insights on polysaccharides from Schinus terebinthifolius and Schinus molle fruits: Physicochemical and functional profiles, in vitro antioxidant, anti-genotoxicity, antidiabetic, and antihemolytic capacities, and in vivo anti-inflammatory and anti-nociceptive properties. International Journal of Biological Macromolecules, 165(Pt B), 2576–2587. https://doi.org/10.1016/j.ijbiomac.2020.10.123

Fernandes, A. C. F., Vieira, N. C., Santana, Á. L. de, Gandra, R. L. de P., Rubia, C., Castro-Gamboa, I., Macedo, J. A., & Macedo, G. A. (2020). Peanut skin polyphenols inhibit toxicity induced by advanced glycation end-products in RAW264.7 macrophages. Food and Chemical Toxicology, 145, 111619. https://doi.org/10.1016/j.fct.2020.111619

Ferreira-Fernandes, H., Barros, M. A. L., Souza Filho, M. D., Medeiros, J. V. R., Vasconcelos, D. F. P., Silva, D. A., Leódido, A. C. M., Silva, F. R. P., França, L. F. C., Di Lenardo, D., Yoshioka, F. K. N., Rey, J. A., Burbano, R. R., & Pinto, G. R. (2019). Topical application of cashew gum or chlorhexidine gel reduces overexpression of proinflammatory genes in experimental periodontitis. International Journal of Biological Macromolecules, 128, 934–940. https://doi.org/10.1016/j.ijbiomac.2019.02.002

Fidelis-de-Oliveira, P., Aparecida-Castro, S., Silva, D. B., Morais, I. B. de M., Miranda, V. H. M. de, de Gobbi, J. I., Canabrava, H. A. N., & Bispo-da-Silva, L. B. (2020). Hypotensive effect of Eugenia dysenterica leaf extract is primarily related to its vascular action: The possible underlying mechanisms. Journal of Ethnopharmacology, 251. https://doi.org/10.1016/j.jep.2019.112520

Fukui, M., & Zhu, B. T. (2010). Mitochondrial superoxide dismutase SOD2, but not cytosolic SOD1, plays a critical role in protection against glutamate-induced oxidative stress and cell death in HT22 neuronal cells. Free Radical Biology and Medicine, 48(6), 821–830. https://doi.org/10.1016/j.freeradbiomed.2009.12.024

Gasca, C. A., Castillo, W. O., Takahashi, C. S., Fagg, C. W., Magalhães, P. O., Fonseca-Bazzo, Y. M., & Silveira, D. (2017). Assessment of anti-cholinesterase activity and cytotoxicity of cagaita (Eugenia dysenterica) leaves. Food and Chemical Toxicology, 109(Pt 2), 996–1002. https://doi.org/10.1016/j.fct.2017.02.032

Gershenzon, J., & Dudareva, N. (2007). The function of terpene natural products in the natural world. Nature Chemical Biology, 3(7), 408–414. https://doi.org/10.1038/nchembio.2007.5

Gomes Júnior, A. L., Tchekalarova, J. D., Machado, K. da C., Moura, A. K. S., Paz, M. F. C. J., da Mata, A. M. O. F., Nogueira, T. R., Islam, M. T., Rios, M. A. de S., Graças Lopes Citó, A. M. das, Uddin, S. J., Shilpi, J. A., Das, A. K., Lopes, L. da S., & Melo-Cavalcante, A. A. de C. (2018a). Anxiolytic effect of anacardic acids from cashew (Anacardium occidentale) nut shell in mice. IUBMB Life, December 2017, 1–12. https://doi.org/10.1002/iub.1738

Gomes Júnior, A. L., Tchekalarova, J. D., Machado, K. da C., Moura, A. K. S., Paz, M. F. C. J., da Mata, A. M. O. F., Nogueira, T. R., Islam, M. T., Rios, M. A. de S., Graças Lopes Citó, A. M. das, Uddin, S. J., Shilpi, J. A., Das, A. K., Lopes, L. da S., & Melo-Cavalcante, A. A. de C. (2018b). Anxiolytic effect of anacardic acids from cashew (Anacardium occidentale) nut shell in mice. IUBMB Life, December 2017, 1–12. https://doi.org/10.1002/iub.1738

Goulart da Silva, G., de Oliveira Braga, L. E., Souza de Oliveira, E. C., Valério Tinti, S., de Carvalho, J. E., Goldoni Lazarini, J., Rosalen, P. L., Dionísio, A. P., & Tasca Gois Ruiz, A. L. (2021a). Cashew apple byproduct: Gastroprotective effects of standardized extract. Journal of Ethnopharmacology, 269(September 2020). https://doi.org/10.1016/j.jep.2020.113744

Goulart da Silva, G., de Oliveira Braga, L. E., Souza de Oliveira, E. C., Valério Tinti, S., de Carvalho, J. E., Goldoni Lazarini, J., Rosalen, P. L., Dionísio, A. P., & Tasca Gois Ruiz, A. L. (2021b). Cashew apple byproduct: Gastroprotective effects of standardized extract. Journal of Ethnopharmacology, 269(September 2020). https://doi.org/10.1016/j.jep.2020.113744

Graf, B. L., Zhang, L., Corradini, M. G., Kuhn, P., Newman, S. S., Salbaum, J. M., & Raskin, I. (2018). Physicochemical differences between malanga (Xanthosoma sagittifolium) and potato (Solanum tuberosum) tubers are associated with differential effects on the gut microbiome. Journal of Functional Foods, 45, 268–276. https://doi.org/10.1016/j.jff.2018.04.032

