Benefícios do uso do mel no tratamento do pé diabético: Scoping Review
DOI:
https://doi.org/10.33448/rsd-v9i7.4663Palavras-chave:
Benefícios; Mel; Tratamento e Pé diabéticoResumo
O pé diabético pode ser compreendido como destruição de tecidos moles, infecção ou ulceração associada a alterações neurológicas e vasculares nos membros inferiores de portadores de diabetes mellitus (DM). É também uma das mais graves, dispendiosas e devastadoras complicações da DM, sendo as úlceras nos pés precursoras, em 85% dos casos, da amputação do membro inferior. Assim, o mel surge como uma alternativa de tratamento, sendo barato, com pouco risco de resistência bacteriana e amplamente disponível, fatores imprescindíveis para a continuidade do tratamento pelos pacientes. Este artigo é uma Scoping Rewiew que pretende descrever as evidências de forma a elucidar os benefícios do mel no tratamento do pé diabético. A pesquisa engloba estudos primários, revisões, metanálises e/ou metassínteses, livros e guidelines, teses e dissertações, publicados em fontes indexadas ou na literatura cinzenta publicados nas bases de dados: Scielo, LILACS, Pubmed, The Cochrane Library, Web of Science, SCOPUS, CINAHL e Academic Search Premier, CAPS, Biblioteca Digital de Teses e Dissertações USP, Busca Integrada USP. Na literatura revisada, foram encontrados 33 diferentes benefícios descritos para o uso do mel. Dentre eles, destacam-se a maior taxa de cicatrização, propriedades antimicrobianas, anti-inflamatórias e desbridantes, entre outras. Portanto, os estudos analisados demonstraram uma grande variedade de benefícios, refletindo a complexidade de ação e a utilidade deste produto.
Referências
Abad, C., & Safdar, N. (2012). From ulcer to infection: An update on clinical practice and adjunctive treatments of diabetic foot ulcers. Current Infectious Disease Reports, 14(5), 540–550. https://doi.org/10.1007/s11908-012-0283-3
Alam, F., Islam, A., Gan, S. & Khalil, I. (2014). Honey: A Potential Therapeutic Agent for Managing Diabetic Wounds: a potential therapeutic agent for managing diabetic wounds. Evidence-based Complementary And Alternative Medicine, 2014(1), 1-16. Retrieved May 06, 2020, from https://www.ncbi.nlm.nih.gov/pubmed/25386217.
Andrade, L.L. de, Carvalho, G.C.P., Valentim, F.A.A.A, Siqueira, W.A., Melo, F.M.A.B. & Costa, M.M.L. (2019). Characteristics and treatment of diabetic foot ulcers in an ambulatory care. Revista Online de Pesquisa: Cuidado é fundamental, 11(1), 124-128.
Armstrong D.G., Boulton A.J.M. & Bus S.A. (2017). Diabetic Foot Ulcers and Their Recurrence. The New England Journal Of Medicine, 376, 2367-2375. Retrieved May 06, 2020, from https://www.ncbi.nlm.nih.gov/pubmed/28614678.
Astrada, A., Nakagami, G., Jais, S., & Sanada, H. (2019). Successful treatment of a diabetic foot ulcer with exposed bone using Trigona honey: A case study. Journal of Wound Care, 28(12), S4–S8. https://doi.org/10.12968/jowc.2019.28.Sup12.S4
Auguskani, J. (2018). A study to assess the chemical composition and antibacterial properties of honey. Biomedical Research, 19(29), 3584–3589.
Bakker, K., Apelqvist, J., Lipsky, B., Van Netten, J., & Schaper, N. (2016). The 2015 IWGDF guidance documents on prevention and management of foot problems in diabetes: development of an evidence-based global consensus. : development of an evidence-based global consensus. Diabetes/Metabolism Research And Reviews, 32, 2–6.
