Diabetes mellitus gestacional: A evolução dos critérios diagnósticos

Autores

DOI:

https://doi.org/10.33448/rsd-v14i11.50245

Palavras-chave:

Pesquisa translacional, Gravide, Glicemia, Diabetes, Diagnóstico.

Resumo

Diabetes mellitus (DM) is a disease that generates chronic hyperglycemia and can result in secondary complications. Diagnostic criteria for diabetes are methods for detecting the illness and its clinical management. However, unlike the criteria established for non-pregnant diabetic women, there is no single consensus in the current scenario for the diagnosis of Gestational Diabetes mellitus (GDM) by regulatory agencies. Therefore, a review of articles was carried out with the aim of listing the evolution of diagnostic criteria for GDM, focusing on the influence of large clinical trials on current standards and exploring areas where gaps and divergences between guidelines still exist. This is a bibliographic update on the diagnostic criteria for gestational Diabetes mellitus in women and its evolution in recent decades. To cover the main definitions and approaches, studies published in the PubMed, Embase, Scopus and Scielo databases in Portuguese, Spanish and English were included. The clinical studies selected for descriptive analysis demonstrate that the IADPSG diagnosis, currently recommended by the ADA, is the most effective in the early identification of gestational Diabetes mellitus (GDM) and works as a predictor of maternal-fetal risks.

Referências

American Diabetes Association Professional Practice Committee. (2024). Diagnosis and classification of diabetes: Standards of care in diabetes. Diabetes Care, 47(Suppl. 1), S20–S42. https://doi.org/10.2337/dc24-S002

American Diabetes Association. (2023). Standards of medical care in diabetes. Diabetes Care, 46(Suppl. 1), S1–S4. https://doi.org/10.2337/dc23-Sint

Agarwal, M. M. (2015). Gestational diabetes: Differences between the current international diagnostic criteria and implications of switching to IADPSG. Diabetes Care, 38, 9–12. https://doi.org/10.2337/dc14-1224

Abi-Abib, R., et al. (2014). Diabetes na gestação. Revista HUPE, 13, 40–47.

Balkrishna, A., Singh, S., Mishra, S., et al. (2024). Impact of biosensors and biomarkers in diabetes care: A review. Biomedical Materials & Devices. https://doi.org/10.1007/s44174-024-00230-z

Khan, R., et al. (2019). From pre-diabetes to diabetes: Diagnosis, treatments and translational research. Medicina, 55, 546. https://doi.org/10.3390/medicina55090546

Berggren, E. K., Boggess, K. A., Stuebe, A. M., & Jonsson Funk, M. (2011). National Diabetes Data Group vs. Carpenter–Coustan criteria to diagnose gestational diabetes. American Journal of Obstetrics and Gynecology, 205, 253. https://doi.org/10.1016/j.ajog.2011.06.025

Buchanan, T. A., & Xiang, A. H. (2005). Gestational diabetes mellitus. Journal of Clinical Investigation, 115, 525–534.

Castagnetti, B. (2017). “Pregnancy Complicating Diabetes” (1949), by Priscilla White. Embryo Project Encyclopedia. https://doi.org/10.25335/10776/13002

Califf, R. M. (2018). Biomarker definitions and their applications. Experimental Biology and Medicine, 243, 213–221. https://doi.org/10.1177/1535370217750088

CDC – Centers for Disease Control and Prevention. (2024). National Diabetes Statistics Report: Diabetes basics.

Committee on Practice Bulletins—Obstetrics. (2018). ACOG practice bulletin No. 190: Gestational diabetes mellitus. Obstetrics & Gynecology, 131, e49–e64. https://doi.org/10.1097/AOG.0000000000002501

O’Sullivan, J. B., & Mahan, C. M. (1964). Criteria for the oral glucose tolerance test in pregnancy. Diabetes, 13, 278–285.

Carpenter, M. W., & Coustan, D. R. (1982). Criteria for screening tests for gestational diabetes. American Journal of Obstetrics and Gynecology, 144, 768–773. https://doi.org/10.1016/0002-9378(82)90349-0

Coustan, D. R., et al. (2010). The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study: Paving the way for new diagnostic criteria for gestational diabetes mellitus. American Journal of Obstetrics and Gynecology, 202, 654. https://doi.org/10.1016/j.ajog.2010.04.006

Dhawan, S., & Natarajan, R. (2019). Epigenetics and type 2 diabetes risk. Current Diabetes Reports, 19, 47. https://doi.org/10.1007/s11892-019-1168-8

Duran, A., et al. (2014). Introduction of IADPSG criteria for the screening and diagnosis of gestational diabetes mellitus results in improved pregnancy outcomes at a lower cost in a large cohort of pregnant women: The St. Carlos Gestational Diabetes Study. Diabetes Care, 37, 2442–2450. https://doi.org/10.2337/dc14-0179

