Resultados maternos e fetais de ratos submetidos à dieta rica em gordura e mistura de micronutrientes
DOI:
https://doi.org/10.33448/rsd-v14i3.48518Palavras-chave:
Roedores, Gravidez, Dieta Hiperlipídica, Micronutrientes, Desenvolvimento Fetal.Resumo
O consumo de dietas ricas em gordura é um problema global. Micronutrientes como cálcio e vitamina D trazem benefícios ao metabolismo da glicose, desempenho reprodutivo e desenvolvimento embriofetal. Este estudo tem como objetivo avaliar os efeitos de uma mistura de micronutrientes no metabolismo da glicose e nos resultados perinatais em ratos expostos a uma dieta rica em gordura (HFD). Ratas fêmeas receberam dieta padrão (DP) ou rica em gordura (DG) do desmame até o final da prenhez. Durante a gestação, um grupo recebeu a mistura de micronutrientes (Mix), formando quatro grupos: DP, DP+Mix, DG e DG+Mix. No final da prenhez, foram coletadas amostras de tecido adiposo, sangue materno e fetal e placenta. Ratas DG apresentaram maior número de fetos com baixo peso ao nascer em comparação às DP. Fetos de mães DP+Mix e DG+Mix tiveram concentrações séricas mais altas de vitamina D. O grupo DG+Mix apresentou maior concentração sérica materna de vitamina D, maior viabilidade fetal, menor peso de gordura visceral e menor taxa de mortes embrionárias em relação ao grupo DG. Assim, o tratamento com Mix trouxe benefícios para mães e filhos expostos à DG, promovendo melhor controle glicêmico materno, menor adiposidade, aumento da vitamina D e maior viabilidade embriofetal. Esse estudo reforça a importância de uma dieta saudável para o bem-estar materno e o desenvolvimento fetal adequado.
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