Covid-19 and tuberculosis: coinfection and risks
DOI:
https://doi.org/10.33448/rsd-v10i2.12257Keywords:
Coinfection; Coronavirus Infections; Prognosis; Tuberculosis.Abstract
Objective: To evaluate the characteristics, evolution and outcome of patients co-infected with COVID-19 and tuberculosis (TB). Methodology: In order to answer the guiding question “What are the risks of coinfection by COVID-19 and tuberculosis?”, an integrative literature review, qualitative, with a descriptive approach, was carried out in the Google Scholar, PubMed, Cochrane Library, SciELO and LILACS databases, using the descriptors “COVID -19”, “Tuberculosis” and “Co-infection”. Inclusion criteria were: article available in full, published in 2020, in Portuguese, English and/or Spanish. Articles unrelated to the topic, with a focus on statistical tools, isolated abstracts, book chapters, editorials, review articles, technical sheets, theses, dissertations and course completion papers were excluded. Results: 8 articles were included. Most of the co-infected patients were male, with a mean age of 47.19 years. The most reported symptoms were fever, cough, dyspnoea and headache. The main laboratory changes included elevation of C-reactive protein, erythrocyte sedimentation rate, D-dimer and fibrinogen. Imagological findings such as opacifications, pleural effusion, “sprouting tree”, ground glass, cavitations, atelectasis and thickening of the lobar septum were frequent. Co-infection was more linked to severe cases of the disease and lethality was up to 33.3%. Socially, co-infection results in difficulties in differential diagnosis, morbidity in vulnerable groups and difficulty in accessing treatment in a pandemic scenario. Conclusion: Some studies differed on lethality, but it was possible to observe a trend towards an association between the severity of the clinical course in co-infected patients.
References
Adepoju, P. (2020). Tuberculosis and HIV responses threatened by COVID-19. The Lancet HIV, 7 (5), e319-e320.
Ata, F., Yousaf, Q., Parambil, J. V., Parengal, J., Mohamedali, M. G., & Yousaf, Z. (2020). A 28-Year-Old Man from India with SARS-Cov-2 and Pulmonary Tuberculosis Co-Infection with Central Nervous System Involvement. The American journal of case reports, 21, e926034-1–e926034-5.
Bandyopadhyay, A., Palepu, S., Bandyopadhyay, K., & Handu, S. (2020). COVID-19 and tuberculosis co-infection: a neglected paradigm. Monaldi Archives for Chest Disease, 90 (3), 518-522.
Boffa, J., Mhlaba, T., Sulis, G., Moyo, S., Sifumba, Z., Pai, M., & Daftary, A. (2020). COVID-19 and tuberculosis in South Africa: A dangerous combination. SAMJ: South African Medical Journal, 110 (5), 1-2.
Chen, Y., Wang, Y., Fleming, J., Yu, Y., Gu, Y., Liu, C., Fan, L., Xiaodan, W., Cheng, M., Bi, L., & Liu, Y. (2020). Active or latent tuberculosis increases susceptibility to COVID-19 and disease severity. MedRxiv. https://doi.org/10.1101/2020.03.10.20033795.
Falavigna, M., Colpani, V., Stein, C., Azevedo, L. C. P., Bagattini, A. M., Brito, G. V. de, Chatkin J. M., Cimerman, S., Corradi, N. de F. D. B., Cunha, C. A. da, Medeiros, F. C. de, Oliveira Junior, H. A. de, Fritscher, L. G., Gazzana, M. B., Gräf1, D. D., Marra, L. P., Matuoka, J. Y., Nunes, M. S., Pachito, D. V., Pagano1, C. G. M., Parreira, P. do C. S., Riera, R., Silva Júnior, A., Tavares, B. de M., Zavascki, A. P., Rosa1, R. G., & Dal-Pizzol, F. (2020). Diretrizes para o tratamento farmacológico da COVID-19. Consenso da Associação de Medicina Intensiva Brasileira, da Sociedade Brasileira de Infectologia e da Sociedade Brasileira de Pneumologia e Tisiologia. Revista Brasileira de Terapia Intensiva, 32 (2), 166-196.
Freij, B. J., Gebara, B. M., Tariq, R., Wang, A. M., Gibson, J., El-Wiher, N., Krasan, G., Patek, P. M., Levasseur, K. A., Amin, M., & Fullmer, J. M. (2020). Fatal Central Nervous System Co-Infection with SARS-CoV-2 and Tuberculosis in a Healthy Child. BMC Pediatrics, 20 (1), 429.