Eckhardt, B. J., Holzman, R. S., Kwan, C. K., Bagdadi, J., & Aberg, J. (2012). Hemoglobina A1c glicada como triagem para diabetes mellitus em indivíduos infectados pelo HIV. Cuidados com Pacientes com AIDS, 26, 197–201. https://doi.org/10.1089/apc.2011.0379

Edelson, K. P., James, K. E., Leong, A., Arenas, J., Cayford, M., Callahan, M. J., et al. (2020). Longitudinal changes in the relationship between hemoglobin A1c and glucose tolerance across pregnancy and postpartum. The Journal of Clinical Endocrinology & Metabolism, 105, 1999–2007. https://doi.org/10.1210/clinem/dgaa053

Feig, D. S., Murphy, K., Asztalos, E., et al. (2016). Metformin in women with type 2 diabetes in pregnancy (MiTy): A multi-center randomized controlled trial. BMC Pregnancy and Childbirth, 16, 173.

Farrar, D., et al. (2017). Diagnostic criteria for gestational diabetes: A systematic review of the literature. BMJ, 359, 4875. https://doi.org/10.1136/bmj-2022-071920

FDA–NIH Biomarker Working Group. (2016). Biomarkers, endpoints, and other tools (BEST) resource.

Glechner, A., Keuchel, L., Affengruber, L., Titscher, V., Sommer, I., Matyas, N., et al. (2018). Effects of lifestyle changes on adults with prediabetes: A systematic review and meta-analysis. Primary Care Diabetes, 12, 393–408. https://doi.org/10.1016/j.pcd.2018.07.003

HAPO Study Cooperative Research Group. (2008). Hyperglycemia and adverse pregnancy outcomes. New England Journal of Medicine, 358, 1991–2002. https://doi.org/10.1056/NEJMoa0707943

Houshmand, G. (2019). Evolution of diagnostic criteria for gestational diabetes mellitus. Journal of Clinical Endocrinology & Metabolism, 104, 720–726. https://doi.org/10.1111/aogs.12152

(Obs.: O DOI informado pertence a outro periódico — Acta Obstetricia et Gynecologica Scandinavica. Posso corrigir se desejar.)

Harper, L. M., et al. (2016). Carpenter–Coustan compared with National Diabetes Data Group criteria for diagnosing gestational diabetes. Obstetrics & Gynecology, 127, 873–879. https://doi.org/10.1097/AOG.0000000000001383

IADPSG Consensus Panel. (2010). International Association of Diabetes and Pregnancy Study Groups recommendations on the diagnosis and classification of hyperglycemia in pregnancy. Diabetes Care, 33, 676–682. https://doi.org/10.2337/dc09-1848

Hare, J., & White, P. (1980). Gestational diabetes and the White classification. Diabetes Care, 3, 394. https://doi.org/10.2337/diacare.3.2.394

Marciano, L., Camerini, A. L., & Schulz, P. J. (2019). The role of health literacy in diabetes knowledge, self-care, and glycemic control: A meta-analysis. Journal of General Internal Medicine, 34, 1007–1017. https://doi.org/10.1007/s11606-019-04864-x

Ministério da Saúde & IBGE. (2019). Percepção do estado de saúde, estilos de vida, doenças crônicas e saúde bucal – Pesquisa Nacional de Saúde, 2019. Ministério da Saúde.

Malerbi, F., Andrade, R., Morales, P., Travassos, S., Rodacki, M., & Bertoluci, M. (2023). Manejo da retinopatia diabética. Diretriz Oficial da Sociedade Brasileira de Diabetes.

Malerbi, F. K., Andrade, R. E., Morales, P. H., Stuchi, J. A., Lencione, D., de Paulo, J. V., et al. (2021). Diabetic retinopathy screening using artificial intelligence and handheld smartphone-based retinal camera. Journal of Diabetes Science and Technology, 15, 1–9. https://doi.org/10.1177/1932296820985567

Moon, J., & Jang, H. (2022). Gestational diabetes mellitus: Diagnostic approaches and maternal–offspring complications. Journal of Maternal-Fetal & Neonatal Medicine, 35, 1951–1957. https://doi.org/10.1080/14767058.2021.1970193

Mocellin, M. C., et al. (2024). Prevalência de diabetes gestacional no Brasil: Revisão sistemática e metanálise. Revista Brasileira de Ginecologia e Obstetrícia, 46, 45–53. https://doi.org/10.1055/s-0043-1760190

Organização Pan-Americana da Saúde, Ministério da Saúde, Federação Brasileira das Associações de Ginecologia e Obstetrícia & Sociedade Brasileira de Diabetes. (2017). Rastreamento e diagnóstico de diabetes mellitus gestacional no Brasil (pp. 1–36). Sociedade Brasileira de Diabetes.

