Ticagrelor no tratamento da síndrome coronariana aguda: Uma revisão integrativa
DOI:
https://doi.org/10.33448/rsd-v13i8.46579Palavras-chave:
Síndrome coronariana aguda; Infarto; Ticagrelor.Resumo
Introdução - A Síndrome Coronariana Aguda (SCA) representa um espectro de condições cardiovasculares agudas, abrangendo o Infarto Agudo do Miocárdio (IAM) e a Angina Instável (AI). Essa emergência médica é caracterizada pela interrupção do fluxo sanguíneo do músculo cardíaco, resultante de uma obstrução parcial ou completa da artéria coronária. O Ticagrelor é um agente antiplaquetário inibidor da P2Y12 notável pela sua potência e eficácia na redução de eventos cardiovasculares em pacientes com SCA. Objetivos - Este estudo visa compilar e avaliar as evidências atuais, destacando a eficácia e/ou superioridade do Ticagrelor em relação a outras abordagens terapêuticas. Métodos - Realizamos uma revisão integrativa da literatura especializada, seguindo etapas de identificação de objetivos, protocolo de planejamento e estratégias de busca nas plataformas EMBASE, Cochrane e MEDLINE. Foram incluídos trabalhos que abordassem o tratamento farmacológico da SCA, com foco no uso do Ticagrelor como principal recurso terapêutico comparado a outros inibidores da P2Y12. Após a seleção e extração de dados, foram analisados 09 estudos. Resultados - Os estudos comparando Ticagrelor com Clopidogrel ou Prasugrel em pacientes com SCA mostram resultados similares nos desfechos principais, indicando equivalência entre esses medicamentos. Porém, nuances nos desfechos secundários revelam que Ticagrelor supera Clopidogrel na redução de trombose de stent e morte cardiovascular, mas traz maior risco de sangramento, especialmente em pacientes idosos. Conclusão - O Ticagrelor apresenta eficácia semelhante ao Clopidogrel e ao Prasugrel em desfechos cardiovasculares cruciais. Entretanto, sua análise aprofundada revela um risco considerável de sangramento, especialmente em pacientes mais velhos.
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Copyright (c) 2024 Sophia Kelly Abreu de Castro; Dayson de Assis Pereira ; Eric Azara Oliveira ; Léo Pedro Rufino ; Lucas Ribeiro Bubula
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