Análisis de Fortalezas, Debilidades, Oportunidades y Amenazas (FODA) para la implementación de políticas de salud pública para la detección del cáncer de cuello uterino basado en el Virus del Papiloma Humano (VPH) en Brasil
DOI:
https://doi.org/10.33448/rsd-v15i2.50636Palabras clave:
Virus del Papiloma Humano, Detección Precoz del Cáncer, Salud Pública, Salud de la Mujer, Pruebas Moleculares.Resumen
En Brasil, la incidencia y mortalidad por cáncer cervicouterino persisten a niveles elevados, afectando desproporcionadamente a las mujeres vulnerables. Este artículo busca presentar y analizar factores que facilitan o dificultan la implementación del cribado basado en el VPH, importante para alcanzar las metas globales de eliminación del cáncer cervicouterino para 2030. Un análisis FODA evaluó factores internos y externos que afectan la adopción del diagnostico molecular. El análisis se basó en documentos nacionales oficiales, directrices internacionales y literatura cientifica, complementados con perspectivas de investigadores, gestores de salud y miembros de la sociedad civil. El análisis FODA identificó factores facilitadores, como un sistema de salud pública unificado, la capacidad de laboratorio existente y la disponibilidad de las pruebas de VPH recomendadas por la Organización Mundial de la Salud (OMS), junto con importantes debilidades, como baja cobertura del cribado, falta de un sistema organizado de llamadas-y-recordatorios, y desigualdades regionales. Las oportunidades incluyen el apoyo global para la eliminación del cancer, expansión del diagnóstico molecular y el potencial de collecta autonoma de muestras para servir poblaciones desatendidas. Las amenazas incluyen vulnerabilidades de la cadena de suministro, la sostenibilidad financiera y incertidumbres en el seguimiento de mujeres con VPH detectado. El análisis destaca prioridades estratégicas para fortalecer la implementación del cribado basado en el VPH, con recomendaciones prácticas para aumentar la cobertura, mejorar la calidad del diagnóstico y optimizar el seguimiento y el tratamiento. Estos hallazgos pueden orientar la planificación y respaldar los esfuerzos para alcanzar las metas mundiales de eliminación del cáncer cervicouterino.
Referencias
Arbyn M., Simon M., PeetersE., Xu L., Meijer C.J.L.M., Berkhof J., Cuschieri K., Bonde J., Vanlencak A.O., ∙ ZhaoF-H., Rezhake R., Gultekin M., Dillner J., de Sanjosé S., Canfell K., Hillemanns P., Almonte M., Wentzensen N., & Poljak M. (2020). List of human papillomavirus assays suitable for primary cervical cancer screening. Clinical Microbiology and Infection, 27 (8), 1083-1095. https://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(21)00219-6/fulltext
Associacao Brasileira da Industria Inovadora no Brasil. (2021). ABIIS report. Challenges and proposals for the medical devices sector in Brazil. https://abiis.org.br/wp-content/uploads/2022/09/livro-desafios-e-propostas-EN.pdf
Azevedo e Silva G., Damacena G.N., Ribeiro C.M., Alcantara L.L.M., Souza Junior P.R.B., & Szwarcwald C.L. (2023). Papanicolaou test in Brazil: analysis of the National Health Survey of 2013 and 2019. Revista de Saúde Pública, 57, 55. https://doi.org/10.11606/s1518-8787.2023057004798 . https://www.scielo.br/j/rsp/a/qrkdYnPtggnLFsGFHMShhGS/?lang=en
Brazil Ministry of Health. Control and Elimination of Cervix Cancer. Ordinance No. 3121, of 14 March 2024. Ministério da Saúde, Gabinete do Ministro. Available at https://bvsms.saude.gov.br/bvs/saudelegis/gm/2024/prt3121_15_03_2024.html
Brazil Ministry of Health. Ministério da Saúde. HPV [Internet]. Brasília (DF): Ministério da Saúde; [atualizado 2025].