Barui, A., Banerjee, P., Chaudhary, A., Conjeti, S., Mondal, B., Dey, S., & Chatterjee, J. (2014). Evaluation of angiogenesis in diabetic lower limb wound healing using a natural medicine: A quantitative approach. Wound Medicine, 6, 26–33. https://doi.org/10.1016/j.wndm.2014.09.003
Bashir, U., Maqsood, R., & Shabbir, H. (2018). No Title. Pakistan Armed Forces, 1(68), 34–38.
Bishop, A. (2018). Using antimicrobial dressings to treat infected wounds. The Diabetic Foot Journal, 3(21), 168–171.
Block, A., & Wu, E. (2019). Topical Antimicrobial Use in Diabetic Wound Healing. The Diabetic Foot Journal, 73–80.
Boateng, J., & Catanzano, O. (2015). Advanced Therapeutic Dressings for Effective Wound Healing - A Review. Journal of Pharmaceutical Sciences, 104(11), 3653–3680. https://doi.org/10.1002/jps.24610
Bowler, P. G. & Duerden, B. I. & Armstrong, D. G. (2001). Wound Microbiology and Associated Approaches to Wound Management [Eletronic version]. Clinical Microbiology Reviews, 14(2), 244-269. Retrieved May 06, 2020, from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC88973/
Brasil, Ministério da Saúde (2016). Manual do pé diabético: estratégias para o cuidado da pessoa com doença crônica. Recuperado em 06 maio, 2020, de http://www.as.saude.ms.gov.br/wp-content/uploads/2016/06/manual_do_pe_diabetico.pdf.
Braun, L. R., Fisk, W. A., Lev-Tov, H., Kirsner, R. S., & Isseroff, R. R. (2014). Diabetic foot ulcer: An evidence-based treatment update. American Journal of Clinical Dermatology, 15(3), 267–281. https://doi.org/10.1007/s40257-014-0081-9
Cooper, R. (2007). Honey in wound care: antibacterial properties. GMS Krankenhaushygiene Interdisziplinar,2(2),Doc51.http://www.ncbi.nlm.nih.gov/pubmed/20204083%0Ahttp://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=PMC2831240
Delshad, E., Tavakkoli-Kakhki, M. & Motavasselian, M. (2016). Successful Repair of Diabetic Foot Ulcer with Honey-Based Treatment: a case report. Iranian Red Crescent Medical Journal, 19(3), 1-4. Retrieved May 06, 2020, from http://ircmj.com/articles/16926.html.
Diehr, S., Hamp, A., Jamieson, B., & Mendoza, M. (2007). Clinical inquiries. Do topical antibiotics improve wound healing? J. Fam. Pract., 56(2), 140–144. http://www.embase.com/search/results?subaction=viewrecord&from=export&id=L46306097%0AU2%0A-%0AL46306097
Eddy, J., & Gideonsen, M. (2005). Topical honey for diabetic foot ulcers. The Journal of Family Practice, 54(6), 533–536.
Eddy, J., Gideonsen, M., & Mack, P. (2008). Practical considerations of using topical honey for neuropathic diabetic foot ulcers: A review. Wisconsin Medical Journal, 107(4), 187–190.
Evers, L. (2011). The use of a new honey dressing on an infected diabetic foot ulcer. Wounds UK, 7(4), 128–130.
Grajales-Conesa, J., Ibarias-Toledo, C., Ruíz-Toledo, J., & Sánchez, D. (2018). Mieles de abejas sin aguijón en el tratamiento de úlceras de pie diabético. Salud Publica de Mexico, 60(1), 102–104. https://doi.org/10.21149/8604
Imran, M., Hussain, M., & Baig, M. (2015). A Randomized, Controlled Clinical Trial of Honey-Impregnated Dressing for Treating Diabetic Foot Ulcer. Journal Of The College Of Physicians And Surgeons Pakistan, 10(25), 721–725.
Jaffe L. & Wu S.C. (2019). Dressings, Topical Therapy, and Negative Pressure Wound Therapy. Clinics In Podiatric Medicine And Surgery, 36(3), 397-411. Retrieved May 06, 2020, from https://www.ncbi.nlm.nih.gov/pubmed/31079606.