Ibrahim, E. H., Kilany, M., Mostafa, O. M. S., Shaker, K. H., Alshehri, M., Alsyaad, K. M., Alshehri, A., Khan, K. A., Qasim, M., Kotb, N., Alahmari, A. S., Ghramh, H. A., & Dajem, S. M. (2019). TH1/TH2 chemokines/cytokines profile in rats treated with tetanus toxoid and Euphorbia tirucalli. Saudi Journal of Biological Sciences, 26(7), 1716–1723. https://doi.org/10.1016/j.sjbs.2018.08.005

Jia, X., Wang, W., Chen, Z., He, Y., & Liu, J. (2014). Concentrations of secondary metabolites in tissues and root exudates of wheat seedlings changed under elevated atmospheric CO2 and cadmium-contaminated soils. Environmental and Experimental Botany, 107, 134–143. https://doi.org/10.1016/j.envexpbot.2014.06.005

Junsathian, P., Yordtong, K., Corpuz, H. M., Katayama, S., Nakamura, S., & Rawdkuen, S. (2018). Biological and neuroprotective activity of Thai edible plant extracts. Industrial Crops and Products, 124(April), 548–554. https://doi.org/10.1016/j.indcrop.2018.08.008

Justino, A. B., de Moura, F. R. B., Franco, R. R., & Espindola, F. S. (2020a). α-Glucosidase and non-enzymatic glycation inhibitory potential of Eugenia dysenterica fruit pulp extracts. Food Bioscience, 35, 100573. https://doi.org/10.1016/j.fbio.2020.100573

Justino, A. B., de Moura, F. R. B., Franco, R. R., & Espindola, F. S. (2020b). α-Glucosidase and non-enzymatic glycation inhibitory potential of Eugenia dysenterica fruit pulp extracts. Food Bioscience, 35, 100573. https://doi.org/10.1016/j.fbio.2020.100573

Kim, S. H., Yuk, H. J., Ryu, H. W., Oh, S. R., Song, D. Y., Lee, K. S., Park, K. I., Choi, S. W., & Seo, W. D. (2019a). Biofunctional soyasaponin Bb in peanut (Arachis hypogaea L.) sprouts enhances bone morphogenetic protein-2-dependent osteogenic differentiation via activation of runt-related transcription factor 2 in C2C12 cells. Phytotherapy Research, 33(5). https://doi.org/10.1002/ptr.6341

Kim, S. H., Yuk, H. J., Ryu, H. W., Oh, S. R., Song, D. Y., Lee, K. S., Park, K. I., Choi, S. W., & Seo, W. D. (2019b). Biofunctional soyasaponin Bb in peanut (Arachis hypogaea L.) sprouts enhances bone morphogenetic protein-2-dependent osteogenic differentiation via activation of runt-related transcription factor 2 in C2C12 cells. Phytotherapy Research, 33(5), 1490–1500. https://doi.org/10.1002/ptr.6341

Kouitcheu Mabeku, L. B., Eyoum Bille, B., & Nguepi, E. (2016). In Vitro and In Vivo Anti- Helicobacter Activities of Eryngium foetidum (Apiaceae), Bidens pilosa (Asteraceae), and Galinsoga ciliata (Asteraceae) against Helicobacter pylori. BioMed Research International, 2016. https://doi.org/10.1155/2016/2171032

Larrauri, M., Zunino, M. P., Zygadlo, J. A., Grosso, N. R., & Nepote, V. (2016). Chemical characterization and antioxidant properties of fractions separated from extract of peanut skin derived from different industrial processes. Industrial Crops and Products, 94, 964–971. https://doi.org/10.1016/j.indcrop.2016.09.066

Leal, A. E. B. P., de Oliveira, A. P., Santos, R. F. dos, Soares, J. M. D., Lavor, E. M. de, Pontes, M. C., Lima, J. T. de, Santos, A. D. da C., Tomaz, J. C., Oliveira, G. G. de, Neto, F. C., Lopes, N. P., Rolim, L. A., & Almeida, J. R. G. da S. (2020). Determination of phenolic compounds, in vitro antioxidant activity and characterization of secondary metabolites in different parts of Passiflora cincinnata by HPLC-DAD-MS/MS analysis. Natural Product Research, 34(7), 995–1001. https://doi.org/10.1080/14786419.2018.1548445

Lepetsos, P., Papavassiliou, K. A., & Papavassiliou, A. G. (2019). Redox and NF-κB signaling in osteoarthritis. In Free Radical Biology and Medicine (Vol. 132, pp. 90–100). Elsevier Inc. https://doi.org/10.1016/j.freeradbiomed.2018.09.025

Lima, A. B., Delwing-de Lima, D., Vieira, M. R., Poletto, M. Z., Delwing-Dal Magro, D., Barauna, S. C., Alberton, M. D., Pereira, E. M., Pereira, N. R., Salamaia, E. M., & Siebert, D. A. (2017). Hypolipemiant and antioxidant effects of Eugenia brasiliensis in an animal model of coconut oil-induced hypertriglyceridemia. Biomedicine and Pharmacotherapy, 96, 642–649. https://doi.org/10.1016/j.biopha.2017.10.047

Lima, M. D. C. L., De Araújo, J. I. F., Gonçalves Mota, C., Magalhães, F. E. A., Campos, A. R., Da Silva, P. T., Rodrigues, T. H. S., Matos, M. G. C., De Sousa, K. C., De Sousa, M. B., Saker-Sampaio, S., Pereira, A. L., Teixeira, E. H., & Dos Santos, H. S. (2020a). Antinociceptive Effect of the Essential Oil of Schinus terebinthifolius (female) Leaves on Adult Zebrafish (Danio rerio). Zebrafish, 17(2), 112–119. https://doi.org/10.1089/zeb.2019.1809

