Analysis of the effectiveness of ozone therapy in the treatment of peri-implantitis: a scoping review




Ozone; Peri-implantitis; Dental implants.


Peri-implantitis is an inflammatory process that affects the tissues around an osseointegrated implant in function, resulting in the loss of the supporting bone. An acceptable cleaning technique must be able to debrid and detoxify the surface without traumatizing it. Therefore, the objective of the present scope review is to assess whether ozone therapy is effective in the treatment of peri-implantitis. For this, the study used the acronym PICOS. Pre-clinical in vivo studies in humans and clinical studies that evaluated the effectiveness of treating peri-implantitis with ozone were included. The searches were carried out in the PubMed, Embase, Scopus and Cochrane Library databases, and as a gray literature, a Google Scholar search was performed. The search strategy “" Ozone "AND (" Peri-Implantitis "OR" Dental Implants "OR" Peri-implant ")" was used. The reference management was performed using the EndNote Basic reference manager software. The Cochrane tool was used to assess the risk of bias in the studies that were included. The results of all studies were described in a narrative manner. This review included three articles. It was possible to see a significant reduction in all clinical parameters analyzed in the ozone group, except for the mucosal recession, which showed no or minimal improvement. Through the results of this review, it was possible to conclude that ozone therapy has great potential for the treatment of peri-implantitis, despite the high heterogeneity and the low quality of the inserted studies do not allow high quality evidence.


Almeida, J. M. et al. (2017). Effectiveness of Mechanical Debridement Combined With Adjunctive Therapies for Nonsurgical Treatment of Periimplantitis. Implant Dentistry, 26 (1), 137-144.

Amo, F. S. D. et al. (2016). Non-Surgical Therapy for Peri-Implant Diseases: a systematic review. Journal Of Oral And Maxillofacial Research, 7 (3), 1-14.

Bocci, V. A. (2006) Scientific and Medical Aspects of Ozone Therapy. State of the Art. Archives Of Medical Research, 37 (4), 425-435.

Busenlechner, D. et al. (2014) Long-term implant success at the Academy for Oral Implantology: 8-year follow-up and risk factor analysis. Journal Of Periodontal & Implant Science, 44 (3), 102-108.

Cosola, S. et al. (2018) Motivation of Patients to use Interdental Toothbrushes for the Domiciliary Management of Peri-Implants Health: different compliance according to the age. Dental Health: Current Research, 4 (2), 1-6.

Domb, W. (2014) Ozone Therapy in Dentistry. Interventional Neuroradiology, 20 (5), 632-636.

Figuero, E. et al. (2000) Management of peri-implant mucositis and peri-implantitis. Periodontology 2000, 66 (1), 255-273.

Gupta, G. (2012) Ozone therapy in periodontics. J Med Life. 22 (5), 59–67. Recuperado em

Hauser-gerspach, I. et al. (2011). Influence of gaseous ozone in peri-implantitis: bactericidal efficacy and cellular response. an in vitro study using titanium and zirconia. Clinical Oral Investigations, 16 (4), 1049-1059.

Isler, S. C. et al. (2020). The effects of decontamination methods of dental implant surface on cytokine expression analysis in the reconstructive surgical treatment of peri-implantitis. Odontology, 1-11.

Isler, S. C. et al. (2018). The effects of ozone therapy as an adjunct to the surgical treatment of peri-implantitis. Journal Of Periodontal & Implant Science, 48 (3), 136-151.

Kshitish, D. & Laxman, V. (2010). The use of ozonated water and 0.2% chlorhexidine in the treatment of periodontitis patients: a clinical and microbiologic study. Indian Journal Of Dental Research, 21 (3), 341-348.

Lindhe, J. & Meyle, J. (2008). Peri-implant diseases: consensus report of the sixth european workshop on periodontology. Journal Of Clinical Periodontology, 35, 282-285.

Liu, J. et al. (2015). Ozone therapy for treating foot ulcers in people with diabetes. Cochrane Database Of Systematic Reviews, 10, 1-35.

Liu, S. et al. (2020). chlorhexidine improve outcomes in non-surgical management of peri-implant mucositis or peri-implantitis?: a systematic review and meta-analysis. Medicina Oral Patología Oral y Cirugia Bucal, 25 (5), 608-615.

Madi, M. et al. (2018). Re-osseointegration of Dental Implants After Periimplantitis Treatments. Implant Dentistry, 27 (1), 101-110.

Nogales, C. G. et al. (2008). Ozone therapy in medicine and dentistry. J Contemp Dent Pract. 9 (4), p. 75–84.

Pommer, B. et al. (2016). Periimplantitis Treatment. Implant Dentistry, 25 (5), 646-649.

Razak, F. A. et al. (2019). Oxidizing Effect of Ozonated-Water on Microbial Balance in the Oral Ecosystem. Journal Of The College Of Physicians And Surgeons Pakistan, 29 (4), 387- 389.

Ren, C. et al. (2016). The effectiveness of low-level laser therapy as an adjunct to non-surgical periodontal treatment: a meta-analysis. Journal Of Periodontal Research, 52 (1), 8-20.

Saffarpour, A. et al. (2018). Microstructural Evaluation of Contaminated Implant Surface Treated by Laser, Photodynamic Therapy, and Chlorhexidine 2%. The International Journal Of Oral & Maxillofacial Implants, 33 (5), 1019-1026.

Saglam, E. (2020). Evaluation of the effect of topical and systemic ozone application in periodontitis: an experimental study in rats. Journal Of Applied Oral Science, 28, 1-8.

Saini, R. (2011). Ozone therapy in dentistry: a strategic review. Journal Of Natural Science, Biology And Medicine, 2 (2), 151-153.

Schmidlin, P. R. et al. (2012). Peri-implantitis prevalence and treatment in implantoriented private practices: A cross-sectional postal and Internet survey. Schweiz Monatsschr Zahnmed. 122 (12), 1136-1144.

Suarez, F. et al. (2013). Implant Surface Detoxification. Implant Dentistry, 22 (5), 465-473.

Suh, Y. et al. (2019). Clinical utility of ozone therapy in dental and oral medicine. Medical Gas Research, 9 (3), 163-167.

Traina, A. A. (2008). Efeitos biológicos do ozônio diluído em água na reparação tecidual de feridas dérmicas em ratos. Tese (Doutorado em Ciências Odontológicas - Universidade de São Paulo), São Paulo.

Tricco, A. C. et al. (2018). PRISMA extension for scoping reviews (PRISMA-ScR): checklist and explanation. Ann Intern Med, 169 (7), 467–473.

Valacchi G, Bocci V. (1999). Studies on the biological effects of ozone: 10. Release of factors from ozonated humsn platelets. Mediat Inflammat; 8 (4-5), 205-209.



How to Cite

SILVA, C. A. da .; PEREIRA, T. S.; QUIRINO, E. . C. S. .; IBIAPINA, I. M. P. .; FERNANDES, A. Úrsula R. . Analysis of the effectiveness of ozone therapy in the treatment of peri-implantitis: a scoping review . Research, Society and Development, [S. l.], v. 10, n. 1, p. e30210111465, 2021. DOI: 10.33448/rsd-v10i1.11465. Disponível em: Acesso em: 1 mar. 2021.



Review Article