Feline squamous cell carcinoma: case report

Authors

DOI:

https://doi.org/10.33448/rsd-v12i4.40881

Keywords:

Cats; Dermatology; Cancer; Imiquimod.

Abstract

Squamous cell carcinoma is a malignant neoplasm that is characterized by invasiveness and a low rate of metastases. It is commonly observed in fair-skinned cats with low hair density and is characterized by edema, ulceration with the presence of granulation tissue and hematic crusts. The diagnosis may require extensive knowledge from the veterinarian, who needs to carry out a differential investigation for other diseases. There are some therapeutic protocols, the effectiveness of which still depends on the extent and evolution of the lesions. In several cases, controlling exposure to perpetuating factors appears to slow disease progression. The objective of the present study was to report a case of squamous cell carcinoma in a feline patient, female, with no racial definition and approximately three years old, treated at a private veterinary dermatology service in the east zone of the city of São Paulo. The patient had ulceration in the cephalic region, with the presence of serosanguinous secretion, hematic crusts, with areas of tissue necrosis and granulation tissue on the lateral face of the left ear and nasal plane. The presumptive diagnosis was made by cytological examination and was confirmed by anatomopathology. The following procedures were adopted: surgery to remove the left auricle and instituted Imiquimod. After 30 days, the patient presented total remission of the lesions, without any recurrence so far. The tutor was instructed to keep the patient under surveillance and that she was not exposed to solar radiation.

Author Biography

Henri Donnarumma Levy Bentubo, Médico Veterinário Autônomo; Universidade Paulista; Universidade do Vale do Paraíba

Self-employed Veterinary Doctor specializing in veterinary dermatology with 17 years of experience. He participated in the Microbiology Teaching Improvement Program (PAE) at the University of São Paulo (USP). Master in Biological Sciences (concentration area: Microbiology) from the Institute of Biomedical Sciences of the University of São Paulo (ICB-USP) and PhD in Sciences (concentration area: Microbiology and Immunology) from the Federal University of São Paulo/Paulista School of Medicine (UNIFESP/EPM). With experience in undergraduate academic routines, he has 14 years of teaching experience, having developed work in basic and professional disciplines in various courses in the health area. He is currently a Full Professor at Universidade Paulista (UNIP), Professor at the University of Vale do Paraíba (UNIVAP) and Career Mentor for undergraduate and graduate students (latu-sensu). Training focused on Preventive Veterinary Medicine and Animal Health provides consistent research into the epidemiological and clinical aspects of the host-parasite relationship in the various dermatopathic diseases in animals, with an emphasis on mycoses and zoonoses of public health importance. Has organizational and administrative skills, with ease of communication and assertiveness. Works in the areas of people development/professional training; microbiology/general immunology and applied to the infectology of small and large animals, as well as wild animals; veterinary and comparative dermatology. He is a researcher at the Research Group in Clinical and Infectious Diseases (CNPq) at Universidade Paulista. Member of the SBDV (Brazilian Society of Veterinary Dermatology) and of the SLDV (Latin American Society of Veterinary Dermatology).

References

Silva, C. E. D., & Galera, P. D. (2008). Carcinoma das células escamosas multicêntrico em cão. Rev. Bras. Saúde Prod. An, 9(1), 103-108.

Cochi, I. C. (2016). Relato de caso: Utilização de eletroquimioterapia como tratamento do carcinoma de células escamosas em felinos. Monografia (Especialização no Curso de Pós-Graduação em Clínica Médica de Felinos)–Fundação Educacional Jayme de Altavila, 24.

Castro, V. S. P., Doyle, R. L., Pinho, R. M., Sprandel, L., Mann, T. R., Dornelles, G. L., ... & Mazzanti, C. M. (2013). Métodos de coleta e a qualidade do esfregaço no exame citopatológico. MEDVEP Derm., 64-72.

Crystal, M. A. (2004). Carcinoma Escamocelular Cutâneo. NORSWORTH, GD; CRYSTAL, MA; GRACE, SF; TILLEY, LP O Paciente Felino: Tópicos Essenciais de Diagnóstico e Tratamento, 2, 532-526.

Daleck, C. R., & De Nardi, A. B. (2016). Oncologia em cães e gatos . Grupo Gen-Editora Roca Ltda.

De Giorgi, V., Salvini, C., Chiarugi, A., Paglierani, M., Maio, V., Nicoletti, P., ... & Massi, D. (2009). In vivo characterization of the inflammatory infiltrate and apoptotic status in imiquimod‐treated basal cell carcinoma. International journal of dermatology, 48(3), 312-321.