Lima, M. D. C. L., De Araújo, J. I. F., Gonçalves Mota, C., Magalhães, F. E. A., Campos, A. R., Da Silva, P. T., Rodrigues, T. H. S., Matos, M. G. C., De Sousa, K. C., De Sousa, M. B., Saker-Sampaio, S., Pereira, A. L., Teixeira, E. H., & Dos Santos, H. S. (2020b). Antinociceptive Effect of the Essential Oil of Schinus terebinthifolius (female) Leaves on Adult Zebrafish (Danio rerio). Zebrafish, 17(2), 112–119. https://doi.org/10.1089/zeb.2019.1809

Limmongkon, A., Nopprang, P., Chaikeandee, P., Somboon, T., Wongshaya, P., & Pilaisangsuree, V. (2018). LC-MS/MS profiles and interrelationships between the anti-inflammatory activity, total phenolic content and antioxidant potential of Kalasin 2 cultivar peanut sprout crude extract. Food Chemistry, 239, 569–578. https://doi.org/10.1016/j.foodchem.2017.06.162

Limmongkon, A., Pankam, J., Somboon, T., Wongshaya, P., & Nopprang, P. (2019). Evaluation of the DNA damage protective activity of the germinated peanut (Arachis hypogaea) in relation to antioxidant and anti-inflammatory activity. LWT, 101. https://doi.org/10.1016/j.lwt.2018.11.009

Lira, S. M., Canabrava, N. V., Benjamin, S. R., Silva, J. Y. G., Viana, D. A., Lima, C. L. S., Paredes, P. F. M., Marques, M. M. M., Pereira, E. O., Queiroz, E. A. M., & Guedes, M. I. F. (2017). Evaluation of the toxicity and hypoglycemic effect of the aqueous extracts of cnidoscolus quercifolius pohl. Brazilian Journal of Medical and Biological Research, 50(10). https://doi.org/10.1590/1414-431x20176361

Locatelli, M., Avato, P., Herman, F., Westfall, S., Brathwaite, J., Pasinetti, G. M., & Peters, J. J. (2018). Suppression of Presymptomatic Oxidative Stress and Inflammation in Neurodegeneration by Grape-Derived Polyphenols. https://doi.org/10.3389/fphar.2018.00867

López-Gutiérrez, N., Romero-González, R., Plaza-Bolaños, P., Martínez Vidal, J. L., & Garrido Frenich, A. (2015). Identification and quantification of phytochemicals in nutraceutical products from green tea by UHPLC-Orbitrap-MS. Food Chemistry, 173, 607–618. https://doi.org/10.1016/j.foodchem.2014.10.092

Luiz Gomes, A., Dimitrova Tchekalarova, J., Atanasova, M., da Conceição Machado, K., de Sousa Rios, M. A., Paz Jardim, M. F., Găman, M. A., Găman, A. M., Yele, S., Shill, M. C., Khan, I. N., Islam, M. A., Ali, E. S., Mishra, S. K., Islam, M. T., Mubarak, M. S., da Silva Lopes, L., & de Carvalho Melo-Cavalcante, A. A. (2018a). Anticonvulsant effect of anacardic acid in murine models: Putative role of GABAergic and antioxidant mechanisms. Biomedicine and Pharmacotherapy, 106(July), 1686–1695. https://doi.org/10.1016/j.biopha.2018.07.121

Luiz Gomes, A., Dimitrova Tchekalarova, J., Atanasova, M., da Conceição Machado, K., de Sousa Rios, M. A., Paz Jardim, M. F., Găman, M. A., Găman, A. M., Yele, S., Shill, M. C., Khan, I. N., Islam, M. A., Ali, E. S., Mishra, S. K., Islam, M. T., Mubarak, M. S., da Silva Lopes, L., & de Carvalho Melo-Cavalcante, A. A. (2018b). Anticonvulsant effect of anacardic acid in murine models: Putative role of GABAergic and antioxidant mechanisms. Biomedicine and Pharmacotherapy, 106(July), 1686–1695. https://doi.org/10.1016/j.biopha.2018.07.121

M Ashraf, S., & Rathinasamy, K. (2018a). Antibacterial and anticancer activity of the purified cashew nut shell liquid: implications in cancer chemotherapy and wound healing. Natural Product Research, 32(23), 2856–2860. https://doi.org/10.1080/14786419.2017.1380022

M Ashraf, S., & Rathinasamy, K. (2018b). Antibacterial and anticancer activity of the purified cashew nut shell liquid: implications in cancer chemotherapy and wound healing. Natural Product Research, 32(23), 2856–2860. https://doi.org/10.1080/14786419.2017.1380022

Martins, C. G., Appel, M. H., Coutinho, D. S. S., Soares, I. P., Fischer, S., de Oliveira, B. C., Fachi, M. M., Pontarolo, R., Bonatto, S. J. R., Fernandes, L. C., Iagher, F., & de Souza, L. M. (2020). Consumption of latex from Euphorbia tirucalli L. promotes a reduction of tumor growth and cachexia, and immunomodulation in Walker 256 tumor-bearing rats. Journal of Ethnopharmacology, 255(February), 112722. https://doi.org/10.1016/j.jep.2020.112722

Menis Candela, F., Giordano, W. F., Quiroga, P. L., Escobar, F. M., Mañas, F., Roma, D. A., Larrauri, M., Comini, L. R., Soria, E. A., & Sabini, M. C. (2020). Evaluation of cellular safety and the chemical composition of the peanut (Arachis hypogaea L.) ethanolic extracts. Heliyon, 6(10), e05119. https://doi.org/10.1016/j.heliyon.2020.e05119

Mittal, M., Siddiqui, M. R., Tran, K., Reddy, S. P., & Malik, A. B. (2014). Reactive oxygen species in inflammation and tissue injury. Antioxidants and Redox Signaling, 20(7), 1126–1167. https://doi.org/10.1089/ars.2012.5149

Moreira, L. N., Silva, G. C., Câmara, D. V, Pádua, R. M., Lemos, V. S., Braga, F. C., & Cortes, S. F. (2019a). The Cyclitol L-()-Bornesitol as an Active Marker for the Cardiovascular Activity of the Brazilian Medicinal Plant Hancornia speciosa. In Biol. Pharm. Bull (Vol. 42, Issue 12).