https://www.gov.br/saude/pt-br/assuntos/saude-de-a-a-z/h/hpv
Bruni L., Serrano B., Roura E., Alemany L., Cowan M., Herrero R., Poljak M., Murillo R., Broutet N., Riley L.M., & de Sanjose S. (2022). Cervical cancer screening programmes and age-specific coverage estimates for 202 countries and territories worldwide: a review and synthetic analysis. The Lancet Global Health, 10 (8), e1115-e1127.https://www.thelancet.com/journals/langlo/article/PIIS2214-109X%2822%2900241-8/fulltext
Cancer Screening Committee Switzerland (2021). Recommendations on screening strategies for cervical cancer: HPV testing compared to cytology. Appraisal report, August 2021. https://cancerscreeningcommittee.ch/wp-content/uploads/2022/11/recommendations-on-screening-strategies-for-cervical-cancer-HPV-testing-compared-to-cytology.pdf
Carvalho C.F., Teixeira J.C., Bragança J.F., Derchain S., Zeferino L.C., & Vale D.B. (2022). Cervical Cancer Screening with HPV Testing: Updates on the Recommendation. Revista Brasileira de Ginecologia e Obstetetricia, 44(3), 264-271. doi: 10.1055/s-0041-1739314. https://pubmed.ncbi.nlm.nih.gov/35170010/
Castañeda K.M., Vermeulen K.M., van Asselt A.D. I., Schuuring E., Wisman G.B.A., Greuter M.J.W., & de Bock G. H. (2025). Molecular Testing as Triage in Cervical Cancer Screening: Economic Evaluation Using Headroom Analysis. Cancers, 17(4), 612;
https://doi.org/10.3390/cancers17040612 https://www.mdpi.com/2072-6694/17/4/612
Centers for Disease Control and Prevention (CDC). (2025). Screening for Cervical Cancer.
https://www.cdc.gov/cervical-cancer/screening/index.html
Clifford G. (2024). Global attribution of HPV genotypes to invasive cervical cancer: a systematic analysis. IARC Press Release No. 353, 1st August 2024. https://www.iarc.who.int/wp-content/uploads/2024/07/pr353_E.pdf
CONITEC. (2024). Report of recommendations No. 878 - Testagem Molecular para Detecção de HPV e rastreamento do câncer do colo do útero. Updated on 08 March 2024. https://www.gov.br/conitec/pt-br/midias/relatorios/2024/testagem-molecular-para-deteccao-de-hpv-e-rastreamento-do-cancer-do-colo-do-utero/view
Dillner J., Mühr L.S.A., Nordqvist Kleppe S., Wang j., Andersson H., Elfström M., Merino R., & Sundström K. (2024). The Swedish Cervical Screening Cohort. Nature Science Data. 2024, 11(1), 697. doi: 10.1038/s41597-024-03519-2 . https://pubmed.ncbi.nlm.nih.gov/38926412/
Fernandez-Deaza G., Serrano B., Rourab E., CastillodJ.S., María Caicedo-Martíneza M., Brunib L., & Murillo
R. (2024). Cervical cancer screening coverage in the Americas region: a synthetic analysis. The Lancet, 30, 100689, February 2024.https://www.thelancet.com/journals/lanam/article/PIIS2667-193X(24)00016-4/fulltext
Fernandez M., Pinto H.A., Fernandes L.M.M., Oliveira J.A.S., Lima A.M.S.L, Santana J.S.S., & Chioro A. (2025). Interoperability in universal healthcare systems: insights from Brazil's experience integrating primary and hospital health care data. Frontiers in Digital Health, 18 August 2025. Section Health Technology Implementation, 7 – 2025. Available at https://doi.org/10.3389/fdgth.2025.1622302 https://www.frontiersin.org/journals/digital-health/articles/10.3389/fdgth.2025.1622302/full
