Molecular Docking of Zingerone and Gamma-Mangostin to Inhibit MAO-B and Catechol-O-Methyltransferase (COMT) in the Treatment of Parkinson’s Disease

Aratã Andrande  Saraiva; João Paulo Oliveira da  Silva; José Vigno Moura  Sousa; Ayrton de Sá  Brandim

doi:10.33448/rsd-v11i16.37853

Autores

Aratã Andrande Saraiva Federal Institute of Education, Science and Technology of Piauí https://orcid.org/0000-0002-3960-697X
João Paulo Oliveira da Silva Faculty of Technology of Piauí https://orcid.org/0000-0003-1984-0264
José Vigno Moura Sousa State University of Piauí https://orcid.org/0000-0002-5164-360X
Ayrton de Sá Brandim Federal Institute of Education, Science and Technology of Piauí https://orcid.org/0000-0003-0626-6152

DOI:

https://doi.org/10.33448/rsd-v11i16.37853

Palavras-chave:

Parkinson; Zingerone; Gamma-Mangostin; Catecol-O-Metiltransferase.

Resumo

Atualmente, não existe nenhum medicamento que tenha propriedades neuroprotetoras comprovadas na doença de Parkinson. O medicamento mais conhecido é a levedopa que atua como inibidores nas enzimas MAO-B e COMT envolvidas na degradação da dopamina. Apesar da levodopa ser o "padrão ouro" no tratamento, à medida que a doença progride, a maioria dos pacientes desenvolvem complicações da terapia e efeitos colaterais. Neste sentido, é abordado a junção de duas substâncias abundantes e fitoterápicos como alternativas ao uso dos medicamentos tradicionais que é o Zingerone e o Gamma-Mangostin. Nos quais apresentaram resultados favoráveis na docagem molecular.

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Docagem Molecular de Zingerone e Gamma-Mangostin para Inibir MAO-B e Catecol-O-Metiltransferase (COMT) no Tratamento da Doença de Parkinson

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