Effect of resveratrol supplementation on muscle damage in animal model: an integrative review

Authors

DOI:

https://doi.org/10.33448/rsd-v9i11.10568

Keywords:

Antioxidant; Supplementation; Skeletal muscle.

Abstract

Introduction: Several functional properties have been proposed for Resveratrol and its natural analogues, such as its antioxidant potential, which can be related to the improvement of muscle damage. Objective: to investigate the effect of Resveratrol supplementation and natural analogues on skeletal muscle damage in animal model. Methodology: The studies were selected in May 2019 from Pubmed, Science direct, and Web of science databases, using the Boolean method in accordance with the inclusion criteria. Results: After the process of choosing and analyzing the articles, eight studies were selected to be included in this integrative review. The supplementation doses ranged from 2 to 25mg / kg for the injectable form and 15 to 100mg / kg for the oral form. Follow-up time ranged from 1 to 24 weeks. The results demonstrated a positive effect of resveratrol supplementation on skeletal muscle damage in all articles examined. Conclusion: The findings obtained in this review point to the benefits of using resveratrol as an important ally in the treatment and prevention of skeletal muscle damage.

References

Baltaci, S., Mogulkoc, R., & Baltaci, A. (2016). Resveratrol and exercise. Biomedical Reports, 5(5), 525–530.

Barroso, G. C., & Thiele, E. S. (2011). Muscle Injuries in Athletes. Revista Brasileira de Ortopedia, 46(4), 354–358. https://doi.org/10.1016/s2255-4971(15)30245-7

Cheng, Y., Di, S., Fan, C., Cai, L., Gao, C., Jiang, P., … Yang, Y. (2016). SIRT1 activation by pterostilbene attenuates the skeletal muscle oxidative stress injury and mitochondrial dysfunction induced by ischemia reperfusion injury. Apoptosis, 21(8), 905–916. https://doi.org/10.1007/s10495-016-1258-x

Feng, Y., He, Z., Mao, C., Shui, X., & Cai, L. (2019). Therapeutic effects of resveratrol liposome on muscle injury in rats. Medical Science Monitor, 25, 2377–2385. https://doi.org/10.12659/MSM.913409

Fisher-Wellman, K., & Bloomer, R. J. (2009). Acute exercise and oxidative stress: A 30 year history. Dynamic Medicine, 8(1), 1–25. https://doi.org/10.1186/1476-5918-8-1

Gordon, B. S., Delgado-Diaz, D. C., Carson, J., Fayad, R., Wilson, L. B., & Kostek, M. C. (2014). Resveratrol improves muscle function but not oxidative capacity in young mdx mice. Canadian Journal of Physiology and Pharmacology, 92(3), 243–251. https://doi.org/10.1139/cjpp-2013-0350

Hopia, H., Latvala, E., & Liimatainen, L. (2016). Reviewing the methodology of an integrative review. Scandinavian Journal of Caring Sciences, 30(4), 662–669. https://doi.org/10.1111/scs.12327

Menzies, K. J., Singh, K., Saleem, A., & Hood, D. A. (2013). Sirtuin 1-mediated effects of exercise and resveratrol on mitochondrial biogenesis. Journal of Biological Chemistry, 288(10), 6968–6979. https://doi.org/10.1074/jbc.M112.431155

Muhammad, M. H., & Allam, M. M. (2018). Resveratrol and/or exercise training counteract aging-associated decline of physical endurance in aged mice; targeting mitochondrial biogenesis and function. Journal of Physiological Sciences, 68(5), 681–688. https://doi.org/10.1007/s12576-017-0582-4

Naylor, A. J. D. (2009). Cellular effects of resveratrol in skeletal muscle. Life Sciences, 84(19–20), 637–640.

Pereira, M. B. P. (2013). O papel dos antioxidantes no combate ao estresse oxidativo observado no exercício físico de musculação. Revista Brasileira de Nutriçao Esportiva, 7(40), 223–245.

Rodríguez-Bies, E., Tung, B. T., Navas, P., & López-Lluch, G. (2016). Resveratrol primes the effects of physical activity in old mice. British Journal of Nutrition, 116(6), 979–988. https://doi.org/10.1017/S0007114516002920

Ryan, M. J., Jackson, J. R., Hao, Y., Williamson, C. L., Dabkowski, E. R., Hollander, J. M., & Alway, S. E. (2010). Suppression of oxidative stress by resveratrol after isometric contractions in gastrocnemius muscles of aged mice. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 65(8), 815–831. https://doi.org/10.1093/gerona/glq080

Sin, T. K., Yung, B. Y., Yip, S. P., Chan, L. W., Wong, C. S., Tam, E. W., & Siu, P. M. (2015). SIRT1-dependent myoprotective effects of resveratrol on muscle injury induced by compression. Frontiers in Physiology, 6(293). https://doi.org/10.3389/fphys.2015.00293

Ventura-Clapier, R. (2012). Potentiating exercise training with resveratrol. Journal of Physiology, 590(14), 3215–3216. https://doi.org/10.1113/jphysiol.2012.237743

Wang, W., Li, P., Xu, J., Wu, X., Guo, Z., Fan, L., … Teng, H. (2018). Resveratrol attenuates high glucose-induced nucleus pulposus cell apoptosis and senescence through activating the ROS-mediated PI3K/Akt pathway. Bioscience Reports, 38(2). https://doi.org/10.1042/BSR20171454

Whittemore, R., & Knafl, K. (2005). The integrative review: Updated methodology. Journal of Advanced Nursing, 52(5), 546–553. https://doi.org/10.1111/j.1365-2648.2005.03621.x

Zhao, Z. Q., & Vinten-Johansen, J. (2006). Postconditioning: Reduction of reperfusion-induced injury. Cardiovascular Research, 70(2), 200–211. https://doi.org/10.1016/j.cardiores.2006.01.024

Published

02/12/2020

How to Cite

BARROS, V. J. da S.; PEREIRA, M. M. L.; SILVINO, V. O.; SEVERO, J. S. .; SILVA, M. S. da .; SOUSA, B. L. S. C. . Effect of resveratrol supplementation on muscle damage in animal model: an integrative review. Research, Society and Development, [S. l.], v. 9, n. 11, p. e73591110568, 2020. DOI: 10.33448/rsd-v9i11.10568. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/10568. Acesso em: 26 apr. 2024.

Issue

Section

Health Sciences