Gao, Y., Liu, M., Chen, Y., Shi, S., Geng, J., & Tian, J. (2020). Association between tuberculosis and COVID‐19 severity and mortality: A rapid systematic review and meta‐analysis. Journal of Medical Virology. 10.1002/jmv.26311
Grenho, F., Lourenço, A., Ventura, S., Bogalho, I., Bargiela, I., Silva, C. S., Martins, F., Hatchbach, L., Lopes, N., Prades, A., & Gomes, M. J. (2020). Características Clínicas de Doentes com COVID-19 num Internamento Dedicado do Hospital CUF Infante Santo: Série de Casos. Gazeta Médica, 7 (2), 82-91.
Guimarães, R. M., Lobo, A. D. P., Siqueira, E. A., Borges, T. F. F., & Melo, S. C. C. (2012). Tuberculose, HIV e pobreza: tendência temporal no Brasil, Américas e mundo. Jornal brasileiro de Pneumologia, 38 (4), 511-517.
He, G., Wu, J., Shi, J., Dai, J., Gamber, M., Jiang, X., Sun, W., & Cai, J. (2020). COVID‐19 in Tuberculosis patients: a report of three cases. Journal of Medical Virology, 92 (10), 1802-1806.
Khurana, A. K., & Aggarwal, D. (2020). The (in) significance of TB and COVID-19 co-infection. European Respiratory Journal, 56 (2), 56-58.
Köche, J. C. (2011). Fundamentos de metodologia científica. (Edição Digital). Rio de Janeiro: Editora Vozes.
Kumar, R., Bhattacharya, B., Meena, V., Soneja, M., & Wig, N. (2020). COVID-19 and TB co-infection-'Finishing touch''in perfect recipe to'severity’or ‘death'. Journal of Infection, 81 (3), e39-e40.
Lai, C. C., & Yu, W. L. (2020). The COVID-19 Pandemic and Tuberculosis in Taiwan. The Journal of Infection, 81 (2), e159-e161.
Luciani, M., Bentivegna, E., Spuntarelli, V., Lamberti, P. A., Guerritore, L., Chiappino, D., Nalli, G., Proietta, M., Porto, F. D., Martelletti P., & Sesti, G. (2020). Coinfection of Tuberculosis Pneumonia and COVID-19 in a Patient Vaccinated with Bacille Calmette-Guérin (BCG): Case Report. SN comprehensive clinical medicine, 2 (11), 2419-2422.
Lüdke, M., & André, M. (2013). Pesquisa em educação: abordagens qualitativas (2a ed.). E.P.U.
Maciel, E. L. N., Gonçalves Júnior, E., & Dalcolmo, M. M. P. (2020). Tuberculose e coronavírus: o que sabemos? Epidemiologia e Serviços de Saúde, 29 (2), e2020128.
Ministério da Saúde. (2017). Brasil Livre da Tuberculose: Plano Nacional pelo Fim da Tuberculose como Problema de Saúde Pública. http://bvsms.saude.gov.br/bvs/publicacoes/brasil_livre_tuberculose_plano_nacional.pdf.
Ministério da Saúde. (2020). Diretrizes para Diagnóstico e Tratamento da COVID-19. https://portalarquivos.saude.gov.br/images/pdf/2020/May/13/Diretriz-Covid19-v4.pdf
Motta, I., Centis, R., D’Ambrosio, L., García-García, J. M., Goletti, D., Gualano, G., Lipani, F., Palmieri, F., Sánchez-Montalvá, A., Pontali, E., Sotgiu, G., Spanevello, A., Stochino, C., Tabernero, E., Tadolini, M., van den Boom, M., Villa, S., Visca, D., & Migliori, G. B. (2020). Tuberculosis, COVID-19 and migrants: preliminary analysis of deaths occurring in 69 patients from two cohorts. Pulmonology, 26 (4), 233-240.
Pereira, A. S., Shitsuka, D. M., Parreira, F. J., & Shitsuka, R. (2018). Metodologia da pesquisa científica.[e-book]. Santa Maria. Ed (pp. 3-9). UAB/NTE/UFSM. https://repositorio. ufsm. br/bitstream/handle/1/15824/Lic_Computacao_Metodologia-Pesquisa-Cientifica. pdf.
Romeral, R. D. A. F., Caldeira, M. E. B., Alves-Olher, V. G., & Vandresen, F. (2020). Repositioning drugs for treatment of SARS-CoV-2. Brazilian Journal of Development, 6 (11), 85263-85283.
