The role of blood type in COVID-19 response: Contributions to resistance and susceptibility
DOI:
https://doi.org/10.33448/rsd-v14i7.49296Keywords:
COVID-19, SARS-CoV-2, ABO Blood-Group System, Genetic Predisposition to Disease.Abstract
Representing one of the most significant pandemics in modern history, the new coronavirus (SARS-CoV-2) and its relationship with ABO blood types, already known for various other diseases and other members of the coronavirus family, are currently under investigation. The objective of the present study is to elucidate how the relationships of resistance and susceptibility to COVID-19 vary according to each ABO blood type. In the methodology, a search was conducted in 4 databases, using the PICO strategy with combinations of descriptors: "Blood Type and COVID" and its relevant variations, such as "ABO blood group COVID-19", "Rh factor SARS-CoV-2", "blood group susceptibility COVID-19", and "blood group severity COVID-19". Initially, 45 studies were found, but after applying exclusion criteria, 19 studies remained for analysis. A significant portion of the authors identified greater susceptibility to infection in individuals with blood type A and greater resistance to the virus in group O. However, the relationships with clinical outcomes are still conflicting. Despite the need for greater contributions from the scientific and medical community, it was possible to draw correlations that characterize group A, especially individuals with Rh-positive blood, as the group at higher risk for complications. This knowledge is important for the proper management of patients and for predicting outcomes in cases of SARS-CoV-2 infection.
References
Barnkob, M. B., Pottegard, A., Støvring, H., Haunstrup, T. M., Homburg, K., Larsen, R., Hansen, M. B., Tittlestad, K., Aagaard, B., & Møller, B. K. (2020). Reduced prevalence of SARS-CoV-2 infection in ABO blood group O. Blood Advances, 4(20), 4990–4993.
Cetin, M., Aksoy, A., Yesilyurt, M., Yilmaz, M., Savrun, A., Can, S., Ozcan, M., Albayrak, C., & Yilmaz, N. (2023). Blood-Type-A is a COVID-19 infection and hospitalization risk in a Turkish cohort. Transfusion Clinique et Biologique, 30(1), 116–122. https://doi.org/10.1016/j.tracli.2022.10.003
Crossetti, M. G. O. (2012). Revisão integrativa de pesquisa na enfermagem: o rigor científico que lhe é exigido. Revista Gaúcha De Enfermagem, 33(2), 8–9. https://seer.ufrgs.br/index.php/rgenf/article/view/31430
Dai, X. (2020). ABO blood group predisposes to COVID-19 severity and cardiovascular diseases. European Journal Of Preventive Cardiology, 27(13), 1436–1437.
Fan, Q., Zhang, W., Li, B., Li, D.-J., Zhang, J., & Zhao, F. (2020). Association Between ABO Blood Group System and COVID-19 Susceptibility in Wuhan. Frontiers In Cellular And Infection Microbiology, 10, 1–7.
Halawani, A. J., Suliman, A. A., Al-Zahrani, M. H., Al-Malki, A. M., Al-Ghamdi, S. S., Al-Shehri, A. M., Al-Ghamdi, A. A., & Al-Amri, A. M. (2024). Lack of association of ABO and RhD blood groups with COVID-19. Annals of Saudi Medicine, 44(4), 279–284. https://pmc.ncbi.nlm.nih.gov/articles/PMC11404961/
Latz, C. A., DeCarlo, C., Boitano, L., Png, C. Y. M., Patell, R., Conrad, M. F., Eagleton, M., & Dua, A. (2020). Blood type and outcomes in patients with COVID-19. Annals Of Hematology, 99(9), 2113–2118.
Stukas, S., Goshua, G., Conway, E. M., Lee, A. Y. Y., Hoiland, R. L., Sekhon, M. S., & Y C Chen, L. (2025). ABO blood group and COVID-19 severity: Associations with endothelial and adipocyte activation in critically ill patients. PloS one, 20(4), e0320251. https://doi.org/10.1371/journal.pone.0320251
Li, J., Wang, X., Chen, J., Cai, Y., Deng, A., & Yang, M. (2020). Association between ABO blood groups and risk of SARS-CoV-2 pneumonia. British Journal Of Haematology, 190(1), 24–27.
