A study of protocols used by Dentists in the management of oral mucositis in critically ill cancer patients

Authors

DOI:

https://doi.org/10.33448/rsd-v15i2.50652

Keywords:

Oral mucositis, Laser therapy, Hospital dentistry, Critically ill patient, Intensive Care Unit.

Abstract

Oral mucositis is a common inflammatory condition in patients undergoing intensive care, being especially prevalent in oncology patients after systemic therapies such as chemotherapy and radiotherapy. Its development is related to the cytotoxic effects of these treatments on the rapidly renewing cells of the oral mucosa. The diagnosis is established based on patient history combined with a thorough clinical examination of the oral cavity. Clinical manifestations vary, including pain, hyperemia, and the presence of ulcerative lesions. The involvement of the dental surgeon in the comprehensive care of critically ill patients with oral mucositis, including the use of laser therapy by this professional, aids in the effective control of mucositis, preventing the onset of comorbidities in patients hospitalized in intensive care units (ICU), and reducing the length of hospital stay. The present study aims to conduct a systematic review comparing the use of low-level laser therapy with other protocols in the prevention and treatment of oral mucositis in critically ill oncology patients, including those admitted to the ICU, highlighting its clinical benefits and the relevance of hospital dentistry in comprehensive care. The results of this study indicate that laser therapy has analgesic, anti-inflammatory, and biostimulatory effects, contributing to pain reduction, accelerated tissue healing, and improved patient comfort, demonstrating that it is a safe and more effective strategy compared to other methods used in the context of intensive care.

References

Anschau, Fernando et al. Efficacy of low-level laser for treatment of cancer oral mucositis: a systematic review and meta-analysis. Lasers Med Sci. 2019 Aug;34(6), 1053-1062. doi: 10.1007/s10103-019-02722-7. Epub 2019 Feb 7. PMID: 30729351.

Bardin, L. Análise de Conteúdo. Lisboa, Portugal; Edições 70, LDA, 2009.

Bersaneti, Mariana Davies Ribeiro et al. Higiene bucal em pacientes críticos em um hospital terciário em São Paulo, Brasil: um projeto de implementação de melhores práticas. JBI Evidence Implementation 23(1), 4-13, janeiro de 2025. | DOI: 10.1097/XEB.0000000000000413

Carvalho, Kesya Lourenço; SILVA, João Victor Uchoa Silva.; MENDES, Roberta Janaina Soares.; SALDANHA, Luanna Marinho Sereno Nery.; LAGO, Andrea Dias Neves.; FERREIRA, Odalace Chaves. A importância da odontologia hospitalar no manejo de pacientes críticos. Revista Delos, [S. l.], 18(75), e8048, 2025. DOI: 10.55905/rdelosv18.n75-181.

Colella, Boschetti et al. Interventions for the Prevention of Oral Mucositis in Patients Receiving Cancer Treatment: Evidence from Randomised Controlled Trials. Curr Oncol. 2023 Jan 10;30(1), 967-980. doi: 10.3390/curroncol30010074. PMID: 36661723; PMCID: PMC9858113.

Correia, Samila Maria Ferreira Correia et al. Laserterapia para tratamento da mucosite em pacientes com carcinoma de células escamosas oral: uma revisão de literatura. Rev. Ciências da Saúde, Volume 28 – Edição 135/JUN 2024. DOI: 10.5281/zenodo.12439883

Donaduzzi, Liziane Cattelan; DACZUK, Ana Flávia Zuke. Uso do laser de baixa potência na prevenção e tratamento da mucosite oral em pacientes oncológicos. Trabalho de Conclusão de Curso de Odontologia. Repositorio Institucional UniGuairaca.

Elad S, Cheng KKF, Lalla RV, Yarom N, Hong C, Logan RM, Bowen J, Gibson R, Saunders DP, Zadik Y, Ariyawardana A, Correa ME, Ranna V, Bossi P; Mucositis Guidelines Leadership Group of the Multinational Association of Supportive Care in Cancer and International Society of Oral Oncology (MASCC/ISOO). MASCC/ISOO clinical practice guidelines for the management of mucositis secondary to cancer therapy. Cancer. 2020 Oct 1;126(19):4423-4431. doi: 10.1002/cncr.33100. Epub 2020 Jul 28. Erratum in: Cancer. 2021 Oct 1;127(19), 3700. doi: 10.1002/cncr.33549. PMID: 32786044; PMCID: PMC7540329.