Sarınoğlu, R. C., Sili, U., Eryuksel, E., Yildizeli, S. O., Cimsit, C., & Yagci, A. K. (2020). Tuberculosis and COVID-19: An overlapping situation during pandemic. The Journal of Infection in Developing Countries, 14 (07), 721-725.
Singh, A., Prasad, R., Gupta, A., Das, K., & Gupta, N. (2020). Severe acute respiratory syndrome coronavirus-2 and pulmonary tuberculosis: convergence can be fatal. Monaldi Archives for Chest Disease, 90 (3), 441-450.
Souza, M. T. D., Silva, M. D. D., & Carvalho, R. D. (2010). Revisão integrativa: o que é e como fazer. Einstein, 8 (1), 102-106.
Stochino, C., Villa, S., Zucchi, P., Parravicini, P., Gori, A., & Raviglione, M. C. (2020). Clinical characteristics of COVID-19 and active tuberculosis co-infection in an Italian reference hospital. European Respiratory Journal, 56 (1), 2001708.
Tadolini, M., Codecasa, L. R., García-García, J. M., Blanc, F. X., Borisov, S., Alffenaar, J. W., Andréjak, C., Bachez, P., Bart, P. A., Belilovski, E., Cardoso-Landivar, J., Centis, R., D'Ambrosio, L., Souza-Galvão, M. L. de, Dominguez-Castellano, A., Dourmane, S., Jachym, M. F., Froissart, A., Giacomet, V., Goletti, D., Grard, S., Gualano, G., Izadifar, A., Du, D. L., Royo, M. M., Mazza-Stalder, J., Motta, I., Ong, C. W. M., Palmieri, F., Rivière, F., Rodrigo, T., Silva, D. R., Sánchez-Montalvá, A., Saporiti, M., Scarpellini, P., Schlemmer, F., Spanevello, A., Sumarokova, E., Tabernero, E., Tambyah, P. A., Tiberi, S., Torre, A., Visca, D., Murguiondo, M. Z., Sotgiu, G. & Migliori, G. B. (2020). Active tuberculosis, sequelae and COVID-19 co-infection: first cohort of 49 cases. European Respiratory Journal, 56 (1), 2001398.
Tadolini, M., García-García, J. M., Blanc, F. X., Borisov, S., Goletti, D., Motta, I., Codecasa, L. R., Tiberi, S., Sotgiu, G., & Migliori, G. B. (2020). On tuberculosis and COVID-19 co-infection. European Respiratory Journal, 56(2), 2002328.
Teich, V. D., Klajner, S., Almeida, F. A. S. D., Dantas, A. C. B., Laselva, C. R., Torritesi, M. G., Canero, T. R., Berwanger, O., Rizzo, L. V., Reis, E. P. & Cendoroglo Neto, M. (2020). Características epidemiológicas e clínicas dos pacientes com COVID-19 no Brasil. Einstein (São Paulo), 18, 1-7.
Tham, S. M., Lim, W. Y., Lee, C. K., Loh, J., Premkumar, A., Yan, B., Kee, A., Chai, L., Tambyah, P. A., & Yan, G. (2020). Four patients with COVID-19 and tuberculosis, Singapore, April–may 2020. Emerging Infectious Diseases, 26 (11), 2763-2765.
Yang, H., & Lu, S. (2020). COVID-19 and tuberculosis. Journal of Translational Internal Medicine, 8 (2), 59-65.
Yao, Z., Chen, J., Wang, Q., Liu, W., Zhang, Q., Nan, J., Huang, H., Wu, Y., Li, L., Liang, L., You, L., Liu, Y., & Yu, H. (2020). Three Patients with COVID-19 and Pulmonary Tuberculosis, Wuhan, China, January–February 2020. Emerging infectious diseases, 26 (11), 2754.
Yousaf, Z., Khan, A. A., Chaudhary, H. A., Mushtaq, K., Parengal, J., Aboukamar, M., Khan, M. U., & Mohamed, M. F. (2020). Cavitary pulmonary tuberculosis with COVID-19 coinfection. IDCases, 22, e00973.
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Copyright (c) 2021 Mellyne Henriques Guerra; Ana Caroline Gusmão de Matos; José Bento dos Santos; Déborah Esteves Carvalho; Manuelli Antunes da Silva; Tatiana Martins Araújo Ribeiro ; Carlos Alberto Góis Barreto; Cristóvão Almeida Barros; Filipe de Almeida Barbosa; Carla Viviane Freitas de Jesus
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