Moreira, L. N., Silva, G. C., Câmara, D. V, Pádua, R. M., Lemos, V. S., Braga, F. C., & Cortes, S. F. (2019b). The Cyclitol L-()-Bornesitol as an Active Marker for the Cardiovascular Activity of the Brazilian Medicinal Plant Hancornia speciosa. In Biol. Pharm. Bull (Vol. 42, Issue 12).

Morvin Yabesh, J. E., Vijayakumar, S., Arulmozhi, P., & Rajalakshmi, S. (2019). Screening the antimicrobial potential of twelve medicinal plants against venereal diseases causing pathogens. Acta Ecologica Sinica, 39(5), 356–361. https://doi.org/10.1016/j.chnaes.2018.09.011

Oliveira, A. S., Nascimento, J. R., Trovão, L. O., Alves, P. C. S., Maciel, M. C. G., Silva, L. D. M., Marques, A. A., Santos, A. P. S. A., Silva, L. A., Nascimento, F. R. F., & Guerra, R. N. M. (2019). The anti-inflammatory activity of Anacardium occidentale L. increases the lifespan of diabetic mice with lethal sepsis. Journal of Ethnopharmacology, 236(July 2018), 345–353. https://doi.org/10.1016/j.jep.2019.03.014

Oliveira de Souza, L. I., Bezzera-Silva, P. C., do Amaral Ferraz Navarro, D. M., da Silva, A. G., dos Santos Correia, M. T., da Silva, M. V., & de Figueiredo, R. C. B. Q. (2017). The chemical composition and trypanocidal activity of volatile oils from Brazilian Caatinga plants. Biomedicine and Pharmacotherapy, 96, 1055–1064. https://doi.org/10.1016/j.biopha.2017.11.121

Oliveira de Veras, B., Melo de Oliveira, M. B., Granja da Silva Oliveira, F., Queiroz dos Santos, Y., Saturnino de Oliveira, J. R., Lúcia de Menezes Lima, V., Guedes da Silva Almeida, J. R., Maria do Amaral Ferraz Navarro, D., Ribeiro de Oliveira Farias de Aguiar, J. C., Aguiar, J. dos S., Gorlach-Lira, K., Dias de Assis, C. R., Vanusa da Silva, M., & Catarina de Souza Lopes, A. (2020). Chemical composition and evaluation of the antinociceptive, antioxidant and antimicrobial effects of essential oil from Hymenaea cangaceira (Pinto, Mansano & Azevedo) native to Brazil: A natural medicine. Journal of Ethnopharmacology, 247(September 2019), 112265. https://doi.org/10.1016/j.jep.2019.112265

Oliveira, M. B. S., Valentim, I. B., Rocha, T. S., Santos, J. C., Pires, K. S. N., Tanabe, E. L. L., Borbely, K. S. C., Borbely, A. U., & Goulart, M. O. F. (2020). Schinus terebenthifolius Raddi extracts: From sunscreen activity toward protection of the placenta to Zika virus infection, new uses for a well-known medicinal plant. Industrial Crops and Products, 152. https://doi.org/10.1016/j.indcrop.2020.112503

Omolaso, B. O., Oluwole, F. S., Odukanmi, O. A., Adesanwo, J. K., Ishola, A. A., & Adewole, K. E. (2020a). Evaluation of the gastrointestinal anti-motility effect of Anacardium occidentale stem bark extract: A mechanistic study of antidiarrheal activity. Journal of Pharmaceutical Analysis. https://doi.org/10.1016/j.jpha.2020.06.009

Omolaso, B. O., Oluwole, F. S., Odukanmi, O. A., Adesanwo, J. K., Ishola, A. A., & Adewole, K. E. (2020b). Evaluation of the gastrointestinal anti-motility effect of Anacardium occidentale stem bark extract: A mechanistic study of antidiarrheal activity. Journal of Pharmaceutical Analysis. https://doi.org/10.1016/j.jpha.2020.06.009

Palit, P., Mukherjee, D., Mahanta, P., Shadab, M., Ali, N., Roychoudhury, S., Asad, M., & Mandal, S. C. (2018). Attenuation of nociceptive pain and inflammatory disorders by total steroid and terpenoid fraction of Euphorbia tirucalli Linn root in experimental in vitro and in vivo model. Inflammopharmacology, 26(1), 235–250. https://doi.org/10.1007/s10787-017-0403-7

Peng, J., Jia, Y., Du, X., Wang, Y., Yang, Z., & Li, K. (2019a). Study of physicochemical stability of anthocyanin extracts from black peanut skin and their digestion enzyme and adipogenesis inhibitory activities. LWT, 107. https://doi.org/10.1016/j.lwt.2019.03.016

Peng, J., Jia, Y., Du, X., Wang, Y., Yang, Z., & Li, K. (2019b). Study of physicochemical stability of anthocyanin extracts from black peanut skin and their digestion enzyme and adipogenesis inhibitory activities. LWT, 107, 107–116. https://doi.org/10.1016/j.lwt.2019.03.016