Jan, W. A., Shah, H., Khan, M., Fayaz, M., & Ullah, N. (2012). Comparison of conventional pyodine dressing with honey dressing for the treatment of diabetic foot ulcers. Journal of Postgraduate Medical Institute, 26(4), 402–407.
Karimi, Z., Behnammoghadam, M., Rafiei, H., Abdi, N., Zoladl, M., Talebianpoor, M. S., Arya, A., & Khastavaneh, M. (2019). Impact of olive oil and honey on healing of diabetic foot: A randomized controlled trial. Clinical, Cosmetic and Investigational Dermatology, 12, 347–354. https://doi.org/10.2147/CCID.S198577
Kateel, R. et al. (2017). Antibacterial action of Tropical honey on various bacteria obtained from diabetic foot ulcer. Complementary Therapies In Clinical Practice, 29(32), 2–13.
Kateel, R., Adhikari, P., Augustine, A. J., & Ullal, S. (2016). Topical honey for the treatment of diabetic foot ulcer: A systematic review. Complementary Therapies in Clinical Practice, 24, 130–133. https://doi.org/10.1016/j.ctcp.2016.06.003
Kefani, P., Putra, I. & Roosseno, R. (2018). Honey clinically stimulates granulation and epithelialization in chronic wounds: a report of two cases. Medical Journal Of Indonesia, 27(1), 62-68. Retrieved May 06, 2020, from https://mji.ui.ac.id/journal/index.php/mji/article/view/1457.
Kolluru, G. K., Bir, S. C., & Kevil, C. G. (2012). Endothelial dysfunction and diabetes: effects on angiogenesis, vascular remodeling, and wound healing. International journal of vascular medicine, 2012.
Labban, L. (2014). Honey as a promising treatment for diabetic foot ulcers (DFU). JMS - Journal of Medical Society, 28(2), 64–68. https://doi.org/10.4103/0972-4958.141064
Leaper, D. J., Schultz, G., Carville, K., Fletcher, J., Swanson, T., & Drake, R. (2012). Extending the TIME concept: What have we learned in the past 10 years? International Wound Journal, 9(SUPPL. 2), 1–19. https://doi.org/10.1111/j.1742-481X.2012.01097.x
Lipsky, B. & Hoey, C. (2009). Topical Antimicrobial Therapy for Treating Chronic Wounds. Clinical Infectious Diseases, 49(10), 1541-1549. Retrieved May 06, 2020, from https://www.ncbi.nlm.nih.gov/pubmed/19842981.
Litwak L., Goh S.Y., Hussein Z., Malek R., Prusty V. & Khamseh M.E. (2013). Prevalence of Diabetes Complications in People With Type 2 Diabetes Mellitus and Its Association With Baseline Characteristics in the Multinational A1chieve Study. Diabetology & Metabolic Syndrome, 5(57), 1-10. Retrieved May 06, 2020, from https://www.ncbi.nlm.nih.gov/pubmed/24228724.
Makhdoom, A., et al. (2009). Management of diabetic foot by natural honey. Journal of Ayub Medical College, Abbottabad : JAMC, 21(1), 103–105.
Megallaa M.H., Ismail A.A., Zeitoun M.H. & Khalifa M.S. (2019). Association of diabetic foot ulcers with chronic vascular diabetic complications in patients with type 2 diabetes. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 13 (2), 1287-1292. Retrieved May 06, 2020, from https://www.ncbi.nlm.nih.gov/pubmed/31336479.
Moghazy, A. et al. (2010). The clinical and cost effectiveness of bee honey dressing in the treatment of diabetic foot ulcers. Diabetes Research and Clinical Practice, 89(3), 276–281.
Mohamed, H. (2016). No Title. Journal Of Diabetes And Related Disorders, 1(1), 1–7.
Mohamed, H., Lenjawi, B., Salma, M., & Abdi, S. (2014). Honey based therapy for the management of a recalcitrant diabetic foot ulcer. Journal of Tissue Viability, 23(1), 29–33.