Freitas da Silveira M., Buffarini R., Gaspar P.C., Machado H.M., Bazzo M.L., Scherer A., Colusso A.L., Travassos A.G.A., Arakaki-Sanchez D., Baia-da-Silva D.C., Oliveira E.C., Zago I.R., Moura M.A., Lacerda M.V.G., Martins S.M., Reuter T., 13, Pinto V.M., Perini W., Pereira G.F.M., & Miranda A.E. (2023). Detection of HPV DNA in vaginal samples self-collected by women living with HIV treated through the Brazilian public health system: Prevalence and analysis of risk factors. Revista da Sociedade Brasileira de Medicina Tropical, 56:e02772023. doi: 10.1590/0037-8682-0277-2023. https://pubmed.ncbi.nlm.nih.gov/37820103/
Gaspar P. C., Miranda A.E., Bigolin A., Morais A.A.C, Aragón M.G., Morais J.A.V., Alonso Neto J.B., Lannoy L.H., Sanchez M.N., Cravo Neto D.B., Díaz Bermúdez X.P.C., & Benzaken A.S. (2024). A national network of molecular tests to detect Chlamydia trachomatis and Neisseria gonorrhoeae: a pilot implementation experience in Brazil. Cadernos de Saude Publica, 40(7):e00123023. doi: 10.1590/0102-311XPT123023.https://www.scielo.br/j/csp/a/CDkcjmygmrH3Gzmcs4YQZwt/?lang=pt
Horn J., Denecke A., Luyten A., Rothe B., Reinecke-Lüthge A., Mikolajczyk R., & Petry K.U. (2019). Reduction of cervical cancer incidence within a primary HPV screening pilot project (WOLPHSCREEN) in Wolfsburg, Germany. British Journal of Cancer, 120(10),1015-1022. doi: 10.1038/s41416-019-0453-2. https://pmc.ncbi.nlm.nih.gov/articles/PMC6734660/
IARC, Global Cancer Observatory (GCO), GLOBOCAN, Cancer Over Time. Webpage
https://gco.iarc.fr/overtime/en/dataviz/trends?populations=76_756_840_752&sexes=2&types=1&multiple_populations=1&cancers=16&years=1950_2020&age_start=5&age_end=8 (consulted on 05 February 2026)
IARC News. 24 April 2024. Why is Brazil changing its HPV vaccine recommendations? Video with Dr Iacopo Baussano.
ICO/IARC Information Centre on HPV and Cancer (HPV Information Centre) 2023. Human Papillomavirus and Related Diseases Report. Version posted at www.hpvcentre.net on 10 March 2023. https://hpvcentre.net/statistics/reports/XWX.pdf
Instituto Nacional de Câncer José Alencar Gomes da Silva (INCA). Coordenação de Prevenção e Vigilância. Divisão de Detecção Precoce e Apoio à Organização de Rede. Diretrizes brasileiras para o rastreamento do câncer do colo do útero. 2ª ed rev e atual. Rio de Janeiro: INCA; 2016, 114 p. https://www.inca.gov.br/publicacoes/livros/diretrizes-brasileiras-para-o-rastreamento-do-cancer-do-colo-do-utero (webpage updated on 22/07/2022)
INCA, Instituto Nacional de Câncer. (2025). Controle do câncer do colo do útero no Brasil: dados e números 2025. https://ninho.inca.gov.br/jspui/bitstream/123456789/17304/1/Controle%20do%20câncer%20do%20colo%20do%20útero_completo.pdf
Kim J, Choe Y J, Park J, Cho J, Cheong C, Oh J-K, Park M, Shim E, & Yu S-Y. (2024). Comparative Effects of Bivalent, Quadrivalent, and Nonavalent Human Papillomavirus Vaccines in The Prevention of Genotype-Specific Infection: A Systematic Review and Network Meta-Analysis Infection and Chemotherapy. 56(1),37-46. doi: 10.3947/ic.2023.0064. https://icjournal.org/DOIx.php?id=10.3947/ic.2023.0064
Marth C., Landoni F., Mahner S., McCormack M., Gonzalez-Martin A., & Colombo N. (2020). eUpdate: Cervical Cancer Treatment Recommendations to Cervical cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Annals of Oncology, 2017, 28 (4), iv72–iv83. https://www.esmo.org/guidelines/esmo-clinical-practice-guideline-cervical-cancer
