Diabetes mellitus in dogs and cats: A literature review
DOI:
https://doi.org/10.33448/rsd-v14i11.50176Keywords:
Ketoacidosis, Diagnosis, Hyperglycemia, Insulin.Abstract
Diabetes mellitus is a chronic and progressive endocrinopathy commonly observed in small animals, with a multifactorial etiology and diverse clinical manifestations. In dogs, the most prevalent form is type 1 diabetes, characterized by autoimmune destruction of pancreatic beta cells, whereas in cats type 2 diabetes predominates, associated with insulin resistance and often linked to obesity. The presente work aimed to carry out a literature review on diabetes mellitus in cats and dogs, adressing its clinical and pathophysiological forms, risk factors, clinical signs, diagnosis, treatment and complications based on recent scientific evidence. A literature review was conducted based on books and scientific articles published between 2007 and 2025, obtained from PubMed, Scopus, ScienceDirect, and Google Scholar, using inclusion criteria that ensured the relevance and up-to-date nature of the information. The studies indicate common clinical signs such as polyuria, polydipsia, polyphagia, and weight loss, as well as complications including cataracts in dogs, neuropathy in cats, and diabetic ketoacidosis. Diagnosis is based on the persistent presence of hyperglycemia and glycosuria, supported by laboratory tests. Treatment involves appropriate insulin therapy, individualized nutritional management, and effective home care. It is concluded that therapeutic success depends on early diagnosis, an understanding of species-specific pathophysiology, and the owner’s commitment to clinical follow-up and glycemic monitoring, promoting the animal’s quality of life.
References
Baldo, F., Canton, C., Testa, S., Swales, H., Drudi, I., Golinelli, S. & Fracassi, F. (2020). Comparison between a flash glucose monitoring system and a portable blood glucose meter for monitoring dogs with diabetes mellitus. Journal of Veterinary Internal Medicine, 34, 2296-2305.
Behrend, E., Holford, A., Lathan, P., Rucinsky, R. & Schulman, R. (2018). AAHA diabetes management guidelines for dogs and cats. Journal of the American Animal Hospital Association, 54, 1-19.
Besen, B. A. M. P., Boer, W. & Honore, P. M. (2021). Fluid management in diabetic ketoacidosis: new tricks for old dogs?. Intensive Care Medicine, 47(11), 1312-1314.
Bloom, C. A. & Rand, J. (2014). Feline diabetes mellitus: clinical use of long-acting glargine and detemir. Journal of Feline Medicine and Surgery, 16(3), 205-215.
Cook, A. K. & Behrend, E. (2025). SGLT2 inhibitor use in the management of feline diabetes mellitus. Journal of Veterinary Pharmacology and Therapeutics, 48(1), 19-30.
Cuddly, L.N., Hopper, K., Burkitt-Creedon, J. M. & Epstein, S.E. (2025). Retrospective evaluation of acid–base analysis in dogs and cats with diabetic ketosis (2017–2021): 96 cases. Journal of Veterinary Emergency & Critical Care, 1-8.
Cunha, D. G., Candido, N., Gabriela, L., Carvalho, M. F. & Silva, M. V. M. (2019). Diabetes mellitus em cães e a sua importância na medicina veterinária. Revista Saúde, 13(2).
Fall, T., Hedhammar, A., Fall, N., Ahlgren, K. M., Hamlim, H. H., Lindbald-Toh, K., Andersson, G. & Kampe, O. (2010). Diabetes mellitus in Elkhounds is associated with diestrus and pregnancy. Journal of Veterinary Internal Medicine, 24(2), 450-456.
Gilor, C. & Graves, T. K. (2016). Diabetes mellitus in cats: a pathophysiologic and clinical update. Journal of Veterinary Internal Medicine, 30(4), 927-940.
Gottlieb, S. & Rand, J. (2018). Managing feline diabetes: current perspectives. Veterinary Medicine: Research and Reports, 9, 33-42.
