The role of the gut microbiota in the pathophysiology of psoriasis: Evidence of the gut-skin axis
DOI:
https://doi.org/10.33448/rsd-v15i3.50829Keywords:
Psoriasis, Gastrointestinal Microbiome, Dysbiosis.Abstract
The intestinal microbiota has been widely investigated as an important modulator of the immune system due to its ability to influence immune responses through the production of metabolites and direct interaction with immunocompetent cells. Changes in its composition, diversity, or functional activity may impair immune homeostasis, favoring inflammatory processes and contributing to the pathogenic mechanisms of several immune-mediated diseases. In this context, psoriasis stands out as a chronic inflammatory, immune-mediated disease characterized by immune system dysregulation, keratinocyte hyperproliferation, and excessive production of proinflammatory cytokines. Recent evidence suggests that intestinal dysbiosis may contribute to the intensification of this inflammatory response, reinforcing the hypothesis of the existence of a gut-skin axis in the pathophysiology of the disease. Thus, the present study consists of an integrative literature review on the influence of the intestinal microbiota on the pathophysiology of psoriasis, with emphasis on the immunological mechanisms involved and its autoimmune character. The review includes articles published between 2021 and 2026, selected according to previously defined inclusion and exclusion criteria, with the aim of synthesizing the main available evidence on this association.
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Copyright (c) 2026 Joanne Conceição Martins Aragão Costa Dias, Ana Clara Oliveira Lima, Yasmin da Silva Matos, Francielle de Meneses Santos, Érika Pereira De Paula, Letícia Almeida Santos, Karolina Freitas, Marina de Carvalho Santos, Emmily Heiner Maia Carvalho, Rafael Ferreira de França
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