Paraneoplastic glomerulopathies and their diagnostic and temporality relationships
DOI:
https://doi.org/10.33448/rsd-v14i8.49382Keywords:
Glomerulopathy, Neoplasm, Paraneoplastic.Abstract
Introduction: Glomerular diseases are pathological conditions affecting the renal glomeruli, microscopic structures responsible for ultrafiltration of blood plasma. These diseases can be primary (directly in the kidneys) or secondary to other conditions, such as diabetes mellitus. They are characterized by alterations in the permeability of the glomerular membrane. There is an increase in the number of cases of glomerulopathies associated with neoplasia, either as an initial manifestation of the condition or as they develop later in life. Objective: To verify the occurrence of glomerulopathies associated with neoplastic diseases, including their implications for diagnosis, clinical progression, and treatment. Methodology: This is an integrative review using PubMed and Google Academy databases over the past five years. The following English-language descriptors indexed in the Health Sciences Descriptors Database (DeCS/MeSH) were also combined: "Glomerulopathy," "Neoplasm," and "Paraneoplastic," along with the Boolean operator "AND" to associate the topics. The article selection process began with 19 articles and culminated in eight articles. This article was motivated by the research conducted by Garkusha et al., 2024. .Results and Discussion: A relationship was observed between a tumor located in the body, except in the kidneys, and glomerulopathies and their clinical manifestations. Conclusion: This review allows for a more critical look at onconephrology and the relationship between glomerulopathies and neoplasms. Interrelationships that were previously seen as irrelevant are now beginning to emerge in the academic field. Little is available for discussion; however, it is important to consider this diagnostic possibility based on the literature consulted.
References
Bermúdez Barrientos, C. G. (2024). Acute glomerulonephritis as a paraneoplastic syndrome secondary to urachal adenocarcinoma: An unknown entity. Cureus, 16(3), e60106. https://doi.org/10.7759/cureus.60106
Brandão, S. C., Freitas, S. B. de, Carvalho, L. M. R., Araújo, L. C., Guedes, J. V. M., M. Oliveira, F. S. de, Silva, F. M. de R. e Otoni, A. (2022). A proteinúria é um preditor independente para progressão da doença renal do diabetes? Research, Society and Development, 11(15), e197111536895. https://doi.org/10.33448/rsd-v11i15.36895
Büttner-Herold, M., Sticht, C., Wiech, T., & Porubsky, S. (2021). Renal disease associated with myeloproliferative neoplasms and myelodysplastic syndrome/myeloproliferative neoplasms. Histopathology, 78(5), 738–748. https://doi.org/10.1111/his.14282
Cozzo, D., Orlando, F., Bruno, M., Ogna, A., & Forni Ogna, V. (2024). Minimal change glomerular disease associated with solid neoplasms: a systematic review. Journal of Nephrology, Advance online publication. https://doi.org/10.1007/s40620-024-02084-6
Crossetti, M. G. O. (2012). Revisão integrativa de pesquisa na enfermagem: o rigor metodológico que lhe é exigido. Revista Gaúcha de Enfermagem, 33(2), 10-11.
Dantas, M., Silva, L. B. B., Pontes, B. T. M., Reis, M. A., Lima, P. S. N., & Neto, M. M. (2023). Nefropatia membranosa. Jornal Brasileiro de Nefrologia, 45(2), 229-243. https://doi.org/10.1590/2175-8239-jbn-2023-0046pt
Garkusha, T. A., Stolyarevich, E. S., Khorzhevskii, V. A., Ivliev, S. V., & Firsov, M. A. (2024). Patologiya pochek pri zlokachestvennykh opukholyakh razlichnoi lokalizatsii i protivoopukholevoi terapii [Pathology of the kidneys in malignant tumors of various localizations and antitumor therapy]. Arkhiv Patologii, 86(3), 59–66. https://doi.org/10.17116/patol20248603159
Gueutin, V., Cardineau, A., Mathian, A., Lanot, A., Comoz, F., Brocheriou, I., & Izzedine, H. (2024). Renal involvement in solid cancers: epidemiological, clinical and histological characteristics study of 154 onconephrology patients. BMC Nephrology, 25(1), 367. https://doi.org/10.1186/s12882-024-03812-7
Jeyabalan, A., & Trivedi, M. (2022). Paraneoplastic glomerular diseases. Advances in Chronic Kidney Disease, 29(2), 116-126.e1. https://doi.org/10.1053/j.ackd.2022.02.009
Kidney Disease: Improving Global Outcomes (KDIGO). (2021). KDIGO glomerular diseases guideline key takeaways. [S. l.].
https://kdigo.org/wp-content/uploads/2017/02/KDIGO-Glomerular-Disease-Guideline-Key-Takeaways.pdf. Acesso em: 27 mar. 2025.