Peng, M., Chen, Z., Deng, Q., Zhu, S., & Wang, G. (2021). The roles of luteolin in peanut shell extract - Mediated protection of erythrocytes against hypoxanthine-xanthine oxidase-induced toxicity. Food Bioscience, 39, 100826. https://doi.org/10.1016/j.fbio.2020.100826

Pinto, I. C., Seibert, J. B., Pinto, L. S., Santos, V. R., de Sousa, R. F., Sousa, L. R. D., Amparo, T. R., dos Santos, V. M. R., do Nascimento, A. M., de Souza, G. H. B., Vasconcellos, W. A., Vieira, P. M. A., & Andrade, Â. L. (2020a). Preparation of glass-ionomer cement containing ethanolic Brazilian pepper extract (Schinus terebinthifolius Raddi) fruits: chemical and biological assays. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-79257-3

Pinto, I. C., Seibert, J. B., Pinto, L. S., Santos, V. R., de Sousa, R. F., Sousa, L. R. D., Amparo, T. R., dos Santos, V. M. R., do Nascimento, A. M., de Souza, G. H. B., Vasconcellos, W. A., Vieira, P. M. A., & Andrade, Â. L. (2020b). Preparation of glass-ionomer cement containing ethanolic Brazilian pepper extract (Schinus terebinthifolius Raddi) fruits: chemical and biological assays. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-79257-3

Prasad, S., Gupta, S. C., & Tyagi, A. K. (2017). Reactive oxygen species (ROS) and cancer: Role of antioxidative nutraceuticals. Cancer Letters, 387, 95–105. https://doi.org/10.1016/j.canlet.2016.03.042

Räisänen, T., Ryyppö, A., & Kellomäki, S. (2008). Effects of elevated CO2 and temperature on monoterpene emission of Scots pine (Pinus sylvestris L.). Atmospheric Environment, 42(18), 4160–4171. https://doi.org/10.1016/j.atmosenv.2008.01.023

Regueira, M. S., Tintino, S. R., da Silva, A. R. P., Costa, M. do S., Boligon, A. A., Matias, E. F. F., de Queiroz Balbino, V., Menezes, I. R. A., & Melo Coutinho, H. D. (2017). Seasonal variation of Brazilian red propolis: Antibacterial activity, synergistic effect and phytochemical screening. Food and Chemical Toxicology, 107, 572–580. https://doi.org/10.1016/j.fct.2017.03.052

Rehman, K., & Akash, M. S. H. (2017). Mechanism of Generation of Oxidative Stress and Pathophysiology of Type 2 Diabetes Mellitus: How Are They Interlinked? Journal of Cellular Biochemistry, 118(11), 3577–3585. https://doi.org/10.1002/jcb.26097

Rhee, S. G., Woo, H. A., Kil, I. S., & Bae, S. H. (2012). Peroxiredoxin functions as a peroxidase and a regulator and sensor of local peroxides. In Journal of Biological Chemistry (287(7), pp. 4403–4410). Elsevier. https://doi.org/10.1074/jbc.R111.283432

Ribeiro, P. P. C., Damasceno, K. S. F. da S. C., de Veras, B. O., de Oliveira, J. R. S., Lima, V. L. de M., de Assis, C. R. D., da Silva, M. V., de Sousa Júnior, F. C., de Assis, C. F., Padilha, C. E. de A., & Stamford, T. C. M. (2021). Chemical and biological activities of faveleira (Cnidoscolus quercifolius Pohl) seed oil for potential health applications. Food Chemistry, 337, 127771. https://doi.org/10.1016/j.foodchem.2020.127771

Ribeiro, P. P. C., E Silva, D. M. D. L., De Assis, C. F., Correia, R. T. P., & Damasceno, K. S. F. D. S. C. (2017). Bioactive properties of faveleira (Cnidoscolus quercifolius) seeds, oil and press cake obtained during oilseed processing. PLoS ONE, 12(8). https://doi.org/10.1371/journal.pone.0183935

Rocha, P. dos S. da, Campos, J. F., Nunes-Souza, V., Vieira, M. do C., Boleti, A. P. de A., Rabelo, L. A., dos Santos, E. L., & de Picoli Souza, K. (2018a). Antioxidant and Protective Effects of Schinus terebinthifolius Raddi Against Doxorubicin-Induced Toxicity. Applied Biochemistry and Biotechnology, 184(3), 869–884. https://doi.org/10.1007/s12010-017-2589-y

Rocha, P. dos S. da, Campos, J. F., Nunes-Souza, V., Vieira, M. do C., Boleti, A. P. de A., Rabelo, L. A., dos Santos, E. L., & de Picoli Souza, K. (2018b). Antioxidant and Protective Effects of Schinus terebinthifolius Raddi Against Doxorubicin-Induced Toxicity. Applied Biochemistry and Biotechnology, 184(3), 869–884. https://doi.org/10.1007/s12010-017-2589-y

Rossi, Y. E., Bohl, L. P., Vanden Braber, N. L., Ballatore, M. B., Escobar, F. M., Bodoira, R., Maestri, D. M., Porporatto, C., Cavaglieri, L. R., & Montenegro, M. A. (2020a). Polyphenols of peanut (Arachis hypogaea L.) skin as bioprotectors of normal cells. Studies of cytotoxicity, cytoprotection and interaction with ROS. Journal of Functional Foods, 67(February), 103862. https://doi.org/10.1016/j.jff.2020.103862