Molan, P. C., & Betts, J. A. (2008). Using honey to heal diabetic foot ulcers. Advances in Skin & Wound Care, 21(7), 313–316. https://doi.org/10.1097/01.ASW.0000323523.38800.9f
Monteiro, H. (2016). Caracterização e Avaliação Psicossocial de Diabéticos Amputados do Concelho do Porto: estudo observacional. Dissertação de mestrado, Escola Nacional de Saúde Pública, Universidade Nova de Lisboa, Lisboa, Portuga 56
Moore, A., & Mcquay, H. (2005). Honey for ulcers. Pulse Clinical, 52–53.
Neville R.F., Kayssi A., Buescher T. & Stempel M.S. (2016). The Diabetic Foot. Current Problems In Surgery, 53(9), 408-437. Retrieved May 06, 2020, from https://www.ncbi.nlm.nih.gov/pubmed/27687301. 54
Nwabudike, L., & Maruhash, E. (2017). Patient education, self-care and medical grade honey: patient education, self-care and medical grade honey. : Patient education, self-care and medical grade honey. Wounds International, 4(8), 40–43.
Nyanchoka L., Tudur-Smith C., Thu V.N., Iversen V., Tricco A.C., & Porcher R. (2019). A scoping review describes methods used to identify, prioritize and display gaps in health research. Journal Of Clinical Epidemiology, 109, 99-110. Retrieved May 06, 2020, from https://www.ncbi.nlm.nih.gov/pubmed/30708176.
Oduwole O., Meremikwu M.M., Oyo-Ita A., Udoh E.E. (2018). Honey for acute cough in children. Cochrane Database Of Systematic Reviews. 2014(4), 1-80. Retrieved May 06, 2020, from https://www.ncbi.nlm.nih.gov/pubmed/25536086. 58.
Oliveira, A.P. de; Oliveira, B.A. de; Sanches, C.C. (2016). O tratamento do pé diabético realizado pelo sistema único de saúde e a câmara: uma abordagem comparativa. Faculdade Paraense de Ensino, Belém, PA, Brasil.
ORRAPIN, S. & REKASEM, K. (2018). Role of Topical Biological Therapies and Dressings in Healing Ischemic Wounds. The International Journal Of Lower Extremity Wounds, 17(4), 236-246. Retrieved May 06, 2020, from https://journals.sagepub.com/doi/abs/10.1177/1534734618815360?journalCode=ijla.
Peters, M. D. J., Godfrey, C., Mcinerney, P., Baldini S.C., Khalil, H. & Parker, D. (2017). Chapter 11: Scoping Reviews. In: Aromataris, E.; Munn, Z. (Ed.). Joanna Briggs Institute Reviewer's Manual. The Joanna Briggs Institute (JBI), 2017. Retrieved May 06, 2020, from https://reviewersmanual.joannabriggs.org/.
Rahimnejad, M., Derakhshanfar, S., & Zhong, W. (2017). Biomaterials and tissue engineering for scar management in wound care. Burns & Trauma, 5, 1–9. https://doi.org/10.1186/s41038-017-0069-9
Reyes, A., González, T., Clavel, O., Tamayo, Y., & R. Y. (2017). Goodness of laser and honey, associated with Heberprot-P® in diabetic foot. Case presentation. Revista Médica Multimed, 5(21), 692–711.
Ritonga, H., & Daulay, M. (2018). Effectiveness of using sialang honey on wound bed preparation in diabetic foot ulcer. Journal of Tissue Viability, 29, 88–90.
Shukrimi, A., Sulaiman, A., Halim, A., & A. A. (2008). Comparative Study Between Honey and Povidone Iodine as Dressing Solution for Wagner Type II Diabetic Foot Ulcers. Medical Journal Of Malaysia, 63(1), 44–46.
Surahio, A., Khan, A., Farooq M., & Fatima, I. (2014). Role of honey in wound dressing in diabetic foot ulcer. Journal of Ayub Medical College Abbottabad, 26(3), 304–306.