Laferreira, M. S., & Kirsztajn, G. M. (2025). Potentially paraneoplastic glomerulopathies in a Brazilian cohort: a retrospective analysis. Jornal Brasileiro de Nefrologia, 47(1), e20240131. https://doi.org/10.1590/2175-8239-JBN-2024-0131en
Lionaki, S., & Derebail, V. K. (2025). Editorial: Pathogenesis and management of glomerular diseases. Revista de Nefrologia Avançada, 12(4), 120-135.
Mattos, M. C. (2015). Revisão integrativa da literatura: orientações para sua elaboração. Revista da Escola de Enfermagem da USP, 49(5), 875-882.
Ministério da Saúde. (2021). Protocolo clínico e diretrizes terapêuticas da síndrome nefrótica primária em adultos. Brasília, DF: Ministério da Saúde. https://www.gov.br/conitec/pt-br/midias/protocolos/publicacoes_ms/20210416_sindrome_nefrotica_primaria_adulto.pdf
Page, M. J., McKenzie, J. E., Bossuyt, P. M., Boutron, I., Hoffmann, T. C., Mulrow, C. D., Shamseer, L., Tetzlaff, J. M., Akl, E. A., Brennan, S. E., Chou, R., Glanville, J., Grimshaw, J. M., Hróbjartsson, A., Lalu, M. M., Li, T., Loder, E. W., Mayo-Wilson, E., McDonald, S., ... Moher, D. (2022). A declaração PRISMA 2020: diretriz atualizada para relatar revisões sistemáticas. Epidemiologia e Serviços de Saúde, 31(2), e2022107.
https://dx.doi.org/10.1590/s1679-49742022000200033
Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). Metodologia da pesquisa científica. Editora UAB/NTE/UFSM.
Pozzi, C. M., & Leme, J. E. G. (2025). Onconephrology: a new frontier in medicine. Jornal Brasileiro de Nefrologia, 47(1), e2025E004. https://doi.org/10.1590/2175-8239-JBN-2025-E004en
Roccatello, D., Cortazzi, S., Bertinetto, F., La Rosa, A., Nescis, L., Sciascia, S., & Fenoglio, R. (2023). Giornale italiano di nefrologia: organo ufficiale della Società italiana di nefrologia, 40(Suppl 81), 2023-S81.
Silva, E. M. A. da, & Cintra, M. R. (2024). Avaliação da proteinúria no diagnóstico e acompanhamento de síndrome nefrótica. Brazilian Journal of Health Review, 7(9), e76040. https://doi.org/10.34119/bjhrv7n9-420
Soares, C. B., Hoga, L. A. K., Peduzzi, M., Sangaleti, C., Yonekura, T., & Silva, D. R. A. D. (2014)/Anima. Revisão integrativa: conceitos e métodos utilizados na enfermagem. Revista da Escola de Enfermagem da USP, 48(2), 335-345. https://doi.org/10.1590/S0080-6234201400002000020
Vinnikov, D. L., Mukhametshina, A. R., Lebedev, P. V., Podverbnaya, Y. S., & Bulanov, D. V. (2025). Clinicopathological features of glomerulopathies and their prognostic significance in cancers of different sites. Kazan medical journal, 106(2), 258-266.
Zhang, X., Luo, F., Chen, R., Shen, J., Liu, X., Shi, Y., Yang, Q., Huang, T., Li, H., Hu, Y., Wan, Q., Chen, C., Jia, N., Cao, Y., Li, Y., Zhao, H., Su, L., Gao, P., Xu, X., Nie, S., & Hou, F. F. (2023). Use of histologic parameters to predict glomerular disease progression: Findings from the China Kidney Biopsy Cohort Study. American Journal of Kidney Diseases, 81(4), 416-424. https://doi.org/10.1053/j.ajkd.2022.08.021
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