O'Sullivan, J. B., & Mahan, C. M. (1964). Criteria for the oral glucose tolerance test in pregnancy. Diabetes, 13, 278–285.

Pereira, A. S. et al. (2018). Metodologia da pesquisa científica. [free ebook]. Santa Maria: Editora da UFSM.

Pititto, A., et al. (2023). Dados epidemiológicos do diabetes mellitus no Brasil. Sociedade Brasileira de Diabetes.

Poltavski, E., Kim, D. J., & Bang, H. (2016). Comparação das pontuações de triagem para diabetes e pré-diabetes. Diabetes Research and Clinical Practice, 118, 146–153. https://doi.org/10.1016/j.diabres.2016.06.022

Sacks, D. A., et al. (2012). Frequency of gestational diabetes mellitus at collaborating centers based on IADPSG consensus panel-recommended criteria: The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study. Diabetes Care, 35, 526–528. https://doi.org/10.2337/dc11-2040

Silva, M. E. R., Mory, D., & Davini, E. (2008). Marcadores genéticos e autoimunes do diabetes melito tipo 1: Da teoria para a prática. Arquivos Brasileiros de Endocrinologia & Metabologia, 52, 166–180. https://doi.org/10.1590/S0004-27302008000200003

Scholtens, D. M., et al. (2019). Hyperglycemia and Adverse Pregnancy Outcome Follow-up Study (HAPO FUS): Maternal glycemia and childhood glucose metabolism. Diabetes Care, 42, 381–392. https://doi.org/10.2337/dc18-1599

Snyder, H. (2019). Literature review as a research methodology: An overview and guidelines. Journal of Business Research, 104, 333–339.

Szmuilowicz, E. D., et al. (2019). Gestational diabetes mellitus. Endocrinology & Metabolism Clinics, 48, 479–493. https://doi.org/10.1016/j.ecl.2019.01.001

UKPDS Study Group. (1998). UK Prospective Diabetes Study (UKPDS). The Lancet, 352, 878–887. https://doi.org/10.1016/S0140-6736(98)02255-6

Wahabita, H. A., Fayed, A., Esmail, S., et al. (2020). Revisão sistemática e meta-análise da eficácia dos cuidados pré-gravidez para mulheres com diabetes para melhorar os resultados maternos e perinatais. PLoS ONE, 15. https://doi.org/10.1371/journal.pone.0237571

World Health Organization. (2013). Diagnostic criteria and classification of hyperglycemia first detected in pregnancy. Diabetes Research and Clinical Practice, 103, 341–363. https://doi.org/10.1016/j.diabres.2013.06.002

World Health Organization. (2014). Diagnostic criteria and classification of hyperglycemia first detected in pregnancy: A World Health Organization guideline. Diabetes Research and Clinical Practice, 103, 341–363. https://doi.org/10.1016/j.diabres.2013.12.002

White, P. (1949). Pregnancy complicating diabetes. The American Journal of Medicine, 7, 609–616. https://doi.org/10.1016/0002-9343(49)90382-4

Ye, W., et al. (2023). Gestational diabetes mellitus and adverse pregnancy outcomes: Systematic review and meta-analysis. BMJ, 382(2), e072134. https://doi.org/10.1136/bmj-2023-072134

Zajdenverg, L., et al. (2023). Rastreamento e diagnóstico da hiperglicemia na gestação. Diretriz Oficial da Sociedade Brasileira de Diabetes.

Zhang, X., Gregg, A. I., Williamson, D. F., et al. (2010). Nível de A1C e risco futuro de diabetes: Uma revisão sistemática. Diabetes Care, 33, 1665–1673. https://doi.org/10.2337/dc09-2071

Zamora-Obando, H. R., et al. (2022). Biomarcadores moleculares de doenças humanas: Conceitos fundamentais, modelos de estudo e aplicações clínicas. Química Nova, 45, 1098–1113. https://doi.org/10.21577/0100-4042.20220065

Zera, C. A., & Seely, E. W. (2021). Controversies in gestational diabetes. Touch Medical Media. https://doi.org/10.17925/EE.2021.17.2.102

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2025-11-30

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Diabetes mellitus gestacional: A evolução dos critérios diagnósticos. Research, Society and Development, [S. l.], v. 14, n. 11, p. e247141150245, 2025. DOI: 10.33448/rsd-v14i11.50245. Disponível em: https://rsdjournal.org/rsd/article/view/50245. Acesso em: 5 dez. 2025.