Dos Santos, N. N., Pereira, L. B. D. S. B., da Fonseca Filho, L. B., de Carvalho, A. J., Pontes, M. B., Bessa, A. L. N. G., ... & de Souza, W. M. A. (2018). Carcinoma de células escamosas em felino: relato de caso. Pubvet, 12, 138.

Ferreira, I., Rahal, S. C., Ferreira, J., & Corrêa, T. P. (2006). Terapêutica no carcinoma de células escamosas cutâneo em gatos. Ciência Rural, 36, 1027-1033.

Goldschmidt, M. H., & Goldschmidt, K. H. (2016). Epithelial and melanocytic tumors of the skin. Tumors in domestic animals, 88-141.

Gross, T. L., Ihrke, P. J., Walder, E. J., & Affolter, V. K. (2008). Skin diseases of the dog and cat: clinical and histopathologic diagnosis. John Wiley & Sons.

Guedes, A. G. P., Shmitt, I., & Pippi, N. L. (1998). Dermatite solar felina associada a carcinoma epidermóide. Ciência Rural, 28, 707-713.

Hirahata, M. (2018). Neoplasias no conduto auditivo de felinos: estudo retrospectivo.

Huppes, R. R., de Nardi, A. B., Uscategui, R. A. R., Pazzini, J. M., & Castro, J. L. C. (2014). Nosectomia em felinos portadores de carcinoma espinocelular-Relato de sete casos. Semina: Ciências Agrárias, 35(2), 919-925.

Ettinger, S. J., & Feldman, E. C. (2004). Tratado de medicina interna veterinária: doenças do cão e do gato.

Layne, E. A., & Graham, M. (2016). Cutaneous squamous cell carcinoma manifesting as follicular isthmus cysts in a cat. Journal of Feline Medicine and Surgery Open Reports, 2(1), 2055116915625356.

Maiolino, P., Papparella, S., Restucci, B., & De Vico, G. (2001). Angiogenesis in squamous cell carcinomas of canine skin: an immunohistochemical and quantitative analysis. Journal of Comparative Pathology, 125(2-3), 117-121.

Marconato, L., Buchholz, J., Keller, M., Bettini, G., Valenti, P., & Kaser‐Hotz, B. (2013). Multimodal therapeutic approach and interdisciplinary challenge for the treatment of unresectable head and neck squamous cell carcinoma in six cats: a pilot study. Veterinary and comparative oncology, 11(2), 101-112.

Munday, J. S., Hardcastle, M., & Dally, N. (2022). In situ squamous cell carcinoma of the gingiva and nictitating membrane associated with Felis catus papillomavirus type 3 in a cat. Veterinary pathology, 59(3), 463–466.

Robbins, S. L., Cotran, R. S., Kumar, V., & Collins, T. (2001). Fundamentos de Robbins: patologia estrutural e funcional. In Fundamentos de Robbins: patologia estrutural e funcional (pp. 766-766).

Otrubova, B. (2006). Treatment options for sunlight-induced squamous cell carcinoma in a cat.

Rocha, N. S. (2008). Exame citológico no diagnóstico de lesões da pele e subcutâneo. Clinica Veterinária, (76), 76-80.

Rodaski, S., & Piekarz, C. H. (2009). Epidemiologia e etiologia do câncer. Oncologia em Cães e Gatos. Roca, São Paulo, 1-21.

Rodríguez Guisado, F., Suárez-Bonnet, A., & Ramírez, G. A. (2021). Cutaneous Spindle Cell Squamous Cell Carcinoma in Cats: Clinical, Histological, and Immunohistochemical Study. Veterinary pathology, 58(3), 503–507.

Rosolem, M. C., Moroz, L. R., & Rodigheri, S. M. (2012). Carcinoma de células escamosas em cães e gatos: Revisão de literatura. Pubvet, 6, Art-1295.

Soltero-Rivera, M. M., Krick, E. L., Reiter, A. M., Brown, D. C., & Lewis, J. R. (2014). Prevalence of regional and distant metastasis in cats with advanced oral squamous cell carcinoma: 49 cases (2005–2011). Journal of feline medicine and surgery, 16(2), 164-169.

Spugnini, E. P., & Baldi, A. (2014). Electrochemotherapy in veterinary oncology: from rescue to first line therapy. Electroporation Protocols: Preclinical and Clinical Gene Medicine, 247-256.

Published

08/04/2023

How to Cite

OLIVEIRA, C. M. F. de .; BARRETO, L. F. G. .; MENDES, L. R. V. .; BENTUBO, H. D. L. Feline squamous cell carcinoma: case report. Research, Society and Development, [S. l.], v. 12, n. 4, p. e17312440881, 2023. DOI: 10.33448/rsd-v12i4.40881. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/40881. Acesso em: 24 apr. 2024.

Issue

Section

Agrarian and Biological Sciences