Jeon, Y., Bae, H. & Yu, D. (2023). A case of transient diabetes mellitus in a dog managed by ovariohysterectomy. Journal of Biomedical and Translational Research, Jinju, 24(3), 93-99.
Kwong, T. C., Chau, E. C. T., Mak, M.C.H., Choy, C.T., Chan, L.T., Pang, C. K., Zhou, J., Poon, P. H. C, Guan, Y., Tsui, S. K. W., Chan, S. W., Leung, G. P. H., Tai, W. C. S. & Kwan, Y. W. (2023). Characterization of the gut microbiome in healthy dogs and dogs with diabetes mellitus. Animals, 13(15), 2479.
Li, K., Xiao, X., Li, Y., Lu, S., Zi, J., Sun, X., Xu, J., Liu, H., Li, X., Song, T. & Cai, D.(2024). Insights into the interplay between gut microbiota and lipid metabolism in the obesity management of canines and felines. Journal of Animal Science and Biotechnology, 15(14).
Massitel, I. L., Viana, D. B., Toyoda, J. M. S., Ferrante, M., Mongelli, M. S., Murgas, L. D. S., Toma, H.S. & Rubim, F. (2020). A terapêutica do felino diabético: revisão. Pubvet, 14(3), 1-7.
Mesquita, G., Dalecio, L. S., Boaretto, M. A., Castro, M.E.D. & Longo, B. F. P. (2022). Diabetes mellitus em cães. Pubvet, 16(3), 1-8.
Mott, J., Gal, A., Tardo, A. M., Berg, A., Claude, R., Hoelmer, A., Mui, M. L., Arjoonsingh, A. & Gilor, C. (2025). Insulin degludec 100 U/mL for treatment of spontaneous diabetes mellitus in dogs. Journal of Veterinary Internal Medicine, 39(1), 17303.
Niessen, S. J. M., Kooistra, H. S., Forcada, Y., Bjornvad, C. R., Albrecth, B., Roessner, F., Herberich, E. & Kroh, C. (2024). Efficacy and safety of once daily oral administration of sodium-glucose cotransporter-2 inhibitor velagliflozin compared with twice daily insulin injection in diabetic cats. Journal of Veterinary Internal Medicine, 38(1), 2099-2119.
Öhlund, M., Egenvall, A., Fall,T., Hamlim, H.H., Rocklinsberg, H. & Holst, B. S. (2017). Environmental risk factors for diabetes mellitus in cats. Journal of Veterinary Internal Medicine, 31(1), 29-35.
Öhlund, M., Fall, T., Holst, H., Hamlim, H.H., Bonnett, B. & Egenvall, A. (2015). Incidence of diabetes mellitus in insured Swedish cats in relation to age, breed and sex. Journal of Veterinary Internal Medicine, 29(5), 1342-1347.
Oliveira, N. M. C., Almeida, P.T., Lima, B. M., Dinóla, L.A., Souza, A. N. A. & Santo, E. F. E. (2021). Estudo multicêntrico retrospectivo de diabetes mellitus em cães de Manaus, Amazonas (2016-2018). Brazilian Journal of Development, 7(1), 5055-5064.
O’Neill, D. G., Gostelow, R., Orme, C., Church, D. B., Niessen, S. J. M., Verheyen, K. & Brodbelt, D. C. (2016). Epidemiology of diabetes mellitus among 193,435 cats attending primary-care veterinary practices in England. Journal of Veterinary Internal Medicine, 30(4), 964-972.
Osto, M. & Lutz, T. (2015). Translational value of animal models of obesity - Focus on dogs and cats. European Journal of Pharmacology, 759, 240-252.
Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka , R. (2018). Metodologia da Pesquisa Científica. Santa Maria: Editora da UFMS.
Prahl, A. L., Guptill, L., Glickman, N. W., Tetrick, M. & Clickman, L. T. (2007). Feline diabetes mellitus: temporal trends in hospital prevalence and risk factors. Journal of Feline Medicine and Surgery, 9(5), 351-358.
