Efficacy and safety of dental protocols used in a hospital setting for the treatment of patients with mucositis and leukoplakia: An integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v14i9.49530

Keywords:

Oral Health Team, Mucositis, Leukoplakia, Hospital Dentistry Team.

Abstract

The objective of this study was to analyze the effectiveness and safety of the procedures adopted by the hospital Dentistry team in the treatment of mucositis and leukoplakia, in order to verify if they are aligned with evidence-based practices for managing these conditions. The methodology of this literature review article is based on content analysis, following a qualitative approach. The material selection was carried out through an integrative search in the electronic databases SCOPUS®, MEDLINE®, and PUBMED®, using the predefined keywords. The inclusion criteria encompassed studies published in Portuguese and English that present results of original research, systematic reviews, case studies, or reports of oral care protocols in patients with mucositis or leukoplakia. The exclusion criteria were established to exclude works that did not fit the defined research parameters, such as studies published before 2010, articles that are not available in full text, research that does not specifically focus on personalized oral care for patients with mucositis and leukoplakia, or that are not linked to hospital Dentistry practice. 10 articles were selected for the study and as a conclusion, there was observed a variability in clinical practices, however, these were based on scientific evidence. The therapeutic approaches demonstrated the effectiveness and safety of the protocols adopted by the dental team in the treatment of mucositis and leukoplakia, resulting in improvements in the quality of life of the patients.

References

Anderson, P. M., & Lalla, R. V. (2020). Glutamine for amelioration of radiation and chemotherapy associated mucositis during cancer therapy. Nutrients, 12(6), 1675.

Aranega, A. M., Marcondes, et al. (2012). Qual a importância da Odontologia Hospitalar? Revista Brasileira de Odontologia, 69(1), 90.

Azevedo, B. A. (2021). Leucoplasia verrucosa proliferativa: Revisão da literatura com ênfase no diagnóstico, manejo e tratamento. Revista Naval de Odontologia, 48(1), 56–63.

Bardin, L. (2011). Análise de conteúdo. São Paulo, SP: Edições 70

Capella, D. L., et al (2017). Leucoplasia verrucosa proliferativa: diagnóstico, conduta e avanços atuais. Brazilian Journal of Otorhinolaryngology, 83(5), 585–593.

Duarte, N. C., Camargo, N., et al. (2016). Perfil dos pacientes com câncer de boca do núcleo de cirurgia de cabeça e pescoço HU/UFSC e encaminhados para suporte odontológico no núcleo de odontologia hospitalar HU/UFSC.

Guterres, Y., Grando, L. J., & Camargo, A. R. (2014). Avaliação dos benefícios da laserterapia no controle da dor causada pela mucosite oral radioinduzida

Hong, C. H. L., Gueiros, L. A., Fulton, J. S., Cheng, K. K. F., Kandwal, A., Galiti, D., Fall-Dickson, J. M., Johansen, J., Ameringer, S., Kataoka, T., Weikel, D., Eilers, J., Ranna, V., Vaddi, A., Lalla, R. V., Bossi, P., & Elad, S. (2019). Systematic review of basic oral care for the management of oral mucositis in cancer patients and clinical practice guidelines. Supportive Care in Cancer, 27(10), 3949–3967

Júnior, O. R., Borba, A. M., & Guimarães Júnior, J. (2010). Prevenção e tratamento da mucosite bucal: o papel fundamental do cirurgião-dentista – revisão. Archives of Oral Research, 6(1), 57–62.

Lanel, V. (2011). Leucoplasia verrucosa proliferativa X leucoplasias oral: um estudo clínico comparativo e análise crítica dos critérios de diagnóstico (Tese de doutorado). Universidade de São Paulo.

Lauritano, D., Lucchese, A., Gabrione, F., Di Stasio, D., Silvestre Rangil, J., & Carinci, F. (2019). The effectiveness of laser-assisted surgical excision of leukoplakias and hyperkeratosis of oral mucosa: A case series in a group of patients. International Journal of Environmental Research and Public Health, 16(2), 210.

Modolon, L. G., Grando, L. J., & Zimmermann, G. S. (2021). Osteorradionecrose dos maxilares em pacientes com câncer de boca e orofaringe: levantamento de casos e estudo dos diferentes tratamentos realizados pelo Núcleo de Odontologia Hospitalar do Hospital Universitário Professor Polydoro Ernani de São Thiago – HU/UFSC/EBSERH.

Saintigny, P., El-Naggar, A. K., Papadimitrakopoulou, V., Ren, H., Fan, Y. H., Feng, L., Lee, J. J., Kim, E. S., Hong, W. K., Lippman, S. M., & Mao, L. (2009). DeltaNp63 overexpression, alone and in combination with other biomarkers, predicts the development of oral cancer in patients with leukoplakia. Clinical Cancer Research, 15(19), 6284–6291.

Saleh, H. A., et al. (2016). Ambulatório odontológico para pacientes onco-hematológicos: estudo do impacto clínico e econômico.

Silva, A. C. T., Brew, M. C., Garcia, F. R., Moura, F. R. R., & Bavaresco, C. S. (2022). Uso da terapia fotodinâmica em lesões de mucosa bucal: uma revisão de literatura / Use of photodynamic therapy in oral mucosal lesions: a review of the literature. Brazilian Journal of Development, 8(2), 12714–1273.

Tofani, L. F. N., Furtado, L. A. C., Guimarães, C. F., Feliciano, D. G. C. F., Silva, G. R. D., Bragagnolo, L. M., Andreazza, R., & Chioro, A. (2021). Chaos, organization and creativity: Integrative review on Health Care Networks. Ciência & Saúde Coletiva, 26

Zadik, Y., Arany, P. R., Fregnani, E. R., Bossi, P., Antunes, H. S., Bensadoun, R. J., Gueiros, L. A., Majorana, A., Nair, R. G., Ranna, V., Tissing, W. J. E., Vaddi, A., Lubart, R., Migliorati, C. A., Lalla, R. V., Cheng, K. K. F., & Elad, S. (2019). Systematic review of photobiomodulation for the management of oral mucositis in cancer patients and clinical practice guidelines. Supportive Care in Cancer, 27(10), 3969–3983

Published

2025-09-18

Issue

Section

Health Sciences

How to Cite

Efficacy and safety of dental protocols used in a hospital setting for the treatment of patients with mucositis and leukoplakia: An integrative review. Research, Society and Development, [S. l.], v. 14, n. 9, p. e5614949530, 2025. DOI: 10.33448/rsd-v14i9.49530. Disponível em: https://rsdjournal.org/rsd/article/view/49530. Acesso em: 5 dec. 2025.