Tchero, H., Kangambega, P., Fluieraru, S., Bekara, F., & Teot, L. (2019). Management of infected diabetic wound: A scoping review of guidelines [version 1; peer review: Awaiting peer review]. F1000Research, 8, 1–12.
Teobaldi, I., Stoico, V., Perrone, F., Bruti, M., Bonora, E., & Mantovani, A. (2018). Honey dressing on a leg ulcer with tendon exposure in a patient with type 2 diabetes. Endocrinology, Diabetes & Metabolism Case Reports, 2018(November). https://doi.org/10.1530/edm-18-0117
Tian, X., Yi, L. J., Ma, L., Zhang, L., Song, G. M., & Wang, Y. (2014). Effects of honey dressing for the treatment of DFUs: A systematic review. International Journal of Nursing Sciences, 1(2), 224–231. https://doi.org/10.1016/j.ijnss.2014.05.013
Trujillo, O., Catrillón, C., Giraldo, L., Guitiérrez, L., & Sepulveda, S. (2016). Venosas/From conventional to alternative ways in the management of venous ulcers. Revista Uruguaya de Enfermería, 2(11), 90–100.
Vandamme, L., Heyneman, A., Hoeksema, H., Verbelen, J., & Monstrey, S. (2013). Honey in modern wound care: A systematic review. Burns, 39(8), 1514–1525. https://doi.org/10.1016/j.burns.2013.06.014
W. J., Vileikyte, L., Boyko, E. J., Armstrong, D. G., & Boulton, A. J. (2018). Current challenges and opportunities in the prevention and management of diabetic foot ulcers. Diabetes care, 41(4), 645-652.
Wang, C., Guo, M., Zhang, N., & Wang, G. (2018). Effectiveness of honey dressing in the treatment of diabetic foot ulcers:: a systematic review and meta-analysis,. : A systematic review and meta-analysis. Complementary Therapies In Clinical Practice, 34, 123–131.
Weaving, L., & Walker, T. (2019). Accelerated healing: what can we do to achieve optimal healing times?. Diabetic Foot Journal, 22(4).
White, R. (2005). The benefits of honey in wound management [Eletronic version]. Nursing Standard, 20 (10), 57-64. Retrieved May 06, 2020, from https://web.a.ebscohost.com/abstract?direct=true&profile=ehost&scope=site&authtype=crawler&jrnl=00296570&AN=18944037&h=XOVgj5IuxO%2bW1trx1MBjaX277Vg%2fD8PQWBcEu2PC3Jo6tyaFVM1lYUN09KaPwxg%2bp3ID3%2fJXefs8R4sVPBcdWw%3d%3d&crl=c&resultNs=AdminWebAuth&resultLocal=ErrCrlNotAuth&crlhashurl=login.aspx%3fdirect%3dtrue%26profile%3dehost%26scope%3dsite%26authtype%3dcrawler%26jrnl%3d00296570%26AN%3d18944037
Wu, L., Norman, G., Dumville, JC., Meara, O., & Bell- syer, S. (2015). Dressings for treating foot ulcers in people with diabetes: an overview of systematic reviews. Dressings for Treating Foot Ulcers in People with Diabetes: An Overview of Systematic Reviews., 7, 1–69.
Yasdanpanah, L., Shahbazian, H., Nazari, I., Arti, H.R., Ahmadi, F., Mohammadianinejad, S.E., Cheraghian, B., Hesam, S. (2018). Incidence and Risk Factors of Diabetic Foot Ulcer: A Population-Based Diabetic Foot Cohort (ADFC Study)—Two-Year Follow-Up Study. International Journal of Endocrinology, 2018 (39), 1-9. Retrieved May 06, 2020, from https://www.ncbi.nlm.nih.gov/pubmed/29736169.
Zhang, X., Sun, D., & Jiang, G. C. (2019). Comparative efficacy of nine different dressings in healing diabetic foot ulcer: A Bayesian network analysis. Journal of Diabetes, 11(6), 418–426. https://doi.org/10.1111/1753-0407.12871
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