Prevalence of sexual dysfunction in patients with inflammatory bowel disease from a northeastern hospital in Brazil
DOI:
https://doi.org/10.33448/rsd-v14i6.49129Keywords:
Inflammatory Bowel Disease, Ulcerative Colitis, Hospitals, Crohn Disease, Prevalence.Abstract
Objective: To evaluate the prevalence of sexual dysfunction (SD) and the main associated factors in patients with inflammatory bowel disease (IBD) undergoing follow-up at the University Hospital of the Federal University of Sergipe. Methods: This is a cross-sectional study with 69 patients diagnosed with Crohn's Disease (CD) or Ulcerative Colitis (UC) of both sexes who have had previous sexual intercourse and are undergoing outpatient follow-up. Clinical and epidemiological aspects were evaluated and the Female Sexual Function Index and the International Index of Erectile Function were applied. The Student's t test was used for parametric analysis between continuous variables, and the Mann-Whitney test for non-parametric analysis. To verify the association between categorical variables, the chi-square test or, if necessary, Fisher's exact test was used. The BioEstat 5.0 software, with free distribution, was used, considering a statistical significance interval of 95%. Results: of the 69 patients, 39 (56.5%) were women, with a mean age of 38 ± 12.2 years. The overall prevalence of SD was 59.4%, with a predominance among women (82%). There was no difference in the mean scores between the phenotypes, and there was no correlation between age or time of diagnosis. A positive association was found between SD and the presence of seton (p = 0.032) among women. Conclusion: the prevalence of SD was high among patients with IBD assisted by the tertiary center, especially among women, being associated with the use of a seton in this group.
References
Akamine, C. T. & Yamamoto, R. K. (2009). Estudo dirigido: estatística descritiva. (3ed). Editora Érica.
Allocca, M., Gilardi, D., Fiorino, G., Furfaro, F., Peyrin-Biroulet, L., & Danese, S. (2018). Sexual and reproductive issues and inflammatory bowel disease: A neglected topic in men. European Journal of Gastroenterology and Hepatology, 30(3), 316–322.
Balestrieri, P., Ribolsi, M., Guarino, M. P. L., Emerenziani, S., Altomare, A., & Cicala, M. (2020). Nutritional aspects in inflammatory bowel diseases. Nutrients, 12(2), 388. https://pubmed.ncbi.nlm.nih.gov/32023881/
Bekman, O. R. & Costa Neto, P. L. O. (2009). Análise estatística da decisão. (2ed). Editora Edgar Blucher.
Bel, L. G. J., Vollebregt, A. M., Van der Meulen-de Jong, A. E., Fidder, H. H., Ten Hove, W. R., Vliet-Vlieland, C. W., et al. (2015). Sexual dysfunctions in men and women with inflammatory bowel disease: The influence of IBD-related clinical factors and depression on sexual function. The Journal of Sexual Medicine, 12(7), 1557–1567.
Domislovic, V., Brinar, M., Cukovic-Cavka, S., Turk, N., Mikolasevic, I., & Krznaric, Z. (2021). Prevalence, predictors and age-related sexual and erectile dysfunction in patients with inflammatory bowel disease: A tertiary centre experience. International Journal of Clinical Practice, 75(9), e14423.
Eluri, S., Cross, R. K., Martin, C., Weinfurt, K. P., Flynn, K. E., Long, M. D., et al. (2018). Inflammatory bowel diseases can adversely impact domains of sexual function such as satisfaction with sex life. Digestive Diseases and Sciences, 63(6), 1572–1582.
Irvine, E. J., Feagan, B., Rochon, J., Archambault, A., Fedorak, R. N., Groll, A., et al. (Canadian Crohn’s Relapse Prevention Trial Study Group). (1994). Quality of life: A valid and reliable measure of therapeutic efficacy in the treatment of inflammatory bowel disease. Gastroenterology, 106(2), 287–296. https://pubmed.ncbi.nlm.nih.gov/8299896/
Leenhardt, R., Rivière, P., Papazian, P., Nion-Larmurier, I., Girard, G., Laharie, D., & Marteau, P. (2019). Sexual health and fertility for individuals with inflammatory bowel disease. World journal of gastroenterology, 25(36), 5423–5433. https://doi.org/10.3748/wjg.v25.i36.5423
Marín, L., Mañosa, M., Garcia-Planella, E., Gordillo, J., Zabana, Y., Cabré, E., et al. (2013). Sexual function and patients’ perceptions in inflammatory bowel disease: A case-control survey. Journal of Gastroenterology, 48(6), 713–720.
Muller, K. R., Prosser, R., Bampton, P., Mountifield, R., & Andrews, J. M. (2010). Female gender and surgery impair relationships, body image, and sexuality in inflammatory bowel disease: Patient perceptions. Inflammatory Bowel Diseases, 16(4), 657–663.