Rossi, Y. E., Bohl, L. P., Vanden Braber, N. L., Ballatore, M. B., Escobar, F. M., Bodoira, R., Maestri, D. M., Porporatto, C., Cavaglieri, L. R., & Montenegro, M. A. (2020b). Polyphenols of peanut (Arachis hypogaea L.) skin as bioprotectors of normal cells. Studies of cytotoxicity, cytoprotection and interaction with ROS. Journal of Functional Foods, 67, 103862. https://doi.org/10.1016/j.jff.2020.103862

Salem, M. Z. M., El-Hefny, M., Ali, H. M., Elansary, H. O., Nasser, R. A., El-Settawy, A. A. A., El Shanhorey, N., Ashmawy, N. A., & Salem, A. Z. M. (2018a). Antibacterial activity of extracted bioactive molecules of Schinus terebinthifolius ripened fruits against some pathogenic bacteria. Microbial Pathogenesis, 120, 119–127. https://doi.org/10.1016/j.micpath.2018.04.040

Salem, M. Z. M., El-Hefny, M., Ali, H. M., Elansary, H. O., Nasser, R. A., El-Settawy, A. A. A., El Shanhorey, N., Ashmawy, N. A., & Salem, A. Z. M. (2018b). Antibacterial activity of extracted bioactive molecules of Schinus terebinthifolius ripened fruits against some pathogenic bacteria. Microbial Pathogenesis, 120, 119–127. https://doi.org/10.1016/j.micpath.2018.04.040

Santos, V. S. dos, Nascimento, T. V., Felipe, J. L., Boaretto, A. G., Damasceno-Junior, G. A., Silva, D. B., Toffoli-Kadri, M. C., & Carollo, C. A. (2017). Nutraceutical potential of Byrsonima cydoniifolia fruits based on chemical composition, anti-inflammatory, and antihyperalgesic activities. Food Chemistry, 237, 240–246. https://doi.org/10.1016/j.foodchem.2017.05.082

Santos, I. B. da S., Santos dos Santos, B., Oliveira, J. R. S. de, Costa, W. K., Zagmignan, A., da Silva, L. C. N., Ferreira, M. R. A., Lermen, V. L., Lermen, M. S. B. de S., da Silva, A. G., Ximenes, R. M., Soares, L. A. L., Paiva, P. M. G., Lima, V. L. de M., Correia, M. T. dos S., & da Silva, M. V. (2020). Antioxidant Action and In Vivo Anti-Inflammatory and Antinociceptive Activities of Myrciaria floribunda Fruit Peels: Possible Involvement of Opioidergic System . Advances in Pharmacological and Pharmaceutical Sciences, 2020, 1–11. https://doi.org/10.1155/2020/1258707

Santos, J. M., Cury, N. M., Yunes, J. A., López, J. A., & Hernández-Macedo, M. L. (2019). Effect of Anacardium occidentale leaf extract on human acute lymphoblastic leukaemia cell lines. Natural Product Research, 33(11), 1633–1636. https://doi.org/10.1080/14786419.2018.1425841

Santos, U. P., Campos, J. F., Torquato, H. F. V., Paredes-Gamero, E. J., Carollo, C. A., Estevinho, L. M., de Picoli Souza, K., & dos Santos, E. L. (2016). Antioxidant, Antimicrobial and Cytotoxic Properties as Well as the Phenolic Content of the Extract from Hancornia speciosa Gomes. PLOS ONE, 11(12), e0167531. https://doi.org/10.1371/journal.pone.0167531

Santos, U. P., Campos, J. F., Torquato, H. F. V., Paredes-Gamero, E. J., Carollo, C. A., Estevinho, L. M., De Picoli Souza, K., & Dos Santos, E. L. (2016). Antioxidant, antimicrobial and cytotoxic properties as well as the phenolic content of the extract from Hancornia speciosa gomes. PLoS ONE, 11(12). https://doi.org/10.1371/journal.pone.0167531

Seyyedebrahimi, S. S., Khodabandehloo, H., Nasli Esfahani, E., & Meshkani, R. (2018). The effects of resveratrol on markers of oxidative stress in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled clinical trial. Acta Diabetologica, 55(4), 341–353. https://doi.org/10.1007/s00592-017-1098-3

Sharma, A., Shahzad, B., Rehman, A., Bhardwaj, R., Landi, M., & Zheng, B. (2019). Response of phenylpropanoid pathway and the role of polyphenols in plants under abiotic stress. In Molecules (24(13), 2452). MDPI AG. https://doi.org/10.3390/molecules24132452

Siebra, A. L. A., Oliveira, L. R., Martins, A. O. B. P. B., Siebra, D. C., Albuquerque, R. S., Lemos, I. C. S., Delmondes, G. A., Tintino, S. R., Figueredo, F. G., da Costa, J. G. M., Coutinho, H. D. M., Menezes, I. R. A., Felipe, C. F. B., & Kerntopf, M. R. (2018). Potentiation of antibiotic activity by Passiflora cincinnata Mast. front of strains Staphylococcus aureus and Escherichia coli. Saudi Journal of Biological Sciences, 25(1), 37–43. https://doi.org/10.1016/j.sjbs.2016.01.019

Sile, I., Romane, E., Reinsone, S., Maurina, B., Tirzite, D., & Dambrova, M. (2020). Data on medicinal plants in the records of Latvian folk medicine from the 19th century. Data in Brief, 28, 105024. https://doi.org/10.1016/j.dib.2019.105024

Silva, C. P. da, Soares-Freitas, R. A. M., Sampaio, G. R., Santos, M. C. B., do Nascimento, T. P., Cameron, L. C., Ferreira, M. S. L., & Arêas, J. A. G. (2019). Identification and action of phenolic compounds of Jatobá-do-cerrado (Hymenaea stignocarpa Mart.) on α-amylase and α-glucosidase activities and flour effect on glycemic response and nutritional quality of breads. Food Research International, 116, 1076–1083. https://doi.org/10.1016/j.foodres.2018.09.050

