Relationship between medication and prognosis in patients with juvenile myoclonic epilepsy

Authors

DOI:

https://doi.org/10.33448/rsd-v15i1.48117

Keywords:

Juvenile Myoclonic Epilepsy, Medicine, Prognosis.

Abstract

Juvenile Myoclonic Epilepsy (JME) is a genetically determined idiopathic generalized epilepsy, which accounts for 5-11% among all patients with epilepsy. JME is characterized by seizures that begin in adolescence and are easily controlled with medication, but persist permanently. Often without related structural causes, however, the classic precipitating factors are sleep deprivation, stress, menstruation, fatigue and alcohol consumption. The present study aims to describe the relationship between medications and prognosis in patients with JME, in addition to correlating medication classes with the quality of life of these patients, being structured in a bibliographical review, of an integrative and qualitative type, of free and complete articles. of systematic reviews and meta-analysis, published between 2019 and 2024, in English, Spanish and Portuguese, collected in the PubMed and SciELO databases. There is a need to carry out new studies that highlight the relationship between medications recommended for JME and their prognosis, aiming to improve the patient's quality of life.

References

Alfradique, I., et al. (2007). Juvenile myoclonic epilepsy. Arquivos De Neuro-Psiquiatria, 65(4B), 1266–1271.

Amrutkar, C. V., & Riel-Romero, R. M. (2023). Juvenile myoclonic epilepsy. Statpearls publishing.

Bastos, M. C., et al. (2009). Epilepsia mioclônica juvenil: estudo clínico, epidemiológico, terapêutico e da qualidade de vida. J Epilepsy Clin Neurophysiol, 15(2), 65-69.

Baykan, B., & Wolf, P. (2017). Juvenile myoclonic epilepsy as a spectrum disorder: a focused review. Seizure, 49, 36-41.

Bin, G., et al. (2017). Patterns of gray matter abnormalities in idiopathic generalized epilepsy: a meta-analysis of voxel-based morphology studies. Plos One, 12(1), 1-11.

Carvalho, A., et al. (2021). Epilepsia mioclônica juvenil: uma análise acerca do tratamento. Brazilian Journal Of Development, 7(2), 10742-10749.

Chu, H., et al. (2023). Antiseizure medications for idiopathic generalized epilepsies: a systematic review and network meta-analysis. Journal Of Neurology, 270(10), 4713–4728.

Cordeiro, A. M., et al. (2007). Revisão sistemática: uma revisão narrativa. Rev Col Bras Cir, 34(6), 428-431.

Fukuda, A., et al. (2015). Circadian rhythm and profile in patients with juvenile myoclonic epilepsy and temporal lobe epilepsy. Arquivos De Neuro-Psiquiatria, 73(1), 3–6.

Giuliano, L., et al. (2021). Long-term prognosis of juvenile myoclonic epilepsy: a systematic review searching for sex differences. Seizure: European Journal Of Epilepsy, 86, 41-48.

Leite, C. DA C., et al. (2017). Proton spectroscopy of the thalamus in a homogeneous sample of patients with easy-to-control juvenile myoclonic epilepsy. Radiologia Brasileira, 50(5), 279–284.

Liu, J., Tai, Y.-J., & Wang, L. N. (2021). Topiramate for juvenile myoclonic epilepsy. Cochrane database of systematic Reviews, 2021(11).

Noffs, M. H. da S., et al. (2006). Desempenho cognitivo de pacientes com epilepsia do lobo temporal e epilepsia mioclônica juvenil: avaliação por meio da escala wais-iii. Journal Of Epilepsy And Clinical Neurophysiology, 12(1), 7–12.

Martins, H. H., et al. (2009). Adherence to treatment in patients with juvenile myoclonic epilepsy: correlation with quality of life and adverse effects of medication. Journal Of Epilepsy And Clinical Neurophysiology, 15(4), 192–196.

Moschetta, S., et al. (2010). Epilepsia mioclônica juvenil: endofenótipos distintos considerando aspectos neuropsicológicos, traços de personalidade e variáveis clínicas. Journal Of Epilepsy And Clinical Neurophysiology, 16(2), 51–58.

Stevelink, R., et al. (2022). Individualised prediction of drug resistance and seizure recurrence after medication withdrawal in people with juvenile myoclonic epilepsy: a systematic review and individual participant data meta-analysis. Eclinicalmedicine, 53, 1-13.

Stevelink, R., et al. (2019). Refractory juvenile myoclonic epilepsy: a meta-analysis of prevalence and risk factors. European Journal Of NeurologY, 26(6), 856–864.

Syvertsen, M. R., et al. (2012). Juvenile myoclonic epilepsy. Tidsskr Nor Laegeforen, 132(14), 1610-1613.

Trinka, E., et al. (2021). Exploring the evidence for broad-spectrum effectiveness of perampanel: a systematic review of clinical data in generalised seizures. Cns Drugs, 35(8), 821-837.

Yacubin, E. M. (2017). Juvenile myoclonic epilepsy: challenges on its 60th anniversary. Seizure, 44, 48-52.

Published

2026-01-21

Issue

Section

Health Sciences

How to Cite

Relationship between medication and prognosis in patients with juvenile myoclonic epilepsy. Research, Society and Development, [S. l.], v. 15, n. 1, p. e4915148117, 2026. DOI: 10.33448/rsd-v15i1.48117. Disponível em: https://rsdjournal.org/rsd/article/view/48117. Acesso em: 23 jan. 2026.