Liu, Y., Häussinger, L., Steinacker, J. M., & Dinse-Lambracht, A. (2021). Association between the dynamics of the COVID-19 epidemic and ABO blood type distribution. Epidemiology and Infection, 149, e19. https://doi.org/10.1017/S0950268821000030
Odoom, P. N., Okoh, O. S., Asare, Y. Y., Mac-Arthur, C. O., Azumah, J. D., Mensah, A., Yalley, A. K., Sagoe, K. W., & Nii-Trebi, N. I. (2025). Blood type susceptibility to SARS-CoV-2 at a tertiary hospital in Accra, Ghana. Microbiology spectrum, 13(5), e0110824. Advance online publication. https://doi.org/10.1128/spectrum.01108-24
Padhi, S., Suvankar, S., Dash, D., Panda, V. K., Pati, A., Panigrahi, J., & Panda, A. K. (2020). ABO blood group system is associated with COVID-19 mortality: an epidemiological investigation in the indian population. Transfusion Clinique Et Biologique, 27(4), 253–258.
Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). Metodologia da pesquisa científica. UFSM, NTE. https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf
Ray, J. G., Schull, M. J., Vermeulen, M. J., & Park, A. L. (2020). Association Between ABO and Rh Blood Groups and SARS-CoV-2 Infection or Severe COVID-19 Illness. Annals Of Internal Medicine, 174(3), 308–315. https://doi.org/10.7326/M20-4511
Sardu, C., Marfella, R., Maggi, P., Messina, V., Cirillo, P., Codella, V., Gambardella, J., Sardu, A., Gatta, G., & Santulli, G. (2020). Implications of ABO blood group in hypertensive patients with COVID-19. BMC Cardiovascular Disorders, 20(1), 376.
Shibeeb, S., & Khan, A. (2022). ABO blood group association and COVID-19. COVID-19 susceptibility and severity: a review. Hematology, Transfusion and Cell Therapy, 44(1), 70–75. https://doi.org/10.1016/j.htct.2021.07.006
Shokri, P., Golmohammadi, S., Noori, M., Nejadghaderi, S. A., Carson-Chahhoud, K., & Safiri, S. (2022). The relationship between blood groups and risk of infection with SARS-CoV-2 or development of severe outcomes: A review. Reviews in Medical Virology, 32(1), e2247. https://doi.org/10.1002/rmv.2247
Soares, D. M. B., de Oliveira-Filho, A. B., de Castro, Í. M. M., da Silva, A. M., da Silva, F. A. S., de Souza, G. C., de Souza, A. C. S., & de Oliveira, J. S. (2022). Correlation between ABO blood type, susceptibility to SARS-CoV-2 infection and COVID-19 disease severity: A systematic review. Hematology, Transfusion and Cell Therapy. https://doi.org/10.1016/j.htct.2022.11.001
Wu, B.-B., Gu, D.-Z., Yu, J.-N., Yang, J., & Shen, W.-Q. (2020). Association between ABO blood groups and COVID-19 infection, severity and demise: a systematic review and meta-analysis. Infection, Genetics And Evolution, 84, 104485. https://doi.org/10.1016/j.meegid.2020.104485
Wu, Y., Feng, Z., Li, P., & Yu, Q. (2020). Relationship between ABO blood group distribution and clinical characteristics in patients with COVID-19. Clinica Chimica Acta, 509, 220–223.
Yaylaci, S., Dheir, H., İşsever, K., Genc, A. B., Şenocak, D., Kocayigit, H., Guclu, E., & Suner, K. (2020). The effects of ABO and Rh blood groups on the clinical course of COVID-19 infection. Revista da Associação Médica Brasileira, 66(Suppl 2), 86–90.
Zendehdel, A., Asoodeh, A., Anasari, M., JamaliMoghaddamsiyahkali, S. (2025). The Investigation of the Distribution of ABO/Rh Blood Group in Hospitalized COVID‐19 Patients and Its Association With Disease Severity, Clinical Outcomes, Lab Tests, and Radiologic Findings. Health Science Reports, 25(1), 1–10. https://pmc.ncbi.nlm.nih.gov/articles/PMC11808318/
Zeng, X., Chen, Y., Tang, T., Luo, S., Li, Y., Wang, J., Shang, Y., & Yu, T. (2023). Analysis between ABO blood group and clinical outcomes in COVID-19 patients and the potential mediating role of ACE2. Frontiers in Medicine, 10, 1167452.
Zietz, M., Zucker, J., & Tatonetti, N. P. (2020). Associations between blood type and COVID-19 infection, intubation, and death. Nature communications, 11(1), 5761. https://doi.org/10.1038/s41467-020-19623-x
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Copyright (c) 2025 Heitor Cruvinel Oliveira Vida, Bernardo Augusto Silveira Correa, Eduarda Rocha Santos, Ana Cecília Cardoso de Sousa
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