Facial aging and the use of hyaluronic acid
DOI:
https://doi.org/10.33448/rsd-v14i12.50261Keywords:
Facial aesthetics, Rejuvenation, Dermal filler.Abstract
Facial aging is a multifactorial biological process characterized by collagen loss, decreased elasticity, reduced hydration, and structural changes that result in wrinkles, folds, and sagging. Considering the increasing demand for minimally invasive aesthetic procedures, hyaluronic acid (HA) has become one of the main fillers used in orofacial harmonization due to its safety, biocompatibility, and predictable clinical outcomes. This study aimed to conduct a systematic literature review on the use of HA in the treatment of facial aging. Searches were performed in the SciELO, PubMed, and Google Scholar databases using DeCS descriptors and combining terms related to HA, rejuvenation, and skin aging. After applying inclusion and exclusion criteria, 16 studies were selected. The results showed that HA provides excellent hydration, volume restoration, and collagen stimulation, being widely recognized for its effectiveness in restoring facial contours and softening signs of aging. Although the procedure is considered safe, complications may occur, especially when inadequate techniques are employed. It is concluded that HA is an effective and safe alternative for facial rejuvenation, offering aesthetic benefits and a positive impact on patients’ self-esteem and well-being.
References
Abduljabbar, M. H., & Basendwh, M. A. (2016). Complications of hyaluronic acid fillers and their management. Journal of Dermatology & Dermatologic Surgery, 20(2), 100–106.
Almeida, A. R. T., & Sampaio, G. A. A. (2020). Hyaluronic acid in upper face rejuvenation: Review and update – Part 1. Surgical & Cosmetic Dermatology, 8(2), 1–5.
Alster, T. S., & West, T. B. (2000). Human-derived and new synthetic injectable materials for soft-tissue augmentation: Current status and role in cosmetic surgery. Plastic and Reconstructive Surgery, 105(7), 2515–2525.
André, P. (2019). Evaluation of the safety of a non-animal stabilized hyaluronic acid (NASHA – Q-Medical, Sweden) in European countries: A retrospective study from 1997 to 2001. Journal of the European Academy of Dermatology and Venereology, 33(2), 234–240.
Boppré, B. (2022). Hyaluronic acid. Simple Organic Blog. https://simpleorganic.com.br/blogs/guia-de-ingredien
Braga, J. B., et al. (2022). Use of hyaluronic acid in facial harmonization procedures by aesthetic pharmacists: An integrative review. Research, Society and Development, 11(4), e5111426949.
Brandt, F. S., & Cazzaniga, A. (2019). Hyaluronic acid gel fillers in the management of facial aging. Clinical Interventions in Aging, 3(1), 153–159.
Cardoso, M. (2021). Hyaluronic acid. InfoEscola. https://www.infoescola.com/bioquimica/acido-hialuronico/
Chacur, R. (2019). Injectable hyaluronic acid. Leger Clinics. https://www.clinicaleger.com.br/tratamento/acido-hialuronico/
Crocco, E. I., Alves, R. O., & Alessi, C. (2019). Adverse events of injectable HA. Surgical & Cosmetic Dermatology, 11(3), 195–200.
Dal Lago, A. C. (2019). Clinical management of adverse effects from the use of hyaluronic acid in facial fillers (Monograph). Universidade Federal do Rio Grande do Sul.
Esteves, A. L. V., Pires, F. R., Miranda, A. M. M. A., Amaral, S. M., & Santos Netto, J. N. (2019). Foreign body reaction due to aesthetic filling materials: Report of four cases. Revista Brasileira de Odontologia, 73(4), 344–347.
Esteves, M. L. D. B., & Brandão, B. J. F. (2022). Collagen and skin aging. BWS Journal, 5, 1–10.
Faria, T. R., & Júnior, J. B. (2020). Possible complications of facial filling with hyaluronic acid. Revista Conexão Ciência Formiga, 15(3), 71–72.
Galvão, T. F., & Pereira, M. G. (2014). Revisões sistemáticas da literatura: Passos para sua elaboração. Epidemiologia e Serviços de Saúde, 23(1), 183–184.
Garbugio, A. F. (2010). The benefits of hyaluronic acid in facial aging. UNINGÁ Review, 10(2), 1–5. https://clinicadepele.com.br/wp-content/uploads/2020/02/20130708_185314.pdf
Johner, K., & Neto, C. F. G. (2021). Analysis of risk factors for skin aging: Nutritional aspects. Brazilian Journal of Health Review, 4(3), 10000–1018.
Maia, M. M., & Salvi, A. M. (2018). Hyaluronic acid: Properties, applications, and perspectives. Revista Científica Multidisciplinar Núcleo do Conhecimento, 2(10), 92–108.
Monteiro, M. R., Tersarop, I. L. S., Moura, G. E. D. D., & Steiner, D. (2019). Culture of human dermal fibroblasts in the presence of hyaluronic acid and polyethylene glycol: Effects on cell proliferation, collagen production, and remodeling enzymes of the extracellular matrix. Surgical & Cosmetic Dermatology, 5(3), 222–225.
Moraes, B. R., Bonami, J. A., & Romualdo, L. (2019). Hyaluronic acid in the field of aesthetics and cosmetics. Revista Saúde em Foco, 9, 1–8.
Palazi, A. P. (2020). Soy flour as an innovative source for hyaluronic acid production. Inova Unicamp. https://inova.unicamp.br/2020/06/farinha-de-soja-e-fonte-inovadora-para-a-produção-de-acido-hialuronico/
Parada, M. B., et al. (2020). Management of complications from dermal fillers. Surgical & Cosmetic Dermatology, 12(2), 1–6.
Pereira, A. S. et al. (2018). Metodologia da pesquisa científica. [free ebook]. Santa Maria: Editora da UFSM.
Saboia, T. P. S., Cabral, M. R. L., & Neres, L. L. F. G. (2021). The use of hyaluronic acid in facial harmonization. Research, Society and Development, 10(14), e94101421731.
Sandoval, M. H. L., Caixeta, C. M., & Ribeiro, N. M. (2020). In vivo and in vitro evaluation of the effectiveness of a product containing vitamin C, fragmented hyaluronic acid, and mannose in preventing skin aging. Surgical & Cosmetic Dermatology, 12(1), 1–8.
Snyder, H. (2019). Literature review as a research methodology: An overview and guidelines. Journal of Business Research, 104, 333–339. https://doi.org/10.1016/J.JBUSRES.2019.07.039.
Ulhoa, F. E., Vieira, J. E. M., & Barcelos, L. C. (2021). The use of hyaluronic acid in facial rejuvenation: A literature review. Humanities and Technology (FINOM), 30(1), 59–69. http://revistas.icesp.br/index.php/FINOM_Humanidade_Tecnologia/article/view/1637
Vasconcelos, D. N., et al. (2020). The use of hyaluronic acid in orofacial harmonization: A review. Brazilian Journal of Aesthetic Dentistry, 2(1), 45–52.
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