Adult female acne: Clinical, pathophysiological and therapeutic approaches in dermatological practice
DOI:
https://doi.org/10.33448/rsd-v15i1.50595Keywords:
Acne, Skin diseases, Inflammation, Therapeutics, Women.Abstract
Objective: To analyze the clinical, pathophysiological, and therapeutic aspects of adult female acne based on current scientific literature, contributing to improved diagnosis and clinical management in dermatological practice. Methodology: A narrative literature review was conducted using PubMed, SciELO, and MEDLINE databases. Studies published between 2013 and 2024 in Portuguese and English addressing clinical, pathophysiological, and therapeutic aspects of adult female acne were included. Results: The analyzed studies showed that adult female acne is characterized by persistent inflammatory lesions, preferential involvement of the lower third of the face, and a chronic course with frequent recurrence. Peripheral androgen hypersensitivity, persistent inflammation, and the role of the cutaneous microbiome were highlighted. Combined therapeutic approaches and long-term maintenance strategies demonstrated superior clinical outcomes and reduced recurrence rates. Conclusion: Adult female acne should be recognized as a distinct clinical entity, requiring individualized and long-term management based on accurate diagnosis, pathophysiological understanding, and appropriate therapeutic planning.
References
Casarin, S. T., Porto, A. R., Gabatz, R. I. B., Bonow, C. A., Ribeiro, J. P. & Mota, M. S. (2020). Tipos de revisão de literatura. Journal of Nursing and Health.J. nurs. health. 10(n.esp.):e20104031.
Del Rosso, J. Q., & Zeichner, J. A. (2021). The clinical relevance of inflammation in adult female acne. Journal of Clinical and Aesthetic Dermatology, 14(6), 32–38.
Del Rosso, J. Q., Tanghetti, E., Webster, G., et al. (2022). Management of truncal and adult female acne: Updated perspectives. Journal of Drugs in Dermatology, 21(4), 402–410.
Dréno, B., Bagatin, E., Blume-Peytavi, U., Rocha, M., & Gollnick, H. (2018). Female acne: A different subtype of acne? Journal of the European Academy of Dermatology and Venereology, 32(1), 1–10.
Dréno, B., Thiboutot, D., Layton, A. M., et al. (2022). Acne as an inflammatory disease: New insights and implications for treatment. Journal of the European Academy of Dermatology and Venereology, 36(2), 170–181.
Dréno, B., Pécastaings, S., Corvec, S., Veraldi, S., Khammari, A., & Roques, C. (2023). Cutibacterium acnes (Propionibacterium acnes) and acne vulgaris: A brief look at the latest updates. Journal of the European Academy of Dermatology and Venereology, 37(1), 7–15.
Fahlén, A., Engstrand, L., Baker, B. S., Powles, A., & Fry, L. (2017). Comparison of bacterial microbiota in acne lesions and unaffected skin. British Journal of Dermatology, 176(1), 170–176.
Fernandes, J. M. B., Vieira, L. T. & Castelhano, M. V. C. (2023). Revisão narrativa enquanto metodologia científica significativa: reflexões técnico-formativas. REDES – Revista Educacional da Sucesso. 3(1), 1-7. ISSN: 2763-6704.
Gil, A. C. (2017). Como elaborar um projeto de pesquisa. Editora Atlas.
Gollnick, H., Cunliffe, W., Berson, D., et al. (2016). Management of acne: A report from a Global Alliance to Improve Outcomes in Acne. Journal of the American Academy of Dermatology, 74(5), 945–973.
Harper, J. C. (2020). An update on the pathogenesis and management of adult female acne. Journal of Clinical and Aesthetic Dermatology, 13(2), 28–34.
Kircik, L. H. (2019). Advances in the understanding of acne pathogenesis and treatment. Journal of Drugs in Dermatology, 18(3), S63–S66.
Layton, A. M. (2016). Disorders of the sebaceous glands. In C. E. M. Griffiths et al. (Eds.), Rook’s textbook of dermatology (9th ed.). Wiley-Blackwell.
Nast, A., Dréno, B., Bettoli, V., et al. (2022). European evidence‐based (S3) guideline for the treatment of acne – Update 2022. Journal of the European Academy of Dermatology and Venereology, 36(Suppl. 1), 5–29.
O’Neill, A. M., & Gallo, R. L. (2022). Host–microbiome interactions and recent progress in acne pathogenesis. Journal of Investigative Dermatology, 142(3), 725–734.
Pereira, A. S. et al. (2018). Metodologia da pesquisa científica. [free ebook]. Santa Maria. Editora da UFSM.
Perkins, A. C., Magin, P., & Williams, A. (2012). Acne in women: Prevalence across the life span and relationship to menopause. International Journal of Women’s Dermatology, 8(1), 12–18.
Preneau, S., & Dréno, B. (2012). Female acne – A different subtype of acne? Journal of the European Academy of Dermatology and Venereology, 26(3), 277–282.
Rocha, M. A., & Bagatin, E. (2018). Adult female acne: A guide to clinical practice. Anais Brasileiros de Dermatologia, 93(6), 749–757.
Tan, J. K. L., Tang, J., Fung, K., et al. (2018). Prevalence and severity of acne vulgaris in the adult population. Journal of Cutaneous Medicine and Surgery, 22(1), 1–6.
Tan, J. K. L., & Bhate, K. (2015). A global perspective on the epidemiology of acne. British Journal of Dermatology, 172(Suppl. 1), 3–12.
Thiboutot, D., Gollnick, H., Bettoli, V., et al. (2020). New insights into the pathogenesis and management of acne. Journal of the American Academy of Dermatology, 82(6), 1261–1273.
Zaenglein, A. L., Pathy, A. L., Schlosser, B. J., et al. (2016). Guidelines of care for the management of acne vulgaris. Journal of the American Academy of Dermatology, 74(5), 945–973.
Zouboulis, C. C., Jourdan, E., & Picardo, M. (2019). Acne is an inflammatory disease. Experimental Dermatology, 28(6), 553–558.
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