Nøhr, E. A., Nielsen, J., Nørgård, B. M., & Friedman, S. (2020). Sexual health in women with inflammatory bowel disease in the Danish National Birth Cohort. Journal of Crohn's and Colitis, 14(8), 1082–1089.
Pereira A. S. et al. (2018). Metodologia da pesquisa científica. [free e-book]. Editora da UAB/NTE/UFSM.
Rivière, P., Zallot, C., Desobry, P., Sabaté, J. M., Vergniol, J., Zerbib, F., et al. (2017). Frequency of and factors associated with sexual dysfunction in patients with inflammatory bowel disease. Journal of Crohn's and Colitis, 11(11), 1347–1352.
Rooy, E. C., Toner, B. B., Maunder, R. G., Greenberg, G. R., Baron, D., Steinhart, A. H., et al. (2001). Concerns of patients with inflammatory bowel disease: Results from a clinical population. The American Journal of Gastroenterology, 96(6), 1816–1821. https://pubmed.ncbi.nlm.nih.gov/11419835/
Roseira, J., Magro, F., Fernandes, S., Simões, C., Portela, F., Vieira, A. I., et al. (2020). Sexual quality of life in inflammatory bowel disease: A multicenter, national-level study. Inflammatory Bowel Diseases, 26(5), 746–755.
Rosen, R. C., Riley, A., Wagner, G., Osterloh, I. H., Kirkpatrick, J., & Mishra, A. (1997). The international index of erectile function (IIEF): A multidimensional scale for assessment of erectile dysfunction. Urology, 49(6), 822–830. http://www.goldjournal.net/article/S0090429597002380/fulltext
Sanders, J. N., Gawron, L. M., & Friedman, S. (2016). Sexual satisfaction and inflammatory bowel diseases: An interdisciplinary clinical challenge. American Journal of Obstetrics and Gynecology, 215(1), 58–62.
Shitsuka et al. (2014). Matemática fundamental para a tecnologia. Editora Érica.
Shmidt, E., Suárez-Fariñas, M., Mallette, M., Moniz, H., Bright, R., Shah, S. A., et al. (2019). Erectile dysfunction is highly prevalent in men with newly diagnosed inflammatory bowel disease. Inflammatory Bowel Diseases, 25(8), 1408–1416. https://academic.oup.com/ibdjournal/article/25/8/1408/5376643
Silva, P. S., O’Toole, A., Marc, L. G., Ulysse, C. A., Testa, M. A., Julsgaard, M., et al. (2018). Development of a sexual dysfunction scale for women with inflammatory bowel disease. Inflammatory Bowel Diseases, 24(11), 2350–2359.
Silverberg, M. S., Satsangi, J., Ahmad, T., Arnott, I. D. R., Bernstein, C. N., Brant, S. R., et al. (2005). Toward an integrated clinical, molecular and serological classification of inflammatory bowel disease: Report of a Working Party of the 2005 Montreal World Congress of Gastroenterology. Canadian Journal of Gastroenterology, 19(Suppl. A), 5A-36A.
Szydlarska, D., Jakubowska, A., & Rydzewska, G. (2019). Assessment of sexual dysfunction in patients with inflammatory bowel disease. Przeglad Gastroenterologiczny, 14(2), 104–108.
Timmer, A., Kemptner, D., Bauer, A., Takses, A., Ott, C., & Fürst, A. (2008). Determinants of female sexual function in inflammatory bowel disease: A survey based cross-sectional analysis. BMC Gastroenterology, 8, Article 45. https://bmcgastroenterol.biomedcentral.com/articles/10.1186/1471-230X-8-45
Wiegel, M., Meston, C., & Rosen, R. (2005). The Female Sexual Function Index (FSFI): Cross-validation and development of clinical cutoff scores. Journal of Sex & Marital Therapy, 31(1), 1–20. https://doi.org/10.1080/00926230590475206
Wolpe, R. E., Zomkowski, K., Silva, F. P., Queiroz, A. P. A., & Sperandio, F. F. (2017). Prevalence of female sexual dysfunction in Brazil: A systematic review. European Journal of Obstetrics and Gynecology and Reproductive Biology, 211, 26–32.
Yanartas, O., Kani, H. T., Bicakci, E., Kilic, I., Banzragch, M., Acikel, C., et al. (2016). The effects of psychiatric treatment on depression, anxiety, quality of life, and sexual dysfunction in patients with inflammatory bowel disease. Neuropsychiatric Disease and Treatment, 12, 673–683.
Zhang, J., Wei, S., Zeng, Q., Wu, X., & Gan, H. (2021). Prevalence and risk factors of sexual dysfunction in patients with inflammatory bowel disease: Systematic review and meta-analysis. International Journal of Colorectal Disease, 36(9), 2027–2038. https://dx.doi.org/10.1007/s00384-021-03958-y
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Rafael Lisboa Prudente; Lucas Pires da Rocha; Ryan Fernando Menezes; José Vicente Neto; Ana Carolina Ribeiro Lisbôa

This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