Ercole, F. F., Melo, L. S. & Alcoforado, C. L. G. C. (2014). Integrative review versus systematic review. Reme: Revista Mineira de Enfermagem. 18(1), 9-11.

Jha, Deepak Kumar et al. Mucosite oral no tratamento do câncer: perspectivas atuais e direções futuras a partir de uma revisão sistemática. International Journal of Pharmaceutical Investigation, 15 (3), 783–792. https://doi.org/10.5530/ijpi.20250174

Kanamori, Daisuke et al. Oral care for intubated patients in the intensive care unit: examination of bacterial count and microbiota. Crit Care. 2025 Jul 23;29(1):320. doi: 10.1186/s13054-025-05576-4. PMID: 40702530; PMCID: PMC12288309.

Mendes, K. D. S. et al. (2008). Revisão integrativa: Método de Pesquisa para a incorporação de evidências na saúde e na enfermagem. Texto & contexto- enfermagem. 17(4), 758-64.

Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009 Jul 21;6(7, :e1000097. doi: 10.1371/journal.pmed.1000097. Epub 2009 Jul 21. PMID: 19621072; PMCID: PMC2707599.

Pereira, A. S. et al. (2018). Metodologia da pesquisa científica. Editora da UFSM. https://repositorio.ufsm.br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf?sequence=1.

Pires, Ester Araújo; SOUZA, Paula Pereira Xavier de; MORAIS, Ângela Dias. O uso da laserterapia em pacientes com mucosite oral: revisão de literatura. Rev. Faculdade de Ciências do Tocantins. 39(2), 196-204

Pulito, Cláudio et al. Mucosite oral: o lado oculto da terapia do câncer. J Exp Clin Cancer Res 39 , 210 (2020). https://doi.org/10.1186/s13046-020-01715-7.

Queiroz, Álvaro F. A.; ROCHA, T. M. O.; FERREIRA JUNIOR, A. E. C. Uso da laserterapia de baixa potência na prevenção e no tratamento da mucosite oral após a quimiorradioterapia na área da cabeça e do pescoço. Brazilian Journal of Health Review, [S. l.], 6(5), 23161–23169, 2023. DOI: 10.34119/bjhrv6n5-333.

Redman, Grace Melodia; HARRIS, Katarina, PHILLIPS, Bob S. Low-level laser therapy for oral mucositis in children with cancer. Arch Dis Child. 2022 Feb;107(2), 128-133. doi: 10.1136/archdischild-2020-321216. Epub 2021 Jul 6. PMID: 34230010.

Risemberg, R. I. C. et al. (2026). A importância da metodologia científica no desenvolvimento de artigos científicos. E-Acadêmica. 7(1), e0171675. https://eacademica.org/eacademica/article/view/675.

Sahebnasagh, Marzieh et al. Prevention of radiotherapy-related oral mucositis with zinc and polyherbal mouthwash: a double-blind, randomized clinical trial. European journal of medical research, 28(1), 109. https://doi.org/10.1186/s40001-023-01015-8

Souza MT, Silva MD, Carvalho R. Revisão integrativa: o que é e como fazer. Einstein (Sao Paulo). 2010;8(1), 102-6.https://doi.org/10.1590/S1679-45082010RW1134

Zhao, Tingting et al. Oral hygiene care for critically ill patients to prevent ventilator- associated pneumonia. Cochrane Database Syst Rev. 2020 Dec 24;12(12), CD008367. doi: 10.1002/14651858.CD008367.pub4. PMID: 33368159; PMCID: PMC8111488.

Published

2026-02-14

Issue

Section

Health Sciences

How to Cite

A study of protocols used by Dentists in the management of oral mucositis in critically ill cancer patients. Research, Society and Development, [S. l.], v. 15, n. 2, p. e5415250652, 2026. DOI: 10.33448/rsd-v15i2.50652. Disponível em: https://rsdjournal.org/rsd/article/view/50652. Acesso em: 1 mar. 2026.