Platelet-Rich Fibrin (PRF) effectiveness in maxillary sinus lift: case report




Sinus lift; Platelet-Rich Fibrin; Bone substitutes.


Incluir o resumo em inglês. The sinus lift surgery is a common procedure with predictable outcomes in dental practice. There is a great diversity and availability of bone substitutes. Hence, the materials to fill the sinus cavity have been studied and searched due to the requirement for a patterned material with the capacity of bone formation in a short period of time. Platelet-rich fibrin (PRF) is one of those materials that, due to its autologous feature, has low cost and a simplified protocol. Therefore, it has been widely used and has shown excellent results. Considering the benefits attributed to PRF, the aim of this study was to evaluate the effectiveness of its association with a bone substitute in maxillary sinus lift surgeries, compared to the exclusive use of that same substitute. This split-mouth study was evaluated clinically and histologically. Despite the histological indifferences between the samples analyzed, the association of PRF with bone substitute improved bone quality in the grafted region when compared to the side where only the bone substitute was used.


Al-Moraissi, E., Alkhutari, A., Abotaleb, B., Altairi, N., & Del Fabbro, M. (2020). Do osteoconductive bone substitutes result in similar bone regeneration for maxillary sinus augmentation when compared to osteogenic and osteoinductive bone grafts? A systematic review and frequentist network meta-analysis. International journal of oral and maxillofacial surgery, 49(1), 107-120.

Ali, S., Bakry, S. A., & Abd-Elhakam, H. (2015). Platelet-rich fibrin in maxillary sinus augmentation: a systematic review. Journal of Oral Implantology, 41(6), 746-753.

Basílio, J. C. S., de Lacerda, E. J. R., Vieira, M. V. S., de Lima Mendes, H., & de Lacerda, L. J. R. (2018). Análise Histológica de Levantamento de Seio Maxilar Utilizando Biomaterial Xenógeno Versus Sintético+ L-Prf (Fibrina Rica em Plaquetas e Leucócitos). The International Journal of Oral and Maxillofacial Implants, 1:25-9.

Browaeys, H., Bouvry, P., & De Bruyn, H. (2007). A literature review on biomaterials in sinus augmentation procedures. Clin Implant Dent Relat Res, 9(3), 166-177.

Chappuis, V., Engel, O., Reyes, M., Shahim, K., Nolte, L.-P., & Buser, D. (2013). Ridge alterations post-extraction in the esthetic zone: a 3D analysis with CBCT. Journal of Dental Research, 92(12_suppl), 195S-201S.

Choukroun, J., Diss, A., Simonpieri, A., Girard, M.-O., Schoeffler, C., Dohan, S. L., Mouhyi, J., & Gogly, B. (2006). Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part IV: clinical effects on tissue healing. Oral Surgery, Oral Medicine, Oral Pathology, and Oral Radiology, 101(3), e56-e60.

Clark, R. A. (2001). Fibrin and wound healing. Annals of the New York Academy of Sciences, 936, 355.

Danesh‐Sani, S., Engebretson, S. P., & Janal, M. N. (2017). Histomorphometric results of different grafting materials and effect of healing time on bone maturation after sinus floor augmentation: a systematic review and meta‐analysis. Journal of Periodontal Research, 52(3), 301-312.

Dohan, D. M., Choukroun, J., Diss, A., Dohan, S. L., Dohan, A. J., Mouhyi, J., & Gogly, B. (2006). Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part I: technological concepts and evolution. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 101(3), e37-e44.

Fardin, A. C., Jardim, E. C. G., Pereira, F. C., Guskuma, M. H., Aranega, A. M., & Garcia Júnior, I. R. (2010). Enxerto ósseo em odontologia: revisão de literatura. Innovations Implant Journal, 5(3), 48-52.

Gassling, V., Purcz, N., Braesen, J.-H., Will, M., Gierloff, M., Behrens, E., Açil, Y., & Wiltfang, J. (2013). Comparison of two different absorbable membranes for the coverage of lateral osteotomy sites in maxillary sinus augmentation: a preliminary study. Journal of Cranio-Maxillo-Facial Surgery, 41(1), 76-82.

Gutierres, M., Lopes, M. A., Hussain, N. S., Cabral, A. T., Almeida, L., & Santos, J. D. J. A. d. m. (2005). Substitutos Ósseos: conceitos gerais e estado actual. Arquivos de medicina, 19(4), 153-162.