Poppl, A. (2023). Canine diabetes mellitus: assessing risk factors to inform preventive measures. Veterinary Record, 192(10), 406-408.
Qadri, K., Ganguly, S., Praveen, P. K. & Wakchaure, R. (2015). Diabetes mellitus in dogs and its associated complications: a review. International Journal of Recent Biotechnology, 3(4), 18-22.
Reece, W. O. (Ed.) (2017). Dukes: fisiologia dos animais domésticos. (13ª ed.).
Rother, E. T. (s.d.). Revisão sistemática x revisão narrativa. Acta Paulista de Enfermagem. 20 (2), 5-6.
Rudloff, E. (2017). Diabetic ketoacidosis in the cat: recognition and essential treatment. Journal of Feline Medicine and Surgery, 19(11), 1167-1174.
Santo, P. N. E. & Zimmermann, A. C. (2025). Diabetes mellitus tipo 1 em cães e gatos: fisioetiopatologia, sinais clínicos e diagnóstico. Revista Científica Sophia, 17(1).
Schulz, L. A. P., Cescon, L. O., Talini, L. P. F. S. & Silveira, S. D. (2023). Aspectos clínicos e a evolução do diabetes mellitus em cão senil: relato de caso. Brazilian Journal of Development, 9(5), 18382-18398.
Shiel, R. E. & Mooney, C. T. (2022). Insulins for the long term management of diabetes mellitus in dogs: a review. Canine Medicine and Genetics, 9(1), 1-11.
Synder, H. (2019). Literature review as a research methodology: An overview and guidelines. Journal of Business Research. 104, 333-9.
Sparkes, A., Cannon, M., Church, D., Fleeman, L., Harvey, A., Hoening, M., Peterson, M. E., Reusch, C. E., Taylor, S. & Rosenberg, D. (2015). ISFM consensus guidelines on the practical management of diabetes mellitus in cats. Journal of Feline Medicine and Surgery, 17, 215-250.
Tardo, A. M., Fleeman, L.M., Fracassi, F., Berg, A.S., Guarino, A. L. & Gilor, C. (2024). A dose titration protocol for once-daily insulin glargine 300 U/mL for the treatment of diabetes mellitus in dogs. Journal of Veterinary Internal Medicine, 38(4), 2120-2128.
Thomovsky, E. (2017). Fluid and electrolyte therapy in diabetic ketoacidosis. Veterinary Clinics of North America: Small Animal Practice, 47(2), 491-503.
Vaitaitis, G., Webb, T., Webb, C., Sharkey, C., Sharkey, S., Waid, D. & Wagner, D. H. (2024). Canine diabetes mellitus demonstrates multiple markers of chronic inflammation including Th40 cell increases and elevated systemic-immune inflammation index, consistent with autoimmune dysregulation. Frontiers in Immunology, 14(1), 1-10.
Verbrugghe, A. & Hesta, M. (2017). Cats and carbohydrates: the carnivore fantasy?. Veterinary Sciences, 4(4), 55.
Waite, O., Gostelow, R., Wright, E., Jepson, R.E., Brodbelt, D.C. & O’Neill, D.G. (2025). Frequency, risk factors, and mortality for diabetes mellitus in 1,225,130 cats under primary veterinary care in the United Kingdom in 2019. Journal of Veterinary Internal Medicine, 39, 1-11.
Yun, T., Kim, H., Koo, Y., Chang, D., Kang, B. T. & Yang, M. P. (2021). Prednisolone-induced diabetes mellitus without pancreatic islet pathology in a dog. Journal of Biomedical and Translational Research, Cheongju, 22(1), 63-69.
Downloads
Published
Issue
Section
License
Copyright (c) 2025 Aguinaldo Francisco Mendes Junior, Nicoly Guimarães Amaral Cabral, Mariana Ribeiro Roboredo

This work is licensed under a Creative Commons Attribution 4.0 International License.
Authors who publish with this journal agree to the following terms:
1) Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal.
2) Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
3) Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work.