Silva, M. V. da, Pandorfi, H., Lopes, P. M. O., Silva, J. L. B. da, de Almeida, G. L. P., Silva, D. A. de O., Santos, A. dos, Rodrigues, J. A. de M., Batista, P. H. D., & Jardim, A. M. da R. F. (2020). Pilot monitoring of caatinga spatial-temporal dynamics through the action of agriculture and livestock in the brazilian semiarid. Remote Sensing Applications: Society and Environment, 19, 100353. https://doi.org/10.1016/j.rsase.2020.100353

Silva, V. A. O., Rosa, M. N., Miranda-Gonçalves, V., Costa, A. M., Tansini, A., Evangelista, A. F., Martinho, O., Carloni, A. C., Jones, C., Lima, J. P., Pianowski, L. F., & Reis, R. M. (2019). Euphol, a tetracyclic triterpene, from Euphorbia tirucalli induces autophagy and sensitizes temozolomide cytotoxicity on glioblastoma cells. Investigational New Drugs, 37(2), 223–237. https://doi.org/10.1007/s10637-018-0620-y

Simpson, D. S. A., & Oliver, P. L. (2020). Ros generation in microglia: Understanding oxidative stress and inflammation in neurodegenerative disease. Antioxidants, 9(8), 1–27. https://doi.org/10.3390/antiox9080743

Soares, J. C., Rosalen, P. L., Lazarini, J. G., Massarioli, A. P., da Silva, C. F., Nani, B. D., Franchin, M., & de Alencar, S. M. (2019). Comprehensive characterization of bioactive phenols from new Brazilian superfruits by LC-ESI-QTOF-MS, and their ROS and RNS scavenging effects and anti-inflammatory activity. Food Chemistry, 281, 178–188. https://doi.org/10.1016/j.foodchem.2018.12.106

Souza dos Santos, B., Bezerra Filho, C. M., Alves do Nascimento Junior, J. A., Brust, F. R., Bezerra-Silva, P. C., Lino da Rocha, S. K., Krogfelt, K. A., Maria do Amaral Ferraz Navarro, D., Tereza dos Santos Correia, M., Napoleão, T. H., Nascimento da Silva, L. C., Macedo, A. J., Vanusa da Silva, M., & Guedes Paiva, P. M. (2019). Anti-staphylococcal activity of Syagrus coronata essential oil: Biofilm eradication and in vivo action on Galleria mellonela infection model. Microbial Pathogenesis, 131, 150–157. https://doi.org/10.1016/j.micpath.2019.04.009

Souza Filho, M. D., Medeiros, J. V. R., Vasconcelos, D. F. P., Silva, D. A., Leódido, A. C. M., Fernandes, H. F., Silva, F. R. P., França, L. F. C., Lenardo, D., & Pinto, G. R. (2018a). Orabase formulation with cashew gum polysaccharide decreases inflammatory and bone loss hallmarks in experimental periodontitis. International Journal of Biological Macromolecules, 107(PartA), 1093–1101. https://doi.org/10.1016/j.ijbiomac.2017.09.087

Souza Filho, M. D., Medeiros, J. V. R., Vasconcelos, D. F. P., Silva, D. A., Leódido, A. C. M., Fernandes, H. F., Silva, F. R. P., França, L. F. C., Lenardo, D., & Pinto, G. R. (2018b). Orabase formulation with cashew gum polysaccharide decreases inflammatory and bone loss hallmarks in experimental periodontitis. International Journal of Biological Macromolecules, 107(PartA), 1093–1101. https://doi.org/10.1016/j.ijbiomac.2017.09.087

Sunderam, V., Thiyagarajan, D., Lawrence, A. V., Mohammed, S. S. S., & Selvaraj, A. (2019). In-vitro antimicrobial and anticancer properties of green synthesized gold nanoparticles using Anacardium occidentale leaves extract. Saudi Journal of Biological Sciences, 26(3), 455–459. https://doi.org/10.1016/j.sjbs.2018.12.001

Taiwo, B. J., Fatokun, A. A., Olubiyi, O. O., Bamigboye-Taiwo, O. T., van Heerden, F. R., & Wright, C. W. (2017). Identification of compounds with cytotoxic activity from the leaf of the Nigerian medicinal plant, Anacardium occidentale L. (Anacardiaceae). Bioorganic and Medicinal Chemistry, 25(8), 2327–2335. https://doi.org/10.1016/j.bmc.2017.02.040

Teixeira, É. W., Message, D., Negri, G., Salatino, A., & Stringheta, P. C. (2010). Seasonal Variation, Chemical Composition and Antioxidant Activity of Brazilian Propolis Samples. Evidence-Based Complementary and Alternative Medicine, 7(3), 307–315. https://doi.org/10.1093/ecam/nem177

Thomas, P., Essien, E., Ntuk, S., & Choudhary, M. (2017). Eryngium foetidum L. Essential Oils: Chemical Composition and Antioxidant Capacity. Medicines, 4(2), 24. https://doi.org/10.3390/medicines4020024

Thomaz, D. V., Peixoto, L. F., de Oliveira, T. S., Fajemiroye, J. O., da Silva Neri, H. F., Xavier, C. H., Costa, E. A., Alcantara dos Santos, F. C., de Souza Gil, E., & Ghedini, P. C. (2018a). Antioxidant and neuroprotective properties of Eugenia dysenterica leaves. Oxidative Medicine and Cellular Longevity, 2018. https://doi.org/10.1155/2018/8601028