Khiste, S. V., & Tari, R. N. (2013). Platelet-rich fibrin as a biofuel for tissue regeneration. ISRN Biomaterials, 2013.

Miron, R. J., Fujioka-Kobayashi, M., Hernandez, M., Kandalam, U., Zhang, Y., Ghanaati, S., & Choukroun, J. (2017). Injectable platelet rich fibrin (i-PRF): opportunities in regenerative dentistry? , Clinical Oral Investigations, 21(8), 2619-2627.

Miron, R. J., Zucchelli, G., Pikos, M. A., Salama, M., Lee, S., Guillemette, V., et al. (2017). Use of platelet-rich fibrin in regenerative dentistry: a systematic review. Clinical Oral Investigations, 21(6), 1913-1927.

Ortega-Mejia, H., Estrugo-Devesa, A., Saka-Herrán, C., Ayuso-Montero, R., López-López, J., & Velasco-Ortega, E. J. M. (2020). Platelet-Rich Plasma in Maxillary Sinus Augmentation: Systematic Review. Materials (Basel), 13(3), 622.

Pereira, A., Shitsuka, D., Parreira, F., & Shitsuka, R. (2018). Metodologia da pesquisa científica.[e-book]. In (Vol. 1): Santa Maria. Ed.

Prakash, S., & Thakur, A. (2011). Platelet concentrates: past, present and future. Journal of Oral and Maxillofacial Surgery, 10(1), 45-49.

Rodolfo, L. M., Machado, L. G., Betoni-Júnior, W., Faeda, R. S., Queiroz, T. P., & de Souza Faloni, A. P. S. (2017). Substitutos ósseos alógenos e xenógenos comparados ao enxerto autógeno: reações biológicas. Revista Brasileira Multidisciplinar, 20(1), 94-105.

Santos, D. D. D. d., de Omena Fragoso, F. C., de Lima Netto, T. J., da Silva Oliveira, E., de Brito, W. T. P., da Silva, C. P., & Cavalcanti, T. C. J. R. d. A.-I.-. (2017). Uso dos concentrados plaquetários rico em fibrina e leucócitos (L-PRF) na cirurgia de levantamento de seio maxilar. Revista da AcBO, 6(2).

Simonpieri, A., Choukroun, J., Del Corso, M., Sammartino, G., & Ehrenfest, D. M. D. J. I. d. (2011). Simultaneous sinus-lift and implantation using microthreaded implants and leukocyte-and platelet-rich fibrin as sole grafting material: a six-year experience. Implant Dentistry, 20(1), 2-12.

Tatullo, M., Marrelli, M., Cassetta, M., Pacifici, A., Stefanelli, L. V., Scacco, S., . . .& Inchingolo, F. J. (2012). Platelet Rich Fibrin (PRF) in reconstructive surgery of atrophied maxillary bones: clinical and histological evaluations. International Journal of Medical Sciences, 9(10), 872.

Woo, I., & Le, B. J. (2004). Maxillary sinus floor elevation: review of anatomy and two techniques. Implant Dentistry, 13(1), 28-32.

Wu, C. L., Lee, S. S., Tsai, C. H., Lu, K. H., Zhao, J. H., & Chang, Y. C. (2012). Platelet‐rich fibrin increases cell attachment, proliferation and collagen‐related protein expression of human osteoblasts. Australian Dental Journal, 57(2), 207-212.

Zhang, Y., Tangl, S., Huber, C. D., Lin, Y., Qiu, L., & Rausch-Fan, X. (2012). Effects of Choukroun’s platelet-rich fibrin on bone regeneration in combination with deproteinized bovine bone mineral in maxillary sinus augmentation: a histological and histomorphometric study. Journal of Cranio-Maxillofacial Surgery, 40(4), 321-328.



How to Cite

TCHEMRA , F. G. C. .; REZENDE, M.; MORELLI, F. M. .; MEDEIROS, S. T. C. B. .; DINIZ, A. G. . Platelet-Rich Fibrin (PRF) effectiveness in maxillary sinus lift: case report. Research, Society and Development, [S. l.], v. 10, n. 1, p. e29210111492, 2021. DOI: 10.33448/rsd-v10i1.11492. Disponível em: Acesso em: 22 jan. 2021.



Health Sciences