Imunologia do Diabetes Mellitus do tipo 1 e vias de glico-oxidação relacionadas a hiperglicemia
DOI:
https://doi.org/10.33448/rsd-v12i8.42986Palavras-chave:
Diabetes Mellitus Tipo 1; Estresse oxidativo; Predisposição genética.Resumo
O Diabetes Mellitus do tipo 1 (DM1) é uma doença autoimune com incidência prevalente na infância (aproximadamente 10 a 14 anos), mas que pode ser desenvolvida em qualquer faixa etária. O conhecimento sobre a fisiopatologia da DM1 é vasto, no entanto, artigos que abordem a reposta imune adaptativa desenvolvida contra autoantígenos e, as consequências oxidativas do excesso de glicose no organismo ainda são necessários. Nesta revisão de literatura o objetivo principal foi abordar as vias da imunidade inata e adaptativa ativadas durante o desenvolvimento do DM1 e, após o desenvolvimento da doença, as vias alternativas de glico-oxidação ativadas diante do excesso de glicose no organismo. Para isto foram utilizadas plataformas de busca como PubMed, Science Direct e Google Acadêmico. Através do conhecimento sobre estes dois processos, é possível que novos métodos de tratamento possam ser projetados. Os mecanismos envolvidos na formação de espécies reativas de oxigênio (EROs) podem ser uma ferramenta valiosa na busca por novos alvos terapêuticos que visam diminuir o risco de desenvolvimento de patologias secundarias ao DM1.
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