Martins L.F., Valente J.G., & Thuler L.C. (2009). Factors related to inadequate cervical cancer screening in two Brazilian state capitals. Revista de Saude Publica Vol. 43:318-‐25. https://www.scielo.br/j/rsp/a/sYMV4tqm39w5RVHSW6zP9Gw/?lang=en
Matias A.F., Medeiros K.M.F., da Costa N.F.M., Figueiredo I.D.T., & Costa H.P. (2022). Public policies for cervical cancer care in Brazil. Research, Society and Development Journal, 11, (16), e328111638160. DOI: 10.33448/rsd-v11i16.38160. https://rsdjournal.org/rsd/article/view/38160/31695
Mavrommatis E., Lytsikas-Sarlis P., & Troupis T. (2021). Historical pearls of HPV research: from condyloma to cervical cancer. Le Infezioni in Medicina, 2, 278-283. https://www.infezmed.it/media/journal/Vol_29_2_2021_16.pdf
Melo M.S., Almeida Lima S.V.M., dos Santos A.D., Ribeiro C.J.N., Brito Júnior P.A., Silva T.K.S., de Resende L.T., Corrêa F., Migowski A., Schiffman M., Rodriguez A.C., Ribeiro A., & Raiol T. (2024). Temporal trends, spatial and spatiotemporal clusters of cervical cancer mortality in Brazil from 2000 to 2021. Nature, Scientific Reports. October 2024, 14, 24436; https://doi.org/10.1038/s41598-024-75378-1. https://www.nature.com/articles/s41598-024-75378-1
Michalas S. P. (2000). The Pap test: George N. Papanicolaou (1883-196. 2). A screening test for the prevention of cancer of uterine cervix. European Journal of Obstetrics, Gynecology and Reproductive Biology, 90(2),135-8. doi: 10.1016/s0301-2115(00)00260-8. https://pubmed.ncbi.nlm.nih.gov/10825631/
Ministry of Health Media. (2025) Brazil advances in HPV vaccination and surpasses global average [Internet]. Brasília: Ministry of Health. https://www.gov.br/saude/pt-br/assuntos/noticias/2025/agosto/brasil-avanca-na-vacinacao-contra-hpv-e-supera-media-global
National Cancer Institute. (2024). Cervical Cancer Causes, Risk Factors, and Prevention: HPV infection causes cervical cancer. Updated: August 2, 2024. https://www.cancer.gov/types/cervical/causes-risk-prevention
Pagliusi S.R. & Aguado M.T. (2004). Efficacy and other milestones for human papillomavirus vaccine introduction. Vaccine, 23(5),569-78. doi: 10.1016/j.vaccine.2004.07.046. https://pubmed.ncbi.nlm.nih.gov/15630792/
PAHO. (2025). Projeto piloto Útero é Vida: Qualificando a Linha do Cuidado do Câncer do Colo do Útero em Pernambuco. PAHO website https://portalbp.paho.org/goodpractices/resource/?id=428 (consulted on 05 February 2026)
Pereira A.S., Shitsuka D.M., Pareira F.J, Shitsuka R. (2018). Metodologia da pesquisa cientifica.[free ebook]. Santa Maria : Editora da UFSM. https://saude.ufpr.br/epmufpr/wp-content/uploads/sites/42/2020/10/Lic_Computacao_Metodologia-Pesquisa-Cientifica.pdf
Porto M.A. & Briglia Habib P.AaB. (2014). Viva Mulher: constructing a cervical cancer control program in Brazil. Dynamis, 34(1),101-23. doi: 10.4321/s0211-95362014000100006. https://pubmed.ncbi.nlm.nih.gov/24987783 /
Ribeiro C.R., Claro I.B., Tomazelli J.G., & Kneipp Dias M.D. (2025). Cervical cancer screening in Brazil: a coverage analysis using the Brazilian Cancer Information System. Cadernos de Saude Publica, 41(8), e00152224. doi: 10.1590/0102-311XPT152224. https://pubmed.ncbi.nlm.nih.gov/40862444/
Risemberg, R. I. C., Wakin, M., & Shitsuka, R. (2026). A importância da metodologia científica no desenvolvimento de artigos científicos. E-Acadêmica, 7(1), e0171675. https://doi.org/10.52076/eacad-v7i1.675.
