Non-parathyroid hypercalcemia secondary to granulomatous disease caused by mineral oil injections: A case report
DOI:
https://doi.org/10.33448/rsd-v14i9.49471Keywords:
Hypercalcemia, Mineral oil, Chronic granulomatous disease, Cosmetic technique.Abstract
The injection of mineral oil for cosmetic enhancement is a public health concern, as it may trigger chronic inflammatory responses and granuloma formation. Although rare, granulomatous inflammation can lead to non–PTH-dependent hypercalcemia through ectopic production of 1,25-dihydroxyvitamin D (calcitriol) by activated macrophages. This report aims to presente a clinical case study involving a 42-year-old man with a history of intramuscular mineral oil injections who presented with severe hypercalcemia, nephrocalcinosis, nephrolithiasis, and chronic kidney disease. Laboratory workup revealed elevated serum calcium and phosphate, suppressed parathyroid hormone (PTH), low 25-hydroxyvitamin D, and markedly elevated calcitriol. The patient responded well to treatment with oral prednisone and hemodialysis, leading to normalization of calcium levels. This case emphasizes the need to consider mineral oil-induced granulomatosis as a potential cause of non–PTH-dependent hypercalcemia, especially in patients with a history of aesthetic procedures involving oil-based substances.
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