Thomaz, D. V., Peixoto, L. F., de Oliveira, T. S., Fajemiroye, J. O., da Silva Neri, H. F., Xavier, C. H., Costa, E. A., Alcantara dos Santos, F. C., de Souza Gil, E., & Ghedini, P. C. (2018b). Antioxidant and neuroprotective properties of Eugenia dysenterica leaves. Oxidative Medicine and Cellular Longevity, 2018. https://doi.org/10.1155/2018/8601028

Tietbohl, L. A. C., Oliveira, A. P., Esteves, R. S., Albuquerque, R. D. D. G., Folly, D., Machado, F. P., Corrêa, A. L., Santos, M. G., Ruiz, A. L. G., & Rocha, L. (2017). Antiproliferative activity in tumor cell lines, antioxidant capacity and total phenolic, flavonoid and tannin contents of Myrciaria floribunda. Anais Da Academia Brasileira de Ciencias, 89(2), 1111–1120. https://doi.org/10.1590/0001-3765201720160461

Todirascu-Ciornea, E., El-Nashar, H. A. S., Mostafa, N. M., Eldahshan, O. A., Boiangiu, R. S., Dumitru, G., Hritcu, L., & Singab, A. N. B. (2019). Schinus terebinthifolius Essential Oil Attenuates Scopolamine-Induced Memory Deficits via Cholinergic Modulation and Antioxidant Properties in a Zebrafish Model. Evidence-Based Complementary and Alternative Medicine, 2019. https://doi.org/10.1155/2019/5256781

Torres-Rêgo, M., Furtado, A. A., Bitencourt, M. A. O., Lima, M. C. J. de S., Andrade, R. C. L. C. de, Azevedo, E. P. de, Soares, T. da C., Tomaz, J. C., Lopes, N. P., da Silva-Júnior, A. A., Zucolotto, S. M., & Fernandes-Pedrosa, M. de F. (2016a). Anti-inflammatory activity of aqueous extract and bioactive compounds identified from the fruits of Hancornia speciosa Gomes (Apocynaceae). BMC Complementary and Alternative Medicine, 16(1), 1–10. https://doi.org/10.1186/s12906-016-1259-x

Torres-Rêgo, M., Furtado, A. A., Bitencourt, M. A. O., Lima, M. C. J. de S., Andrade, R. C. L. C. de, Azevedo, E. P. de, Soares, T. da C., Tomaz, J. C., Lopes, N. P., da Silva-Júnior, A. A., Zucolotto, S. M., & Fernandes-Pedrosa, M. de F. (2016b). Anti-inflammatory activity of aqueous extract and bioactive compounds identified from the fruits of Hancornia speciosa Gomes (Apocynaceae). BMC Complementary and Alternative Medicine, 16(1), 1–10. https://doi.org/10.1186/s12906-016-1259-x

Treuter, E., Fan, R., Huang, Z., Jakobsson, T., & Venteclef, N. (2017). Transcriptional repression in macrophages—basic mechanisms and alterations in metabolic inflammatory diseases. FEBS Letters, 591(19), 2959–2977. https://doi.org/10.1002/1873-3468.12850

Velagapudi, R., Ajileye, O. O., Okorji, U., Jain, P., Aderogba, M. A., & Olajide, O. A. (2018a). Agathisflavone isolated from Anacardium occidentale suppresses SIRT1-mediated neuroinflammation in BV2 microglia and neurotoxicity in APPSwe-transfected SH-SY5Y cells. Phytotherapy Research, 32(10), 1957–1966. https://doi.org/10.1002/ptr.6122

Velagapudi, R., Ajileye, O. O., Okorji, U., Jain, P., Aderogba, M. A., & Olajide, O. A. (2018b). Agathisflavone isolated from Anacardium occidentale suppresses SIRT1-mediated neuroinflammation in BV2 microglia and neurotoxicity in APPSwe-transfected SH-SY5Y cells. Phytotherapy Research, 32(10), 1957–1966. https://doi.org/10.1002/ptr.6122

Yang, L., Yang, C., Li, C., Zhao, Q., Liu, L., Fang, X., & Chen, X. Y. (2016). Recent advances in biosynthesis of bioactive compounds in traditional Chinese medicinal plants. In Science Bulletin (Vol. 61, Issue 1, pp. 3–17). Science in China Press. https://doi.org/10.1007/s11434-015-0929-2

Zhang, T., Jiang, J., Liu, J., Xu, L., Duan, S., Sun, L., Zhao, W., & Qian, F. (2020). MK2 Is Required for Neutrophil-Derived ROS Production and Inflammatory Bowel Disease. Frontiers in Medicine, 7. https://doi.org/10.3389/fmed.2020.00207

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16/08/2022

Como Citar

DINIZ, K. . M. .; SANTOS, M. M. D. dos .; BARBOSA, J. M. de L. .; BORGES, Y. W. B. .; SILVA, W. M. do N. .; VERAS, B. de O. .; SILVA, M. V. da .; CORREIA, M. T. dos S. Caatinga: celeiro de antioxidantes e bioativos nutracêuticos . Research, Society and Development, [S. l.], v. 11, n. 11, p. e100111133442, 2022. DOI: 10.33448/rsd-v11i11.33442. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/33442. Acesso em: 21 nov. 2024.

Edição

v. 11 n. 11

Seção

Artigos de Revisão

Licença

Copyright (c) 2022 Katharina Marques Diniz; Milena Maia Dantas dos Santos; Julyanne Maria de Lima Barbosa; Yan Wagner Brandão Borges; Wilka Maria do Nascimento Silva; Bruno de Oliveira Veras; Márcia Vanusa da Silva; Maria Tereza dos Santo Correia

Creative Commons License
Este trabalho está licenciado sob uma licença Creative Commons Attribution 4.0 International License.

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