Schiffmann M., Kinney W.K., Cheung L.C., Gage J.C., Fetterman B., Poitras N.E., Lorey T.S., Wentzensen N., Befano B., Schussler J., Katki H.A., & Castle P.E. (2018). Relative Performance of HPV and Cytology Components of Co-testing in Cervical Screening. Journal of the National Cancer Institute, 110(5),501-508. doi: 10.1093/jnci/djx225. https://pubmed.ncbi.nlm.nih.gov/29145648/
Serrano B., Ibáñez R., Robles C., Peremiquel-Trillas P., de Sanjosé S., & Bruni L. (2022). Worldwide use of HPV self-sampling for cervical cancer screening. Preventive Medicine, 154, 106900. https://doi.org/10.1016/j.ypmed.2021.106900 https://www.sciencedirect.com/science/article/pii/S0091743521004734#
Silva Filho A.L., Roteli-Martins C.M., Speck N.M.G., Carvalho N.S., Cândido E.B., & Teixeira J.C. (2024). The path to elimination: FEBRASGO 2023's targeted strategies against cervical cancer in Brazil. Revista Brasileira de Ginecologia e Obstetricia [Internet], 46:e–rbgoedt2. https://doi.org/10.61622/rbgo/2024EDT02
Smith J. (2024). 70 years of progress in cervical cancer research. Cancer Research UK.
https://news.cancerresearchuk.org/shorthand_story/70-years-progress-cervical-cancer/
Teixeira J.C. (2014). From gynaecology offices to screening campaigns: a brief history of cervical cancer prevention in Brazil. História, Ciências, Saúde – Manguinhos, Rio de Janeiro, 20(1), 653. https://www.scielo.br/j/hcsm/a/jB3QhTffmYww3VmjcD6SNjf/?format=pdf&lang=en
Teixeira J.C., Vale D.B., Campos C.S., Polegatto I., Bragança J.F., Discacciati M.G., & Zeferino L.C. (2024). Transition from opportunistic cytological to organized screening program with DNA-HPV testing detected prevalent cervical cancers 10 years in advance. Nature, Scientific Reports 14, 20761. https://doi.org/10.1038/s41598-024-71735-2
Teoli D., Sanvictores T., & An J. (2023) SWOT Analysis. [Updated 2023 Sep 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK537302/#
Termrungruanglert W., Khemapech N., Vasuratna A., Havanond P., & Tantitamit T. (2024) Cost-effectiveness analysis of single-dose or 2-dose of bivalent, quadrivalent, or nonavalent HPV vaccine in a low/middle-income country setting. Journal of Gynecologic Oncology, 35(6), e85. doi: 10.3802/jgo.2024.35.e85. https://www.ejgo.org/pdf/10.3802/jgo.2024.35.e85
Vilos G.A. (1998). The history of the papanicolaou smear and the Odyssey of George and Andromache
Papanicolaou. Obstetrics & Gynecology. 91(3), 479-483. https://www.sciencedirect.com/science/article/abs/pii/S0029784497006959?via%3Dihub
Walboomers J. M., Jacobs M.V., Manos M.M., Bosch F.C., Kummer J.A., Shah K.V., Snijders P.J., Peto J., Meijer C.J., & N Muñoz. (1999). Human papillomavirus is a necessary cause of invasive cervical cancer worldwide. Journal of Pathology . 189(1),12-9. https://pubmed.ncbi.nlm.nih.gov/10451482/
Wei F., Georges D., Man I., Baussano I., Clifford G.M. (2024). Causal attribution of human papillomavirus genotypes to invasive cervical cancer worldwide: a systematic analysis of the global literature. The Lancet, 404(10451), 435-444.
https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(24)01097-3/abstract
World Health Organization, Newsroom. 2025. Cervical Cancer – Key Facts. [internet]
https://www.who.int/news-room/fact-sheets/detail/cervical-cancer
WHO position paper, Strategic Advisory Group of Experts (SAGE). (2022). Human papillomavirus vaccines: WHO position paper. Weekly Epidemiological Records, 50(97), 645–672. https://www.who.int/publications/i/item/who-wer9750-645-672
World Health Organization. (2020) Global strategy to accelerate the elimination of cervical cancer as a public health problem. 17 November 2020. https://www.who.int/publications/i/item/9789240014107
World Health Organization. (2022). Human papillomavirus (HPV) nucleic acid amplification tests (NAATs) to screen for cervical pre-cancer lesions and prevent cervical cancer. Policy brief of 16 March 2022. https://www.who.int/publications/i/item/9789240045248
WHO guideline for screening and treatment of cervical pre-cancer lesions for cervical cancer prevention. (2021).
https://www.who.int/publications/i/item/9789240030824
Zur Hausen H. (2009). Papillomaviruses in the causation of human cancers — a brief historical account. Virology, 384(2), 260-265.
https://www.sciencedirect.com/science/article/pii/S0042682208007721
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