Pentose phosphate pathway and phospholipid synthesis as future cancer treatment: a systematic review

Authors

DOI:

https://doi.org/10.33448/rsd-v9i12.10984

Keywords:

Glucose-6-phosphate; Metabolism; Neoplasia; Block; Oncogenic therapies.

Abstract

Understanding cell balance and interference with proliferative fate makes the pentose phosphate pathway an essential target in metabolic processes. The objective of this work was to review the scientific journals for indications and reasons to block the pentose phosphate pathway as an alternative practice in the treatment of neoplasia. This review was developed from an exploratory review of articles selected in the database platforms of Latin American and Caribbean Literature in Health Sciences (Lilacs), and Scientific Eletronic Libray Online (SciELO), Medical Literature Analysis and Retrieval System Online (MedLine) and Google Scholar, whose documents are crucial to raise proposals that the theme aims at. The studies reviewed in this article, demonstrated positive results and of great importance for the activity of the pentose phosphate pathway. When thinking about metabolic reprogramming, we obtain a significant link related to cancer, and the mechanisms that cells use to support environments with intense energy needs and the involvement of PPP pathway activity, still need to be better understood, considering that, be positively regulated in cancer and become an attractive target in search of tumor prognosis and define new cancer treatments.

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Published

21/12/2020

How to Cite

MARIANO, M. de C. S.; SILVA, M. B. .; LIMA , C. C. de .; SILVA, H. L. R. da; CARVALHO, M. das G. de S. .; ANDRADE, C. U. B. .; OLIVEIRA, W. R. M. .; SOARES, E. A.; LIMA, S. J. F. de; GARCIA, J. A. D. . Pentose phosphate pathway and phospholipid synthesis as future cancer treatment: a systematic review. Research, Society and Development, [S. l.], v. 9, n. 12, p. e25591210984, 2020. DOI: 10.33448/rsd-v9i12.10984. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/10984. Acesso em: 22 nov. 2024.

Issue

Vol. 9 No. 12

Section

Health Sciences

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Copyright (c) 2020 Mônica de Cássia Silvério Mariano; Milena Barros Silva; Ciderleia Castro de Lima ; Hélder Luiz Ribeiro da Silva; Maria das Graças de Souza Carvalho; Cláudia Umbelina Baptista Andrade; Wilson Roberto Mesquita Oliveira; Evelise Aline Soares; Samuel José Fernandes de Lima; José Antônio Dias Garcia

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