Thermographic evaluation of piroxicam’s effect as an adjuvant treatment in canine mammary tumors

Authors

DOI:

https://doi.org/10.33448/rsd-v10i2.12236

Keywords:

Canine; Oncology; Inflammation; Mammary Gland; COX-2 Inhibitors.

Abstract

Mammary tumors are the second most diagnosed neoplasms in dogs. Canine females are largely affected by malignant mammary tumours. Several factors are involved in the development and determination of the malignancy of these lesions, including the action of cyclooxygenase-2. Use of non-steroidal anti-inflammatory drugs as enzyme-inhibiting drugs has been studied as a promising adjuvant treatment for neoplasms. The aim of this study was to evaluate the effect of piroxicam in reducing inflammation caused by mammary tumours in 25 bitches during 10 days of administration based on the measurement of peritumoral temperature using thermography. The results indicated a significant difference (p=0,003) between the average temperatures at the first and last day of treatment. When performing the evaluation of malignant and benign neoplasms separately, it was possible to observe that, statistically, malignant neoplasms (n=19) showed a significant reduction in peritumoral temperatures (P=<0.001), however, benign neoplasms (n=6) have not obtained a significant difference in temperature after the therapeutic protocol (P=0.954). Therefore, it was possible to demonstrate the efficacy of the medication in reducing the heat caused by inflammation and allowing advances in the development of therapeutic protocols for mammary tumors in bitches, such as the inclusion of the drug in the period prior to the mastectomy surgeries.

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Published

10/02/2021

How to Cite

GREGHI, J. R.; FERNANDES, M. P.; GROTH, A.; SILVA, L. A. dos S.; SCHNITZER, J. de F.; DI SANTIS, G. W. .; MARTINS, M. I. M. Thermographic evaluation of piroxicam’s effect as an adjuvant treatment in canine mammary tumors. Research, Society and Development, [S. l.], v. 10, n. 2, p. e18710212236, 2021. DOI: 10.33448/rsd-v10i2.12236. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/12236. Acesso em: 17 nov. 2024.

Issue

Vol. 10 No. 2

Section

Agrarian and Biological Sciences

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Copyright (c) 2021 Julia Rodrigues Greghi; Maíra Planzo Fernandes, Aline Groth, Letícia Amanda dos Santos Silva, Josiana de Fátima Schnitzer, Giovana Wingeter Di Santis, Maria Isabel Mello Martins

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